Research graph
References from Untargeted metabolomics to evaluate polymyxin B toxicodynamics following direct intracerebroventricular administration into the rat brain. Local targets link to admitted publications; unresolved targets remain external evidence.
Entering a post-antibiotic era?
10.1038/nrmicro2983 · 2013 · External reference
The Multidrug-resistant gram-negative superbugs threat require intelligent use of the last weapon
2015 · External reference
Pharmacology of polymyxins: new insights into an ‘old’class of antibiotics
10.2217/fmb.13.39 · 2013 · External reference
Polymyxins for CNS infections: pharmacology and neurotoxicity
10.1016/j.pharmthera.2017.07.012 · 2018 · External reference
Polymyxins: a new hope in combating Gram-negative superbugs?
10.4155/fmc-2016-0091 · 2016 · External reference
The renaissance of polymyxins
10.2174/09298673113209990185 · 2013 · External reference
Pharmacokinetics/pharmacodynamics of colistin and polymyxin B: are we there yet?
10.1016/j.ijantimicag.2016.09.010 · 2016 · External reference
Personalizing polymyxin B dosing using an adaptive feedback control algorithm
10.1128/aac.00483-18 · 2018 · External reference
Combined intravenous and intraventricular administration of colistin methanesulfonate in critically ill patients with central nervous system infection
10.1128/aac.01461-12 · 2013 · External reference
Penetration of colistin into cerebrospinal fluid
10.1128/aac.00345-09 · 2009 · External reference
Dosing guidance for intravenous colistin in critically ill patients
10.1093/cid/ciw839 · 2017 · External reference
Colistin and polymyxin B: peas in a pod, or chalk and cheese?
10.1093/cid/ciu213 · 2014 · External reference
Intraventricular and lumbar intrathecal administration of antibiotics in postneurosurgical patients with meningitis and/or ventriculitis in a serious clinical state
10.3171/2013.6.jns122126 · 2013 · External reference
Intrathecal or intraventricular therapy for post-neurosurgical Gram-negative meningitis: matched cohort study
10.1016/j.cmi.2015.09.023 · 2016 · External reference
Cure of multiresistant Acinetobacter baumannii central nervous system infections with intraventricular or intrathecal colistin: case series and literature review
10.1093/jac/dkl347 · 2006 · External reference
Intrathecal colistin for drug-resistant Acinetobacter baumannii central nervous system infection: a case series and systematic review
10.1111/j.1469-0691.2009.03019.x · 2010 · External reference
Unresolved reference
External reference
A clinical study on the use of intraventricular polymyxin b supplemented by continuous external ventricular drainage in the treatment of drug-resistant gram-negative bacilli intracranial infection
10.2147/idr.s261510 · 2020 · External reference
The pharmacokinetics of colistin in patients with cystic fibrosis
10.1177/00912700122010537 · 2001 · External reference
Studies in experimental meningitis in rhesus monkeys: III. The effect of intracisternal injection of streptokinase and streptodornase of the exudate of experimental meningitis
10.1093/infdis/97.3.305 · 1955 · External reference
10.1177/003591575104401223
10.1177/003591575104401223 · External reference
Experimental intraventricular and intracerebral injection of polymyxin B in the cat
10.1212/wnl.3.12.896 · 1953 · External reference
Minocycline attenuates colistin-induced neurotoxicity via suppression of apoptosis, mitochondrial dysfunction and oxidative stress
10.1093/jac/dkx037 · 2017 · External reference
Cauda equina syndrome misdiagnosed as aggravated hydrocephalus: neurological complication of intrathecal colistin in post-surgical meningitis
