Research graph
References from ProxyBind: A compendium of binding sites for proximity-induced pharmacology. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1016/j.ddtec.2019.01.002
10.1016/j.ddtec.2019.01.002 · External reference
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10.1021/acs.jmedchem.0c00293
10.1021/acs.jmedchem.0c00293 · External reference
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10.1021/jacs.0c05537 · External reference
10.1021/acs.jmedchem.9b01167
10.1021/acs.jmedchem.9b01167 · External reference
Deubiquitinase-targeting chimeras for targeted protein stabilization
2022 · External reference
10.1021/jacs.1c07850
10.1021/jacs.1c07850 · External reference
Structural basis of PROTAC cooperative recognition for selective protein degradation
10.1038/nchembio.2329 · 2017 · External reference
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
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10.1038/s41573-019-0047-y · External reference
10.1016/j.chembiol.2020.07.020
10.1016/j.chembiol.2020.07.020 · External reference
PROTACs: great opportunities for academia and industry
2019 · External reference
Ubiquitin ligases: guardians of mammalian development
2022 · External reference
10.1093/nar/gkaa1100
10.1093/nar/gkaa1100 · External reference
10.1093/nar/gkaa977
10.1093/nar/gkaa977 · External reference
10.1093/nar/gkx1012
10.1093/nar/gkx1012 · External reference
Drug-like density: a method of quantifying the “bindability” of a protein target based on a very large set of pockets and drug-like ligands from the Protein Data Bank
10.1021/ci100312t · 2010 · External reference
10.1038/nature18002
10.1038/nature18002 · External reference
10.1016/j.ebiom.2019.10.013
10.1016/j.ebiom.2019.10.013 · External reference
10.1021/acs.jmedchem.8b01872
10.1021/acs.jmedchem.8b01872 · External reference
p38α MAP Kinase C-Terminal Domain Binding Pocket Characterized by Crystallographic and Computational Analyses
10.1016/j.jmb.2009.06.005 · 2009 · External reference
Turning a protein kinase on or off from a single allosteric site via disulfide trapping
10.1073/pnas.1102376108 · 2011 · External reference
FragLites - Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation
10.1021/acs.jmedchem.9b00304 · 2019 · External reference
10.1074/jbc.ra118.004883
10.1074/jbc.ra118.004883 · External reference
Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin
10.1093/carcin/8.9.1343 · 1987 · External reference
Synthesis and pharmacological evaluation of 8- and 9-substituted benzolactam-v8 derivatives as potent ligands for protein kinase C, a therapeutic target for Alzheimer’s disease
10.1002/cmdc.200500068 · 2006 · External reference
10.1016/0092-8674(95)90011-x
10.1016/0092-8674(95)90011-x · External reference
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
2019 · External reference
10.1038/nrd.2017.179
10.1038/nrd.2017.179 · External reference
10.1002/prot.26162
10.1002/prot.26162 · External reference
10.1002/anie.202017200
10.1002/anie.202017200 · External reference
Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule
10.1021/acs.jmedchem.8b00857 · 2019 · External reference
10.1016/j.cell.2020.03.038
10.1016/j.cell.2020.03.038 · External reference
10.1016/s0092-8674(00)81307-0
10.1016/s0092-8674(00)81307-0 · External reference
Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein
10.1038/s41598-019-43932-x · 2019 · External reference
Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction
2018 · External reference
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3
10.1038/s41589-019-0310-x · 2019 · External reference
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization
2021 · External reference
A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
2021 · External reference
In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression
10.1182/blood-2002-06-1675 · 2003 · External reference
10.1038/s41586-020-03170-y
10.1038/s41586-020-03170-y · External reference
Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis
10.1038/onc.2013.239 · 2014 · External reference
NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
10.1016/j.molcel.2021.08.034 · 2021 · External reference
10.1038/nrd4286
10.1038/nrd4286 · External reference
10.1016/j.bmcl.2018.04.050
10.1016/j.bmcl.2018.04.050 · External reference
10.1038/nrm3931
10.1038/nrm3931 · External reference
10.1126/science.1175371
10.1126/science.1175371 · External reference
10.1021/acs.jproteome.7b00451
10.1021/acs.jproteome.7b00451 · External reference
10.1021/acs.jmedchem.8b00258
10.1021/acs.jmedchem.8b00258 · External reference
10.1021/acs.jmedchem.9b00988
10.1021/acs.jmedchem.9b00988 · External reference
10.1016/j.molcel.2011.06.034
10.1016/j.molcel.2011.06.034 · External reference
10.1038/s41581-019-0129-4
10.1038/s41581-019-0129-4 · External reference
10.1021/acschembio.0c00074
10.1021/acschembio.0c00074 · External reference
Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2
10.1021/acs.jmedchem.0c01768 · 2021 · External reference
10.1021/acs.jmedchem.7b00933
10.1021/acs.jmedchem.7b00933 · External reference
Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase
10.1038/s41589-021-00757-y · 2021 · External reference
10.1073/pnas.1608069113
10.1073/pnas.1608069113 · External reference
10.1038/s41589-020-0622-x
10.1038/s41589-020-0622-x · External reference
10.1021/acschembio.8b01083
10.1021/acschembio.8b01083 · External reference
10.1038/s41589-019-0279-5
10.1038/s41589-019-0279-5 · External reference
10.1038/s41589-019-0304-8
10.1038/s41589-019-0304-8 · External reference
Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function
10.1016/j.chembiol.2021.01.005 · 2021 · External reference
Bardoxolone conjugation enables targeted protein degradation of BRD4
10.1038/s41598-020-72491-9 · 2020 · External reference
The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex
10.1038/nchembio.2306 · 2017 · External reference
An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED
10.1038/nchembio.2304 · 2017 · External reference
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
10.1038/nchembio.1859 · 2015 · External reference
AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models
2021 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
10.1126/science.abj8754
10.1126/science.abj8754 · External reference
10.1021/acs.jcim.8b00872
10.1021/acs.jcim.8b00872 · External reference
10.1021/acs.jcim.0c00897
10.1021/acs.jcim.0c00897 · External reference
PRosettaC: Rosetta based modeling of PROTAC mediated ternary complexes
10.1021/acs.jcim.0c00589 · 2020 · External reference
10.21203/rs.3.rs-1318882/v1
10.21203/rs.3.rs-1318882/v1 · External reference
In Silico Modeling and Scoring of PROTAC-Mediated Ternary Complex Poses
2022 · External reference
