Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureResearch graph
References from Structure-guided machine learning prediction of drug resistance mutations in Abelson 1 kinase. Local targets link to admitted publications; unresolved targets remain external evidence.
Kinase inhibitors in chronic myelogenous leukemia
2006 · External reference
10.1056/nejmoa022457
10.1056/nejmoa022457 · External reference
BCR-ABL1 tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia
10.1177/1078155217710553 · 2018 · External reference
Finding the right BCR-ABL1 tyrosine kinase inhibitor: a case report of successful treatment of a patient with chronic myeloid leukemia and a V299L mutation using nilotinib
10.1186/s12885-018-5004-3 · 2018 · External reference
Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy
10.1186/s13045-018-0624-2 · 2018 · External reference
Landscape of drug-resistance mutations in kinase regulatory hotspots
2021 · External reference
10.1016/j.csbj.2020.02.007
10.1016/j.csbj.2020.02.007 · External reference
10.1021/acschembio.9b00283
10.1021/acschembio.9b00283 · External reference
Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations
10.1038/s42003-018-0075-x · 2018 · External reference
A combined computational and experimental strategy identifies mutations conferring resistance to drugs targeting the BCR-ABL fusion protein
10.1038/s42003-019-0743-5 · 2020 · External reference
10.1021/acscentsci.9b00590 · 2019 · Admitted local publication
Analysis of a Novel pncA Mutation for Susceptibility to Pyrazinamide Therapy
10.1164/rccm.201712-2572le · 2018 · External reference
10.1371/journal.pone.0217169
10.1371/journal.pone.0217169 · External reference
Structure guided prediction of Pyrazinamide resistance mutations in pncA
10.1038/s41598-020-58635-x · 2020 · External reference
Prediction of rifampicin resistance beyond the RRDR using structure-based machine learning approaches
10.1038/s41598-020-74648-y · 2020 · External reference
Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis
10.1038/s41598-018-33370-6 · 2018 · External reference
10.1093/bioinformatics/btt691
10.1093/bioinformatics/btt691 · External reference
pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures
10.1021/acs.jmedchem.5b00104 · 2015 · External reference
mycoCSM: Using Graph-Based Signatures to Identify Safe Potent Hits against Mycobacteria
10.1021/acs.jcim.0c00362 · 2020 · External reference
10.1093/nar/28.1.235
10.1093/nar/28.1.235 · External reference
10.1021/jm0306430
10.1021/jm0306430 · External reference
EasyVS: a user-friendly web-based tool for molecule library selection and structure-based virtual screening
10.1093/bioinformatics/btaa480 · 2020 · External reference
10.1016/j.jmb.2016.12.004
10.1016/j.jmb.2016.12.004 · External reference
10.1093/nar/gks539
10.1093/nar/gks539 · External reference
10.1517/13543784.2011.546344
10.1517/13543784.2011.546344 · External reference
Acquired Resistance to Drugs Targeting Tyrosine Kinases
10.1016/bs.acr.2018.02.003 · 2018 · External reference
The ins and outs of bcr-abl inhibition
10.1177/1947601912462126 · 2012 · External reference
Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation
10.1038/nature14119 · 2015 · External reference
10.1016/j.ccr.2009.09.028
10.1016/j.ccr.2009.09.028 · External reference
10.1111/j.1747-0285.2010.01054.x
10.1111/j.1747-0285.2010.01054.x · External reference
Scikit-learn: Machine Learning in Python
2011 · External reference
10.1093/nar/28.1.374
10.1093/nar/28.1.374 · External reference
Context-dependent optimal substitution matrices
10.1093/protein/8.7.641 · 1995 · External reference
DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability
10.1093/nar/gky300 · 2018 · External reference
10.1002/pro.3942
10.1002/pro.3942 · External reference
10.1021/cb9002656
10.1021/cb9002656 · External reference
10.1093/nar/gkt503
10.1093/nar/gkt503 · External reference
10.1093/nar/gkab428
10.1093/nar/gkab428 · External reference
10.1093/nar/gkz457
10.1093/nar/gkz457 · External reference
10.1101/gr.226589.117
10.1101/gr.226589.117 · External reference
10.1093/bioinformatics/btv195
10.1093/bioinformatics/btv195 · External reference
Better prediction of functional effects for sequence variants
10.1186/1471-2164-16-s8-s1 · 2015 · External reference
NGL viewer: web-based molecular graphics for large complexes
10.1093/bioinformatics/bty419 · 2018 · External reference
Dual EGFR and ABL Tyrosine Kinase Inhibitor Treatment in a Patient with Concomitant EGFR-Mutated Lung Adenocarcinoma and BCR-ABL1-Positive CML
10.1155/2020/4201727 · 2020 · External reference
SDM: a server for predicting effects of mutations on protein stability
10.1093/nar/gkx439 · 2017 · External reference
pdCSM-cancer: Using Graph-Based Signatures to Identify Small Molecules with Anticancer Properties
10.1021/acs.jcim.1c00168 · 2021 · External reference
10.1101/2020.11.01.364240
10.1101/2020.11.01.364240 · External reference
CSM-lig: a web server for assessing and comparing protein-small molecule affinities
10.1093/nar/gkw390 · 2016 · External reference
mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance
10.1038/srep29575 · 2016 · External reference
10.1093/nar/gku411
10.1093/nar/gku411 · External reference
10.1093/bioinformatics/btl461
10.1093/bioinformatics/btl461 · External reference
