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References from Use of ubiquitous chromatin opening elements (UCOE) as tools to maintain transgene expression in biotechnology. Local targets link to admitted publications; unresolved targets remain external evidence.
Recombinant protein therapeutics from CHO cells-20 years and counting
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10.1002/jcp.1041430223
10.1002/jcp.1041430223 · External reference
A mechanistic understanding of production instability in CHO cell lines expressing recombinant monoclonal antibodies
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10.3109/07388551.2015.1084266 · External reference
Unresolved reference
External reference
The fickle CHO: a review of the causes, implications, and potential alleviation of the CHO cell line instability problem
10.1016/j.copbio.2019.01.011 · 2019 · External reference
10.1038/nbt.4305
10.1038/nbt.4305 · External reference
Position effect variegation in Drosophila: towards a genetics of chromatin assembly
10.1002/bies.950110105 · 1989 · External reference
DNA methylation contributes to loss in productivity of monoclonal antibody-producing CHO cell lines
10.1016/j.jbiotec.2010.04.004 · 2010 · External reference
Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell lines
10.1186/s12896-016-0238-0 · 2016 · External reference
10.1002/btpr.2271
10.1002/btpr.2271 · External reference
Stability of single copy transgene expression in CHOK1 cells is affected by histone modifications but not by DNA methylation
10.1016/j.jbiotec.2014.12.009 · 2015 · External reference
A study of monoclonal antibody-producing CHO cell lines: what makes a stable high producer?
10.1002/bit.22158 · 2009 · External reference
Molecular definition of predictive indicators of stable protein expression in recombinant NS0 myeloma cells
10.1002/bit.10893 · 2004 · External reference
How to train your cell - Towards controlling phenotypes by harnessing the epigenome of Chinese hamster ovary production cell lines
10.1016/j.biotechadv.2022.107924 · 2022 · External reference
10.1038/ncb0107-2
10.1038/ncb0107-2 · External reference
10.1007/s00018-002-8420-z
10.1007/s00018-002-8420-z · External reference
Unresolved reference
External reference
Interplay between different epigenetic modifications and mechanisms
10.1016/b978-0-12-380866-0.60005-8 · 2010 · External reference
Unstable expression of recombinant antibody during long-term culture of CHO cells is accompanied by histone H3 hypoacetylation
10.1007/s10529-013-1168-8 · 2013 · External reference
Promoter methylation and transgene copy numbers predict unstable protein production in recombinant Chinese hamster ovary cell lines
10.1002/bit.23216 · 2011 · External reference
Development of stable cell lines for production or regulated expression using matrix attachment regions
10.1016/s0168-1656(00)00423-5 · 2001 · External reference
Use of the chicken lysozyme 5’ matrix attachment region to generate high producer CHO cell lines
10.1002/bit.20563 · 2005 · External reference
10.1016/0092-8674(84)90208-3
10.1016/0092-8674(84)90208-3 · External reference
A nuclear DNA attachment element mediates elevated and position-independent gene activity
10.1038/341343a0 · 1989 · External reference
10.1016/j.jbiotec.2003.09.015
10.1016/j.jbiotec.2003.09.015 · External reference
10.1038/nbt814
10.1038/nbt814 · External reference
Promoter suppression in cultured mammalian cells can be blocked by the chicken beta-globin chromatin insulator 5’HS4 and matrix/scaffold attachment regions
10.1006/jmbi.2001.5015 · 2001 · External reference
Chromatin function modifying elements in an industrial antibody production platform–comparison of UCOE, MAR, STAR and cHS4 elements
10.1371/journal.pone.0120096 · 2015 · External reference
Unresolved reference
External reference
10.1006/geno.2002.6728
10.1006/geno.2002.6728 · External reference
10.1016/s0888-7543(03)00107-1
10.1016/s0888-7543(03)00107-1 · External reference
10.1016/j.cell.2009.04.020
10.1016/j.cell.2009.04.020 · External reference
A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells
