Research graph
References from Drug repositioning based on network-specific core genes identifies potential drugs for the treatment of autism spectrum disorder in children. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1038/nrneurol.2013.278
10.1038/nrneurol.2013.278 · External reference
10.1016/s1474-4422(15)00050-2
10.1016/s1474-4422(15)00050-2 · External reference
Unresolved reference
External reference
10.1097/yco.0000000000000132
10.1097/yco.0000000000000132 · External reference
Drug treatments for core symptoms of autism spectrum disorder: unmet needs and future directions
10.1055/s-0037-1602823 · 2017 · External reference
10.7150/ijbs.24612
10.7150/ijbs.24612 · External reference
10.1038/nrd.2018.168
10.1038/nrd.2018.168 · External reference
10.1038/nrd1468
10.1038/nrd1468 · External reference
In silico methods for drug repurposing and pharmacology
10.1002/wsbm.1337 · 2016 · External reference
10.1038/nrc2044
10.1038/nrc2044 · External reference
Transcriptome signature reversion as a method to reposition drugs against cancer for precision oncology
10.1097/ppo.0000000000000370 · 2019 · External reference
Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease
10.1126/scitranslmed.3002648 · 2011 · External reference
10.1038/nn.4618
10.1038/nn.4618 · External reference
10.1038/nrn3992
10.1038/nrn3992 · External reference
10.1371/journal.pgen.1003523
10.1371/journal.pgen.1003523 · External reference
10.1038/nature20612
10.1038/nature20612 · External reference
10.1038/nrg2918
10.1038/nrg2918 · External reference
Network mirroring for drug repositioning
10.1186/s12911-017-0449-x · 2017 · External reference
Altered expression of histamine signaling genes in autism spectrum disorder
10.1038/tp.2017.87 · 2017 · External reference
10.1371/journal.pbio.1002558
10.1371/journal.pbio.1002558 · External reference
Conserved expression of lincRNA during human and macaque prefrontal cortex development and maturation
2014 · External reference
10.15252/msb.20145487
10.15252/msb.20145487 · External reference
10.1093/bioinformatics/btu170
10.1093/bioinformatics/btu170 · External reference
10.1093/bioinformatics/btp120
10.1093/bioinformatics/btp120 · External reference
HTSeq—a Python framework to work with high-throughput sequencing data
10.1093/bioinformatics/btu638 · 2015 · External reference
10.1186/s13059-014-0550-8
10.1186/s13059-014-0550-8 · External reference
Unresolved reference
External reference
WGCNA: an R package for weighted correlation network analysis
10.1186/1471-2105-9-559 · 2008 · External reference
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
2010 · External reference
10.1186/2040-2392-4-36
10.1186/2040-2392-4-36 · External reference
10.1093/nar/gkr1145
10.1093/nar/gkr1145 · External reference
DrugBank: a comprehensive resource for in silico drug discovery and exploration
10.1093/nar/gkj067 · 2006 · External reference
10.1093/bioinformatics/bty982
10.1093/bioinformatics/bty982 · External reference
10.1073/pnas.0506580102
10.1073/pnas.0506580102 · External reference
10.1016/j.cell.2017.10.049
10.1016/j.cell.2017.10.049 · External reference
Unresolved reference
2016 · External reference
10.18653/v1/k18-2016
10.18653/v1/k18-2016 · External reference
Disease Ontology: improving and unifying disease annotations across species
2018 · External reference
10.1093/nar/gku955
10.1093/nar/gku955 · External reference
Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action
10.1371/journal.pone.0102579 · 2014 · External reference
Unresolved reference
External reference
10.1089/omi.2011.0118
10.1089/omi.2011.0118 · External reference
Alzheimer's disease master regulators analysis: search for potential molecular targets and drug repositioning candidates
10.1186/s13195-018-0394-7 · 2018 · External reference
10.1152/physiolgenomics.00208.2006
10.1152/physiolgenomics.00208.2006 · External reference
Functions of the left superior frontal gyrus in humans: a lesion study
10.1093/brain/awl244 · 2006 · External reference
10.1016/j.neuroimage.2017.04.024
10.1016/j.neuroimage.2017.04.024 · External reference
10.1038/nrn3978
10.1038/nrn3978 · External reference
10.1016/j.bbr.2014.12.044
10.1016/j.bbr.2014.12.044 · External reference
Mitochondrial dysfunction in Autism Spectrum Disorder: clinical features and perspectives
10.1016/j.conb.2017.05.018 · 2017 · External reference
