Research graph
References from Whole-body metabolic modelling predicts isoleucine dependency of SARS-CoV-2 replication. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1016/j.clim.2020.108427
10.1016/j.clim.2020.108427 · External reference
Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis
2020 · External reference
SARS-CoV-2 Infection in Children
2020 · External reference
Organ-specific manifestations of COVID-19 infection
10.1007/s10238-020-00648-x · 2020 · External reference
Coronavirus biology and replication: implications for SARS-CoV-2
2021 · External reference
COVID-19 and the liver: overview
10.1097/meg.0000000000001808 · 2021 · External reference
10.1038/nbt1210-1248
10.1038/nbt1210-1248 · External reference
10.1002/path.1570
10.1002/path.1570 · External reference
Unresolved reference
2020 · External reference
Covid-19 and the digestive system
2020 · External reference
10.1053/j.gastro.2020.02.055
10.1053/j.gastro.2020.02.055 · External reference
10.1101/2022.01.07.475453
10.1101/2022.01.07.475453 · External reference
10.1016/s2215-0366(21)00084-5
10.1016/s2215-0366(21)00084-5 · External reference
10.1186/s12915-019-0678-9
10.1186/s12915-019-0678-9 · External reference
10.1017/cbo9781139854610
10.1017/cbo9781139854610 · 2015 · External reference
10.1038/nprot.2009.203
10.1038/nprot.2009.203 · External reference
Systems medicine and metabolic modelling
10.1111/j.1365-2796.2011.02493.x · 2012 · External reference
Computational modeling of human metabolism and its application to systems biomedicine
10.1007/978-1-4939-3283-2_12 · 2016 · External reference
Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions
10.1038/msb.2010.68 · 2010 · External reference
10.1093/hmg/ddt119
10.1093/hmg/ddt119 · External reference
10.15252/msb.20198982
10.15252/msb.20198982 · External reference
10.1016/j.cmet.2015.07.001
10.1016/j.cmet.2015.07.001 · External reference
A compendium of inborn errors of metabolism mapped onto the human metabolic network
10.1039/c2mb25075f · 2012 · External reference
Rare genetic variants affecting urine metabolite levels link population variation to inborn errors of metabolism
10.1038/s41467-020-20877-8 · 2021 · External reference
Analysis of omics data with genome-scale models of metabolism
10.1039/c2mb25453k · 2013 · External reference
10.1016/j.copbio.2014.02.011
10.1016/j.copbio.2014.02.011 · External reference
10.1101/2021.11.08.467803
10.1101/2021.11.08.467803 · External reference
FBA reveals guanylate kinase as a potential target for antiviral therapies against SARS-CoV-2
2020 · External reference
Genome-scale metabolic model of infection with SARS-CoV-2 mutants confirms guanylate kinase as robust potential antiviral target
10.3390/genes12060796 · 2021 · External reference
Genome-scale metabolic modeling reveals SARS-CoV-2-induced metabolic changes and antiviral targets
10.15252/msb.202110260 · 2021 · External reference
Unresolved reference
External reference
10.1038/nbt.4072
10.1038/nbt.4072 · External reference
10.1093/nar/gks1065
10.1093/nar/gks1065 · External reference
10.1016/j.bpj.2010.01.060
10.1016/j.bpj.2010.01.060 · External reference
Epidemiological study of Yersinia enterocolitica and Yersinia pseudotuberculosis in Shimane Prefecture, Japan
1987 · External reference
Coronavirus M proteins accumulate in the Golgi complex beyond the site of virion budding
10.1128/jvi.68.10.6523-6534.1994 · 1994 · External reference
10.1128/jvi.00645-06
10.1128/jvi.00645-06 · External reference
Isolation of coronavirus envelope glycoproteins and interaction with the viral nucleocapsid
10.1128/jvi.33.1.449-462.1980 · 1980 · External reference
10.1016/0042-6822(92)90521-p
10.1016/0042-6822(92)90521-p · External reference
Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3
10.1128/jvi.02631-07 · 2008 · External reference
10.1126/science.abb2507
10.1126/science.abb2507 · External reference
10.2217/fvl-2018-0008
10.2217/fvl-2018-0008 · External reference
10.1016/j.virol.2010.05.031
10.1016/j.virol.2010.05.031 · External reference
10.1007/s11426-011-4428-2
10.1007/s11426-011-4428-2 · External reference
Integrated human-virus metabolic stoichiometric modelling predicts host-based antiviral targets against Chikungunya, Dengue and Zika viruses
10.1098/rsif.2018.0125 · 2018 · External reference
10.7554/elife.57309
10.7554/elife.57309 · External reference
Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26
10.1080/22221751.2020.1739565 · 2020 · External reference
Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19
10.1038/s41591-020-0819-2 · 2020 · External reference
The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease
10.1093/nar/gky992 · 2019 · External reference
10.1038/nbt.1614
10.1038/nbt.1614 · External reference
ReconMap: an interactive visualization of human metabolism
2017 · External reference
Vlasov V et al.: Creation and analysis of biochemical constraint-based models using the COBRA Toolbox vol 3.0
10.1038/s41596-018-0098-2 · 2019 · External reference
10.1038/nmeth.3176
10.1038/nmeth.3176 · External reference
SARS-CoV-2: virus dynamics and host response
10.1016/s1473-3099(20)30235-8 · 2020 · External reference
10.1016/j.cell.2020.05.032
10.1016/j.cell.2020.05.032 · External reference
A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing
2003 · External reference
10.1007/s00705-022-05385-y
10.1007/s00705-022-05385-y · External reference
10.1016/j.tim.2015.08.007
10.1016/j.tim.2015.08.007 · External reference
Interferons Reprogramming the metabolic network against viral infection
10.3390/v10010036 · 2018 · External reference
10.1053/j.gastro.2021.10.013
10.1053/j.gastro.2021.10.013 · External reference
Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City
2004 · External reference
Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implications
10.1210/endrev/bnaa011 · 2020 · External reference
Expanding roles for CD4(+) T cells in immunity to viruses
2012 · External reference
Long covid-mechanisms, risk factors, and management
10.1136/bmj.n1648 · 2021 · External reference
10.1093/ajcn/69.2.179
10.1093/ajcn/69.2.179 · External reference
10.1371/journal.pone.0253293
10.1371/journal.pone.0253293 · External reference
Carnitine and COVID-19 susceptibility and severity: A Mendelian randomization study
10.3389/fnut.2021.780205 · 2021 · External reference
The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism
10.1038/s41598-020-73966-5 · 2020 · External reference
Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes
10.3389/fgene.2015.00148 · 2015 · External reference
Pharmacometabolomics of statin response
10.1038/clpt.2013.164 · 2013 · External reference
Pharmacometabolomic signature links simvastatin therapy and insulin resistance
10.1007/s11306-016-1141-3 · 2017 · External reference
10.1038/s41586-020-2286-9
10.1038/s41586-020-2286-9 · External reference
10.1016/j.biochi.2006.04.002
10.1016/j.biochi.2006.04.002 · External reference
10.1093/jn/nxab059
10.1093/jn/nxab059 · External reference
Omicron blindspots: why it's hard to track coronavirus variants
10.1038/d41586-021-03698-7 · 2021 · External reference
10.1038/nrm1570
10.1038/nrm1570 · External reference
Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19): A multi-center study in Wenzhou city, Zhejiang, China
10.1016/j.jinf.2020.02.016 · 2020 · External reference
Baseline Characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy
10.1001/jama.2020.5394 · 2020 · External reference
Temporal dynamics in viral shedding and transmissibility of COVID-19
2020 · External reference
