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References from Delineating the mechanisms and design principles of Caenorhabditis elegans embryogenesis using in toto high-resolution imaging data and computational modeling. Local targets link to admitted publications; unresolved targets remain external evidence.
The life cycle of the nematode Caenorhabditis elegans. I. Wild-type growth and reproduction
10.1016/0012-1606(76)90119-6 · 1976 · External reference
Unresolved reference
1997 · External reference
Regulation of Caenorhabditis elegans body size and male tail development by the novel gene lon-8
10.1186/1471-213x-7-20 · 2007 · External reference
Caenorhabditis elegans as a powerful tool in natural product bioactivity research
10.1186/s13765-022-00685-y · 2022 · External reference
Die Zellkonstanz und ihre Beziehungen zu anderen zoologischen Vorwürfen
10.1007/bf02117179 · 1923 · External reference
Eutely or cell constancy in its relation to body size
10.1086/394396 · 1932 · External reference
Cell lineage and the control of Caenorhabditis elegans development
10.1098/rstb.1985.0175 · 1985 · External reference
Post-embryonic development in the ventral cord of Caenorhabditis elegans
10.1098/rstb.1976.0084 · 1976 · External reference
10.1016/0012-1606(77)90158-0
10.1016/0012-1606(77)90158-0 · External reference
Cell lineages of the embryo of the nematode Caenorhabditis elegans
10.1073/pnas.75.1.376 · 1978 · External reference
10.1016/0012-1606(79)90035-6
10.1016/0012-1606(79)90035-6 · External reference
10.1016/0012-1606(83)90201-4
10.1016/0012-1606(83)90201-4 · External reference
10.1006/dbio.1997.8509
10.1006/dbio.1997.8509 · External reference
10.1016/j.ydbio.2012.11.034
10.1016/j.ydbio.2012.11.034 · External reference
Systems-level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry
10.15252/msb.20145857 · 2015 · External reference
Introduction to the germ line
10.1895/wormbook.1.18.1 · 2005 · External reference
10.1016/s1097-2765(00)80246-4
10.1016/s1097-2765(00)80246-4 · External reference
Establishment and maintenance of heritable chromatin in C. elegans
2017 · External reference
Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm
10.1016/s0092-8674(00)80530-9 · 1997 · External reference
10.1016/s0092-8674(00)80531-0
10.1016/s0092-8674(00)80531-0 · External reference
10.1371/journal.pgen.1005585
10.1371/journal.pgen.1005585 · External reference
The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo
10.1016/0092-8674(94)90238-0 · 1994 · External reference
glp-1 and inductions establishing embryonic axes in C. elegans
10.1242/dev.120.7.2051 · 1994 · External reference
Two maternal genes, apx-1 and pie-1, are required to distinguish the fates of equivalent blastomeres in the early Caenorhabditis elegans embryo
10.1242/dev.120.8.2305 · 1994 · External reference
10.1016/j.cub.2006.08.090
10.1016/j.cub.2006.08.090 · External reference
10.1242/dev.122.12.4105
10.1242/dev.122.12.4105 · External reference
The genetics of behaviour
10.1093/oxfordjournals.bmb.a071019 · 1973 · External reference
10.1093/genetics/77.1.71
10.1093/genetics/77.1.71 · External reference
The DNA of Caenorhabditis elegans
10.1093/genetics/77.1.95 · 1974 · External reference
10.1126/science.282.5396.2012
10.1126/science.282.5396.2012 · External reference
Unresolved reference
External reference
10.1371/journal.pbio.0000045
10.1371/journal.pbio.0000045 · External reference
10.1101/gr.3729105
10.1101/gr.3729105 · External reference
Web resources for C. elegans studies
2005 · External reference
WormBase in 2022 - Data, processes, and tools for analyzing Caenorhabditis elegans
10.1093/genetics/iyac003 · 2022 · External reference
Working with worms: Caenorhabditis elegans as a model organism
