Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Role of the nuclear receptor subfamily 4a in mast cells in the development of irritable bowel syndrome. Local targets link to admitted publications; unresolved targets remain external evidence.
Mast cell regulation and irritable bowel syndrome: effects of food components with potential nutraceutical use
10.3390/molecules25184314 · 2020 · External reference
Mast cell: an emerging partner in immune interaction
2012 · External reference
Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome
10.1053/j.gastro.2009.07.005 · 2009 · External reference
The role of mast cells in the gut and brain
10.31083/j.jin.2021.01.313 · 2021 · External reference
Mast cells and irritable bowel syndrome: from the bench to the bedside
10.5056/jnm15137 · 2016 · External reference
10.1080/14728222.2017.1279146
10.1080/14728222.2017.1279146 · External reference
Nuclear receptor 4a3 (nr4a3) regulates murine mast cell responses and granule content
10.1371/journal.pone.0089311 · 2014 · External reference
Altered gene expression signatures by calcitonin gene-related peptide promoted mast cell activity in the colon of stress-induced visceral hyperalgesia mice
10.1111/nmo.14073 · 2021 · External reference
10.1038/nri2327
10.1038/nri2327 · External reference
10.1182/blood-2010-01-257287
10.1182/blood-2010-01-257287 · External reference
10.1053/j.gastro.2003.11.055
10.1053/j.gastro.2003.11.055 · External reference
Mast cell function: a new vision of an old cell
10.1369/0022155414545334 · 2014 · External reference
Mast cell-nerve axis with a focus on the human gut
10.1016/j.bbadis.2011.06.004 · 2012 · External reference
Mast cells and sensory nerves contribute to neurogenic inflammation and pruritus in chronic skin inflammation
10.3389/fncel.2019.00422 · 2019 · External reference
10.1016/j.coi.2020.09.007
10.1016/j.coi.2020.09.007 · External reference
The dual regulation of substance P-mediated inflammation via human synovial mast cells in rheumatoid arthritis
10.1016/j.alit.2017.03.002 · 2017 · External reference
Neuropeptide blood levels correlate with mast cell load in patients with mastocytosis
10.1111/j.1398-9995.2011.02550.x · 2011 · External reference
Mast cell-nerve interaction in the colon of Trypanosoma cruzi-infected individuals with chagasic megacolon
10.1007/s00436-018-5792-z · 2018 · External reference
10.1111/fcp.12537
10.1111/fcp.12537 · External reference
Downregulation of iNOS, IL-1β, and P2X7 expression in mast cells via activation of PAR4 contributes to the inhibition of visceral hyperalgesia in rats
2018 · External reference
Activation of protease-activated receptor 4 of mast cells could downregulate proinflammatory cytokines in irritable bowel syndrome
10.1136/gutjnl-2016-313504 · 2017 · External reference
Expression of inducible nitric oxide synthase in mast cells contributes to the regulation of inflammatory cytokines in irritable bowel syndrome with diarrhea
10.1111/nmo.12811 · 2016 · External reference
Tryptase and protease-activated receptor 2 expression levels in irritable bowel syndrome
10.5009/gnl14319 · 2016 · External reference
Histamine intolerance originates in the gut
10.3390/nu13041262 · 2021 · External reference
10.3390/nu12020341
10.3390/nu12020341 · External reference
10.1128/iai.01004-09
10.1128/iai.01004-09 · External reference
Differential regulation of Nr4a subfamily nuclear receptors following mast cell activation
10.1016/j.molimm.2011.04.017 · 2011 · External reference
10.1126/science.294.5548.1866
10.1126/science.294.5548.1866 · External reference
10.1126/science.284.5415.757
10.1126/science.284.5415.757 · External reference
The NR4A orphan nuclear receptors: mediators in metabolism and diseases
10.3109/10799893.2014.948555 · 2015 · External reference
10.1158/1541-7786.mcr-20-0707
10.1158/1541-7786.mcr-20-0707 · External reference
