Research graph
References from Deregulated molecules and pathways in the predisposition and dissemination of breast cancer cells to bone. Local targets link to admitted publications; unresolved targets remain external evidence.
Incidence of bone metastases in patients with solid tumors: analysis of oncology electronic medical records in the United States
10.1186/s12885-017-3922-0 · 2018 · External reference
Remarks on a Case of Alternate Partial Anaesthesia
10.1136/bmj.1.1462.1 · 1889 · External reference
10.1038/nrc867
10.1038/nrc867 · External reference
Unresolved reference
2017 · External reference
Osteoclast differentiation by RANKL and OPG signaling pathways
10.1007/s00774-020-01162-6 · 2021 · External reference
DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis
10.1172/jci71812 · 2014 · External reference
10.1210/edrv.20.3.0367
10.1210/edrv.20.3.0367 · External reference
Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid
10.1200/jco.2005.06.091 · 2005 · External reference
Molecular Mechanisms of Bone Metastasis
2016 · External reference
Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis
10.1186/1476-4598-9-258 · 2010 · External reference
Cadherin-11 promotes the metastasis of prostate cancer cells to bone
10.1158/1541-7786.mcr-08-0077 · 2008 · External reference
Bone Metastasis of Breast Cancer
10.1007/978-3-030-20301-6_7 · 2019 · External reference
10.1002/cncr.11129
10.1002/cncr.11129 · External reference
10.1038/nrclinonc.2016.144
10.1038/nrclinonc.2016.144 · External reference
Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone
2002 · External reference
Tumor-derived exosomes promote the in vitro osteotropism of melanoma cells by activating the SDF-1/CXCR4/CXCR7 axis
10.1186/s12967-019-1982-4 · 2019 · External reference
10.1007/s00223-013-9733-7
10.1007/s00223-013-9733-7 · External reference
10.1002/jcp.25821
10.1002/jcp.25821 · External reference
Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation
10.1182/blood-2006-05-021352 · 2007 · External reference
10.1007/s10456-017-9541-1
10.1007/s10456-017-9541-1 · External reference
VEGF-VEGFR System as a Target for Suppressing Inflammation and other Diseases
10.2174/1871530315666150316121956 · 2015 · External reference
10.1007/s00018-019-03351-7
10.1007/s00018-019-03351-7 · External reference
Mechanisms of bone metastasis
2004 · External reference
Mechanism and treatment of cancer metastasis to bone
2005 · External reference
10.1038/ncomms12794
10.1038/ncomms12794 · External reference
A GDF11/myostatin inhibitor, GDF11 propeptide-Fc, increases skeletal muscle mass and improves muscle strength in dystrophic mdx mice
10.1186/s13395-019-0197-y · 2019 · External reference
METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling
10.3390/ijms21010199 · 2019 · External reference
Tetraspanin CD151 mediates communication between PC3 prostate cancer cells and osteoblasts
10.18388/abp.2016_1356 · 2017 · External reference
CD151 knockdown inhibits osteosarcoma metastasis through the GSK-3beta/beta-catenin/MMP9 pathway
10.3892/or.2015.4517 · 2016 · External reference
Preferential adhesion of prostate cancer cells to bone is mediated by binding to bone marrow endothelial cells as compared to extracellular matrix components in vitro
2000 · External reference
10.1093/jnci/90.2.118
10.1093/jnci/90.2.118 · External reference
10.1016/j.pharmthera.2013.10.006
10.1016/j.pharmthera.2013.10.006 · External reference
The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression
10.1155/2017/6138145 · 2017 · External reference
Intravascular cell-to-cell adhesive interactions and bone metastasis
10.1007/s10555-006-9029-8 · 2006 · External reference
Mechanical entrapment is insufficient and intercellular adhesion is essential for metastatic cell arrest in distant organs
10.1593/neo.04646 · 2005 · External reference
10.1016/s1535-6108(03)00132-6
10.1016/s1535-6108(03)00132-6 · External reference
A novel role of dipeptidyl peptidase 9 in epidermal growth factor signaling
10.1158/1541-7786.mcr-10-0272 · 2011 · External reference
Dipeptidyl peptidases as survival factors in Ewing sarcoma family of tumors: implications for tumor biology and therapy
10.1074/jbc.m111.224089 · 2011 · External reference
10.1186/ar3101
10.1186/ar3101 · External reference
Circular RNA TTBK2 promotes the development of human glioma cells via miR-520b/EZH2 axis
2019 · External reference
