Research graph
References from Host-pathogen protein-nucleic acid interactions: A comprehensive review. Local targets link to admitted publications; unresolved targets remain external evidence.
Innate immunity and pathogen-host interaction
10.1016/s0264-410x(03)00195-6 · 2003 · External reference
10.1146/annurev.immunol.20.083001.084359
10.1146/annurev.immunol.20.083001.084359 · External reference
10.1146/annurev.iy.12.040194.005015
10.1146/annurev.iy.12.040194.005015 · External reference
10.1016/j.cell.2006.02.015
10.1016/j.cell.2006.02.015 · External reference
10.1016/j.immuni.2011.05.001
10.1016/j.immuni.2011.05.001 · External reference
10.1038/nrmicro.2016.45
10.1038/nrmicro.2016.45 · External reference
10.1038/41131
10.1038/41131 · External reference
10.1016/j.coi.2014.12.002
10.1016/j.coi.2014.12.002 · External reference
10.1016/j.cell.2010.01.022
10.1016/j.cell.2010.01.022 · External reference
10.1128/cmr.00046-08
10.1128/cmr.00046-08 · External reference
10.1111/j.1462-5822.2005.00564.x
10.1111/j.1462-5822.2005.00564.x · External reference
10.1016/j.mib.2013.07.010
10.1016/j.mib.2013.07.010 · External reference
10.5772/22016
10.5772/22016 · External reference
10.1016/j.chom.2008.05.002
10.1016/j.chom.2008.05.002 · External reference
10.1146/annurev.micro.112408.134243
10.1146/annurev.micro.112408.134243 · External reference
10.3389/fcimb.2013.00024
10.3389/fcimb.2013.00024 · External reference
10.1038/mt.2014.29
10.1038/mt.2014.29 · External reference
Structural studies of protein–nucleic acid interaction: the sources of sequence-specific binding | Quarterly Reviews of Biophysics | Cambridge Core
10.1017/s0033583500005552 · 1990 · External reference
10.1093/nar/gkn573
10.1093/nar/gkn573 · External reference
Protein-DNA Interactions
2018 · External reference
A rapid method for detecting protein-nucleic acid interactions by protein induced fluorescence enhancement
10.1038/srep39653 · 2016 · External reference
10.1146/annurev.biophys.33.110502.140414
10.1146/annurev.biophys.33.110502.140414 · External reference
Protein–DNA/RNA interactions: an overview of investigation methods in the -omics era
10.1021/acs.jproteome.1c00074 · 2021 · External reference
Amino acid-base interactions: a three-dimensional analysis of protein-DNA interactions at an atomic level
10.1093/nar/29.13.2860 · 2001 · External reference
10.1073/pnas.0402319101
10.1073/pnas.0402319101 · External reference
10.1073/pnas.73.3.804
10.1073/pnas.73.3.804 · External reference
Unresolved reference
External reference
An overview of the structures of protein-DNA complexes
10.1186/gb-2000-1-1-reviews001 · 2000 · External reference
10.1038/372432a0
10.1038/372432a0 · External reference
Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome
10.1016/s0092-8674(00)80668-6 · 2000 · External reference
10.1093/emboj/19.5.997
10.1093/emboj/19.5.997 · External reference
10.1038/nature02088
10.1038/nature02088 · External reference
10.1038/nsmb738
10.1038/nsmb738 · External reference
10.1038/nsmb1038
10.1038/nsmb1038 · External reference
10.1038/nrm2178
10.1038/nrm2178 · External reference
10.1016/j.tim.2004.09.004
10.1016/j.tim.2004.09.004 · External reference
Extracellular RNA sensing by pattern recognition receptors
10.1159/000494034 · 2018 · External reference
10.1084/jem.20050914
10.1084/jem.20050914 · External reference
10.1084/jem.20081370
10.1084/jem.20081370 · External reference
Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis
10.1186/ar787 · 2003 · External reference
10.1016/j.molmed.2009.06.003
10.1016/j.molmed.2009.06.003 · External reference
Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus
10.1074/jbc.m410592200 · 2005 · External reference
10.4049/jimmunol.174.3.1259
10.4049/jimmunol.174.3.1259 · External reference
10.4049/jimmunol.180.9.5799
10.4049/jimmunol.180.9.5799 · External reference
10.1146/annurev.immunol.22.012703.104514
10.1146/annurev.immunol.22.012703.104514 · External reference
10.1038/ni1280
10.1038/ni1280 · External reference
10.1111/j.1749-6632.2012.06667.x
10.1111/j.1749-6632.2012.06667.x · External reference
10.1016/j.immuni.2006.07.013
10.1016/j.immuni.2006.07.013 · External reference
10.1084/jem.20101048
10.1084/jem.20101048 · External reference
10.4049/jimmunol.1402425
10.4049/jimmunol.1402425 · External reference
10.1124/mol.113.089821
10.1124/mol.113.089821 · External reference
10.4049/jimmunol.0902592
10.4049/jimmunol.0902592 · External reference
10.1038/nm1176
10.1038/nm1176 · External reference
10.4049/jimmunol.173.3.2134
10.4049/jimmunol.173.3.2134 · External reference
10.4049/jimmunol.178.2.693
10.4049/jimmunol.178.2.693 · External reference
10.1016/j.intimp.2014.12.030
10.1016/j.intimp.2014.12.030 · External reference
10.1093/rheumatology/ker257
10.1093/rheumatology/ker257 · External reference
10.1128/iai.02045-14
10.1128/iai.02045-14 · External reference
10.1002/art.20678
10.1002/art.20678 · External reference
Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis
10.4049/jimmunol.176.11.7021 · 2006 · External reference
Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis
10.1002/art.24140 · 2008 · External reference
Induction of experimental arthritis by borrelial lipoprotein and CpG motifs: are toll-like receptors 2, 4, 9 or CD-14 involved?