10.1007/s00701-010-0810-7 · 2011 · External reference
Adverse effects of sodium colistimethate: manifestations and specific reaction rates during 317 courses of therapy
10.7326/0003-4819-72-6-857 · 1970 · External reference
Antimicrobial agents and the central nervous system
10.1227/00006123-198006000-00016 · 1980 · External reference
Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections
10.1086/429323 · 2005 · External reference
Metabolomics: an emerging but powerful tool for precision medicine
10.1101/mcs.a000588 · 2015 · External reference
Mechanisms underlying synergistic killing of polymyxin B in combination with cannabidiol against Acinetobacter baumannii: a metabolomic study
10.3390/pharmaceutics14040786 · 2022 · External reference
10.1038/nrm.2016.25
10.1038/nrm.2016.25 · External reference
10.1016/j.csbj.2020.08.008
10.1016/j.csbj.2020.08.008 · External reference
Drug discovery and development: biomarkers of neurotoxicity and neurodegeneration
10.1177/1535370218801309 · 2018 · External reference
A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine
10.1016/j.neuro.2007.09.007 · 2008 · External reference
10.3791/63540
10.3791/63540 · External reference
10.1007/s11010-017-3203-x
10.1007/s11010-017-3203-x · External reference
Inverse phosphatidylcholine/phosphatidylinositol levels as peripheral biomarkers and phosphatidylcholine/lysophosphatidylethanolamine-phosphatidylserine as hippocampal indicator of postischemic cognitive impairment in rats
10.3389/fnins.2018.00989 · 2018 · External reference
Genetic diseases of the Kennedy pathways for membrane synthesis
10.1074/jbc.rev120.013529 · 2020 · External reference
The Kennedy pathway—de novo synthesis of phosphatidylethanolamine and phosphatidylcholine
10.1002/iub.337 · 2010 · External reference
Unresolved reference
2002 · External reference
10.1016/j.plipres.2014.06.002
10.1016/j.plipres.2014.06.002 · External reference
10.3390/nu8020099
10.3390/nu8020099 · External reference
10.7205/milmed-d-14-00162
10.7205/milmed-d-14-00162 · External reference
10.1046/j.1471-4159.2000.0752392.x
10.1046/j.1471-4159.2000.0752392.x · External reference
Arachidonic acid metabolism in brain physiology and pathology: lessons from genetically altered mouse models
10.1111/j.1471-4159.2007.04558.x · 2007 · External reference
10.13188/2332-3469.1000035
10.13188/2332-3469.1000035 · External reference
Unresolved reference
2018 · External reference
Monitoring the sphingolipid de novo synthesis by stable-isotope labeling and liquid chromatography-mass spectrometry
10.3389/fcell.2019.00210 · 2019 · External reference
Sphingosine-1 phosphate and central nervous system
2014 · External reference
10.1016/j.bbamem.2017.03.008
10.1016/j.bbamem.2017.03.008 · External reference
Unresolved reference
2010 · External reference
10.1007/s11033-019-04646-5
10.1007/s11033-019-04646-5 · External reference
Unresolved reference
2020 · External reference
Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability
10.2741/222 · 2011 · External reference
Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species
10.1046/j.1432-1327.2000.01597.x · 2000 · External reference
10.1124/jpet.116.237503
10.1124/jpet.116.237503 · External reference
Colistin-induced apoptosis of neuroblastoma-2a cells involves the generation of reactive oxygen species, mitochondrial dysfunction, and autophagy
10.1007/s12035-015-9396-7 · 2016 · External reference
Polymyxin-induced metabolic perturbations in human lung epithelial cells
10.1128/aac.00835-21 · 2021 · External reference
Ferroptosis in neurological diseases
2020 · External reference
Ferroptosis in acute central nervous system injuries The Future Direction?