Knockdown of circ-TTBK2 Inhibits Glioma Progression by Regulating miR-1283 and CHD1
10.2147/cmar.s252916 · 2020 · External reference
10.1371/journal.pone.0086476
10.1371/journal.pone.0086476 · External reference
Circ-TTC17 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma
10.1007/s10620-018-5382-z · 2019 · External reference
10.3389/fendo.2020.567844
10.3389/fendo.2020.567844 · 2020 · External reference
FAU regulates carboplatin resistance in ovarian cancer
10.1002/gcc.20721 · 2010 · External reference
10.1002/pros.21186
10.1002/pros.21186 · External reference
10.1073/pnas.97.4.1566
10.1073/pnas.97.4.1566 · External reference
Unresolved reference
External reference
10.1016/j.bone.2007.12.006
10.1016/j.bone.2007.12.006 · External reference
10.1161/circulationaha.119.041059
10.1161/circulationaha.119.041059 · External reference
Recent Insights into Long Bone Development: Central Role of Hedgehog Signaling Pathway in Regulating Growth Plate
10.3390/ijms20235840 · 2019 · External reference
10.1016/j.yjmcc.2018.01.013
10.1016/j.yjmcc.2018.01.013 · External reference
10.1038/s41380-019-0512-3
10.1038/s41380-019-0512-3 · External reference
Overexpression of CST4 promotes gastric cancer aggressiveness by activating the ELFN2 signaling pathway
2017 · External reference
10.1007/s10911-005-5399-8
10.1007/s10911-005-5399-8 · External reference
The role of zoledronic acid in cancer: clinical studies in the treatment and prevention of bone metastases
10.1016/s0093-7754(01)90260-x · 2001 · External reference
Molecular mechanisms of tumor-bone interactions in osteolytic metastases
10.1615/critreveukargeneexpr.v10.i2.50 · 2000 · External reference
10.1056/nejmra0805239
10.1056/nejmra0805239 · External reference
10.1038/nature13145
10.1038/nature13145 · External reference
10.1261/rna.2293906
10.1261/rna.2293906 · External reference
10.1164/rccm.201503-0418oc
10.1164/rccm.201503-0418oc · External reference
10.18632/oncotarget.4352
10.18632/oncotarget.4352 · External reference
Frameshift mutations of OGDH, PPAT and PCCA genes in gastric and colorectal cancers
10.4149/neo_2016_504 · 2016 · External reference
A novel stop-gain mutation in ARMC2 is associated with multiple morphological abnormalities of the sperm flagella
10.1016/j.rbmo.2021.07.021 · 2021 · External reference
Bone specific immunity and its impact on metastasis
10.1038/bonekey.2015.32 · 2015 · External reference
10.1158/0008-5472.can-04-1987
10.1158/0008-5472.can-04-1987 · External reference
Induction of heme oxygenase-1 modulates the profibrotic effects of transforming growth factor-beta in human renal tubular epithelial cells
2005 · External reference
10.1038/36593
10.1038/36593 · External reference
10.1111/febs.14292
10.1111/febs.14292 · External reference
ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3
10.7150/thno.49384 · 2021 · External reference
10.1002/cam4.1295
10.1002/cam4.1295 · External reference
Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment
10.1371/journal.pone.0006896 · 2009 · External reference
PTHrP regulates angiogenesis and bone resorption via VEGF expression
2010 · External reference
10.1016/j.devcel.2017.05.005
10.1016/j.devcel.2017.05.005 · External reference
10.1186/s11658-017-0035-3
10.1186/s11658-017-0035-3 · External reference
Thrombin impairs human endometrial endothelial angiogenesis; implications for progestin-only contraceptive-induced abnormal uterine bleeding
10.1016/j.contraception.2017.04.001 · 2017 · External reference
Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents
10.1016/j.ejmech.2019.111962 · 2020 · External reference
Aldehyde dehydrogenases and cell proliferation
10.1016/j.freeradbiomed.2011.11.033 · 2012 · External reference
Changes in bone after high-dose irradiation. Biomechanics and histomorphology
10.1302/0301-620x.73b3.1670456 · 1991 · External reference
Raman spectroscopy demonstrates prolonged alteration of bone chemical composition following extremity localized irradiation
10.1016/j.bone.2013.08.014 · 2013 · External reference
Bone-Targeted Therapies in Cancer-Induced Bone Disease
10.1007/s00223-017-0353-5 · 2018 · External reference
Therapeutic approaches to myeloma bone disease: an evolving story
10.1016/j.ctrv.2012.03.004 · 2012 · External reference
Consequences of daily administered parathyroid hormone on myeloma growth, bone disease, and molecular profiling of whole myelomatous bone
10.1371/journal.pone.0015233 · 2010 · External reference