NR4A expression by human marginal zone B-cells
10.3390/antib8040050 · 2019 · External reference
The NR4A subfamily of nuclear receptors: new early genes regulated by growth factors in vascular cells
10.1016/j.cardiores.2004.10.002 · 2005 · External reference
10.1111/j.1471-4159.2004.02777.x
10.1111/j.1471-4159.2004.02777.x · External reference
10.1038/nature01645
10.1038/nature01645 · External reference
10.1038/nchembio.106
10.1038/nchembio.106 · External reference
10.1038/nchembio.1069
10.1038/nchembio.1069 · External reference
10.1016/j.bcp.2005.10.017
10.1016/j.bcp.2005.10.017 · External reference
10.1128/mcb.19.11.7549
10.1128/mcb.19.11.7549 · External reference
10.1016/j.bbamcr.2014.06.010
10.1016/j.bbamcr.2014.06.010 · External reference
10.1074/jbc.m203572200
10.1074/jbc.m203572200 · External reference
Molecular pathways: the role of NR4A orphan nuclear receptors in cancer
10.1158/1078-0432.ccr-11-2953 · 2012 · External reference
10.1210/endo.138.10.5464
10.1210/endo.138.10.5464 · External reference
10.1016/s0021-9258(19)74536-0
10.1016/s0021-9258(19)74536-0 · External reference
10.1038/35017072
10.1038/35017072 · External reference
10.1007/s12079-010-0104-0
10.1007/s12079-010-0104-0 · External reference
10.1074/jbc.m502606200
10.1074/jbc.m502606200 · External reference
Endothelium-specific endothelin-1 expression promotes pro-inflammatory macrophage activation by regulating miR-33/NR4A axis
10.1016/j.yexcr.2020.112443 · 2021 · External reference
Nurr1 expression and its modulation in microglia
10.1159/000204229 · 2009 · External reference
10.1016/j.cell.2009.01.038
10.1016/j.cell.2009.01.038 · External reference
The Nurr1 activator 1,1-bis (3'-indolyl)-1-(p-chlorophenyl) methane blocks inflammatory gene expression in BV-2 microglial cells by inhibiting nuclear factor κB
10.1124/mol.114.095398 · 2015 · External reference
Nuclear receptors of NR1 and NR4 subfamilies in the regulation of microglial functions and pathology
10.1002/prp2.766 · 2021 · External reference
SOCS, SPRED, and NR4a: negative regulators of cytokine signaling and transcription in immune tolerance
10.2183/pjab.97.016 · 2021 · External reference
10.1038/s12276-021-00568-0
10.1038/s12276-021-00568-0 · External reference
Deletion of the NR4A nuclear receptor NOR1 in hematopoietic stem cells reduces inflammation but not abdominal aortic aneurysm formation
10.1186/s12872-017-0701-4 · 2017 · External reference
NR4A orphan nuclear receptors: transcriptional regulators of gene expression in metabolism and vascular biology
10.1161/atvbaha.109.191163 · 2010 · External reference
10.1182/blood-2013-02-483792
10.1182/blood-2013-02-483792 · External reference
Immunological Genome Project Consortium. Expression profiling of constitutive mast cells reveals a unique identity within the immune system
10.1038/ni.3445 · 2016 · External reference
10.1016/j.immuni.2020.01.012
10.1016/j.immuni.2020.01.012 · External reference
10.1016/j.cbi.2014.10.021
10.1016/j.cbi.2014.10.021 · External reference
10.1084/jem.20051982
10.1084/jem.20051982 · External reference
Inhibition of IKK down-regulates antigen + IgE-induced TNF production by mast cells: a role for the IKK-IkappaB-NF-kappaB pathway in IgE-dependent mast cell activation
10.1189/jlb.0204115 · 2005 · External reference
10.1002/eji.201444546
10.1002/eji.201444546 · External reference
10.1038/ni817
10.1038/ni817 · External reference
The orphan nuclear receptor NR4A1 promotes FcεRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis
10.1111/all.13702 · 2019 · External reference
The role of corticotropin-releasing hormone in immune-mediated cutaneous inflammatory disease
10.1111/j.1600-0625.2006.00382.x · 2006 · External reference
Role of nuclear receptor NR4A2 in gastrointestinal inflammation and cancers
10.3748/wjg.v18.i47.6865 · 2012 · External reference
Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome
