Research graph
References from Crystallographic mining of ASK1 regulators to unravel the intricate PPI interfaces for the discovery of small molecule. Local targets link to admitted publications; unresolved targets remain external evidence.
A systematic approach to orient the human protein-protein interaction network
10.1038/s41467-019-10887-6 · 2019 · External reference
10.1172/jci88881
10.1172/jci88881 · External reference
10.1038/s41591-018-0104-9
10.1038/s41591-018-0104-9 · External reference
10.1016/j.cmet.2012.05.012
10.1016/j.cmet.2012.05.012 · External reference
10.1002/hep.29466
10.1002/hep.29466 · External reference
Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress
10.1038/srep20848 · 2016 · External reference
Liver disease: Conscious uncoupling in NASH
10.1038/nrd.2017.60 · 2017 · External reference
Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease
2007 · External reference
10.1172/jci41636
10.1172/jci41636 · External reference
10.1038/srep39170
10.1038/srep39170 · External reference
10.1007/s00535-018-1451-5
10.1007/s00535-018-1451-5 · External reference
10.1038/nature07976
10.1038/nature07976 · External reference
A systems biology analysis protein-protein interaction of NASH and IBD based on comprehensive gene information
2017 · External reference
10.1038/nm.3293
10.1038/nm.3293 · External reference
10.1038/nature05485
10.1038/nature05485 · External reference
10.1146/annurev-immunol-031210-101322
10.1146/annurev-immunol-031210-101322 · External reference
Bile acids mediated potential functional interaction between FXR and FATP5 in the regulation of Lipid Metabolism
10.7150/ijbs.44774 · 2020 · External reference
Corrigendum: targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates
10.1038/nm1017-1241b · 2017 · External reference
10.1016/j.jhep.2016.03.008
10.1016/j.jhep.2016.03.008 · External reference
10.1016/j.jhep.2016.02.002
10.1016/j.jhep.2016.02.002 · External reference
10.1074/mcp.m115.057364
10.1074/mcp.m115.057364 · External reference
10.1016/j.cmet.2014.06.010
10.1016/j.cmet.2014.06.010 · External reference
10.1128/mcb.00503-14
10.1128/mcb.00503-14 · External reference
10.1038/nm.3800
10.1038/nm.3800 · External reference
10.1126/science.1160794
10.1126/science.1160794 · External reference
Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease
10.1159/000369152 · 2015 · External reference
10.1038/cdd.2010.47
10.1038/cdd.2010.47 · External reference
Therapeutic targets in the ASK1-dependent stress signaling pathways
10.2183/pjab.88.434 · 2012 · External reference
10.1007/s00109-020-01878-y
10.1007/s00109-020-01878-y · External reference
10.2210/pdb6xih/pdb
10.2210/pdb6xih/pdb · External reference
10.21037/atm-20-4354
10.21037/atm-20-4354 · External reference
STELLAR 3 and STELLAR 4: lessons from the fall of Icarus
10.1016/j.jhep.2020.04.034 · 2020 · External reference
10.1016/j.jbior.2017.05.004
10.1016/j.jbior.2017.05.004 · External reference
10.1002/hep.30822
10.1002/hep.30822 · External reference
10.1080/15548627.2015.1058473
10.1080/15548627.2015.1058473 · External reference
10.1016/j.cmet.2010.04.005
10.1016/j.cmet.2010.04.005 · External reference
10.1038/cddis.2014.162
10.1038/cddis.2014.162 · External reference
10.1172/jci74068
10.1172/jci74068 · External reference
Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes
10.1007/s00125-014-3255-3 · 2014 · External reference
Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1
10.1073/pnas.1620813114 · 2017 · External reference
10.1016/j.str.2007.08.011
10.1016/j.str.2007.08.011 · External reference
10.14218/jcth.2020.00057
10.14218/jcth.2020.00057 · External reference
10.1038/nm.4453
10.1038/nm.4453 · External reference
Liver ASK1 protects from non-alcoholic fatty liver disease and fibrosis
10.15252/emmm.201810124 · 2019 · External reference
ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model
10.1172/jci.insight.123294 · 2020 · External reference
10.1002/hep.29514
10.1002/hep.29514 · External reference
10.1016/j.cell.2013.03.034
10.1016/j.cell.2013.03.034 · External reference
10.1038/nature13001
