Research graph
References from Network-based stage-specific drug repurposing for Alzheimer’s disease. Local targets link to admitted publications; unresolved targets remain external evidence.
10.2478/v10136-011-0013-4
10.2478/v10136-011-0013-4 · External reference
10.1038/nature20411
10.1038/nature20411 · External reference
Unresolved reference
External reference
Challenges in neurodegeneration research
10.3389/fpsyt.2010.00007 · 2010 · External reference
Alzheimer’s disease hypothesis and related therapies
2018 · External reference
Failure to demonstrate efficacy of aducanumab: An analysis of the EMERGE and ENGAGE trials as reported by Biogen, December 2019
10.1002/alz.12213 · 2021 · External reference
10.1186/s13195-020-00663-w
10.1186/s13195-020-00663-w · External reference
A preliminary assessment of longitudinal amyloid status in the ongoing open-label extension phase in subjects with early Alzheimer’s disease
2021 · External reference
How to improve RD productivity: The pharmaceutical industry’s grand challenge
2010 · External reference
10.1016/j.trci.2016.07.001
10.1016/j.trci.2016.07.001 · External reference
10.1016/j.trci.2017.05.002
10.1016/j.trci.2017.05.002 · External reference
10.1016/j.trci.2018.03.009
10.1016/j.trci.2018.03.009 · External reference
10.1016/j.trci.2019.05.008
10.1016/j.trci.2019.05.008 · External reference
Alzheimer’s disease drug development pipeline: 2020
2020 · External reference
10.1186/1471-2105-10-s5-s4
10.1186/1471-2105-10-s5-s4 · External reference
10.1016/j.drudis.2015.05.001
10.1016/j.drudis.2015.05.001 · External reference
Screening novel drug candidates for Alzheimer’s disease by an integrated network and transcriptome analysis
10.1093/bioinformatics/btaa563 · 2020 · External reference
10.1093/bioinformatics/btz418
10.1093/bioinformatics/btz418 · External reference
10.1111/febs.12672
10.1111/febs.12672 · External reference
10.1016/j.phrs.2016.09.024
10.1016/j.phrs.2016.09.024 · External reference
10.1093/bib/bbv048
10.1093/bib/bbv048 · External reference
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
10.1093/nar/30.1.207 · 2002 · External reference
10.1093/cercor/bht101
10.1093/cercor/bht101 · External reference
Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: Implications for CSF homeostasis
10.1186/s12987-018-0102-9 · 2018 · External reference
Gene expression changes in the course of normal brain aging are sexually dimorphic
10.1073/pnas.0806883105 · 2008 · External reference
Unresolved reference
External reference
Limma powers differential expression analyses for RNA-sequencing and microarray studies
2015 · External reference
10.1016/j.cell.2017.10.049
10.1016/j.cell.2017.10.049 · External reference
L1000CDS2: LINCS L1000 characteristic direction signatures search engine
10.1038/npjsba.2016.15 · 2016 · External reference
10.1093/bioinformatics/bty060
10.1093/bioinformatics/bty060 · External reference
Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd
2016 · External reference
A Web Tool for Ranking Candidate Drugs Against a Selected Disease Based on a Combination of Functional and Structural Criteria
2019 · External reference
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
10.1016/j.addr.2012.09.019 · 2012 · External reference
Molecular properties that influence the oral bioavailability of drug candidates
2002 · External reference
LightBBB: Computational prediction model of blood-brain-barrier penetration based on LightGBM
10.1093/bioinformatics/btaa918 · 2021 · External reference
DisGeNET: A comprehensive platform integrating information on human disease-associated genes and variants
2017 · External reference
10.1093/bioinformatics/bts551
10.1093/bioinformatics/bts551 · External reference
ChemBioServer 2.0: An advanced web server for filtering, clustering and networking of chemical compounds facilitating both drug discovery and repurposing
10.1093/bioinformatics/btz976 · 2020 · External reference
10.1016/j.lfs.2019.05.006
10.1016/j.lfs.2019.05.006 · External reference
Paroxetine ameliorates prodromal emotional dysfunction and late-onset memory deficit in Alzheimer’s disease mice
2020 · External reference
Quinacrine directly dissociates amyloid plaques in the brain of 5XFAD transgenic mouse model of Alzheimer’s disease
2021 · External reference
10.1016/s0006-3223(98)00329-1
10.1016/s0006-3223(98)00329-1 · External reference
Formulation and optimization of intranasal nanolipid carriers of pioglitazone for the repurposing in Alzheimer’s disease using Box-Behnken design
10.1080/03639045.2019.1593439 · 2019 · External reference
Signalling pathways implicated in alzheimer′s disease neurodegeneration in individuals with and without down syndrome
10.3390/ijms21186906 · 2020 · External reference
MKP-1 reduces aβ generation and alleviates cognitive impairments in Alzheimer’s disease models
2019 · External reference
Hippocampal asymmetry in angiotensin II modulatory effects on learning and memory in rats
10.55782/ane-2015-2015 · 2015 · External reference
Aβ-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice
10.1126/scitranslmed.aaz2541 · 2020 · External reference
Progression from amnesic mild cognitive impairment to alzheimer’s disease: ESR1 and ESR2 polymorphisms and APOE gene
10.1159/000335541 · 2012 · External reference
Estrogen receptor 1 gene (ESR1) variants in alzheimer’s disease. Results of a meta-analysis
10.1007/bf03324684 · 2007 · External reference
Impact of CYP2D6 and CYP3A4 Genetic Polymorphism on Combined Cholinesterase Inhibitors and Memantine Treatment in Mild to Moderate Alzheimer’s Disease
10.1159/000350050 · 2014 · External reference
Perindopril: An updated review of its use in hypertension
10.2165/00003495-200161060-00020 · 2001 · External reference
Iloperidone in the treatment of schizophrenia: An evidence-based review of its place in therapy
10.2147/ce.s114094 · 2016 · External reference
Paroxetine loaded PLGA nanoparticles
10.1016/j.matpr.2020.01.568 · 2020 · External reference
Computational Drug Repurposing for Alzheimer’s Disease Using Risk Genes From GWAS and Single-Cell RNA Sequencing Studies
2021 · External reference
Drug repositioning for Alzheimer’s disease based on systematic “omics” data mining
2016 · External reference
