Research graph
References from Network-based identification and prioritization of key transcriptional factors of diabetic kidney disease. Local targets link to admitted publications; unresolved targets remain external evidence.
GLUT-1 overexpression: Link between hemodynamic and metabolic factors in glomerular injury?
10.1161/01.hyp.0000075949.19968.ef · 2003 · External reference
Age at diagnosis and the risk of diabetic nephropathy in young patients with type 1 diabetes mellitus
2021 · External reference
Early-onset type 2 diabetes as a risk factor for end-stage renal disease in patients with diabetic kidney disease
10.5888/pcd17.200076 · 2020 · External reference
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10.1159/000492633 · 2018 · External reference
Liraglutide suppresses production of extracellular matrix proteins and ameliorates renal injury of diabetic nephropathy by enhancing Wnt/β-catenin signaling
10.1152/ajprenal.00128.2020 · 2020 · External reference
Neogenin pathway positively regulates fibronectin production by glomerular mesangial cells
10.1152/ajpcell.00359.2021 · 2022 · External reference
Management of hypertension and renin-angiotensin-aldosterone system blockade in adults with diabetic kidney disease: Association of British Clinical Diabetologists and the Renal Association UK guideline update 2021
10.1186/s12882-021-02587-5 · 2022 · External reference
Multi-omics analysis of diabetic nephropathy reveals potential new mechanisms and drug targets
2020 · External reference
Systems biology and machine learning approaches identify drug targets in diabetic nephropathy
10.1038/s41598-021-02282-3 · 2021 · External reference
In-silico analysis of interacting pathways through KIM-1 protein interaction in diabetic nephropathy
2022 · External reference
Computational segmentation and classification of diabetic glomerulosclerosis
10.1681/asn.2018121259 · 2019 · External reference
Progression of diabetic nephropathy
10.1053/ajkd.2003.50077 · 2003 · External reference
10.1074/jbc.274.9.5830
10.1074/jbc.274.9.5830 · External reference
Role of advanced glycation end products in diabetic nephropathy
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10.2337/diabetes.52.10.2570
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Glomerular endothelial cell stress and cross-talk with podocytes in early [corrected] diabetic kidney disease
2018 · External reference
10.1152/ajprenal.00533.2014
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High glucose induction of DNA-binding activity of the transcription factor NFkappaB in patients with diabetic nephropathy
10.1016/j.bbadis.2008.01.009 · 2008 · External reference
Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFβ1
2019 · External reference
Increased glomerular and tubular expression of transforming growth factor-beta1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse
10.1016/s0002-9440(10)64121-1 · 2001 · External reference
Bone morphogenetic protein 4 and Smad1 mediate extracellular matrix production in the development of diabetic nephropathy
10.2337/db14-0893 · 2015 · External reference
Podocyte-specific JAK2 overexpression worsens diabetic kidney disease in mice
10.1016/j.kint.2017.03.027 · 2017 · External reference
Role of the JAK/STAT signaling pathway in diabetic nephropathy
10.1152/ajprenal.00181.2005 · 2006 · External reference
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2012 · External reference
High glucose-induced O-GlcNAcylated carbohydrate response element-binding protein (ChREBP) mediates mesangial cell lipogenesis and fibrosis: the possible role in the development of diabetic nephropathy
10.1074/jbc.m113.530139 · 2014 · External reference
Islet ChREBP-β is increased in diabetes and controls ChREBP-α and glucose-induced gene expression via a negative feedback loop
10.1016/j.molmet.2016.09.010 · 2016 · External reference
Carbohydrate responsive element-binding protein (ChREBP): A key regulator of glucose metabolism and fat storage
10.1016/s0006-2952(02)01012-2 · 2002 · External reference
Excess dietary carbohydrate affects mitochondrial integrity as observed in brown adipose tissue
10.1016/j.celrep.2021.109488 · 2021 · External reference
Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression
10.1371/journal.pone.0022544 · 2011 · External reference
10.1016/j.bbadis.2011.03.015
10.1016/j.bbadis.2011.03.015 · External reference
Effects of ChREBP deficiency on adrenal lipogenesis and steroidogenesis
10.1530/joe-20-0442 · 2021 · External reference
Expression Omnibus: NCBI gene expression and hybridization array data repository
10.1093/nar/30.1.207 · 2002 · External reference
Unresolved reference
External reference
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10.1093/jnci/djw146 · 2016 · External reference
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10.1093/bioinformatics/btu027 · 2014 · External reference