10.2174/1874312901105010018 · 2011 · External reference
A TLR 9 antagonist diminishes arthritis severity in a rat model of rheumatoid arthritis
10.1136/ard.2010.148973.8 · 2011 · External reference
10.1084/jem.20070285
10.1084/jem.20070285 · External reference
Emerging role of endosomal toll-like receptors in rheumatoid arthritis
2014 · External reference
Activation of toll-like receptor 3 protects against DSS-induced acute colitis
10.1002/ibd.20142 · 2007 · External reference
TLR9 is important for protection against intestinal damage and for intestinal repair
2012 · External reference
Multiple sclerosis: modulation of toll-like receptor (TLR) expression by interferon-β includes upregulation of TLR7 in plasmacytoid dendritic cells
10.1371/journal.pone.0070626 · 2013 · External reference
10.4049/jimmunol.1001992
10.4049/jimmunol.1001992 · External reference
10.1016/j.celrep.2016.07.002
10.1016/j.celrep.2016.07.002 · External reference
Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response
10.15252/embj.201593339 · 2016 · External reference
10.4049/jimmunol.1500969
10.4049/jimmunol.1500969 · External reference
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
2015 · External reference
10.1038/nature12306
10.1038/nature12306 · External reference
10.1016/j.it.2017.07.013
10.1016/j.it.2017.07.013 · External reference
10.1016/j.celrep.2018.11.097
10.1016/j.celrep.2018.11.097 · External reference
10.1016/j.immuni.2014.10.019
10.1016/j.immuni.2014.10.019 · External reference
10.1038/nature23470
10.1038/nature23470 · External reference
10.1016/j.immuni.2014.10.017
10.1016/j.immuni.2014.10.017 · External reference
10.1038/35099560
10.1038/35099560 · External reference
10.1126/science.1093616
10.1126/science.1093616 · External reference
10.1126/science.1093620
10.1126/science.1093620 · External reference
10.1084/jem.20030162
10.1084/jem.20030162 · External reference
10.1073/pnas.161293498
10.1073/pnas.161293498 · External reference
10.1038/35047123
10.1038/35047123 · External reference
TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification
10.1126/science.1220363 · 2012 · External reference
The human metapneumovirus matrix protein stimulates the inflammatory immune response in vitro
10.1371/journal.pone.0017818 · 2011 · External reference
10.1038/nm1140
10.1038/nm1140 · External reference
10.1371/journal.pntd.0000926
10.1371/journal.pntd.0000926 · External reference
Detrimental contribution of the toll-like receptor (TLR)3 to Influenza A virus-induced acute pneumonia
10.1371/journal.ppat.0020053 · 2006 · External reference
Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from Toll-like receptor 3
10.1084/jem.20081761 · 2009 · External reference
Activation of chemokine and inflammatory cytokine response in hepatitis C virus-infected hepatocytes depends on Toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates
10.1002/hep.24763 · 2012 · External reference
TLR3 deficiency in patients with herpes simplex encephalitis
10.1126/science.1139522 · 2007 · External reference
10.1126/science.1155406
10.1126/science.1155406 · External reference
10.1126/science.1115253
10.1126/science.1115253 · External reference
10.4049/jimmunol.180.6.3729
10.4049/jimmunol.180.6.3729 · External reference
10.1038/nsmb.2943
10.1038/nsmb.2943 · External reference
10.1016/j.immuni.2016.09.011
10.1016/j.immuni.2016.09.011 · External reference
10.1126/science.1229159
10.1126/science.1229159 · External reference
Optimal oligonucleotide sequences for TLR9 inhibitory activity in human cells: lack of correlation with TLR9 binding
10.1093/intimm/dxq473 · 2011 · External reference
10.1038/374546a0
10.1038/374546a0 · External reference
10.4049/jimmunol.164.2.944
10.4049/jimmunol.164.2.944 · External reference
10.4049/jimmunol.166.4.2372
10.4049/jimmunol.166.4.2372 · External reference
10.1038/nature14138
10.1038/nature14138 · External reference
10.1002/embj.201386117
10.1002/embj.201386117 · External reference
10.1146/annurev-immunol-031210-101340
10.1146/annurev-immunol-031210-101340 · External reference
10.1073/pnas.0403555101
10.1073/pnas.0403555101 · External reference
10.1016/j.cell.2011.01.031
10.1016/j.cell.2011.01.031 · External reference
Innate immune effectors in mycobacterial infection
10.1155/2011/347594 · 2011 · External reference
Sequence specific detection of bacterial 23S ribosomal RNA by TLR13
10.7554/elife.00102 · 2012 · External reference
10.1038/nsmb.3080
10.1038/nsmb.3080 · External reference
10.1016/j.it.2016.10.006
10.1016/j.it.2016.10.006 · External reference
10.1073/pnas.0912986107
10.1073/pnas.0912986107 · External reference
Unresolved reference
External reference
The, RNA Recognition, LOOP IN RIG-I-LIKE RECEPTORS
2009 · External reference
10.1016/j.molcel.2007.10.032
10.1016/j.molcel.2007.10.032 · External reference