10.1002/cpet.35 · 2019 · External reference
Unresolved reference
External reference
Genetic control of programmed cell death in the nematode C. elegans
10.1016/0092-8674(86)90004-8 · 1986 · External reference
10.1242/dev.112.2.591
10.1242/dev.112.2.591 · External reference
10.1038/356494a0
10.1038/356494a0 · External reference
10.1093/genetics/129.1.79
10.1093/genetics/129.1.79 · External reference
10.1038/35888
10.1038/35888 · External reference
10.1002/0471142727.mb2603s109
10.1002/0471142727.mb2603s109 · External reference
10.1016/j.devcel.2015.07.014
10.1016/j.devcel.2015.07.014 · External reference
10.1093/nar/gkv1119
10.1093/nar/gkv1119 · External reference
Timing of tissue-specific cell division requires a differential onset of zygotic transcription during metazoan embryogenesis
10.1074/jbc.m115.705426 · 2016 · External reference
10.1126/science.8303295
10.1126/science.8303295 · External reference
Über die Entstehung des Gegensatzes zwischen den Geschlechtszellen und den somatischen Zellen bei Ascaris megalocephala, nebst Bemerkungen zur Entwicklungsgeschichte der Nematoden
1892 · External reference
Das Nervensystem von Ascaris lumbricoides und megalocephala, I
1908 · External reference
Das Nervensystem von Ascaris lumbricoides und megalocephala, II
1909 · External reference
Cortical and cytoplasmic flow polarity in early embryonic cells of Caenorhabditis elegans
10.1083/jcb.121.6.1343 · 1993 · External reference
10.1016/j.ydbio.2006.03.004
10.1016/j.ydbio.2006.03.004 · External reference
10.1016/j.ydbio.2006.03.005
10.1016/j.ydbio.2006.03.005 · External reference
10.1073/pnas.0511111103
10.1073/pnas.0511111103 · External reference
10.1038/nprot.2006.222
10.1038/nprot.2006.222 · External reference
AceTree: A tool for visual analysis of Caenorhabditis elegans embryogenesis
10.1186/1471-2105-7-275 · 2006 · External reference
10.1371/journal.pcbi.1009755
10.1371/journal.pcbi.1009755 · External reference
WormGUIDES: An interactive single cell developmental atlas and tool for collaborative multidimensional data exploration
10.1186/s12859-015-0627-8 · 2015 · External reference
Using machine learning to speed up manual image annotation: Application to a 3D imaging protocol for measuring single cell gene expression in the developing C. elegans embryo
10.1186/1471-2105-11-84 · 2010 · External reference
A hybrid blob-slice model for accurate and efficient detection of fluorescence labeled nuclei in 3D
10.1186/1471-2105-11-580 · 2010 · External reference
A semi-local neighborhood-based framework for probabilistic cell lineage tracing
10.1186/1471-2105-15-217 · 2014 · External reference
AceTree: A major update and case study in the long term maintenance of open-source scientific software
10.1186/s12859-018-2127-0 · 2018 · External reference
10.1371/journal.pbio.0050237
10.1371/journal.pbio.0050237 · External reference
10.1038/nmeth.1228
10.1038/nmeth.1228 · External reference
10.1101/gr.131920.111
10.1101/gr.131920.111 · External reference
Automated lineage and expression profiling in live Caenorhabditis elegans embryos
2012 · External reference
10.1007/s00427-020-00662-9
10.1007/s00427-020-00662-9 · External reference
10.1016/j.cell.2013.11.046
10.1016/j.cell.2013.11.046 · External reference
Inference of cellular level signaling networks using single-cell gene expression data in Caenorhabditis elegans reveals mechanisms of cell fate specification
10.1093/bioinformatics/btw796 · 2017 · External reference
10.1109/icmlc.2015.7340936
10.1109/icmlc.2015.7340936 · 2015 · External reference
Comparative analysis of embryonic cell lineage between Caenorhabditis briggsae and Caenorhabditis elegans
10.1016/j.ydbio.2007.11.015 · 2008 · External reference
