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References from Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1038/nn.3708
10.1038/nn.3708 · External reference
10.1016/j.mam.2019.07.004
10.1016/j.mam.2019.07.004 · External reference
10.1038/nn0206-157
10.1038/nn0206-157 · External reference
10.1038/nrn.2016.178
10.1038/nrn.2016.178 · External reference
10.1038/nrn3961
10.1038/nrn3961 · External reference
Alzheimer’s disease and other dementias
10.1093/oxfordhb/9780199542475.013.0030 · 2010 · External reference
Huntington Disease, Parkinson Disease, and Other Neurodegenerative Diseases
2013 · External reference
Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases
10.1038/sdata.2016.89 · 2016 · External reference
Unresolved reference
2016 · External reference
Brain disorders?
2015 · External reference
Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
10.1038/s41588-019-0450-7 · 2019 · External reference
Astrocyte Heterogeneity: Impact to Brain Aging and Disease
10.3389/fnagi.2019.00059 · 2019 · External reference
10.1038/s41467-019-13564-w
10.1038/s41467-019-13564-w · External reference
10.1038/nrg3934
10.1038/nrg3934 · External reference
Common Themes in the Pathogenesis of Neurodegeneration
10.1007/978-3-319-23309-3_1 · 2016 · External reference
Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network Biology
10.3389/fnagi.2017.00166 · 2017 · External reference
Unresolved reference
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Mental Disorders and Criminal Behavior
2019 · External reference
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
10.1038/nature08185 · 2009 · External reference
10.1016/s0140-6736(12)62129-1
10.1016/s0140-6736(12)62129-1 · External reference
10.1126/science.aad6469
10.1126/science.aad6469 · External reference
Unresolved reference
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Integrative functional genomic analysis of human brain development and neuropsychiatric risks
2018 · External reference
Single-Cell Transcriptional Changes In Neurodegenerative Diseases
10.1016/j.neuroscience.2021.10.025 · 2021 · External reference
10.1038/nm.4386
10.1038/nm.4386 · External reference
10.1038/s41593-018-0197-y
10.1038/s41593-018-0197-y · External reference
10.1371/journal.pone.0036351
10.1371/journal.pone.0036351 · External reference
Transcriptome sequencing implicates dorsal striatum-specific gene network, immune response and energy metabolism pathways in bipolar disorder
10.1038/mp.2016.94 · 2017 · External reference
10.1016/j.gene.2016.12.033
10.1016/j.gene.2016.12.033 · External reference
10.1038/mp.2013.170
10.1038/mp.2013.170 · External reference
10.1016/j.biopsych.2006.06.019
10.1016/j.biopsych.2006.06.019 · External reference
The DNA methylome and transcriptome of different brain regions in schizophrenia and bipolar disorder
10.1371/journal.pone.0095875 · 2014 · External reference
10.1038/tp.2017.154
10.1038/tp.2017.154 · External reference
10.1371/journal.pone.0166944
10.1371/journal.pone.0166944 · External reference
Altered expression of histamine signaling genes in autism spectrum disorder
10.1038/tp.2017.87 · 2017 · External reference
Integrated systems analysis reveals a molecular network underlying autism spectrum disorders
10.15252/msb.20145487 · 2014 · External reference
10.1038/mp.2016.130
10.1038/mp.2016.130 · External reference
Integrative analyses of proteomics and RNA transcriptomics implicate mitochondrial processes, protein folding pathways and GWAS loci in Parkinson disease
10.1186/s12920-016-0164-y · 2016 · External reference
The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer’s disease
10.1038/sdata.2018.185 · 2018 · External reference
10.1261/rna.043075.113
10.1261/rna.043075.113 · External reference
10.1371/journal.pbio.1002558
10.1371/journal.pbio.1002558 · External reference
10.1186/s13073-017-0458-5
10.1186/s13073-017-0458-5 · External reference
Unresolved reference
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Unresolved reference
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Visualizing Data using t-SNE
2008 · External reference
Chitinase 3-like 1 is neurotoxic in primary cultured neurons
10.1038/s41598-020-64093-2 · 2020 · External reference
10.1016/j.jns.2016.08.029
10.1016/j.jns.2016.08.029 · External reference
Genetic susceptibility and neurotransmitters in Tourette syndrome
10.1016/b978-0-12-411546-0.00006-8 · 2013 · External reference
10.1002/glia.23993
10.1002/glia.23993 · External reference
10.1016/j.neurobiolaging.2005.07.015
10.1016/j.neurobiolaging.2005.07.015 · External reference
10.1016/j.neurobiolaging.2014.08.012
10.1016/j.neurobiolaging.2014.08.012 · External reference
A role of BAG3 in regulating SNCA/α-synuclein clearance via selective macroautophagy
10.1016/j.neurobiolaging.2017.08.023 · 2017 · External reference
Mutations in HspB1 and hereditary neuropathies
10.1007/s12192-020-01099-9 · 2020 · External reference
10.1016/j.cell.2014.03.058
10.1016/j.cell.2014.03.058 · External reference
WGCNA: an R package for weighted correlation network analysis
10.1186/1471-2105-9-559 · 2008 · External reference
10.1093/database/baz046
10.1093/database/baz046 · External reference
10.1016/j.neuron.2015.11.013
10.1016/j.neuron.2015.11.013 · External reference
