Research graph
References from Function, molecular mechanisms, and therapeutic potential of bacterial HtrA proteins: An evolving view. Local targets link to admitted publications; unresolved targets remain external evidence.
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HtrA protease family as therapeutic targets
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DegP functions as a critical protease for bacterial acid resistance
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Conserved DegP protease in gram-positive bacteria is essential for thermal and oxidative tolerance and full virulence in Streptococcus pyogenes
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Molecular Basis of the Versatile Regulatory Mechanism of HtrA-Type Protease AlgW from Pseudomonas aeruginosa
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New Insights into Beta-Lactam Resistance of Streptococcus pneumoniae: Serine Protease HtrA Degrades Altered Penicillin-Binding Protein 2x
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Chemical validation of DegS as a target for the development of antibiotics with a novel mode of action
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HtrA-mediated E-cadherin cleavage is limited to DegP and DegQ homologs expressed by gram-negative pathogens
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Shigella flexneri DegP facilitates IcsA surface expression and is required for efficient intercellular spread
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Pseudomonas aeruginosa MucD protease mediates keratitis by inhibiting neutrophil recruitment and promoting bacterial survival
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Identification of a periplasmic AlgK–AlgX–MucD multiprotein complex in Pseudomonas aeruginosa involved in biosynthesis and regulation of alginate
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10.1016/j.csbj.2021.04.045 · Admitted local publication
The Cpx two-component signal transduction pathway of Escherichia coli regulates transcription of the gene specifying the stress-inducible periplasmic protease
10.1101/gad.9.4.387 · 1995 · External reference
CpxR/CpxA controls scsABCD transcription to counteract copper and oxidative stress in Salmonella enterica serovar Typhimurium
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The lipoprotein NlpE is a Cpx sensor that serves as a sentinel for protein sorting and folding defects in the Escherichia coli envelope
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Role of the two-component regulator CpxAR in the virulence of Salmonella enterica serotype Typhimurium
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Unresolved reference
External reference
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2020 · External reference
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HtrA is a major virulence determinant of Bacillus anthracis
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2019 · External reference
HtrA-family proteases of bacterial pathogens: pros and cons for their therapeutic use
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Fragment-based de novo design reveals a small-molecule inhibitor of Helicobacter pylori HtrA
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