Twenty million years of evolution: The embryogenesis of four Caenorhabditis species are indistinguishable despite extensive genome divergence
10.1016/j.ydbio.2018.12.022 · 2019 · External reference
10.1109/icbcb52223.2021.9459206
10.1109/icbcb52223.2021.9459206 · 2021 · External reference
10.1242/dev.096040
10.1242/dev.096040 · External reference
System-level quantification and phenotyping of early embryonic morphogenesis of Caenorhabditis elegans
2019 · External reference
10.1038/s41467-020-19863-x
10.1038/s41467-020-19863-x · External reference
10.1126/science.aar5663
10.1126/science.aar5663 · External reference
Spatiotemporal dynamics of single cell stiffness in the early developing ascidian chordate embryo
10.1038/s42003-021-01869-w · 2021 · External reference
10.1016/j.cub.2020.06.041
10.1016/j.cub.2020.06.041 · External reference
10.7554/elife.57964
10.7554/elife.57964 · External reference
10.1038/s41586-018-0479-2
10.1038/s41586-018-0479-2 · External reference
10.1016/j.cell.2021.02.017
10.1016/j.cell.2021.02.017 · External reference
On mechanics and morphology
10.1038/nphys2088 · 2011 · External reference
10.1016/j.devcel.2020.11.025
10.1016/j.devcel.2020.11.025 · External reference
10.1016/j.semcdb.2017.01.001
10.1016/j.semcdb.2017.01.001 · External reference
10.1016/j.ydbio.2021.09.007
10.1016/j.ydbio.2021.09.007 · External reference
10.1016/j.devcel.2010.08.014
10.1016/j.devcel.2010.08.014 · External reference
Left-right patterning in the C. elegans embryo: Unique mechanisms and common principles
10.4161/cib.14144 · 2011 · External reference
Power law relationship between cell cycle duration and cell volume in the early embryonic development of Caenorhabditis elegans
10.3389/fphys.2014.00529 · 2015 · External reference
Setting the clock for fail-safe early embryogenesis
10.1103/physrevlett.117.188101 · 2016 · External reference
Anti-correlation of cell volumes and cell-cycle times during the embryogenesis of a simple model organism
10.1088/1367-2630/aaea91 · 2018 · External reference
Volume segregation programming in a nematode's early embryogenesis
10.1103/physreve.104.054409 · 2021 · External reference
10.1016/j.devcel.2004.10.008
10.1016/j.devcel.2004.10.008 · External reference
Cell contacts orient some cell division axes in the Caenorhabditis elegans embryo
10.1083/jcb.129.4.1071 · 1995 · External reference
10.1016/j.devcel.2018.06.020
10.1016/j.devcel.2018.06.020 · External reference
In vitro reconstitution of spatial cell contact patterns with isolated Caenorhabditis elegans embryo blastomeres and adhesive polystyrene beads
2019 · External reference
10.1023/a:1013178514397
10.1023/a:1013178514397 · External reference
10.1515/crll.1908.133.97
10.1515/crll.1908.133.97 · External reference
Unresolved reference
External reference
Voronoi diagrams and Delaunay triangulations: Ubiquitous siamese twins
10.4171/dms/6/40 · 2012 · External reference
Unresolved reference
External reference
Unresolved reference
2002 · External reference
Development and validation of computational models of cellular interaction
10.1007/s10735-004-2660-1 · 2004 · External reference
10.1016/j.ydbio.2009.06.014
10.1016/j.ydbio.2009.06.014 · External reference
Quantitative semi-automated analysis of morphogenesis with single-cell resolution in complex embryos
10.1242/dev.086256 · 2012 · External reference
10.1371/journal.pone.0126947
10.1371/journal.pone.0126947 · External reference
10.1016/j.cels.2016.07.005
10.1016/j.cels.2016.07.005 · External reference
Unresolved reference
2017 · External reference
Establishment of signaling interactions with cellular resolution for every cell cycle of embryogenesis
10.1534/genetics.118.300820 · 2018 · External reference