10.1126/science.1132505
10.1126/science.1132505 · External reference
RNA helicase retinoic acid-inducible gene I as a sensor of Hantaan virus replication
10.1099/vir.0.032367-0 · 2011 · External reference
10.1038/nature07106
10.1038/nature07106 · External reference
10.1016/j.cytogfr.2014.06.005
10.1016/j.cytogfr.2014.06.005 · External reference
10.1128/jvi.02449-08
10.1128/jvi.02449-08 · External reference
In vivo ligands of MDA5 and RIG-I in measles virus-infected cells
10.1371/journal.ppat.1004081 · 2014 · External reference
Comparative analysis of viral RNA signatures on different RIG-I-like receptors
10.7554/elife.11275 · 2016 · External reference
10.1073/pnas.1005077107
10.1073/pnas.1005077107 · External reference
10.1084/jem.20080091
10.1084/jem.20080091 · External reference
10.1016/j.cell.2010.01.020
10.1016/j.cell.2010.01.020 · External reference
10.1073/pnas.0603082103
10.1073/pnas.0603082103 · External reference
Establishment and maintenance of the innate antiviral response to West Nile Virus involves both RIG-I and MDA5 signaling through IPS-1
10.1128/jvi.01305-07 · 2008 · External reference
10.1128/jvi.01080-07
10.1128/jvi.01080-07 · External reference
10.1016/j.str.2010.05.007
10.1016/j.str.2010.05.007 · External reference
10.4049/jimmunol.175.5.2851
10.4049/jimmunol.175.5.2851 · External reference
10.1073/pnas.0606699104
10.1073/pnas.0606699104 · External reference
10.1016/j.mito.2010.02.005
10.1016/j.mito.2010.02.005 · External reference
10.1038/nature06013
10.1038/nature06013 · External reference
10.1038/nature06537
10.1038/nature06537 · External reference
10.1038/ni.1876
10.1038/ni.1876 · External reference
10.1038/ni.1779
10.1038/ni.1779 · External reference
10.1016/j.cell.2009.06.015
10.1016/j.cell.2009.06.015 · External reference
10.1038/ni.1932
10.1038/ni.1932 · External reference
10.1128/jvi.01339-09
10.1128/jvi.01339-09 · External reference
10.7554/elife.00047
10.7554/elife.00047 · External reference
10.1073/pnas.1222694110
10.1073/pnas.1222694110 · External reference
Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells
10.1073/pnas.1006539107 · 2010 · External reference
10.1038/ni.1859
10.1038/ni.1859 · External reference
10.1016/j.chom.2011.04.008
10.1016/j.chom.2011.04.008 · External reference
10.1016/j.coi.2017.11.004
10.1016/j.coi.2017.11.004 · External reference
cGAS-STING, an important pathway in cancer immunotherapy
10.1186/s13045-020-00916-z · 2020 · External reference
10.1038/nature12305
10.1038/nature12305 · External reference
10.1038/nature12306
10.1038/nature12306 · External reference
10.1016/j.cell.2013.07.023
10.1016/j.cell.2013.07.023 · External reference
10.1158/0008-5472.can-08-2281
10.1158/0008-5472.can-08-2281 · External reference
10.1016/j.immuni.2018.09.016
10.1016/j.immuni.2018.09.016 · External reference
10.1038/nri3875
10.1038/nri3875 · External reference
10.1038/s41573-019-0043-2
10.1038/s41573-019-0043-2 · External reference
10.1038/nrd914
10.1038/nrd914 · External reference
10.1016/j.vaccine.2017.09.052
10.1016/j.vaccine.2017.09.052 · External reference
A phase I-II trial of multiple-dose polyriboinosic-polyribocytidylic acid in patieonts with leukemia or solid tumors
10.1093/jnci/57.3.599 · 1976 · External reference
A controlled clinical trial with a specifically configured RNA drug, poly(I).poly(C12U), in chronic fatigue syndrome
10.1093/clinids/18.supplement_1.s88 · 1994 · External reference
Mismatched double-stranded RNA (ampligen) reduces concentration of zidovudine (azidothymidine) required for in-vitro inhibition of human immunodeficiency virus
10.1016/s0140-6736(87)92862-5 · 1987 · External reference
A clinical grade poly I:C-analogue (Ampligen) promotes optimal DC maturation and Th1-type T cell responses of healthy donors and cancer patients in vitro
10.1016/j.vaccine.2008.10.024 · 2009 · External reference
Poly(I:C) primes primary human glioblastoma cells for an immune response invigorated by PD-L1 blockade
10.1080/2162402x.2017.1407899 · 2018 · External reference
10.1158/1078-0432.ccr-17-1866
10.1158/1078-0432.ccr-17-1866 · External reference
Anti-tumor macrophages activated by ferumoxytol combined or surface-functionalized with the TLR3 agonist poly (I : C) promote melanoma regression
10.7150/thno.29746 · 2018 · External reference
Toll-like receptor 3 signal in dendritic cells benefits cancer immunotherapy
10.3389/fimmu.2017.01897 · 2017 · External reference
Tumoricidal efficacy coincides with CD11c up-regulation in antigen-specific CD8+ T cells during vaccine immunotherapy
10.1186/s13046-016-0416-x · 2016 · External reference
Toll-like receptor 3-induced immune response by poly(d, l-lactide-co-glycolide) nanoparticles for dendritic cell-based cancer immunotherapy
10.2147/ijn.s109001 · 2016 · External reference
10.1038/s41591-019-0410-x
10.1038/s41591-019-0410-x · External reference