10.1038/nature13001 · External reference
Allo-network drugs: extension of the allosteric drug concept to protein- protein interaction and signaling networks
10.2174/1568026611313010007 · 2013 · External reference
Protein-protein interactions
2016 · External reference
10.1017/s1462399408000641
10.1017/s1462399408000641 · External reference
10.1038/npp.2008.151
10.1038/npp.2008.151 · External reference
10.1080/17460441.2018.1430763
10.1080/17460441.2018.1430763 · External reference
10.1042/bj20140587
10.1042/bj20140587 · External reference
10.1039/c4cc08565e
10.1039/c4cc08565e · External reference
Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials
2020 · External reference
10.1021/jm300060k
10.1021/jm300060k · External reference
10.1021/jm401753e
10.1021/jm401753e · External reference
10.1021/acs.jmedchem.5b00810
10.1021/acs.jmedchem.5b00810 · External reference
10.2210/pdb4c66/pdb
10.2210/pdb4c66/pdb · External reference
10.1038/nrd.2017.227
10.1038/nrd.2017.227 · External reference
10.1038/s41392-020-00315-3
10.1038/s41392-020-00315-3 · External reference
Allosteric modulators of protein-protein interactions (PPIs)
10.1007/978-981-13-8719-7_13 · 2019 · External reference
10.1371/journal.pone.0181748
10.1371/journal.pone.0181748 · External reference
Chemical control over protein-protein interactions: beyond inhibitors
10.2174/138620707782507296 · 2007 · External reference
Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions
10.1002/bip.22893 · 2016 · External reference
Macrophages and Fc-receptor interactions contribute to the antitumour activities of the anti-CD40 antibody SGN-40
10.1038/sj.bjc.6604812 · 2009 · External reference
Platelet pro-aggregatory effects of CD40L monoclonal antibody
10.1016/j.molimm.2007.08.006 · 2008 · External reference
The development of 9-substituted purines as immunomodulators
10.1007/978-94-009-4267-7_21 · 1987 · External reference
10.1073/pnas.0901823106
10.1073/pnas.0901823106 · External reference
Redox characterization of functioning skeletal muscle
2015 · External reference
Redox roles of reactive oxygen species in cardiovascular diseases
10.3390/ijms161126059 · 2015 · External reference
10.1152/physrev.00018.2001
10.1152/physrev.00018.2001 · External reference
10.1016/s1471-4914(01)02173-6
10.1016/s1471-4914(01)02173-6 · External reference
10.1007/s11064-007-9482-y
10.1007/s11064-007-9482-y · External reference
Protein aggregation, metals and oxidative stress in neurodegenerative diseases
10.1042/bst20051082 · 2005 · External reference
10.1016/j.freeradbiomed.2008.07.021
10.1016/j.freeradbiomed.2008.07.021 · External reference
10.1016/j.freeradbiomed.2009.12.022
10.1016/j.freeradbiomed.2009.12.022 · External reference
10.1155/2012/439587
10.1155/2012/439587 · External reference
10.1016/j.tcb.2008.10.003
10.1016/j.tcb.2008.10.003 · External reference
SMN depleted mice offer a robust and rapid onset model of nonalcoholic fatty liver disease
2021 · External reference
Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling
10.1074/mcp.m600147-mcp200 · 2006 · External reference
10.1073/pnas.0406871102
10.1073/pnas.0406871102 · External reference
10.1038/sj.emboj.7600194
10.1038/sj.emboj.7600194 · External reference
10.1074/jbc.m311129200
10.1074/jbc.m311129200 · External reference
10.1073/pnas.96.15.8511
10.1073/pnas.96.15.8511 · External reference
10.1128/mcb.26.10.3785-3797.2006
10.1128/mcb.26.10.3785-3797.2006 · External reference
Novel cardiac apoptotic pathway: the dephosphorylation of apoptosis repressor with caspase recruitment domain by calcineurin
10.1161/circulationaha.107.750869 · 2008 · External reference
Calcineurin suppresses AMPK-dependent cytoprotective autophagy in cardiomyocytes under oxidative stress
10.1038/cddis.2013.533 · 2014 · External reference
10.1128/mcb.00047-13
10.1128/mcb.00047-13 · External reference
10.1128/mcb.01067-08
10.1128/mcb.01067-08 · External reference
10.1074/jbc.m506771200
10.1074/jbc.m506771200 · External reference
10.1021/bi602462q
10.1021/bi602462q · External reference
10.1016/j.bbamcr.2015.10.006
