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References from A mathematical model of the circadian clock and drug pharmacology to optimize irinotecan administration timing in colorectal cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1093/hmg/ddl207
10.1093/hmg/ddl207 · External reference
10.1126/science.1086271
10.1126/science.1086271 · External reference
10.1126/science.1195027
10.1126/science.1195027 · External reference
10.1038/nri3386
10.1038/nri3386 · External reference
10.1016/j.coisb.2020.07.007
10.1016/j.coisb.2020.07.007 · External reference
10.1126/science.abd4964
10.1126/science.abd4964 · External reference
Escaping Circadian Regulation: An Emerging Hallmark of Cancer?
10.1016/j.cels.2018.03.006 · 2018 · External reference
10.1124/pr.116.013441
10.1124/pr.116.013441 · External reference
Circadian rhythms - from genes to physiology and disease
10.4414/smw.2014.13984 · 2014 · External reference
10.1111/bph.15017
10.1111/bph.15017 · External reference
10.1073/pnas.1408886111
10.1073/pnas.1408886111 · External reference
10.1111/bph.14712
10.1111/bph.14712 · External reference
Efficacy and safety of chronomodulated irinotecan, oxaliplatin, 5-fluorouracil and leucovorin combination as first- or second-line treatment against metastatic colorectal cancer: Results from the International EORTC 05011 Trial
2020 · External reference
10.1007/s00280-010-1327-8
10.1007/s00280-010-1327-8 · External reference
Sex moderates circadian chemotherapy effects on survival of patients with metastatic colorectal cancer: a meta-analysis
10.1093/annonc/mds148 · 2012 · External reference
10.1002/cam4.3056
10.1002/cam4.3056 · External reference
10.1371/journal.pgen.1004338
10.1371/journal.pgen.1004338 · External reference
10.3390/cancers12113103
10.3390/cancers12113103 · External reference
10.1073/pnas.1132112100
10.1073/pnas.1132112100 · External reference
10.1073/pnas.2036281100
10.1073/pnas.2036281100 · External reference
10.1529/biophysj.104.040824
10.1529/biophysj.104.040824 · External reference
10.1073/pnas.0904837106
10.1073/pnas.0904837106 · External reference
10.1371/journal.pcbi.1002309
10.1371/journal.pcbi.1002309 · External reference
10.1038/msb.2012.62
10.1038/msb.2012.62 · External reference
Mathematical models converge on PGC1α as the key metabolic integrator of SIRT1 and AMPK regulation of the circadian clock
10.1073/pnas.1907751116 · 2019 · External reference
10.1016/j.celrep.2016.09.060
10.1016/j.celrep.2016.09.060 · External reference
A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery
10.1371/journal.pcbi.1002143 · 2011 · External reference
Identification of Circadian Determinants of Cancer Chronotherapy through In Vitro Chronopharmacology and Mathematical Modeling
10.1158/1535-7163.mct-15-0129 · 2015 · External reference
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)
2001 · External reference
10.1007/s40262-018-0644-7
10.1007/s40262-018-0644-7 · External reference
10.1016/j.ebiom.2018.07.002
10.1016/j.ebiom.2018.07.002 · External reference
Mass spectrometry-based absolute quantification reveals rhythmic variation of mouse circadian clock proteins
10.1073/pnas.1603799113 · 2016 · External reference
10.1006/meth.2001.1262
10.1006/meth.2001.1262 · External reference
10.1016/j.ebiom.2018.06.012
10.1016/j.ebiom.2018.06.012 · External reference
A Computational Analysis of Alternative Splicing across Mammalian Tissues Reveals Circadian and Ultradian Rhythms in Splicing Events
10.3390/ijms20163977 · 2019 · External reference
10.1162/106365601750190398
10.1162/106365601750190398 · External reference
10.1016/j.celrep.2014.09.021
10.1016/j.celrep.2014.09.021 · External reference
10.1146/annurev.physiol.63.1.647
10.1146/annurev.physiol.63.1.647 · External reference