Phase II trial of a complex polyriboinosinic-polyribocytidylic acid with poly-L-lysine and carboxymethyl cellulose in the treatment of children with acute leukemia and neuroblastoma: a report from the Children’s Cancer Study Group
1985 · External reference
Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer
10.1186/s13045-017-0459-2 · 2017 · External reference
A pilot study of the immunogenicity of a 9-peptide breast cancer vaccine plus poly-ICLC in early stage breast cancer
10.1186/s40425-017-0295-5 · 2017 · External reference
Combined immunotherapy encompassing intratumoral poly-ICLC, dendritic-cell vaccination and radiotherapy in advanced cancer patients
10.1093/annonc/mdy089 · 2018 · External reference
ROBUST INDUCTION OF TYPE-1 CD8+ T-CELL RESPONSES IN WHO GRADE II LOW-GRADE GLIOMA PATIENTS RECEIVING PEPTIDE-BASED VACCINES IN COMBINATION WITH POLY-ICLC
10.1093/neuonc/nou208.62 · 2022 · External reference
Antigen-specific immune responses and clinical outcome after vaccination with glioma-associated antigen peptides and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in children with newly diagnosed malignant brainstem and nonbrainstem gliomas
10.1200/jco.2013.54.0526 · 2014 · External reference
Poly-ICLC, a TLR3 agonist, induces transient innate immune responses in patients with treated HIV-infection: a randomized double-blinded placebo controlled trial
10.3389/fimmu.2019.00725 · 2019 · External reference
IL-27 enhances the expression of TRAIL and TLR3 in human melanomas and inhibits their tumor growth in cooperation with a TLR3 agonist poly(I:C) partly in a TRAIL-dependent manner
10.1371/journal.pone.0076159 · 2013 · External reference
10.1016/j.addr.2019.07.008
10.1016/j.addr.2019.07.008 · External reference
Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes
10.1073/pnas.58.3.1004 · 1967 · External reference
10.1002/ijc.2910210113
10.1002/ijc.2910210113 · External reference
10.1002/1873-3468.12749
10.1002/1873-3468.12749 · External reference
10.1016/j.celrep.2017.05.015
10.1016/j.celrep.2017.05.015 · External reference
Down modulation of human TLR3 function by a monoclonal antibody
10.1016/j.cellimm.2007.10.002 · 2007 · External reference
10.1016/j.cellimm.2010.10.008
10.1016/j.cellimm.2010.10.008 · External reference
10.1021/ja111312h
10.1021/ja111312h · External reference
10.1021/acs.accounts.9b00631
10.1021/acs.accounts.9b00631 · External reference
Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection
10.1128/aac.00268-07 · 2007 · External reference
Synthesis and structure-activity-relationships of 1H-imidazo[4,5-c]quinolines that induce interferon production
10.1021/jm049211v · 2005 · External reference
10.1046/j.1365-2230.2002.01151.x
10.1046/j.1365-2230.2002.01151.x · External reference
10.3390/pharmaceutics13020142
10.3390/pharmaceutics13020142 · External reference
Modification of immunological responses and clinical disease during topical R-837 treatment of genital HSV-2 infection
10.1016/0166-3542(88)90032-0 · 1988 · External reference
Topical imiquimod plus nab-paclitaxel for breast cancer cutaneous metastases: a phase 2 clinical trial
10.1001/jamaoncol.2016.6007 · 2017 · External reference
10.1111/1471-0528.15124
10.1111/1471-0528.15124 · External reference
Successful treatment of nivolumab-resistant multiple in-transit melanomas with ipilimumab and topical imiquimod
10.1159/000485612 · 2018 · External reference
Imiquimod in dermatology: an overview
10.1111/ijd.13235 · 2016 · External reference
10.1152/ajplung.00440.2005
10.1152/ajplung.00440.2005 · External reference
VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC
10.1158/1078-0432.ccr-11-1625 · 2012 · External reference
10.1007/s00262-013-1437-3
10.1007/s00262-013-1437-3 · External reference
10.1158/2326-6066.cir-14-0202
10.1158/2326-6066.cir-14-0202 · External reference
R-848 triggers the expression of TLR7/8 and suppresses HIV replication in monocytes
10.1186/1471-2334-12-5 · 2012 · External reference
10.1016/j.jhep.2007.02.025
10.1016/j.jhep.2007.02.025 · External reference
A major role for the minor capsid protein of human papillomavirus type 16 in immune escape
10.4049/jimmunol.0902145 · 2009 · External reference
10.1016/j.imbio.2009.09.003
10.1016/j.imbio.2009.09.003 · External reference
10.1038/sj.mt.6300240
10.1038/sj.mt.6300240 · External reference
DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivo
10.1186/ar2710 · 2009 · External reference
Oligodeoxynucleotide inhibition of Toll-like receptors 3, 7, 8, and 9 suppresses cytokine production in a human rheumatoid arthritis model
10.1002/eji.201546123 · 2016 · External reference
Natural modulators of endosomal toll-like receptor-mediated psoriatic skin inflammation
2017 · External reference
Targeting Toll-like receptors: emerging therapeutics?