10.1016/j.bbamcr.2015.10.006 · External reference
10.1016/j.bbamcr.2013.05.005
10.1016/j.bbamcr.2013.05.005 · External reference
10.1093/nar/gkp335
10.1093/nar/gkp335 · External reference
10.1016/s0092-8674(00)81067-3
10.1016/s0092-8674(00)81067-3 · External reference
10.1093/emboj/17.9.2596
10.1093/emboj/17.9.2596 · External reference
10.1128/mcb.00227-07
10.1128/mcb.00227-07 · External reference
Crystal structure of the human thioredoxin reductase-thioredoxin complex
10.1038/ncomms1382 · 2011 · External reference
The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein
10.1038/ncomms3958 · 2014 · External reference
10.1016/j.cell.2006.01.021
10.1016/j.cell.2006.01.021 · External reference
10.1073/pnas.0812453106
10.1073/pnas.0812453106 · External reference
Cellular repressor of E1A-stimulated gene overexpression in bone mesenchymal stem cells protects against rat myocardial infarction
10.1016/j.ijcard.2015.01.059 · 2015 · External reference
10.1016/j.yjmcc.2015.07.001
10.1016/j.yjmcc.2015.07.001 · External reference
10.1097/01.hjh.0000133717.48334.cf
10.1097/01.hjh.0000133717.48334.cf · External reference
Cellular repressor of E1A-stimulated genes attenuates cardiac hypertrophy and fibrosis
10.1111/j.1582-4934.2008.00633.x · 2009 · External reference
Up-regulation of CREG expression by the transcription factor GATA1 inhibits high glucose- and high palmitate-induced apoptosis in human umbilical vein endothelial cells
10.1371/journal.pone.0154861 · 2016 · External reference
Nanoporous CREG-eluting stent attenuates in-stent neointimal formation in porcine coronary arteries
10.1371/journal.pone.0060735 · 2013 · External reference
10.1016/j.jvs.2008.01.061
10.1016/j.jvs.2008.01.061 · External reference
10.1016/j.jhep.2016.04.005
10.1016/j.jhep.2016.04.005 · External reference
Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor?
10.1093/eurheartj/ehr453 · 2012 · External reference
The novel intracellular protein CREG inhibits hepatic steatosis, obesity, and insulin resistance
10.1002/hep.29257 · 2017 · External reference
10.1126/scisignal.2004822
10.1126/scisignal.2004822 · External reference
10.1016/j.molcel.2009.10.016
10.1016/j.molcel.2009.10.016 · External reference
10.1038/sj.onc.1210054
10.1038/sj.onc.1210054 · External reference
10.1016/s0960-9822(01)00290-1
10.1016/s0960-9822(01)00290-1 · External reference
10.1038/35083081
10.1038/35083081 · External reference
A novel high-content imaging-based technique for measuring binding of Dickkopf-1 to low-density lipoprotein receptor-related protein 6
10.1016/j.vascn.2018.11.003 · 2019 · External reference
10.1128/mcb.22.17.6100-6110.2002
10.1128/mcb.22.17.6100-6110.2002 · External reference
10.1038/nature756
10.1038/nature756 · External reference
10.1074/jbc.m111131200
10.1074/jbc.m111131200 · External reference
Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy
10.1038/s41467-018-04038-6 · 2018 · External reference
10.1016/s1097-2765(00)80283-x
10.1016/s1097-2765(00)80283-x · External reference
10.1128/mcb.20.6.2198-2208.2000
10.1128/mcb.20.6.2198-2208.2000 · External reference
10.1002/cbic.201800436
10.1002/cbic.201800436 · External reference
10.1016/j.celrep.2017.11.007
10.1016/j.celrep.2017.11.007 · External reference
10.1182/blood-2011-12-399808
10.1182/blood-2011-12-399808 · External reference
10.1002/hep.24357
10.1002/hep.24357 · External reference
10.1007/978-4-431-55855-2
10.1007/978-4-431-55855-2 · 2016 · External reference
10.1016/j.cell.2006.03.009
10.1016/j.cell.2006.03.009 · External reference
10.1016/j.molcel.2010.10.009
10.1016/j.molcel.2010.10.009 · External reference
10.1073/pnas.94.14.7337
10.1073/pnas.94.14.7337 · External reference
The role of JNk signaling pathway in obesity -driven insulin resistance
10.2147/dmso.s236127 · 2020 · External reference
Targeting incretin hormones and the ASK-1 pathway as therapeutic options in the treatment of non-alcoholic steatohepatitis
10.1007/s12072-018-9854-1 · 2018 · External reference
10.1038/sj.cr.7290257
10.1038/sj.cr.7290257 · External reference
10.1016/j.bbrc.2012.07.066
