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References from Allosteric pockets and dynamic residue network hubs of falcipain 2 in mutations including those linked to artemisinin resistance. Local targets link to admitted publications; unresolved targets remain external evidence.
The complex of Plasmodium falciparum falcipain-2 protease with an (E)-chalcone-based inhibitor highlights a novel, small, molecule-binding site
10.1186/s12936-019-3043-0 · 2019 · External reference
Artemisinin resistance: Current status and scenarios for containment
2010 · External reference
Unresolved reference
2016 · External reference
10.1016/j.jgar.2015.02.002
10.1016/j.jgar.2015.02.002 · External reference
10.3390/tropicalmed4020089
10.3390/tropicalmed4020089 · External reference
Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum
10.1038/ncomms10111 · 2015 · External reference
10.1586/14787210.2016.1106938
10.1586/14787210.2016.1106938 · External reference
10.1038/ng.3189
10.1038/ng.3189 · External reference
No Evidence of Plasmodium falciparum k13 Artemisinin Resistance-Conferring Mutations over a 24-Year Analysis in Coastal Kenya but a near Complete Reversion to Chloroquine-Sensitive Parasites
10.1128/aac.01067-19 · 2019 · External reference
10.1038/nature12876
10.1038/nature12876 · External reference
10.1093/infdis/jiy188
10.1093/infdis/jiy188 · External reference
10.1007/978-1-4419-8414-2_3
10.1007/978-1-4419-8414-2_3 · External reference
Cysteine proteases of parasitic organisms☆
10.1016/s0166-6851(01)00438-8 · 2002 · External reference
10.1016/j.molbiopara.2004.11.009
10.1016/j.molbiopara.2004.11.009 · External reference
Autocatalytic processing of recombinant human procathepsin B is a bimolecular process
10.1016/s0014-5793(99)01302-2 · 1999 · External reference
10.1021/jm8013663
10.1021/jm8013663 · External reference
10.1042/bj20031487
10.1042/bj20031487 · External reference
10.1371/journal.pone.0051619
10.1371/journal.pone.0051619 · External reference
10.1111/cmi.12124
10.1111/cmi.12124 · External reference
10.1016/j.exppara.2009.03.003
10.1016/j.exppara.2009.03.003 · External reference
10.1073/pnas.0307720101
10.1073/pnas.0307720101 · External reference
Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3
10.1371/journal.pone.0005156 · 2009 · External reference
10.1111/febs.14130
10.1111/febs.14130 · External reference
10.1073/pnas.1011560108
10.1073/pnas.1011560108 · External reference
Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems
10.1073/pnas.0601876103 · 2006 · External reference
Hemoglobin Degrading Proteases of Plasmodium falciparum as Antimalarial Drug Targets
10.2174/1389450116666150304104123 · 2015 · External reference
Plasmodium falciparum Cysteine Proteases as Key Drug Targets Against Malaria
10.2174/092986711795328328 · 2011 · External reference
10.1073/pnas.1104063108
10.1073/pnas.1104063108 · External reference
10.1038/nature12876
10.1038/nature12876 · External reference
Chemical proteomics approach reveals the direct targets and the heme-dependent activation mechanism of artemisinin in plasmodium falciparum using an artemisinin-based activity probe
10.15698/mic2016.05.503 · 2016 · External reference
10.1016/j.pt.2016.05.010
10.1016/j.pt.2016.05.010 · External reference
Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin
10.1016/j.bmc.2008.02.034 · 2008 · External reference
PlasmoDB: the Plasmodium genome resource. A database integrating experimental and computational data
10.1093/nar/gkg081 · 2003 · External reference
Characterizing early drug resistance-related events using geometric ensembles from HIV protease dynamics
10.1038/s41598-018-36041-8 · 2018 · External reference
10.1016/j.csbj.2020.05.009 · Admitted local publication
Allosteric drugs and mutations: chances, challenges, and necessity
2020 · External reference
10.1016/j.sbi.2015.10.004
10.1016/j.sbi.2015.10.004 · External reference
Structure-Based Analysis of Single Nucleotide Variants in the Renin-Angiotensinogen Complex
10.1016/j.gheart.2017.01.006 · 2017 · External reference
10.1016/j.gheart.2017.01.009
10.1016/j.gheart.2017.01.009 · External reference
10.1093/bioinformatics/btx349
10.1093/bioinformatics/btx349 · External reference
10.1016/j.csbj.2021.08.043
10.1016/j.csbj.2021.08.043 · External reference
10.1021/acs.jcim.0c00634
10.1021/acs.jcim.0c00634 · External reference
10.26434/chemrxiv-2021-7thm1
10.26434/chemrxiv-2021-7thm1 · External reference
10.1016/j.str.2007.03.012
10.1016/j.str.2007.03.012 · External reference
The Protein Data Bank (www.rcsb.org)
10.1093/nar/28.1.235 · 2000 · External reference
10.1093/nar/gky1004
10.1093/nar/gky1004 · External reference
An open-source molecular graphics tool
2002 · External reference
10.1093/nar/gky1049
10.1093/nar/gky1049 · External reference
10.1093/nar/gkn814