10.1038/nrd3203 · 2022 · External reference
10.1073/pnas.0707882105
10.1073/pnas.0707882105 · External reference
Maintenance treatment with the immunomodulator MGN1703, a Toll-like receptor 9 (TLR9) agonist, in patients with metastatic colorectal carcinoma and disease control after chemotherapy: a randomised, double-blind, placebo-controlled trial
10.1007/s00432-014-1682-7 · 2014 · External reference
10.1016/j.critrevonc.2014.12.002
10.1016/j.critrevonc.2014.12.002 · External reference
10.4049/jimmunol.171.8.3941
10.4049/jimmunol.171.8.3941 · External reference
Peritumoral CpG DNA elicits a coordinated response of CD8 T cells and innate effectors to cure established tumors in a murine colon carcinoma model
10.4049/jimmunol.169.7.3892 · 2002 · External reference
10.1182/blood-2008-07-170274
10.1182/blood-2008-07-170274 · External reference
Effects of 24-week Toll-like receptor 9 agonist treatment in HIV type 1+ individuals
10.1097/qad.0000000000002213 · 2019 · External reference
10.1016/j.jaci.2019.03.008
10.1016/j.jaci.2019.03.008 · External reference
CpG motifs in bacterial DNA and their immune effects
10.1146/annurev.immunol.20.100301.064842 · 2002 · External reference
10.1007/s002810000021
10.1007/s002810000021 · External reference
Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide
10.1189/jlb.71.5.813 · 2002 · External reference
10.1002/eji.200324032
10.1002/eji.200324032 · External reference
10.1089/oli.2009.0210
10.1089/oli.2009.0210 · External reference
Immunogenicity and safety of a 2-dose hepatitis B vaccine, HBsAg/CpG 1018, in persons with diabetes mellitus aged 60–70 years
10.1016/j.vaccine.2019.08.005 · 2019 · External reference
Heplisav-B: A Hepatitis B vaccine with a novel adjuvant
10.1177/1060028020962050 · 2021 · External reference
CPG 7909 adjuvant plus hepatitis B virus vaccination in HIV-infected adults achieves long-term seroprotection for up to 5 years
10.1086/533467 · 2008 · External reference
10.4049/jimmunol.1502393
10.4049/jimmunol.1502393 · External reference
TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons
10.1038/s41467-018-04569-y · 2018 · External reference
The novel TLR9 antagonist COV08-0064 protects from ischemia/reperfusion injury in non-steatotic and steatotic mice livers
10.1016/j.bcp.2016.05.003 · 2016 · External reference
Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells
2009 · External reference
Targeting the cytosolic innate immune receptors RIG-I and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma
10.1002/stem.1350 · 2013 · External reference
10.18632/oncotarget.25626
10.18632/oncotarget.25626 · External reference
10.1371/journal.pone.0161313
10.1371/journal.pone.0161313 · External reference
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
10.1038/ni.1823 · 2010 · External reference
10.1038/nature04515
10.1038/nature04515 · External reference
Antiviral efficacy and host immune response induction during sequential treatment with SB 9200 followed by Entecavir in woodchucks
10.1371/journal.pone.0169631 · 2017 · External reference
Immunotherapeutic effects of intratumoral nanoplexed poly I:C
10.1186/s40425-019-0568-2 · 2019 · External reference
10.1128/jvi.03114-13
10.1128/jvi.03114-13 · External reference
Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity
10.1371/journal.ppat.1003298 · 2013 · External reference
10.1126/sciadv.1701854
10.1126/sciadv.1701854 · External reference
10.1016/j.vaccine.2017.01.053
10.1016/j.vaccine.2017.01.053 · External reference
Molecular basis for ebolavirus VP35 suppression of human dendritic cell maturation
10.1128/jvi.02163-14 · 2014 · External reference
10.1016/j.virol.2006.09.023
10.1016/j.virol.2006.09.023 · External reference
10.1016/j.coviro.2011.04.004
10.1016/j.coviro.2011.04.004 · External reference
10.1038/nature24050
10.1038/nature24050 · External reference
10.1158/0008-5472.can-18-1972
10.1158/0008-5472.can-18-1972 · External reference
10.1074/jbc.m112.382986
10.1074/jbc.m112.382986 · External reference
10.1128/aac.04321-14
10.1128/aac.04321-14 · External reference
10.1016/j.virol.2019.01.006
10.1016/j.virol.2019.01.006 · External reference
10.1016/j.celrep.2016.05.023
10.1016/j.celrep.2016.05.023 · External reference
10.1080/2162402x.2017.1346765
10.1080/2162402x.2017.1346765 · External reference
10.1158/1078-0432.ccr-05-1939
10.1158/1078-0432.ccr-05-1939 · External reference
Phase II study on the addition of ASA404 (vadimezan; 5,6-dimethylxanthenone-4-acetic acid) to docetaxel in CRMPC