10.1016/j.bbrc.2012.07.066 · External reference
10.1016/s0092-8674(00)00116-1
10.1016/s0092-8674(00)00116-1 · External reference
10.1016/s1357-2725(00)00003-0
10.1016/s1357-2725(00)00003-0 · External reference
MKK4 and metastasis suppression: a marriage of signal transduction and metastasis research
10.1023/a:1022586318678 · 2003 · External reference
Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers
2001 · External reference
Mitogen-activated protein kinase kinase 4 (MKK4) acts as a metastasis suppressor gene in human ovarian carcinoma
2002 · External reference
10.1016/j.bbrc.2010.08.071
10.1016/j.bbrc.2010.08.071 · External reference
10.1126/scisignal.2003004
10.1126/scisignal.2003004 · External reference
10.1073/pnas.1419528112
10.1073/pnas.1419528112 · External reference
10.1016/j.cell.2013.03.026
10.1016/j.cell.2013.03.026 · External reference
From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4)
2020 · External reference
A Protoberberine derivative HWY336 selectively inhibits MKK4 and MKK7 in mammalian cells: the importance of activation loop on selectivity
10.1371/journal.pone.0091037 · 2014 · External reference
Small changes huge impact: the role of protein posttranslational modifications in cellular homeostasis and disease
10.4061/2011/207691 · 2011 · External reference
10.1038/cr.2013.151
10.1038/cr.2013.151 · External reference
10.1016/j.tibs.2012.07.001
10.1016/j.tibs.2012.07.001 · External reference
10.1074/jbc.m109.045229
10.1074/jbc.m109.045229 · External reference
10.1074/jbc.m807219200
10.1074/jbc.m807219200 · External reference
10.4161/15384101.2014.952165
10.4161/15384101.2014.952165 · External reference
Thioredoxin inhibits MPK38-induced ASK1, TGF-β, and p53 function in a phosphorylation-dependent manner
10.1016/j.freeradbiomed.2013.05.020 · 2013 · External reference
Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress
10.1093/emboj/20.21.6028 · 2001 · External reference
10.1016/j.biocel.2010.07.014
10.1016/j.biocel.2010.07.014 · External reference
10.1042/bj20070231
10.1042/bj20070231 · External reference
10.1038/cdd.2015.2
10.1038/cdd.2015.2 · External reference
10.1016/j.molcel.2012.09.018
10.1016/j.molcel.2012.09.018 · External reference
10.1074/jbc.m111.329771
10.1074/jbc.m111.329771 · External reference
10.1074/jbc.m408320200
10.1074/jbc.m408320200 · External reference
10.1074/jbc.m401208200
10.1074/jbc.m401208200 · External reference
10.5607/en.2011.20.1.35
10.5607/en.2011.20.1.35 · External reference
10.1074/jbc.m511744200
10.1074/jbc.m511744200 · External reference
10.1039/b920805d
10.1039/b920805d · External reference
CaMKII activates ASK1 and NF-kappaB to induce cardiomyocyte hypertrophy
10.1016/j.bbrc.2004.12.002 · 2005 · External reference
CaMKII activates ASK1 to induce apoptosis of spinal astrocytes under oxygen-glucose deprivation
10.1007/s10571-013-9920-0 · 2013 · External reference
Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II
10.1186/1472-6769-8-2 · 2008 · External reference
10.1038/sj.embor.7400072
10.1038/sj.embor.7400072 · External reference
10.1128/mcb.21.3.893-901.2001
10.1128/mcb.21.3.893-901.2001 · External reference
10.1038/sj.onc.1208548
10.1038/sj.onc.1208548 · External reference
10.1158/0008-5472.can-08-1484
10.1158/0008-5472.can-08-1484 · External reference
10.1007/s00018-010-0353-3
10.1007/s00018-010-0353-3 · External reference
10.1002/jcp.22568
10.1002/jcp.22568 · External reference
10.1073/pnas.0908458106
10.1073/pnas.0908458106 · External reference
10.1111/jcmm.12206
10.1111/jcmm.12206 · External reference
10.1007/s00018-012-0925-5
10.1007/s00018-012-0925-5 · External reference
Estrogen inhibits paclitaxel-induced apoptosis via the phosphorylation of apoptosis signal-regulating kinase 1 in human ovarian cancer cell lines
10.1210/en.2003-0792 · 2004 · External reference
10.1016/j.neuroscience.2016.04.026
10.1016/j.neuroscience.2016.04.026 · External reference
10.1038/sj.onc.1209406
10.1038/sj.onc.1209406 · External reference
10.1038/onc.2009.276
10.1038/onc.2009.276 · External reference
10.1074/jbc.m116.724310
10.1074/jbc.m116.724310 · External reference
