Research graph
References from Diet-gut microbiota interactions on cardiovascular disease. Local targets link to admitted publications; unresolved targets remain external evidence.
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Unresolved reference
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10.1038/nrmicro.2017.149
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Intestinal microbiota in cardiovascular health and disease: JACC state-of-the-art review
10.1016/j.jacc.2019.03.024 · 2019 · External reference
Gut microbiota in health and disease
10.1152/physrev.00045.2009 · 2010 · External reference
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The possible involvement of intestinal bacteria in steroidal hypertension
10.1210/endo-110-1-285 · 1982 · External reference
Microbiota introduced to germ-free rats restores vascular contractility and blood pressure
10.1161/hypertensionaha.120.15939 · 2020 · External reference
10.5551/jat.3285
10.5551/jat.3285 · External reference
Gut microbiota promote angiotensin II-induced arterial hypertension and vascular dysfunction
2016 · External reference
Gut dysbiosis is linked to hypertension
10.1161/hypertensionaha.115.05315 · 2015 · External reference
The microbiota promotes arterial thrombosis in low-density lipoprotein receptor-deficient mice
10.1128/mbio.02298-19 · 2019 · External reference
Gut microbiota dysbiosis contributes to the development of hypertension
2017 · External reference
Differential analysis of hypertension-associated intestinal microbiota
10.7150/ijms.29322 · 2019 · External reference
Gut microbiota composition and blood pressure: the CARDIA study
10.1161/hypertensionaha.118.12109 · 2019 · External reference
Symptomatic atherosclerosis is associated with an altered gut metagenome
10.1038/ncomms2266 · 2012 · External reference
The gut microbiome in atherosclerotic cardiovascular disease
2017 · External reference
10.1096/fj.202000622r
10.1096/fj.202000622r · External reference
Analysis of gut microbiota in coronary artery disease patients: a possible link between gut microbiota and coronary artery disease
2016 · External reference
Dysbiosis signatures of gut microbiota in coronary artery disease
10.1152/physiolgenomics.00070.2018 · 2018 · External reference
Alterations in the gut microbiome and metabolism with coronary artery disease severity
2019 · External reference
Pathogenic gut flora in patients with chronic heart failure
10.1016/j.jchf.2015.10.009 · 2016 · External reference
Gut microbiota signature in heart failure defined from profiling of 2 independent cohorts
10.1016/j.jacc.2017.12.057 · 2018 · External reference
10.1253/circj.cj-18-0468
10.1253/circj.cj-18-0468 · External reference
Dysbiosis of gut microbiota with reduced trimethylamine-N-oxide level in patients with large-artery atherosclerotic stroke or transient ischemic attack
10.1161/jaha.115.002699 · 2015 · External reference
Change of intestinal microbiota in cerebral ischemic stroke patients
2019 · External reference
10.1002/jpen.1861
10.1002/jpen.1861 · External reference
Methodology challenges in studying human gut microbiota - effects of collection, storage, DNA extraction and next generation sequencing technologies
10.1038/s41598-018-23296-4 · 2018 · External reference
The effects of sequencing platforms on phylogenetic resolution in 16 S rRNA gene profiling of human feces
10.1038/sdata.2018.68 · 2018 · External reference
Comparison between 16S rRNA and shotgun sequencing data for the taxonomic characterization of the gut microbiota
10.1038/s41598-021-82726-y · 2021 · External reference
10.1126/science.aad3503
10.1126/science.aad3503 · External reference
Unresolved reference
External reference
10.1038/ctg.2016.54
10.1038/ctg.2016.54 · External reference
10.1016/j.jacc.2007.07.016
10.1016/j.jacc.2007.07.016 · External reference
10.1042/cs20180087
10.1042/cs20180087 · External reference
Gut microbiota and cardiovascular disease
10.1161/circresaha.120.316242 · 2020 · External reference
10.1136/gutjnl-2018-317609
10.1136/gutjnl-2018-317609 · External reference
Risk factors associated with intestinal permeability in an adult population: a systematic review
10.1111/ijcp.13385 · 2019 · External reference
10.1051/ocl/2020070
10.1051/ocl/2020070 · External reference
10.1161/cir.0000000000000510