Systems properties and spatiotemporal regulation of cell position variability during embryogenesis
10.1016/j.celrep.2018.12.052 · 2019 · External reference
10.7554/elife.58626
10.7554/elife.58626 · External reference
Automatic inference of cell neighborhood in 2D and 3D using nuclear markers
2021 · External reference
10.1038/s42256-021-00431-x
10.1038/s42256-021-00431-x · External reference
Limits of applicability of the Voronoi tessellation determined by centers of cell nuclei to epithelium morphology
10.3389/fphys.2016.00551 · 2016 · External reference
10.1016/j.cub.2006.09.030
10.1016/j.cub.2006.09.030 · External reference
10.1534/genetics.116.197160
10.1534/genetics.116.197160 · External reference
10.1242/dev.129.2.387
10.1242/dev.129.2.387 · External reference
10.1016/j.ydbio.2010.09.012
10.1016/j.ydbio.2010.09.012 · External reference
Biologically constrained optimization based cell membrane segmentation in C. elegans embryos
10.1186/s12859-017-1717-6 · 2017 · External reference
3DMMS: Robust 3D membrane morphological segmentation of C. elegans embryo
10.1186/s12859-019-2720-x · 2019 · External reference
10.1371/journal.pone.0238955
10.1371/journal.pone.0238955 · External reference
10.1093/bioinformatics/btab557
10.1093/bioinformatics/btab557 · External reference
Analysis of initial cell spreading using mechanistic contact formulations for a deformable cell model
10.1371/journal.pcbi.1003267 · 2013 · External reference
10.1016/j.bpj.2019.01.015
10.1016/j.bpj.2019.01.015 · External reference
10.1371/journal.pone.0030224
10.1371/journal.pone.0030224 · External reference
A scheme for 3-dimensional morphological reconstruction and force inference in the early C. elegans embryo
10.1371/journal.pone.0199151 · 2018 · External reference
Unresolved reference
2019 · External reference
10.1371/journal.pbio.2005970
10.1371/journal.pbio.2005970 · External reference
FusionNet: A deep fully residual convolutional neural network for image segmentation in connectomics
10.3389/fcomp.2021.613981 · 2021 · External reference
10.1016/j.devcel.2015.12.028
10.1016/j.devcel.2015.12.028 · External reference
10.1016/j.compbiomed.2019.04.006
10.1016/j.compbiomed.2019.04.006 · External reference
Epidermal morphogenesis
2005 · External reference
A novel cell nuclei segmentation method for 3D C. elegans embryonic time-lapse images
10.1186/1471-2105-14-328 · 2013 · External reference
10.1534/g3.113.005918
10.1534/g3.113.005918 · External reference
Comparative proteome analysis between C . briggsae embryos and larvae reveals a role of chromatin modification proteins in embryonic cell division
10.1038/s41598-017-04533-8 · 2017 · External reference
10.1126/science.1100035
10.1126/science.1100035 · External reference
Light sheet fluorescence microscopy: A review
10.1369/0022155410394857 · 2011 · External reference
10.1038/s41592-018-0211-z
10.1038/s41592-018-0211-z · External reference
10.1088/2515-7647/abdb04
10.1088/2515-7647/abdb04 · External reference
10.1073/pnas.1108494108
10.1073/pnas.1108494108 · External reference
Untwisting the Caenorhabditis elegans embryo
10.7554/elife.10070 · 2015 · External reference
10.1038/nbt.2713
10.1038/nbt.2713 · External reference
10.1038/nprot.2014.172
10.1038/nprot.2014.172 · External reference
10.1086/689589
10.1086/689589 · External reference
Isotropic light-sheet microscopy and automated cell lineage analyses to catalogue Caenorhabditis elegans embryogenesis with subcellular resolution
2019 · External reference
10.1016/j.devcel.2017.10.021
10.1016/j.devcel.2017.10.021 · External reference
10.1126/sciadv.abl7663
10.1126/sciadv.abl7663 · External reference
Eutely, cell lineage, and fate within the ascidian larval nervous system: determinacy or to be determined?
