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References from Direct interaction between ABCA1 and HIV-1 Nef: Molecular modeling and virtual screening for inhibitors. Local targets link to admitted publications; unresolved targets remain external evidence.
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Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA
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Nef secretion into extracellular vesicles or exosomes is conserved across Human and Simian Immunodeficiency Viruses
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Nef exosomes isolated from the plasma of individuals with HIV-associated dementia (HAD) can induce Abeta1-42 secretion in SH-SY5Y neural cells
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Modification of lipid rafts by extracellular vesicles carrying HIV-1 protein Nef induces redistribution of APP and Tau causing neuronal dysfunction
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Mutation of the ATP cassette binding transporter A1 (ABCA1) C-terminus disrupts HIV-1 Nef binding but does not block the Nef enhancement of ABCA1 protein degradation
10.1021/bi100466q · 2010 · External reference
HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux
10.1194/jlr.m023119 · 2012 · External reference
How HIV Nef Proteins Hijack membrane traffic to promote infection
10.1128/jvi.01322-19 · 2019 · External reference
The ABCA1 domain responsible for interaction with HIV-1 Nef is conformational and not linear
10.1016/j.bbrc.2013.12.141 · 2014 · External reference
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Interaction between HIV-1 Nef and calnexin: from modeling to small molecule inhibitors reversing HIV-induced lipid accumulation
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HIV-1 protein Nef inhibits activity of ATP-binding cassette transporter A1 by targeting endoplasmic reticulum chaperone calnexin
10.1074/jbc.m114.583591 · 2014 · External reference
Inhibition of HIV replication by apolipoprotein A-I binding protein targeting the lipid rafts
2020 · External reference
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10.1016/j.lfs.2019.01.025 · 2019 · External reference
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10.1016/j.jmb.2009.09.047 · External reference
Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix
10.1186/1742-4690-9-47 · 2012 · External reference
HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase
10.1186/1472-6769-12-1 · 2012 · External reference
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10.1073/pnas.0707130104 · External reference
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