10.1128/mcb.00047-13
10.1128/mcb.00047-13 · External reference
10.1158/0008-5472.can-16-0232
10.1158/0008-5472.can-16-0232 · External reference
10.1074/jbc.m211398200
10.1074/jbc.m211398200 · External reference
10.1074/jbc.m109.064295
10.1074/jbc.m109.064295 · External reference
10.1371/journal.pone.0067586
10.1371/journal.pone.0067586 · External reference
10.1128/mcb.01067-08
10.1128/mcb.01067-08 · External reference
10.1371/journal.pone.0141968
10.1371/journal.pone.0141968 · External reference
10.1371/journal.pone.0139914
10.1371/journal.pone.0139914 · External reference
10.1161/circresaha.107.168153
10.1161/circresaha.107.168153 · External reference
10.1371/journal.pone.0137177
10.1371/journal.pone.0137177 · External reference
Apoptosis signal-regulating kinase 1 in peptidoglycan-induced COX-2 expression in macrophages
10.1189/jlb.1009668 · 2010 · External reference
Protective effect of FK506 on myocardial ischemia/reperfusion injury by suppression of CaN and ASK1 signaling circuitry
10.1007/s12012-010-9095-6 · 2011 · External reference
10.1038/onc.2009.382
10.1038/onc.2009.382 · External reference
10.1074/jbc.m809740200
10.1074/jbc.m809740200 · External reference
10.1128/mcb.01677-12
10.1128/mcb.01677-12 · External reference
10.1021/acs.chemrestox.6b00339
10.1021/acs.chemrestox.6b00339 · External reference
10.1016/j.neuroscience.2012.10.055
10.1016/j.neuroscience.2012.10.055 · External reference
10.1074/jbc.m304183200
10.1074/jbc.m304183200 · External reference
PI3 kinase and direct S-nitrosation are involved in down-regulation of apoptosis signal-regulating kinase 1 during LPS-induced Toll-like receptor 4 signalling
10.1016/j.imlet.2007.10.013 · 2008 · External reference
10.1007/978-981-10-3292-9
10.1007/978-981-10-3292-9 · 2017 · External reference
10.1016/s0003-9861(03)00199-1
10.1016/s0003-9861(03)00199-1 · External reference
Nitrative inactivation of thioredoxin-1 and its role in postischemic myocardial apoptosis
10.1161/circulationaha.106.625061 · 2006 · External reference
10.1016/j.abb.2004.06.004
10.1016/j.abb.2004.06.004 · External reference
Nitrative thioredoxin inactivation as a cause of enhanced myocardial ischemia/reperfusion injury in the aging heart
10.1016/j.freeradbiomed.2007.03.016 · 2007 · External reference
10.1158/0008-5472.can-08-0625
10.1158/0008-5472.can-08-0625 · External reference
10.1371/journal.pone.0007059
10.1371/journal.pone.0007059 · External reference
10.1038/sj.cdd.4402273
10.1038/sj.cdd.4402273 · External reference
SOCS1 inhibits tumor necrosis factor-induced activation of ASK1-JNK inflammatory signaling by mediating ASK1 degradation
10.1074/jbc.m512338200 · 2006 · External reference
10.1165/rcmb.2007-0287oc
10.1165/rcmb.2007-0287oc · External reference
10.1074/jbc.m609146200
10.1074/jbc.m609146200 · External reference
10.1379/csc-90r.1
10.1379/csc-90r.1 · External reference
10.1016/j.cellsig.2009.03.010
10.1016/j.cellsig.2009.03.010 · External reference
10.1096/fj.06-8029com
10.1096/fj.06-8029com · External reference
10.3892/ijmm.2016.2586
10.3892/ijmm.2016.2586 · External reference
10.1161/01.res.0000022160.64355.62
10.1161/01.res.0000022160.64355.62 · External reference
Abstract 2153: P34SEI-1inhibits ROS-induced cell death through suppression of ASK1
2011 · External reference
10.3892/ol.2016.4659
10.3892/ol.2016.4659 · External reference
10.1016/j.yexcr.2011.03.022
10.1016/j.yexcr.2011.03.022 · External reference
Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response
2016 · External reference
10.1038/35056591
10.1038/35056591 · External reference
Erratum: SUMO-1 represses apoptosis signal-regulating kinase 1 activation through physical interaction and not through covalent modification
10.1038/sj.embor.7400570 · 2005 · External reference
10.1038/cdd.2011.168
10.1038/cdd.2011.168 · External reference
10.1091/mbc.e15-10-0738
10.1091/mbc.e15-10-0738 · External reference
Adenosine 5’-monophosphate blocks acetaminophen toxicity by increasing ubiquitination-mediated ASK1 degradation
10.18632/oncotarget.14059 · 2017 · External reference