10.1161/cir.0000000000000510 · External reference
10.1038/s41386-019-0437-1
10.1038/s41386-019-0437-1 · External reference
10.1093/advances/nmz061
10.1093/advances/nmz061 · External reference
Interferon-γ and tumor necrosis factor-α synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression
10.1016/s0002-9440(10)62264-x · 2005 · External reference
10.4049/jimmunol.180.8.5653
10.4049/jimmunol.180.8.5653 · External reference
10.1111/j.1749-6632.2012.06526.x
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10.1210/er.2009-0030
10.1210/er.2009-0030 · External reference
10.1016/j.vph.2017.05.005
10.1016/j.vph.2017.05.005 · External reference
Akkermansia muciniphila protects against atherosclerosis by preventing metabolic endotoxemia-induced inflammation in Apoe−/− mice
10.1161/circulationaha.115.019645 · 2016 · External reference
10.1039/c9fo00583h
10.1039/c9fo00583h · External reference
10.1161/atvbaha.118.311233
10.1161/atvbaha.118.311233 · External reference
The intestinal microbiota regulates host cholesterol homeostasis
10.1186/s12915-019-0715-8 · 2019 · External reference
Commensal bacteria at the crossroad between cholesterol homeostasis and chronic inflammation in atherosclerosis
10.1194/jlr.m072165 · 2017 · External reference
10.1073/pnas.1011383107
10.1073/pnas.1011383107 · External reference
Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism
2010 · External reference
10.3390/microorganisms9091881
10.3390/microorganisms9091881 · External reference
Exploring the bacterial impact on cholesterol cycle: a numerical study
10.3389/fmicb.2020.01121 · 2020 · External reference
Cholesterol metabolism by uncultured human gut bacteria influences host cholesterol level
10.1016/j.chom.2020.05.013 · 2020 · External reference
Germ-free housing conditions do not affect aortic root and aortic arch lesion size of late atherosclerotic low-density lipoprotein receptor-deficient mice
10.1080/19490976.2020.1767463 · 2020 · External reference
10.1038/nature09922
10.1038/nature09922 · External reference
10.1128/mbio.02481-14
10.1128/mbio.02481-14 · External reference
Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women
10.1093/eurheartj/ehy799 · 2019 · External reference
Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme
10.1073/pnas.1215689109 · 2012 · External reference
10.1073/pnas.1316569111
10.1073/pnas.1316569111 · External reference
10.3390/nu12051330
10.3390/nu12051330 · External reference
Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis [S]
10.1194/jlr.m051680 · 2015 · External reference
Uncovering the trimethylamine-producing bacteria of the human gut microbiota
10.1186/s40168-017-0271-9 · 2017 · External reference
Characterization of TMAO productivity from carnitine challenge facilitates personalized nutrition and microbiome signatures discovery
2020 · External reference
l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans
10.1172/jci94601 · 2019 · External reference
10.1074/jbc.m114.618249
10.1074/jbc.m114.618249 · External reference
10.1016/j.cell.2016.02.011
10.1016/j.cell.2016.02.011 · External reference
Gut microbiota-dependent marker TMAO in promoting cardiovascular disease: inflammation mechanism, clinical prognostic, and potential as a therapeutic target
10.3389/fphar.2019.01360 · 2019 · External reference
10.1161/jaha.115.002767
10.1161/jaha.115.002767 · External reference
Gut microbiota-dependent metabolite trimethylamine N-oxide contributes to cardiac dysfunction in western diet-induced obese mice
10.3389/fphys.2017.00139 · 2017 · External reference
Dietary choline or trimethylamine N-oxide supplementation does not influence atherosclerosis development in Ldlr−/− and Apoe−/− male mice
10.1093/jn/nxz214 · 2020 · External reference
10.3390/toxins11090490
10.3390/toxins11090490 · External reference
Trimethylamine but not trimethylamine oxide increases with age in rat plasma and affects smooth muscle cells viability
10.1093/gerona/glz181 · 2020 · External reference
TMA (trimethylamine), but not its oxide TMAO (trimethylamine-oxide), exerts haemodynamic effects: implications for interpretation of cardiovascular actions of gut microbiome
10.1093/cvr/cvz231 · 2019 · External reference
10.1056/nejmoa1109400
10.1056/nejmoa1109400 · External reference