10.1093/nar/gkn814 · External reference
Unresolved reference
2013 · External reference
10.1110/ps.062416606
10.1110/ps.062416606 · External reference
10.1016/s0076-6879(97)77022-8
10.1016/s0076-6879(97)77022-8 · External reference
10.1093/nar/gkm290
10.1093/nar/gkm290 · External reference
10.1107/s0021889892009944
10.1107/s0021889892009944 · External reference
Protein Interactions Calculator
10.1093/nar/gkm423 · 2007 · External reference
10.1093/nar/gkm276
10.1093/nar/gkm276 · External reference
10.1093/nar/gkh381
10.1093/nar/gkh381 · External reference
10.1038/nprot.2015.043
10.1038/nprot.2015.043 · External reference
10.1093/bioinformatics/btp036
10.1093/bioinformatics/btp036 · External reference
10.1093/bioinformatics/btt399
10.1093/bioinformatics/btt399 · External reference
10.1093/bioinformatics/btu002
10.1093/bioinformatics/btu002 · External reference
10.1021/ci800324m
10.1021/ci800324m · External reference
10.1002/prot.21645
10.1002/prot.21645 · External reference
10.1016/j.softx.2015.06.001 · Admitted local publication
Improved side-chain torsion potentials for the Amber ff99SB protein force field
10.1002/prot.22711 · 2010 · External reference
10.1063/1.328693
10.1063/1.328693 · External reference
LINCS: A Linear Constraint Solver for molecular simulations
1997 · External reference
10.1063/1.470043
10.1063/1.470043 · External reference
Unresolved reference
External reference
10.1109/mcse.2007.55
10.1109/mcse.2007.55 · External reference
10.1093/bioinformatics/btx789
10.1093/bioinformatics/btx789 · External reference
10.1109/mcse.2011.37
10.1109/mcse.2011.37 · External reference
Data Structures for Statistical Computing in Python
10.25080/majora-92bf1922-00a · 2010 · External reference
Unresolved reference
External reference
10.25080/tcwv9851
10.25080/tcwv9851 · External reference
10.1016/b978-0-12-405531-5.00003-1
10.1016/b978-0-12-405531-5.00003-1 · External reference
Integration of network models and evolutionary analysis into high-throughput modeling of protein dynamics and allosteric regulation: Theory, tools and applications
10.1093/bib/bbz029 · 2020 · External reference
10.1007/978-1-4419-9863-7_935
10.1007/978-1-4419-9863-7_935 · External reference
10.1093/bioinformatics/btx430
10.1093/bioinformatics/btx430 · External reference
10.1371/journal.pcbi.1004678
10.1371/journal.pcbi.1004678 · External reference
Reversing allosteric communication: From detecting allosteric sites to inducing and tuning targeted allosteric response
10.1371/journal.pcbi.1006228 · 2018 · External reference
10.3390/ijms21030847
10.3390/ijms21030847 · External reference
Characteristics of Allosteric Proteins, Sites, and Modulators
10.1007/978-981-13-8719-7_6 · 2019 · External reference
10.1016/j.str.2019.01.003
10.1016/j.str.2019.01.003 · External reference
An Overview of Its History, Concepts, Methods, and Applications
10.1371/journal.pcbi.1004966 · 2016 · External reference
10.1016/j.jmb.2019.07.012
10.1016/j.jmb.2019.07.012 · External reference
10.1093/nar/gkz958
10.1093/nar/gkz958 · External reference
10.1021/ar9500675
10.1021/ar9500675 · External reference
10.1021/ct300400x
10.1021/ct300400x · External reference
Unresolved reference
External reference
Small-world view of the amino acids that play a key role in protein folding
10.1103/physreve.65.061910 · 2002 · External reference
10.1007/s00249-019-01384-1
10.1007/s00249-019-01384-1 · External reference
10.1016/j.sbi.2013.07.004
10.1016/j.sbi.2013.07.004 · External reference
10.3390/molecules24213987
10.3390/molecules24213987 · External reference
10.3390/molecules25040904
10.3390/molecules25040904 · External reference
Comparing sequence and structure of falcipains and human homologs at prodomain and catalytic active site for malarial peptide based inhibitor design
2019 · External reference
10.1021/acs.jcim.7b00630
10.1021/acs.jcim.7b00630 · External reference
South African Abietane Diterpenoids and Their Analogs as Potential Antimalarials: Novel Insights from Hybrid Computational Approaches
10.3390/molecules24224036 · 2019 · External reference
Modulation of Human Hsp90α Conformational Dynamics by Allosteric Ligand Interaction at the C-Terminal Domain
10.1038/s41598-018-35835-0 · 2019 · External reference
Con-Struct Map: a comparative contact map analysis tool
10.1093/bioinformatics/btm356 · 2007 · External reference
CMView: Interactive contact map visualization and analysis
10.1093/bioinformatics/btr163 · 2011 · External reference
10.1093/nar/gks488
10.1093/nar/gks488 · External reference
PConPy - A Python module for generating 2D protein maps
10.1093/bioinformatics/btn566 · 2008 · External reference
10.3390/ijms21113803
10.3390/ijms21113803 · External reference
10.3390/ijms22042138
10.3390/ijms22042138 · External reference
10.1101/cshperspect.a025619
10.1101/cshperspect.a025619 · External reference