10.1093/nar/gkv019 · 2015 · External reference
CpG-island fragments from the HNRPA2B1/CBX3 genomic locus reduce silencing and enhance transgene expression from the hCMV promoter/enhancer in mammalian cells
10.1186/1472-6750-5-17 · 2005 · External reference
10.1101/626713
10.1101/626713 · External reference
10.1016/j.semcdb.2018.07.020
10.1016/j.semcdb.2018.07.020 · External reference
10.1016/j.biotechadv.2017.05.004
10.1016/j.biotechadv.2017.05.004 · External reference
Unresolved reference
External reference
Correlation of DNA methylation with histone modifications across the HNRPA2B1-CBX3 ubiquitously-acting chromatin open element (UCOE)
10.4161/epi.2.4.5231 · 2007 · External reference
10.1038/mt.2010.132
10.1038/mt.2010.132 · External reference
10.1093/nar/gkt880
10.1093/nar/gkt880 · External reference
Physiological regulation of transgene expression by a lentiviral vector containing the A2UCOE linked to a myeloid promoter
10.1038/gt.2011.167 · 2011 · External reference
Initial sequencing and analysis of the human genome
10.1038/35057062 · 2001 · External reference
10.1093/bioinformatics/btt637
10.1093/bioinformatics/btt637 · External reference
10.1101/gr.229102
10.1101/gr.229102 · External reference
Structure, function and evolution of CpG island promoters
10.1007/s00018-003-3088-6 · 2003 · External reference
Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time
10.1002/bit.25990 · 2016 · External reference
10.1002/bit.26891
10.1002/bit.26891 · External reference
The use of UCOE vectors in combination with a preadapted serum free, suspension cell line allows for rapid production of large quantities of protein
10.1023/a:1021141712344 · 2002 · External reference
Simple scale-up of recombinant antibody production using an UCOE containing vector
10.1016/j.nbt.2011.12.005 · 2012 · External reference
Sustained transgene expression from sleeping beauty DNA transposons containing a core fragment of the HNRPA2B1-CBX3 ubiquitous chromatin opening element (UCOE)
10.1186/s12896-019-0570-2 · 2019 · External reference
Improving the expression of anti-IL-2Rα monoclonal antibody in the CHO cells through optimization of the expression vector and translation efficiency
10.1016/j.jbiotec.2020.09.006 · 2020 · External reference
10.1021/acssynbio.0c00519
10.1021/acssynbio.0c00519 · External reference
Amplification using CHO cell expression vectors
10.1002/0471142727.mb1623s60 · 2002 · External reference
10.1016/s0021-9258(17)34875-5
10.1016/s0021-9258(17)34875-5 · External reference
10.1016/s0021-9258(17)43493-4
10.1016/s0021-9258(17)43493-4 · External reference
Evaluating the interaction between UCOE and DHFR-linked amplification and stability of recombinant protein expression
10.1002/btpr.2083 · 2015 · External reference
Assessment of UCOE on Recombinant EPO Production and Expression Stability in Amplified Chinese Hamster Ovary Cells
10.1007/s12033-015-9877-y · 2015 · External reference
Ubiquitous Chromatin Opening Elements (UCOEs) effect on transgene position and expression stability in CHO cells following methotrexate (MTX) amplification
10.1002/biot.201500159 · 2016 · External reference
Effects of ubiquitous chromatin opening element (UCOE) on recombinant anti-TNFα antibody production and expression stability in CHO-DG44 cells
10.1007/s10616-021-00503-1 · 2022 · External reference
Stable expression of H1C2 monoclonal antibody in NS0 and CHO cells using pFUSE and UCOE expression system
10.1007/s10616-013-9615-x · 2014 · External reference
High-throughput ClonePix FL analysis of mAb-expressing clones using the UCOE expression system
10.1016/j.nbt.2014.02.002 · 2014 · External reference
Effect of different UCOE-promoter combinations in creation of engineered cell lines for the production of Factor VIII
10.1186/1756-0500-4-178 · 2011 · External reference
Evaluating the expression profile and stability of different UCOE containing vector combinations in mAb-producing CHO cells
10.1186/s12896-017-0330-0 · 2017 · External reference
10.1016/j.pep.2017.01.014
10.1016/j.pep.2017.01.014 · External reference
