Research graph
References from Structure-function relationship between soluble epoxide hydrolases structure and their tunnel network. Local targets link to admitted publications; unresolved targets remain external evidence.
Anatomy of enzyme channels
10.1186/s12859-014-0379-x · 2014 · External reference
F429 regulation of tunnels in cytochrome P450 2B4: a top down study of multiple molecular dynamics simulations
10.1371/journal.pone.0137075 · 2015 · External reference
10.1021/jp101894k
10.1021/jp101894k · External reference
10.1021/cr300384w
10.1021/cr300384w · External reference
10.1002/med.21430
10.1002/med.21430 · External reference
10.1002/prot.24772
10.1002/prot.24772 · External reference
Perforation of the tunnel wall in carbamoyl phosphate synthetase derails the passage of ammonia between sequential active sites
10.1021/bi049945+ · 2004 · External reference
10.1126/science.1127156
10.1126/science.1127156 · External reference
Molecular modeling study on tunnel behavior in different histone deacetylase isoforms
10.1371/journal.pone.0049327 · 2012 · External reference
Structural determinants of protein evolution are context-sensitive at the residue level
10.1093/molbev/msp146 · 2009 · External reference
10.1093/molbev/msj048
10.1093/molbev/msj048 · External reference
10.1534/genetics.111.128025
10.1534/genetics.111.128025 · External reference
Protein misinteraction avoidance causes highly expressed proteins to evolve slowly
2012 · External reference
10.1038/nrg.2015.18
10.1038/nrg.2015.18 · External reference
Evolution of tunnels in α/β-hydrolases fold proteins – what can we learn from studying epoxide hydrolases?
2021 · External reference
Of barn owls and bankers: a lush variety of α/β hydrolases
10.1016/s0969-2126(99)80079-3 · 1999 · External reference
10.1002/prot.20013
10.1002/prot.20013 · External reference
10.1128/aem.72.4.2905-2917.2006
10.1128/aem.72.4.2905-2917.2006 · External reference
10.1107/s0907444902003451
10.1107/s0907444902003451 · External reference
10.1073/pnas.96.19.10637
10.1073/pnas.96.19.10637 · External reference
Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis
10.1021/bi036189j · 2004 · External reference
X-ray structure of potato epoxide hydrolase sheds light on substrate specificity in plant enzymes
10.1110/ps.051792106 · 2006 · External reference
Regioselectivity engineering of epoxide hydrolase: near-perfect enantioconvergence through a single site mutation
10.1021/acscatal.8b02622 · 2018 · External reference
Structure of a soluble epoxide hydrolase identified in Trichoderma reesei
10.1016/j.bbapap.2017.05.004 · 2017 · External reference
10.1073/pnas.1404915111
10.1073/pnas.1404915111 · External reference
New thermophilic α/β Class epoxide hydrolases found in metagenomes from hot environments
10.3389/fbioe.2018.00144 · 2018 · External reference
mTM-align: an algorithm for fast and accurate multiple protein structure alignment
10.1093/bioinformatics/btx828 · 2018 · External reference
Sea view version 4: a multiplatform graphical user interface for sequence alignment and phylogenetic tree building
10.1093/molbev/msp259 · 2010 · External reference
3.0: Automating pK prediction and the preparation of biomolecular structures for atomistic molecular modeling and simulations
10.1093/nar/gks375 · 2012 · External reference
Three-dimensional molecular theory of solvation coupled with molecular dynamics in amber
10.1021/ct900460m · 2010 · External reference
10.1002/jcc.22984
10.1002/jcc.22984 · External reference
10.1016/j.csbj.2020.02.001 · Admitted local publication
Unresolved reference
2014 · External reference
10.1021/acs.jctc.5b00255
10.1021/acs.jctc.5b00255 · External reference
10.1093/bioinformatics/btz946
10.1093/bioinformatics/btz946 · External reference
The α/β hydrolase fold
10.1093/protein/5.3.197 · 1992 · External reference
Exploring solanum tuberosum epoxide hydrolase internal architecture by water molecules tracking
10.3390/biom8040143 · 2018 · External reference
The modular structure of α/β-hydrolases
10.1111/febs.15071 · 2020 · External reference
10.1002/cbic.201000771
10.1002/cbic.201000771 · External reference
Importance of the lid and cap domains for the catalytic activity of gastric lipases
10.1016/s1096-4959(03)00183-0 · 2003 · External reference
10.1016/s0021-9258(19)74009-5
10.1016/s0021-9258(19)74009-5 · External reference
Greatly enhancing the enantioselectivity of PvEH2, a Phaseolus vulgaris epoxide hydrolase, towards racemic 1,2-epoxyhexane via replacing its partial cap-loop
10.1016/j.ijbiomac.2020.04.071 · 2020 · External reference
Role of the NC-loop in catalytic activity and stability in lipase from Fervidobacterium changbaicum
2012 · External reference
Computational insights into the known inhibitors of human soluble epoxide hydrolase
10.1016/j.drudis.2021.05.017 · 2021 · External reference
Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids
10.1110/ps.051720206 · 2006 · External reference
The real “kingdoms” of eukaryotes
10.1016/j.cub.2004.08.038 · 2004 · External reference
Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis
10.1006/abbi.1995.1059 · 1995 · External reference
Epoxide hydrolases: biochemistry and molecular biology
10.1016/s0009-2797(00)00197-6 · 2000 · External reference
Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function
10.1194/jlr.m082701 · 2018 · External reference
Biosynthesis of cutin monomers: involvement of a lipoxygenase/peroxygenase pathway
10.1046/j.1365-313x.1993.04010113.x · 1993 · External reference
Purification, molecular cloning and ethylene-inducible expression of a soluble-type epoxide hydrolase from soybean (Glycine max[L.] Merr.)