10.1038/s41598-017-09635-x · 2017 · External reference
Mast cell corticotropin-releasing factor subtype 2 suppresses mast cell degranulation and limits the severity of anaphylaxis and stress-induced intestinal permeability
10.1016/j.jaci.2018.08.053 · 2019 · External reference
Novel insights in the role of peripheral corticotropin-releasing factor and mast cells in stress-induced visceral hypersensitivity
10.1111/j.1365-2982.2011.01867.x · 2012 · External reference
Mast cells in stress, pain, blood-brain barrier, neuroinflammation and Alzheimer's disease
10.3389/fncel.2019.00054 · 2019 · External reference
The role of peripheral corticotropin-releasing factor signaling in a rat model of stress-induced gastric hyperalgesia
10.1016/j.bbrc.2019.09.040 · 2019 · External reference
Pituitary adenylate cyclase-activating polypeptide controls stimulus-transcription coupling in the hypothalamic-pituitary-adrenal axis to mediate sustained hormone secretion during stress
10.1111/j.1365-2826.2011.02202.x · 2011 · External reference
10.1002/jnr.23366
10.1002/jnr.23366 · External reference
10.1002/jnr.22377
10.1002/jnr.22377 · External reference
Nuclear orphan receptor Nor-1 contributes to depressive behavior in the Wistar-Kyoto rat model of depression
10.1016/j.brainres.2010.09.041 · 2010 · External reference
Neuroendocrine regulation of the hypothalamic pituitary adrenal axis by the nurr1/nur77 subfamily of nuclear receptors
10.1210/mend.11.1.9874 · 1997 · External reference
10.1128/mcb.23.3.763-776.2003
10.1128/mcb.23.3.763-776.2003 · External reference
Modulation of steroidogenic enzymes by orphan nuclear transcriptional regulation may control diverse production of cortisol and androgens in the human adrenal
10.1677/joe.0.1810355 · 2004 · External reference
10.3390/cells9040900
10.3390/cells9040900 · External reference
10.1081/erc-200043715
10.1081/erc-200043715 · External reference
10.1111/jnc.15284
10.1111/jnc.15284 · External reference
10.1016/j.cobeha.2019.01.011
10.1016/j.cobeha.2019.01.011 · External reference
Mast cells at the crossroads of microbiota and IBD
10.1002/eji.201847504 · 2018 · External reference
10.1016/j.cell.2019.08.010
10.1016/j.cell.2019.08.010 · External reference
Chronic stress and intestinal permeability: Lubiprostone regulates glucocorticoid receptor-mediated changes in colon epithelial tight junction proteins, barrier function, and visceral pain in the rodent and human
10.1111/nmo.13477 · 2019 · External reference
Impact of psychological stress on irritable bowel syndrome
10.3748/wjg.v20.i39.14126 · 2014 · External reference
10.1016/j.pbb.2013.02.014
10.1016/j.pbb.2013.02.014 · External reference
10.1016/j.csbj.2020.02.018 · Admitted local publication
10.1152/ajpgi.00125.2014
10.1152/ajpgi.00125.2014 · External reference
CGRP, a neurotransmitter of enteric sensory neurons, contributes to the development of food allergy due to the augmentation of microtubule reorganization in mucosal mast cells
10.2220/biomedres.35.285 · 2014 · External reference
Neurotransmitter and neuropeptide regulation of mast cell function: a systematic review
10.1186/s12974-020-02029-3 · 2020 · External reference
10.1210/en.2003-1609
10.1210/en.2003-1609 · External reference
10.1080/10253890701801448
10.1080/10253890701801448 · External reference
Modulation of the immune response by the neuro-endocrine axis in rheumatoid arthritis
1994 · External reference
Anxiogenic effects of CGRP within the BNST may be mediated by CRF acting at BNST CRFR1 receptors
10.1016/j.bbr.2013.01.024 · 2013 · External reference
Stress and the gastrointestinal tract
10.1111/j.1440-1746.2004.03508.x · 2005 · External reference
Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT3 receptors in conscious rats
10.1152/ajpgi.00419.2006 · 2007 · External reference
10.1097/00004836-200207001-00004
10.1097/00004836-200207001-00004 · External reference