10.1158/1078-0432.ccr-09-3026 · 2010 · External reference
10.4049/jimmunol.1300097
10.4049/jimmunol.1300097 · External reference
10.1038/nature10429
10.1038/nature10429 · External reference
10.1158/2326-6066.cir-14-0099
10.1158/2326-6066.cir-14-0099 · External reference
10.1158/2326-6066.cir-13-0123
10.1158/2326-6066.cir-13-0123 · External reference
Challenges and opportunities in the clinical development of STING agonists for cancer immunotherapy
10.3390/jcm9103323 · 2020 · External reference
10.1016/j.celrep.2015.04.031
10.1016/j.celrep.2015.04.031 · External reference
Design of amidobenzimidazole STING receptor agonists with systemic activity
10.1038/s41586-018-0705-y · 2018 · External reference
Drug developers switch gears to inhibit STING
10.1038/s41587-019-0060-z · 2019 · External reference
cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model
10.1016/j.jaut.2019.03.001 · 2019 · External reference
10.1038/s41577-021-00524-z
10.1038/s41577-021-00524-z · External reference
Natterin-induced neutrophilia is dependent on cGAS/STING activation via type I IFN signaling pathway
10.3390/ijms23073600 · 2022 · External reference
10.3389/fimmu.2021.795401
10.3389/fimmu.2021.795401 · External reference
10.1158/0008-5472.can-15-1885
10.1158/0008-5472.can-15-1885 · External reference
10.1016/j.clim.2016.09.015
10.1016/j.clim.2016.09.015 · External reference
10.1038/nrd3203
10.1038/nrd3203 · External reference
10.1016/j.ejmech.2020.112238
10.1016/j.ejmech.2020.112238 · External reference
Toll-like receptor-mediated dendritic cell-dependent and -independent stimulation of innate and adaptive immunity
10.1016/j.immuni.2008.05.016 · 2008 · External reference
10.1038/90609
10.1038/90609 · External reference
10.1038/35100529
10.1038/35100529 · External reference
10.1016/s0167-4889(01)00182-3
10.1016/s0167-4889(01)00182-3 · External reference
10.1038/ni1112
10.1038/ni1112 · External reference
TLR agonists as mediators of trained immunity: mechanistic insight and immunotherapeutic potential to combat infection
10.3389/fimmu.2020.622614 · 2021 · External reference
10.1038/cmi.2012.61
10.1038/cmi.2012.61 · External reference
10.1038/cmi.2012.61
10.1038/cmi.2012.61 · External reference
10.1111/j.1365-2567.2012.03587.x
10.1111/j.1365-2567.2012.03587.x · External reference
10.1016/j.coi.2009.12.002
10.1016/j.coi.2009.12.002 · External reference
Unresolved reference
2014 · External reference
10.1182/blood-2011-10-388579
10.1182/blood-2011-10-388579 · External reference
10.1016/j.cyto.2016.04.001
10.1016/j.cyto.2016.04.001 · External reference
Unresolved reference
2015 · External reference
Unresolved reference
2019 · External reference
10.1016/j.jmb.2017.10.023
10.1016/j.jmb.2017.10.023 · External reference
Protein-protein interactions in virus-host systems
10.3389/fmicb.2017.01557 · 2017 · External reference
Unresolved reference
2016 · External reference
10.1016/j.jmb.2020.01.025
10.1016/j.jmb.2020.01.025 · External reference
Unresolved reference
2019 · External reference
Oncoviruses can drive cancer by rewiring signaling pathways through interface mimicry
10.3389/fonc.2019.01236 · 2019 · External reference
Unresolved reference
2017 · External reference
Prediction of molecular mimicry candidates in human pathogenic bacteria
10.4161/viru.25180 · 2013 · External reference
Prediction of host - pathogen protein interactions between Mycobacterium tuberculosis and Homo sapiens using sequence motifs
2015 · External reference
DeNovo: virus-host sequence-based protein-protein interaction prediction
10.1093/bioinformatics/btv737 · 2016 · External reference
10.1186/1471-2105-9-s12-s11
10.1186/1471-2105-9-s12-s11 · External reference
Host-microbiome protein-protein interactions reveal mechanisms in human disease
2019 · External reference
Prediction of HIV-1 virus-host protein interactions using virus and host sequence motifs
10.1186/1755-8794-2-27 · 2009 · External reference
Prediction of virus-host protein-protein interactions mediated by short linear motifs
10.1186/s12859-017-1570-7 · 2017 · External reference
10.1110/ps.073228407
10.1110/ps.073228407 · External reference
Structural similarity-based predictions of protein interactions between HIV-1 and Homo sapiens
10.1186/1743-422x-7-82 · 2010 · External reference
Using structural knowledge in the protein data bank to inform the search for potential host-microbe protein interactions in sequence space: application to Mycobacterium tuberculosis
10.1186/s12859-017-1550-y · 2017 · External reference
10.1371/journal.pone.0071526