10.1046/j.1432-1327.2000.01276.x · 2000 · External reference
The expression of cytochrome P-450, epoxide hydrolase, and glutathione s-transferase in hepatocellular carcinoma
10.1002/1097-0142(19930101)71:1<36::aid-cncr2820710107>3.0.co;2-j · 1993 · External reference
Characterization of an Arabidopsis cDNA for a soluble epoxide hydrolase gene that is inducible by auxin and water stress
10.1046/j.1365-313x.1994.6020259.x · 1994 · External reference
Characterization of a tobacco epoxide hydrolase gene induced during the resistance response to TMV
1998 · External reference
10.1023/b:plan.0000009287.95682.24
10.1023/b:plan.0000009287.95682.24 · External reference
Molecular characterization of NbEH1 and NbEH2, two epoxide hydrolases from Nicotiana benthamiana
10.1016/j.phytochem.2013.02.020 · 2013 · External reference
Comparison of fatty acid epoxide hydrolase activity in seeds from different plant species
10.1016/0031-9422(94)00646-b · 1995 · External reference
Structure and occurrence of unusual fatty acids in minor seed oils
10.1016/0163-7827(80)90002-8 · 1980 · External reference
Stereochemical features of the hydrolysis of 9,10-epoxystearic acid catalysed by plant and mammalian epoxide hydrolases
10.1042/bj20011778 · 2002 · External reference
Arabidopsis thaliana EPOXIDE HYDROLASE1 (AtEH1) is a cytosolic epoxide hydrolase involved in the synthesis of poly-hydroxylated cutin monomers
10.1111/nph.14590 · 2017 · External reference
Mammalian epoxide hydrolases in xenobiotic metabolism and signalling
10.1007/s00204-009-0416-0 · 2009 · External reference
10.1110/ps.034173.107
10.1110/ps.034173.107 · External reference
Mutations in salt-bridging residues at the interface of the core and lid domains of epoxide hydrolase StEH1 affect regioselectivity, protein stability and hysteresis
10.1016/j.abb.2010.01.007 · 2010 · External reference
10.1021/bi3007725
10.1021/bi3007725 · External reference
Conformational diversity and enantioconvergence in potato epoxide hydrolase 1
10.1039/c6ob00060f · 2016 · External reference
Highly regio- and enantio-selective hydrolysis of two racemic epoxides by GmEH3, a novel epoxide hydrolase from Glycine max
10.1016/j.ijbiomac.2020.08.011 · 2020 · External reference
Near-perfect kinetic resolution of racemic p-chlorostyrene oxide by SlEH1, a novel epoxide hydrolase from Solanum lycopersicum with extremely high enantioselectivity
10.1016/j.ijbiomac.2019.10.091 · 2020 · External reference
10.1016/s0021-9258(19)49780-9
10.1016/s0021-9258(19)49780-9 · External reference
Catalysis of potato epoxide hydrolase, StEH1
10.1042/bj20050526 · 2005 · External reference
Epoxide hydrolysis as a model system for understanding flux through a branched reaction scheme
10.1107/s2052252518003573 · 2018 · External reference
Laboratory-evolved enzymes provide snapshots of the development of enantioconvergence in enzyme-catalyzed epoxide hydrolysis
10.1002/cbic.201600330 · 2016 · External reference
Quantum chemical modeling of enantioconvergency in soluble epoxide hydrolase
10.1021/acscatal.6b01562 · 2016 · External reference
Significant improvement in catalytic activity and enantioselectivity of a Phaseolus vulgaris epoxide hydrolase, PvEH3, towards ortho-cresyl glycidyl ether based on the semi-rational design
2020 · External reference
10.1002/cbic.201700197
10.1002/cbic.201700197 · External reference
10.1021/acscatal.6b02081
10.1021/acscatal.6b02081 · External reference
10.1089/dna.2008.0751
10.1089/dna.2008.0751 · External reference
10.1016/j.gene.2013.05.008
10.1016/j.gene.2013.05.008 · External reference
10.1073/pnas.0437829100
10.1073/pnas.0437829100 · External reference
The role of a putative peroxisomal-targeted epoxide hydrolase of Nicotiana benthamiana in interactions with Colletotrichum destructivum, C. orbiculare or Pseudomonas syringae pv. tabaci
10.1016/j.plantsci.2011.05.004 · 2011 · External reference
Enhancing the enantioselectivity of an epoxide hydrolase by directed evolution
10.1021/ol035898m · 2004 · External reference
10.1021/ja809673d
10.1021/ja809673d · External reference
10.1002/cbic.201100078
10.1002/cbic.201100078 · External reference
Directed evolution of enantioselective enzymes: Iterative cycles of CASTing for probing protein-sequence space
10.1002/anie.200502746 · 2006 · External reference
10.1016/j.jbiotec.2007.08.014
10.1016/j.jbiotec.2007.08.014 · External reference
Laboratory evolution of an epoxide hydrolase – towards an enantioconvergent biocatalyst
10.1016/j.jbiotec.2011.08.003 · 2011 · External reference