Intestinal microbiota-generated metabolite trimethylamine-N-oxide and 5-year mortality risk in stable coronary artery disease: the contributory role of intestinal microbiota in a COURAGE-like patient cohort
10.1161/jaha.115.002816 · 2016 · External reference
Trimethylamine-N-oxide has prognostic value in coronary heart disease: a meta-analysis and dose-response analysis
2020 · External reference
Gut microbiota–dependent trimethylamine N-oxide predicts risk of cardiovascular events in patients with stroke and is related to proinflammatory monocytes
10.1161/atvbaha.118.311023 · 2018 · External reference
Novel findings of the association between gut microbiota–derived metabolite trimethylamine N-oxide and inflammation: results from a systematic review and dose-response meta-analysis
10.1080/10408398.2020.1770199 · 2020 · External reference
Microbiota-dependent metabolite trimethylamine N-oxide and coronary artery calcium in the coronary artery risk development in young adults study (CARDIA)
10.1161/jaha.116.003970 · 2016 · External reference
Association of trimethylamine, trimethylamine n-oxide, and dimethylamine with cardiovascular risk in children with chronic kidney disease
2020 · External reference
Metabolism of cholesterol and bile acids by the gut microbiota
10.3390/pathogens3010014 · 2014 · External reference
The importance of keeping bile salts in their place
10.1136/gut.10.10.857 · 1969 · External reference
10.1016/j.cmet.2013.01.003
10.1016/j.cmet.2013.01.003 · External reference
10.1194/jlr.r900012-jlr200
10.1194/jlr.r900012-jlr200 · External reference
10.7554/elife.37182
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10.1007/978-3-030-15147-8_32
10.1007/978-3-030-15147-8_32 · 2020 · External reference
10.1194/jlr.r500013-jlr200
10.1194/jlr.r500013-jlr200 · External reference
10.1016/j.jsbmb.2011.08.002
10.1016/j.jsbmb.2011.08.002 · External reference
Epimerization of chenodeoxycholic acid to ursodeoxycholic acid by Clostridium baratii isolated from human feces
10.1111/j.1574-6968.2004.tb09568.x · 2004 · External reference
10.1016/j.cmet.2016.05.005
10.1016/j.cmet.2016.05.005 · External reference
Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR−/− and apoE−/− mice
10.1194/jlr.m800619-jlr200 · 2009 · External reference
10.1194/jlr.m500390-jlr200
10.1194/jlr.m500390-jlr200 · External reference
10.1016/j.bbalip.2006.09.018
10.1016/j.bbalip.2006.09.018 · External reference
10.1161/01.atv.0000235697.35431.05
10.1161/01.atv.0000235697.35431.05 · External reference
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation
10.1016/j.cmet.2012.12.011 · 2013 · External reference
TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading
10.1016/j.cmet.2011.11.006 · 2011 · External reference
10.1194/jlr.m800608-jlr200
10.1194/jlr.m800608-jlr200 · External reference
10.1194/jlr.m017376
10.1194/jlr.m017376 · External reference
Increased secondary/primary bile acid ratio in chronic heart failure
10.1016/j.cardfail.2017.06.007 · 2017 · External reference
Fasting serum total bile acid level is associated with coronary artery disease, myocardial infarction and severity of coronary lesions
10.1016/j.atherosclerosis.2019.11.026 · 2020 · External reference
10.1038/nrendo.2015.128
10.1038/nrendo.2015.128 · External reference
10.1016/j.cell.2016.05.041
10.1016/j.cell.2016.05.041 · External reference
The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health
10.1080/19490976.2021.1897212 · 2021 · External reference
High-fiber diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice
10.1161/circulationaha.116.024545 · 2017 · External reference
10.1161/circulationaha.118.036652
10.1161/circulationaha.118.036652 · External reference
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10.1152/physiolgenomics.00089.2016
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10.3389/fphys.2020.00277
10.3389/fphys.2020.00277 · External reference
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2005 · External reference
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10.1016/j.numecd.2017.09.007 · 2018 · External reference
10.1093/ajcn/nqz322
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10.1038/nature24661
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Essential amino acids: master regulators of nutrition and environmental footprint?