10.1371/journal.pone.0071526 · External reference
10.1016/j.ymeth.2012.06.011
10.1016/j.ymeth.2012.06.011 · External reference
Computational analysis of host-pathogen protein interactions between humans and different strains of enterohemorrhagic Escherichia coli
10.3389/fcimb.2017.00128 · 2017 · External reference
Comparative interactomics for virus-human protein-protein interactions: DNA viruses versus RNA viruses
10.1002/2211-5463.12167 · 2017 · External reference
Computational approaches for prediction of pathogen-host protein-protein interactions
10.3389/fmicb.2015.00094 · 2015 · External reference
Computational prediction of virus-human protein-protein interactions using embedding kernelized heterogeneous data
10.1039/c6mb00065g · 2016 · External reference
Detection of microbial infections through innate immune sensing of nucleic acids
2018 · External reference
10.1093/intimm/dxy016
10.1093/intimm/dxy016 · External reference
Computational prediction of molecular pathogen-host interactions based on dual transcriptome data
10.3389/fmicb.2015.00065 · 2015 · External reference
10.1093/bioinformatics/btq394
10.1093/bioinformatics/btq394 · External reference
Prediction of interactions between HIV-1 and human proteins by information integration
2009 · External reference
10.1145/1401890.1401969
10.1145/1401890.1401969 · External reference
10.1002/cbdv.201100392
10.1002/cbdv.201100392 · External reference
Stringent homology-based prediction of H. sapiens-M. tuberculosis H37Rv protein-protein interactions
10.1186/1745-6150-9-5 · 2014 · External reference
10.1371/journal.pntd.0000954
10.1371/journal.pntd.0000954 · External reference
SFCscore: scoring functions for affinity prediction of protein-ligand complexes
10.1002/prot.22058 · 2008 · External reference
Integration of element specific persistent homology and machine learning for protein-ligand binding affinity prediction
10.1002/cnm.2914 · 2018 · External reference
NNScore: a neural-network-based scoring function for the characterization of protein−ligand complexes
10.1021/ci100244v · 2010 · External reference
10.1021/acsomega.9b01997
10.1021/acsomega.9b01997 · External reference
Designing template-free predictor for targeting protein-ligand binding sites with classifier ensemble and spatial clustering
10.1109/tcbb.2013.104 · 2013 · External reference
Prediction of novel mouse TLR9 agonists using a random forest approach
10.1186/s12860-019-0241-0 · 2019 · External reference
10.1093/nar/gkq360
10.1093/nar/gkq360 · External reference
10.1093/nar/gkn573
10.1093/nar/gkn573 · External reference
PSSM-based prediction of DNA binding sites in proteins
10.1186/1471-2105-6-33 · 2005 · External reference
Conformational changes in DNA-binding proteins: relationships with precomplex features and contributions to specificity and stability
10.1002/prot.24462 · 2014 · External reference
Moment-based prediction of DNA-binding proteins
10.1016/j.jmb.2004.05.058 · 2004 · External reference
Integrating sequence and gene expression information predicts genome-wide DNA-binding proteins and suggests a cooperative mechanism
10.1093/nar/gkx1166 · 2018 · External reference
Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA
10.1093/nar/gkm1040 · 2008 · External reference
10.1038/nature08473
10.1038/nature08473 · External reference
Transcription factors: structural families and principles of DNA recognition
10.1146/annurev.bi.61.070192.005201 · 1992 · External reference
10.1093/nar/gkx915
10.1093/nar/gkx915 · External reference
Large-scale DNA-based phenotypic recording and deep learning enable highly accurate sequence-function mapping
10.1038/s41467-020-17222-4 · 2020 · External reference
Deep learning for genomics using Janggu
10.1038/s41467-020-17155-y · 2020 · External reference
10.1146/annurev-genom-121719-010946
10.1146/annurev-genom-121719-010946 · External reference
10.1371/journal.pcbi.1007624
10.1371/journal.pcbi.1007624 · External reference
Uncovering tissue-specific binding features from differential deep learning
10.1093/nar/gkaa009 · 2020 · External reference
PreDBA: a heterogeneous ensemble approach for predicting protein-DNA binding affinity
2020 · External reference
TFBSshape: an expanded motif database for DNA shape features of transcription factor binding sites
2020 · External reference
SMARTIV: combined sequence and structure de-novo motif discovery for in-vivo RNA binding data
2018 · External reference
A systems perspective of host-pathogen interactions: predicting disease outcome in tuberculosis