10.3389/fnagi.2019.00233
10.3389/fnagi.2019.00233 · External reference
Microglia Response During Parkinson’s Disease: Alpha-Synuclein Intervention
10.3389/fncel.2018.00247 · 2018 · External reference
Evidence of microglial activation in autism and its possible role in brain underconnectivity
10.1017/s1740925x12000142 · 2011 · External reference
10.1016/j.pneurobio.2017.01.002
10.1016/j.pneurobio.2017.01.002 · External reference
10.1111/j.1750-3639.1990.tb00630.x
10.1111/j.1750-3639.1990.tb00630.x · External reference
10.1093/brain/awv404
10.1093/brain/awv404 · External reference
Astrocytes: Role and Functions in Brain Pathologies
10.3389/fphar.2019.01114 · 2019 · External reference
Functional regulation of FoxO1 in neural stem cell differentiation
10.1038/cdd.2015.123 · 2015 · External reference
Reactive Astrocytes in Neurodegenerative Diseases
10.14336/ad.2018.0720 · 2019 · External reference
10.1038/nn.4063
10.1038/nn.4063 · External reference
The genetic architecture of the human thalamus and its overlap with ten common brain disorders
10.1038/s41467-021-23175-z · 2021 · External reference
10.3389/fneur.2011.00042
10.3389/fneur.2011.00042 · External reference
10.1016/j.nicl.2017.05.026
10.1016/j.nicl.2017.05.026 · External reference
Astrocytes in Neurodegenerative Disease
2015 · External reference
10.1016/j.neurobiolaging.2016.12.029
10.1016/j.neurobiolaging.2016.12.029 · External reference
Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis
10.1093/hmg/ddi022 · 2005 · External reference
Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders
10.1038/sj.mp.4001830 · 2006 · External reference
The organization of the transcriptional network in specific neuronal classes
10.1038/msb.2009.46 · 2009 · External reference
Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss
10.1016/j.redox.2020.101558 · 2020 · External reference
10.26508/lsa.201900453
10.26508/lsa.201900453 · External reference
10.3389/fnhum.2016.00566
10.3389/fnhum.2016.00566 · External reference
Microglia and Astrocytes in Alzheimer’s Disease: Implications for Therapy
10.2174/1570159x15666170720095240 · 2018 · External reference
10.1016/j.neuron.2011.06.031
10.1016/j.neuron.2011.06.031 · External reference
Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms
10.1186/s13073-018-0518-5 · 2018 · External reference
10.1038/nm.4397
10.1038/nm.4397 · External reference
10.1007/s11515-013-1260-4
10.1007/s11515-013-1260-4 · External reference
10.1038/nrn3156
10.1038/nrn3156 · External reference
Disruption of mitochondrial complex I induces progressive parkinsonism
10.1038/s41586-021-04059-0 · 2021 · External reference
Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice
10.1038/s42003-020-01584-y · 2021 · External reference
10.1038/nrn3229
10.1038/nrn3229 · External reference
The development of ‘mis-wired’ limbic lobe circuitry in schizophrenia and bipolar disorder
10.1017/cbo9780511735103.018 · 2004 · External reference
Maternal immune conditions are increased in males with autism spectrum disorders and are associated with behavioural and emotional but not cognitive co-morbidity
10.1038/s41398-020-00976-2 · 2020 · External reference
Role of Neuroinflammation in Autism Spectrum Disorder and the Emergence of Brain Histaminergic System. Lessons Also for BPSD?
10.3389/fphar.2020.00886 · 2020 · External reference
High rates of parkinsonism in adults with autism
10.1186/s11689-015-9125-6 · 2015 · External reference
Microglial Activation in Young Adults With Autism Spectrum Disorder
10.1001/jamapsychiatry.2013.272 · 2013 · External reference
10.3390/cells9071687
10.3390/cells9071687 · External reference
Evidence of neurodegeneration in autism spectrum disorder
10.1186/2047-9158-2-17 · 2013 · External reference
Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
10.1038/ncomms11173 · 2016 · External reference
10.1016/j.jpsychires.2020.07.013
10.1016/j.jpsychires.2020.07.013 · External reference
10.1016/j.bbi.2019.04.037
10.1016/j.bbi.2019.04.037 · External reference
Glutamatergic-dopaminergic balance in the brain. Its importance in motor disorders and schizophrenia
1992 · External reference
10.1002/wps.20693
10.1002/wps.20693 · External reference
10.1586/ern.09.152
10.1586/ern.09.152 · External reference
10.1016/s0278-5846(01)00159-2
10.1016/s0278-5846(01)00159-2 · External reference
Identification and quantification of oligodendrocyte precursor cells in multiple system atrophy, progressive supranuclear palsy and Parkinson’s disease
10.1111/j.1750-3639.2012.00637.x · 2013 · External reference
Preclinical Alzheimer’s disease: Definition, natural history, and diagnostic criteria
10.1016/j.jalz.2016.02.002 · 2016 · External reference
10.1016/j.parkreldis.2020.04.014
10.1016/j.parkreldis.2020.04.014 · External reference
Progressive Supranuclear Palsy: Pathology and Genetics
10.1111/j.1750-3639.2007.00054.x · 2007 · External reference
Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions
10.1016/j.molcel.2020.01.006 · 2020 · External reference
Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links
10.1212/wnl.0b013e3182166dc7 · 2011 · External reference
Is pathological aging a successful resistance against amyloid-beta or preclinical Alzheimer’s disease?
