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References from Recognition motifs for importin 4 [(L)PPRS(G/P)P] and importin 5 [KP(K/Y)LV] binding, identified by bio-informatic simulation and experimental in vitro validation. Local targets link to admitted publications; unresolved targets remain external evidence.
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Importin α: a multipurpose nuclear-transport receptor
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Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-α11Edited by K. Nagai
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Transport pathways of macromolecules between the nucleus and the cytoplasm
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Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response
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Nuclear import of BCL11B is mediated by a classical nuclear localization signal and not the Kruppel-like zinc fingers
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10.3390/cells7110221 · 2018 · External reference
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1843 · External reference
Graphene oxide sensitizes cancer cells to chemotherapeutics by inducing early autophagy events, promoting nuclear trafficking and necrosis
10.7150/thno.24173 · 2018 · External reference
Therapeutic effects of XPO1 inhibition in thymic epithelial tumors
10.1158/0008-5472.can-17-1323 · 2017 · External reference
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IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation
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Human enzyme PADI4 binds to the nuclear carrier importin alpha3
10.3390/cells11142166 · 2022 · External reference
10.1111/tra.12098
10.1111/tra.12098 · External reference
Importin-4 functions as a driving force in human primary gastric cancer
10.1002/jcb.28530 · 2019 · External reference
10.1128/jvi.77.6.3734-3748.2003
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Small GTPase Ran and Ran-binding proteins
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Unresolved reference
External reference
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A novel function of karyopherin beta3 associated with apolipoprotein A-I secretion
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Identification of nuclear import mechanisms for the neuronal Cdk5 activator
10.1074/jbc.m512663200 · 2006 · External reference
The carboxyl-terminus directs TAF(I)48 to the nucleus and nucleolus and associates with multiple nuclear import receptors
10.1093/jb/mvh051 · 2004 · External reference
Nuclear import of c-Jun is mediated by multiple transport receptors
10.1074/jbc.m703301200 · 2007 · External reference
10.1091/mbc.e03-11-0839
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Structural basis of high-affinity nuclear localization signal interactions with importin-alpha
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Structural basis for the final steps of human 40S ribosome maturation
10.1038/s41586-020-2929-x · 2020 · External reference
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Transport of hypoxia-inducible factor HIF-1α into the nucleus involves importins 4 and 7
10.1016/j.bbrc.2009.09.093 · 2009 · External reference
Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains
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Nuclear import of c-Jun is mediated by multiple transport receptors
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10.1074/jbc.m602189200 · External reference
Multiple pathways contribute to nuclear import of core histones
10.1093/embo-reports/kve168 · 2001 · External reference
Core histones and linker histones are imported into the nucleus by different pathways
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