10.1139/z04-159 · 2005 · External reference
The invariant cleavage pattern displayed by ascidian embryos depends on spindle positioning along the cell’s longest axis in the apical plane and relies on asynchronous cell divisions
10.7554/elife.19290 · 2017 · External reference
A workflow to process 3D+time microscopy images of developing organisms and reconstruct their cell lineage
10.1038/ncomms9674 · 2016 · External reference
Unresolved reference
1993 · External reference
Unresolved reference
2000 · External reference
10.1038/nmeth.3036
10.1038/nmeth.3036 · External reference
10.1242/dev.107730
10.1242/dev.107730 · External reference
10.1002/aja.1002030302
10.1002/aja.1002030302 · External reference
Cell-cycle control in oocytes and during early embryonic cleavage cycles in ascidians
10.1016/b978-0-12-394308-8.00006-6 · 2012 · External reference
10.1242/dev.033183
10.1242/dev.033183 · External reference
10.1242/dev.161471
10.1242/dev.161471 · External reference
Polarity establishment, asymmetric division and segregation of fate determinants in early C. elegans embryos
2014 · External reference
Physically asymmetric division of the C. elegans zygote ensures invariably successful embryogenesis
10.7554/elife.61714 · 2021 · External reference
10.1016/j.devcel.2007.10.007
10.1016/j.devcel.2007.10.007 · External reference
10.1002/wdev.177
10.1002/wdev.177 · External reference
A cell-size threshold limits cell polarity and asymmetric division potential
10.1038/s41567-019-0601-x · 2019 · External reference
10.1242/dev.122.5.1467
10.1242/dev.122.5.1467 · External reference
Cell polarity: Getting the PARty started
10.1016/j.cub.2019.05.032 · 2019 · External reference
Going with the flow: Insights from Caenorhabditis elegans zygote polarization
10.1098/rstb.2019.0555 · 2020 · External reference
10.1242/dev.00284
10.1242/dev.00284 · External reference
10.1038/35002131
10.1038/35002131 · External reference
10.1038/35002125
10.1038/35002125 · External reference
10.1201/9781420011432
10.1201/9781420011432 · External reference
10.1016/j.cell.2009.06.013
10.1016/j.cell.2009.06.013 · External reference
10.1016/j.cell.2012.08.040
10.1016/j.cell.2012.08.040 · External reference
10.1083/jcb.201011094
10.1083/jcb.201011094 · External reference
10.1111/dgd.12652
10.1111/dgd.12652 · External reference
10.1529/biophysj.108.136416
10.1529/biophysj.108.136416 · External reference
10.1126/science.1208619
10.1126/science.1208619 · External reference
Mechanochemical pattern formation in the polarization of the one-cell C. elegans embryo
2013 · External reference
Actomyosin regulation and symmetry breaking in a model of polarization in the early Caenorhabditis elegans embryo: Symmetry breaking in cell polarization
10.1007/s11538-014-0016-x · 2014 · External reference
Self-organization and advective transport in the cell polarity formation for asymmetric cell division
10.1016/j.jtbi.2015.06.032 · 2015 · External reference
Transitions to slow or fast diffusions provide a general property for in-phase or anti-phase polarity in a cell
10.1007/s00285-020-01484-z · 2020 · External reference
10.1038/s41567-018-0358-7
10.1038/s41567-018-0358-7 · External reference
10.1016/j.celrep.2021.109326
10.1016/j.celrep.2021.109326 · External reference
10.1016/j.jtbi.2013.04.024
10.1016/j.jtbi.2013.04.024 · External reference
10.1371/journal.pcbi.1006294
10.1371/journal.pcbi.1006294 · External reference
Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans
10.1038/s41467-020-14317-w · 2020 · External reference