10.1039/b912129c · 2010 · External reference
Computational prediction of molecular pathogen-host interactions based on dual transcriptome data
10.3389/fmicb.2015.00065 · 2015 · External reference
Inference of dynamical gene-regulatory networks based on time-resolved multi-stimuli multi-experiment data applying NetGenerator V2.0
10.1186/1752-0509-7-1 · 2013 · External reference
Gene regulatory networks on transfer entropy (GRNTE): a novel approach to reconstruct gene regulatory interactions applied to a case study for the plant pathogen Phytophthora infestans
10.1186/s12976-019-0103-7 · 2019 · External reference
LRRML: a conformational database and an XML description of leucine-rich repeats (LRRs)
2008 · External reference
10.1007/s00894-009-0640-9
10.1007/s00894-009-0640-9 · External reference
PRRDB 2.0: a comprehensive database of pattern-recognition receptors and their ligands
10.1093/database/baz076 · 2019 · External reference
Thermodynamic database for protein-nucleic acid interactions (ProNIT)
10.1093/bioinformatics/17.11.1027 · 2001 · External reference
10.7717/peerj.8013
10.7717/peerj.8013 · External reference
10.1002/bies.201400142
10.1002/bies.201400142 · External reference
10.1038/mi.2008.5
10.1038/mi.2008.5 · External reference
10.1371/journal.ppat.0040002
10.1371/journal.ppat.0040002 · External reference
10.1016/s0020-7519(98)00153-2
10.1016/s0020-7519(98)00153-2 · External reference
10.1073/pnas.0803232105
10.1073/pnas.0803232105 · External reference
Ecosystem energetic implications of parasite and free-living biomass in three estuaries
10.1038/nature06970 · 2008 · External reference
Unresolved reference
2014 · External reference
10.1080/21505594.2018.1460979
10.1080/21505594.2018.1460979 · External reference
10.1111/j.1469-0691.2008.02070.x
10.1111/j.1469-0691.2008.02070.x · External reference
10.1038/nrmicro2949
10.1038/nrmicro2949 · External reference
10.1146/annurev-pathol-012615-044305
10.1146/annurev-pathol-012615-044305 · External reference
High-throughput sequencing for understanding the ecology of emerging infectious diseases at the wildlife-human interface
10.3389/fevo.2019.00126 · 2019 · External reference
10.1016/j.mib.2013.05.001
10.1016/j.mib.2013.05.001 · External reference
Next-generation sequencing in clinical virology: Discovery of new viruses
10.5501/wjv.v4.i3.265 · 2015 · External reference
10.1152/physrev.00045.2009
10.1152/physrev.00045.2009 · External reference
10.1038/ni.2608
10.1038/ni.2608 · External reference
10.1128/mmbr.00014-10
10.1128/mmbr.00014-10 · External reference
10.1016/j.cell.2019.03.040
10.1016/j.cell.2019.03.040 · External reference
Polymorphisms at the innate immune receptor TLR2 are associated with Borrelia infection in a wild rodent population
2013 · External reference
10.3390/ijms161125957
10.3390/ijms161125957 · External reference
10.1016/j.fsi.2014.09.022
10.1016/j.fsi.2014.09.022 · External reference
10.1016/j.fsi.2017.09.081
10.1016/j.fsi.2017.09.081 · External reference
Molecular population genetics of Drosophila immune system genes
10.1093/genetics/147.2.713 · 1997 · External reference
10.1111/j.1420-9101.2005.00925.x
10.1111/j.1420-9101.2005.00925.x · External reference
Distinct antimicrobial peptide expression determines host species-specific bacterial associations
10.1073/pnas.1304960110 · 2013 · External reference
Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages
10.1073/pnas.1807690115 · 2018 · External reference
Avian Toll-like receptor allelic diversity far exceeds human polymorphism: an insight from domestic chicken breeds
10.1038/s41598-018-36226-1 · 2018 · External reference
Integrative genomics reveals the genetics and evolution of the honey bee’s social immune system
10.1093/gbe/evz018 · 2022 · External reference
10.1016/j.cub.2019.01.058
10.1016/j.cub.2019.01.058 · External reference
10.1038/nrrheum.2011.121
10.1038/nrrheum.2011.121 · External reference
10.1016/j.tins.2013.01.005
10.1016/j.tins.2013.01.005 · External reference
10.1016/j.vaccine.2006.03.071
10.1016/j.vaccine.2006.03.071 · External reference
10.3390/pharmaceutics13020142
10.3390/pharmaceutics13020142 · External reference
Anticancer function of polyinosinic-polycytidylic acid
10.4161/cbt.10.12.13450 · 2010 · External reference
10.1093/intimm/dxp017
10.1093/intimm/dxp017 · External reference
10.3390/cells11071159
10.3390/cells11071159 · External reference
Challenges and Opportunities in the Clinical Development of STING Agonists for Cancer Immunotherapy
10.3390/jcm9103323 · 2020 · External reference