10.1038/srep26074 · 2016 · External reference
A cardiovascular disease-linked gut microbial metabolite acts via adrenergic receptors
10.1016/j.cell.2020.02.016 · 2020 · External reference
Gut-derived metabolite phenylacetylglutamine and white matter hyperintensities in patients with acute ischemic stroke
10.3389/fnagi.2021.675158 · 2021 · External reference
The gut microbiota-related metabolite phenylacetylglutamine associates with increased risk of incident coronary artery disease
10.1097/hjh.0000000000002569 · 2020 · External reference
Indoxyl sulfate predicts cardiovascular disease and renal function deterioration in advanced chronic kidney disease
10.1016/j.arcmed.2012.08.002 · 2012 · External reference
10.1093/ndt/gfab004
10.1093/ndt/gfab004 · External reference
Aryl hydrocarbon receptor inhibition restores indoxyl sulfate-mediated endothelial dysfunction in rat aortic rings
10.3390/toxins14020100 · 2022 · External reference
10.1681/asn.2013101062
10.1681/asn.2013101062 · External reference
Plasma microbiome-modulated indole-and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes
10.1016/j.jvs.2017.09.029 · 2018 · External reference
Results of the HEMO Study suggest that p-cresol sulfate and indoxyl sulfate are not associated with cardiovascular outcomes
10.1016/j.kint.2017.05.012 · 2017 · External reference
10.1161/circresaha.120.318155
10.1161/circresaha.120.318155 · External reference
Effects of the Mediterranean diet on cardiovascular outcomes—a systematic review and meta-analysis
10.1371/journal.pone.0159252 · 2016 · External reference
Primary prevention of cardiovascular disease with a Mediterranean diet
10.1056/nejmoa1200303 · 2013 · External reference
Gut microbiome-Mediterranean diet interactions in improving host health
10.12688/f1000research.18992.1 · 2019 · External reference
Metabolomic pattern analysis after mediterranean diet intervention in a nondiabetic population: a 1-and 3-year follow-up in the PREDIMED study
10.1021/pr5007894 · 2015 · External reference
Gut-derived serum lipopolysaccharide is associated with enhanced risk of major adverse cardiovascular events in atrial fibrillation: Effect of adherence to mediterranean diet
10.1161/jaha.117.005784 · 2017 · External reference
10.1038/s41591-020-01223-3
10.1038/s41591-020-01223-3 · External reference
Effects of the Dietary Approach to Stop Hypertension (DASH) diet on cardiovascular risk factors: a systematic review and meta-analysis
10.1017/s0007114514003341 · 2015 · External reference
10.1210/clinem/dgaa644
10.1210/clinem/dgaa644 · External reference
Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients
10.1038/s41467-021-22097-0 · 2021 · External reference
10.1111/bph.14850
10.1111/bph.14850 · External reference
10.1128/mbio.02210-15
10.1128/mbio.02210-15 · External reference
Quercetin reduces atherosclerotic lesions by altering the gut microbiota and reducing atherogenic lipid metabolites
10.1111/jam.14441 · 2019 · External reference
Diets naturally rich in polyphenols and/or long-chain n-3 polyunsaturated fatty acids differently affect microbiota composition in high-cardiometabolic-risk individuals
10.1007/s00592-020-01494-9 · 2020 · External reference
10.1016/j.chom.2018.05.012
10.1016/j.chom.2018.05.012 · External reference
10.1089/jmf.2020.4800
10.1089/jmf.2020.4800 · External reference
10.3945/jn.114.199778
10.3945/jn.114.199778 · External reference
Emerging science on benefits of whole grain oat and barley and their soluble dietary fibers for heart health, glycemic response, and gut microbiota
10.1093/nutrit/nuz085 · 2020 · External reference
10.1093/ajcn/nqaa026
10.1093/ajcn/nqaa026 · External reference
10.3390/molecules26041172
10.3390/molecules26041172 · External reference
10.1080/19490976.2017.1290756
10.1080/19490976.2017.1290756 · External reference
Effect of prebiotic fibre supplementation on hepatic gene expression and serum lipids: a dose–response study in JCR: LA-cp rats
10.1017/s0007114509993539 · 2010 · External reference
Inulin attenuates atherosclerosis in apolipoprotein E-deficient mice
10.1017/bjn20061913 · 2006 · External reference
Meta-analysis of the effect of β-glucan intake on blood cholesterol and glucose levels
10.1016/j.nut.2010.11.006 · 2011 · External reference
10.1007/s00125-007-0791-0
10.1007/s00125-007-0791-0 · External reference
10.1161/circulationaha.119.043081
10.1161/circulationaha.119.043081 · External reference
10.1161/circresaha.118.313565
10.1161/circresaha.118.313565 · External reference
The probiotic Lactobacillus fermentum prevents dysbiosis and vascular oxidative stress in rats with hypertension induced by chronic nitric oxide blockade
10.1002/mnfr.201800298 · 2018 · External reference
Probiotic yogurt improves antioxidant status in type 2 diabetic patients
10.1016/j.nut.2011.08.013 · 2012 · External reference
Effects of Bifidobacterium longum BB536 on lipid profile and histopathological changes in hypercholesterolaemic rats
10.3920/bm2014.0032 · 2015 · External reference
Evaluation of the effect of Lactobacillus reuteri V3401 on biomarkers of inflammation, cardiovascular risk and liver steatosis in obese adults with metabolic syndrome: a randomized clinical trial (PROSIR)
10.1186/s12906-018-2371-x · 2018 · External reference
Effect of berberine on atherosclerosis and gut microbiota modulation and their correlation in high-fat diet-fed ApoE−/− mice
10.3389/fphar.2020.00223 · 2020 · External reference
Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome
2021 · External reference
10.3389/fphar.2020.599760
10.3389/fphar.2020.599760 · External reference
Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota
2015 · External reference