10.1186/alzrt254 · 2014 · External reference
Clinical heterogeneity in major depressive disorder
10.1016/j.euroneuro.2017.12.090 · 2018 · External reference
10.3389/fneur.2019.01059
10.3389/fneur.2019.01059 · External reference
Left dorsolateral prefrontal cortex atrophy is associated with frontal lobe function in Alzheimer’s disease and contributes to caregiver burden
10.1002/gps.4843 · 2018 · External reference
The Role of the Frontal Lobe in Complex Walking Among Patients With Parkinson’s Disease and Healthy Older Adults: An fNIRS Study
10.1177/1545968316650426 · 2016 · External reference
Distinct alterations in Parkinson’s medication-state and disease-state connectivity
10.1016/j.nicl.2017.09.004 · 2017 · External reference
10.1016/j.neurobiolaging.2016.09.011
10.1016/j.neurobiolaging.2016.09.011 · External reference
Abnormal relationship between medial temporal lobe and subcortical dopamine function in people with an ultra high risk for psychosis
10.1093/schbul/sbr017 · 2012 · External reference
Longitudinal progression of frontal and temporal lobe changes in schizophrenia
10.1016/j.schres.2012.05.002 · 2012 · External reference
Cerebellum and neurodegenerative diseases: Beyond conventional magnetic resonance imaging
10.4329/wjr.v9.i10.371 · 2017 · External reference
10.1038/s41593-019-0471-7
10.1038/s41593-019-0471-7 · External reference
Identification of discriminative imaging proteomics associations in alzheimer’s disease via a novel sparse correlation model
2017 · External reference
Imaging proteomics for diagnosis, monitoring and prediction of Alzheimer’s disease
10.1016/j.neuroimage.2014.08.041 · 2014 · External reference
Transcriptome profiling in human diseases: new advances and perspectives
10.3390/ijms18081652 · 2017 · External reference
10.1038/s41593-019-0560-7
10.1038/s41593-019-0560-7 · External reference
10.1016/j.yfrne.2018.11.003
10.1016/j.yfrne.2018.11.003 · External reference
Sex-specific transcriptional and proteomic signatures in schizophrenia
10.1038/s41467-019-11797-3 · 2019 · External reference
10.1016/j.neubiorev.2018.06.013
10.1016/j.neubiorev.2018.06.013 · External reference
Unresolved reference
2011 · External reference
bio-samtools: Ruby bindings for SAMtools, a library for accessing BAM files containing high-throughput sequence alignments
10.1186/2042-5767-1-1 · 2012 · External reference
10.1093/bioinformatics/btt016
10.1093/bioinformatics/btt016 · External reference
10.1038/nbt.3820
10.1038/nbt.3820 · External reference
10.1093/bioinformatics/bts635
10.1093/bioinformatics/bts635 · External reference
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
2011 · External reference
10.1093/bioinformatics/btv566
10.1093/bioinformatics/btv566 · External reference
10.1093/nar/gkv007
10.1093/nar/gkv007 · External reference
D. sva: Surrogate Variable Analysis
2014 · External reference
Outliers detection and treatment: a review
10.21500/20112084.844 · 2010 · External reference
Maximum Z Scores and Outliers
10.1080/00031305.1988.10475530 · 1988 · External reference
Brain Cell Type Specific Gene Expression and Co-expression Network Architectures
10.1038/s41598-018-27293-5 · 2018 · External reference
Principal Component Analysis: A Powerful Interpretative Tool at the Service of Analytical Methodology
10.5772/36929 · 2012 · External reference
Unresolved reference
2012 · External reference
An R package to test and visualize gene overlaps
2014 · External reference
10.1023/a:1017934522171
10.1023/a:1017934522171 · 2001 · External reference
10.1093/nar/gkq636
10.1093/nar/gkq636 · External reference
10.1523/jneurosci.4488-13.2014
10.1523/jneurosci.4488-13.2014 · External reference
10.1093/bioinformatics/btu393
10.1093/bioinformatics/btu393 · External reference
10.1007/s11064-008-9855-x
10.1007/s11064-008-9855-x · External reference