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10.1007/s13253-016-0272-3 · 2016 · External reference
Unresolved reference
External reference
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10.1093/nar/gkv007 · External reference
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10.1093/biostatistics/kxj037 · External reference
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10.1186/1471-2105-13-s2-s11 · 2012 · External reference
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10.1007/s00357-014-9161-z · External reference
Unresolved reference
External reference
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10.1089/omi.2011.0118 · External reference
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10.1186/1471-2105-7-s1-s7 · 2006 · External reference
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Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method
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10.7717/peerj.4473 · 2018 · External reference
10.1098/rsif.2013.0950
10.1098/rsif.2013.0950 · External reference
DACH1 protects podocytes from experimental diabetic injury and modulates PTIP-H3K4Me3 activity
2021 · External reference
The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes
10.1172/jci0213961 · 2002 · External reference
Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy
10.1053/j.ajkd.2003.12.028 · 2004 · External reference
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10.2337/db10-1181 · External reference
Identification of transcription regulatory relationships in diabetic nephropathy
2018 · External reference
The role of podocytes and podocyte-associated biomarkers in diagnosis and treatment of diabetic kidney disease
10.1210/jendso/bvaa029 · 2020 · External reference
Diabetic nephropathy: The proteinuria hypothesis
10.1159/000084286 · 2005 · External reference
The transcription factor Dach1 is essential for podocyte function
10.1111/jcmm.13544 · 2018 · External reference
DACH: Genomic Characterization, Evaluation as a Candidate for Postaxial Polydactyly Type A2, and Developmental Expression Pattern of the Mouse Homologue
10.1006/geno.2001.6618 · 2001 · External reference
Decreased DACH1 expression in glomerulopathy is associated with disease progression and severity
2016 · External reference
10.1091/mbc.e06-09-0793
10.1091/mbc.e06-09-0793 · External reference
Molecular Interaction and Synergistic Activation of a Promoter by Six, Eya, and Dach Proteins Mediated through CREB Binding Protein
2002 · External reference
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10.1128/mcb.21.5.1484-1490.2001 · External reference
Transcriptional regulation by WT1 in development
10.1016/j.gde.2005.08.004 · 2005 · External reference
Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome
10.1038/ng0598-51 · 1998 · External reference
10.1038/73902
10.1038/73902 · External reference
Lmx1b is essential for the development of serotonergic neurons
10.1038/nn1104 · 2003 · External reference
10.1016/s0092-8674(00)00022-2
10.1016/s0092-8674(00)00022-2 · External reference
Activation of podocyte Notch mediates early Wt1 glomerulopathy
10.1016/j.kint.2017.11.014 · 2018 · External reference
10.1038/ng0598-47
10.1038/ng0598-47 · External reference
Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract
10.1242/dev.127.7.1387 · 2000 · External reference
10.1016/j.kint.2020.09.027
10.1016/j.kint.2020.09.027 · External reference
10.1002/cne.10532
10.1002/cne.10532 · External reference
PodNet, a proteinprotein interaction network of the podocyte
10.1038/ki.2013.64 · 2013 · External reference
Overactive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy
10.1073/pnas.1419901111 · 2014 · External reference
Protein S protects against podocyte injury in diabetic nephropathy
10.1681/asn.2017030234 · 2018 · External reference
Tyro3 is a podocyte protective factor in glomerular disease
2018 · External reference
Inflammation in diabetic nephropathy
10.1155/2012/146154 · 2012 · External reference
Nephrotic Syndrome in Diabetic Kidney Disease: An Evaluation and Update of the Definition
10.1053/j.ajkd.2009.04.016 · 2009 · External reference
CXCL6 Promotes Renal Interstitial Fibrosis in Diabetic Nephropathy by Activating JAK/STAT3 Signaling Pathway
2019 · External reference
Potential Repressive Impact of microRNA-20a on Renal Tubular Damage in Diabetic Kidney Disease by Targeting C-X-C Motif Chemokine Ligand 6
10.1016/j.arcmed.2020.08.005 · 2021 · External reference
Identification of C3 as a therapeutic target for diabetic nephropathy by bioinformatics analysis
10.1038/s41598-020-70540-x · 2020 · External reference
Renal C3 complement component: feed forward to diabetic kidney disease
10.1159/000371426 · 2015 · External reference
Growth and Maturation in the Zebrafish,iDanio rerio/i: A Staging Tool for Teaching and Research
10.1089/zeb.2014.0976 · 2014 · External reference
The systemic nature of CKD
10.1038/nrneph.2017.52 · 2017 · External reference