Long time behavior and stable patterns in high-dimensional polarity models of asymmetric cell division
10.1007/s00285-021-01619-w · 2021 · External reference
PAR-3 oligomerization may provide an actin-independent mechanism to maintain distinct par protein domains in the early Caenorhabditis elegans embryo
10.1016/j.bpj.2011.07.030 · 2011 · External reference
10.3390/cells9092036
10.3390/cells9092036 · External reference
The role of cytoplasmic MEX-5/6 polarity in asymmetric cell division
10.1007/s11538-021-00860-0 · 2021 · External reference
Positioning of polarity formation by extracellular signaling during asymmetric cell division
10.1016/j.jtbi.2016.04.004 · 2016 · External reference
10.1038/nrm3558
10.1038/nrm3558 · External reference
Computer simulation of the cellular arrangement using physical model in early cleavage of the nematode Caenorhabditis elegans
10.1093/bioinformatics/btg069 · 2003 · External reference
Physical modeling of the cellular arrangement in C. elegans early embryo: Effect of rounding and stiffening of the cells
2002 · External reference
10.1016/j.bpj.2013.09.005
10.1016/j.bpj.2013.09.005 · External reference
Why and how the nematode’s early embryogenesis can be precise and robust: A mechanical perspective
10.1088/1478-3975/ab6356 · 2020 · External reference
An asymmetric attraction model for the diversity and robustness of cell arrangement in nematodes
10.1242/dev.154609 · 2017 · External reference
Microinjection into the Caenorhabditis elegans embryo using an uncoated glass needle enables cell lineage visualization and reveals cell-non-autonomous adhesion control
2018 · External reference
10.1371/journal.pcbi.1007994
10.1371/journal.pcbi.1007994 · External reference
10.1007/978-981-16-5018-5
10.1007/978-981-16-5018-5 · 2022 · External reference
Unresolved reference
External reference
Reconstructing the multicellular structure of a developing metazoan embryo with repulsion-attraction model and cell-cell connection atlas in vivo
2020 · External reference
Thermodynamische theorie der kapillarität unter voraussetzung stetiger dichteänderung
1894 · External reference
10.1063/1.1744102
10.1063/1.1744102 · External reference
10.1146/annurev.matsci.32.112001.132041
10.1146/annurev.matsci.32.112001.132041 · External reference
10.1146/annurev.matsci.32.101901.155803
10.1146/annurev.matsci.32.101901.155803 · External reference
Phase-field model of cellular migration: Three-dimensional simulations in fibrous networks
10.1016/j.cma.2017.03.025 · 2017 · External reference
Plasticity of cell migration resulting from mechanochemical coupling
10.7554/elife.48478 · 2019 · External reference
A diffuse interface framework for modeling the evolution of multi-cell aggregates as a soft packing problem driven by the growth and division of cells
10.1007/s11538-019-00577-1 · 2019 · External reference
Planar asymmetries in the C. elegans embryo emerge by differential retention of aPARs at cell-cell contacts
10.3389/fcell.2019.00209 · 2019 · External reference
10.1038/s41540-023-00265-w
10.1038/s41540-023-00265-w · External reference
The extra-embryonic space and the local contour are crucial geometric constraints regulating cell arrangement
10.1242/dev.200401 · 2022 · External reference
10.1016/s0960-9822(03)00295-1
10.1016/s0960-9822(03)00295-1 · External reference
“What I cannot create, I do not understand”
10.1242/jcs.209791 · 2017 · External reference
10.1126/science.7939707
10.1126/science.7939707 · External reference
10.1016/j.coisb.2018.09.003
10.1016/j.coisb.2018.09.003 · External reference