10.1016/j.bbrc.2008.12.186
10.1016/j.bbrc.2008.12.186 · External reference
10.1042/bj20041150
10.1042/bj20041150 · External reference
10.1016/s0092-8674(02)00825-5
10.1016/s0092-8674(02)00825-5 · External reference
10.1038/s41419-019-1346-2
10.1038/s41419-019-1346-2 · External reference
10.1016/j.cmet.2016.10.003
10.1016/j.cmet.2016.10.003 · External reference
10.1002/j.1460-2075.1984.tb02055.x
10.1002/j.1460-2075.1984.tb02055.x · External reference
10.1371/journal.pone.0025231
10.1371/journal.pone.0025231 · External reference
10.1016/j.molcel.2017.07.017
10.1016/j.molcel.2017.07.017 · External reference
10.1038/nature10098
10.1038/nature10098 · External reference
Effects of meta-tetrahydroxyphenylchlorin photodynamic therapy on isogenic colorectal cancer SW480 and SW620 cells with different metastatic potentials
10.1007/s10103-018-2524-7 · 2018 · External reference
Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan
2002 · External reference
Irinotecan pathway genotype analysis to predict pharmacokinetics
2003 · External reference
10.1038/nrc1977
10.1038/nrc1977 · External reference
Pharmacogenetics of irinotecan metabolism and transport: an update
10.1016/j.tiv.2005.06.045 · 2006 · External reference
Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus
10.1006/bbrc.1999.0453 · 1999 · External reference
10.1038/ng1504
10.1038/ng1504 · External reference
10.1038/ni.1787
10.1038/ni.1787 · External reference
10.1093/nar/gks779
10.1093/nar/gks779 · External reference
E4bp4 regulates carboxylesterase 2 enzymes through repression of the nuclear receptor Rev-erbalpha in mice
10.1016/j.bcp.2018.04.005 · 2018 · External reference
10.1016/j.febslet.2011.02.027
10.1016/j.febslet.2011.02.027 · External reference
10.1007/s00018-014-1574-7
10.1007/s00018-014-1574-7 · External reference
10.1016/j.febslet.2010.03.017
10.1016/j.febslet.2010.03.017 · External reference
10.1016/j.tcb.2018.01.006
10.1016/j.tcb.2018.01.006 · External reference
10.1136/bmjsem-2020-000876
10.1136/bmjsem-2020-000876 · External reference
Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling
10.1038/s41598-019-46977-0 · 2019 · External reference
Model learning to identify systemic regulators of the peripheral circadian clock
10.1093/bioinformatics/btab297 · 2021 · External reference
10.1146/annurev.pharmtox.48.113006.094626
10.1146/annurev.pharmtox.48.113006.094626 · External reference
A circadian clock transcription model for the personalization of cancer chronotherapy
2013 · External reference
10.1126/science.aao0318
10.1126/science.aao0318 · External reference
TimeTeller: a New Tool for Precision Circadian Medicine and Cancer Prognosis
2019 · External reference
Dose adjustment of irinotecan based on UGT1A1 polymorphisms in patients with colorectal cancer
10.1007/s00280-018-3711-8 · 2019 · External reference
10.1016/j.drup.2016.03.001
10.1016/j.drup.2016.03.001 · External reference
Time will tell: Circadian clock dysregulation in triple negative breast cancer
10.2741/s533 · 2019 · External reference
Bright light therapy protects women from circadian rhythm desynchronization during chemotherapy for breast cancer
10.1080/15402002.2011.634940 · 2012 · External reference
10.1038/s41574-019-0237-z
10.1038/s41574-019-0237-z · External reference
10.1016/j.cub.2016.04.011
10.1016/j.cub.2016.04.011 · External reference
10.3109/07853890.2014.916990
10.3109/07853890.2014.916990 · External reference
10.1002/med.21582
10.1002/med.21582 · External reference
10.1016/j.trecan.2019.07.002
10.1016/j.trecan.2019.07.002 · External reference
Optimizing circadian drug infusion schedules towards personalized cancer chronotherapy
10.1371/journal.pcbi.1007218 · 2020 · External reference