Mitochondrial dysfunction in autism
10.1001/jama.2010.1706 · 2010 · External reference
Autism spectrum disorders associated to a deficiency of the enzymes of the mitochondrial respiratory chain
10.1007/s11011-013-9419-x · 2013 · External reference
Unresolved reference
External reference
10.1111/j.1471-4159.2011.07189.x
10.1111/j.1471-4159.2011.07189.x · External reference
Downregulation of the expression of mitochondrial electron transport complex genes in autism brains
10.1111/bpa.12002 · 2013 · External reference
Unresolved reference
External reference
Evaluating Protein-protein Interaction (PPI) Networks for Diseases Pathway, Target Discovery, and Drug-design Using ‘In silico Pharmacology‘
2014 · External reference
10.1016/j.ymeth.2012.06.003
10.1016/j.ymeth.2012.06.003 · External reference
The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour
10.1038/s41467-019-11203-y · 2019 · External reference
Glutamatergic and GABAergic gene sets in attention-deficit/hyperactivity disorder: association to overlapping traits in ADHD and autism
10.1038/tp.2016.273 · 2017 · External reference
Commonality in dysregulated expression of gene sets in cortical brains of individuals with autism, schizophrenia, and bipolar disorder
10.1038/s41398-019-0488-4 · 2019 · External reference
10.1016/s0140-6736(85)90228-4
10.1016/s0140-6736(85)90228-4 · External reference
10.1007/s00787-019-01333-5
10.1007/s00787-019-01333-5 · External reference
Sulpiride augmentation for schizophrenia
10.1093/schbul/sbp163 · 2010 · External reference
Use of sulpiride in a case of atypical autism
10.1007/bf02211825 · 1988 · External reference
Abnormal fatty acids in Canadian children with autism
10.1016/j.nut.2015.10.019 · 2016 · External reference
The n-3 polyunsaturated fatty acid/dopamine hypothesis of schizophrenia
10.1016/j.pnpbp.2006.11.013 · 2007 · External reference
10.1016/j.tins.2009.04.003
10.1016/j.tins.2009.04.003 · External reference
10.1001/jamanetworkopen.2019.6126
10.1001/jamanetworkopen.2019.6126 · External reference
Mechanistic evaluation of neuroprotective effect of estradiol on rotenone and 6-OHDA induced Parkinson's disease
2017 · External reference
Unresolved reference
External reference
10.1186/s13229-018-0199-3
10.1186/s13229-018-0199-3 · External reference
Complex effects of 17β-estradiol on mitochondrial function
2012 · External reference
10.1016/0169-328x(86)90006-9
10.1016/0169-328x(86)90006-9 · External reference
Hierarchical cortical transcriptome disorganization in autism
10.1186/s13229-017-0147-7 · 2017 · External reference
Transcriptome of iPSC-derived neuronal cells reveals a module of co-expressed genes consistently associated with autism spectrum disorder
2020 · External reference
Histone deacetylase inhibitor MS-275 restores social and synaptic function in a Shank3-deficient mouse model of autism
2018 · External reference
Beneficial effects of everolimus on autism and attention-deficit/hyperactivity disorder symptoms in a group of patients with tuberous sclerosis complex
2016 · External reference
Everolimus for epilepsy and autism spectrum disorder in tuberous sclerosis complex: EXIST-3 substudy in Japan
2019 · External reference
A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder
10.1001/archpsyc.1996.01830110037005 · 1996 · External reference
Clinical evaluation of treatment with fluvoxamine, a selective serotonin reuptake inhibitor in children with autistic disorder
2001 · External reference
Neuropsychopharmacotherapeutic efficacy of curcumin in experimental paradigm of autism spectrum disorders
10.1016/j.lfs.2015.09.012 · 2015 · External reference
The Kv7/KCNQ channel blocker XE991 protects nigral dopaminergic neurons in the 6-hydroxydopamine rat model of Parkinson's disease
10.1016/j.brainresbull.2017.11.011 · 2018 · External reference
10.1002/hipo.20717
10.1002/hipo.20717 · External reference
Experimental traumatic brain injury results in estrous cycle disruption, neurobehavioral deficits, and impaired GSK3β/β-catenin signaling in females
10.1016/j.expneurol.2019.01.017 · 2019 · External reference
10.1038/nn.2213
10.1038/nn.2213 · External reference
Increase of cytosolic phospholipase A2 as hydrolytic enzyme of phospholipids and autism cognitive, social and sensory dysfunction severity
10.1186/s12944-016-0391-4 · 2017 · External reference