2020 · External reference
Insight into the mechanism of ferroptosis inhibition by ferrostatin-1
10.1016/j.redox.2019.101328 · 2020 · External reference
10.1042/bj3360001
10.1042/bj3360001 · External reference
10.1038/nrn2214
10.1038/nrn2214 · External reference
10.1016/s0301-0082(00)00056-3
10.1016/s0301-0082(00)00056-3 · External reference
Histidine provides long-term neuroprotection after cerebral ischemia through promoting astrocyte migration
2015 · External reference
Histidine: a systematic review on metabolism and physiological effects in human and different animal species
10.3390/nu12051414 · 2020 · External reference
Taurine biosynthesis by neurons and astrocytes
10.1074/jbc.m111.253344 · 2011 · External reference
Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms
10.1016/j.redox.2019.101223 · 2019 · External reference
Polymyxin-induced metabolic perturbations in human lung epithelial cells
10.1128/aac.00835-21 · 2021 · External reference
10.1080/15476286.2017.1330245
10.1080/15476286.2017.1330245 · External reference
Loss-of-function mutations in Lysyl-tRNA synthetase cause various leukoencephalopathy phenotypes
2019 · External reference
10.1016/j.ajhg.2014.03.003
10.1016/j.ajhg.2014.03.003 · External reference
L-homocysteic acid: an endogenous excitotoxic ligand of the NMDA receptor
10.1016/0361-9230(87)90077-3 · 1987 · External reference
N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system
10.1046/j.1471-4159.2000.0750443.x · 2000 · External reference
Understanding cerebral L-lysine metabolism: the role of L-pipecolate metabolism in Gcdh-deficient mice as a model for glutaric aciduria type I
10.1007/s10545-014-9762-z · 2015 · External reference
Inactivation of the mouse L-proline transporter PROT alters glutamatergic synapse biochemistry and perturbs behaviors required to respond to environmental changes
10.3389/fnmol.2018.00279 · 2018 · External reference
Identification of a novel biomarker for pyridoxine-dependent epilepsy: implications for newborn screening
10.1002/jimd.12059 · 2019 · External reference
10.1073/pnas.0710766105
10.1073/pnas.0710766105 · External reference
Cerebral creatine deficiencies: a group of treatable intellectual developmental disorders
2014 · External reference
L-carnitine and acetyl-L-carnitine roles and neuroprotection in developing brain
10.1007/s11064-017-2288-7 · 2017 · External reference
Cerebral gluconeogenesis and diseases
2017 · External reference
10.1093/bioinformatics/bts069
10.1093/bioinformatics/bts069 · External reference
10.1021/ac2000994
10.1021/ac2000994 · External reference
Unresolved reference
2019 · External reference
10.1007/s00702-014-1180-8
10.1007/s00702-014-1180-8 · External reference
10.3389/fpsyt.2018.00767
10.3389/fpsyt.2018.00767 · External reference
Use of carnosine for oxidative stress reduction in different pathologies
10.1155/2016/2939087 · 2016 · External reference
10.3390/nu11061196
10.3390/nu11061196 · External reference
10.1016/b978-012431152-7/50017-3
10.1016/b978-012431152-7/50017-3 · 2005 · External reference
Carnosine as an effective neuroprotector in brain pathology and potential neuromodulator in normal conditions
10.1007/s00726-018-2667-7 · 2019 · External reference
10.1007/s11064-016-2099-2
10.1007/s11064-016-2099-2 · External reference
10.1016/j.celrep.2016.09.029
10.1016/j.celrep.2016.09.029 · External reference
10.3389/fendo.2019.00158
10.3389/fendo.2019.00158 · External reference
Influence of rapid tryptophan depletion on laboratory-provoked aggression in children with ADHD
10.1159/000112951 · 2007 · External reference
Unresolved reference
External reference
Effects of oral gamma-aminobutyric acid (GABA) administration on stress and sleep in humans: a systematic review
2020 · External reference
10.1016/b978-012374240-7.50012-7
10.1016/b978-012374240-7.50012-7 · External reference
10.1038/sj.mp.4000805
10.1038/sj.mp.4000805 · External reference
Fructose-1, 6-bisphosphate protects astrocytes from hypoxic damage
10.1038/jcbfm.1989.4 · 1989 · External reference
Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy
10.1016/j.neuron.2013.08.013 · 2013 · External reference
