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References from Liquid-liquid phase separation in hair cell stereocilia development and maintenance. Local targets link to admitted publications; unresolved targets remain external evidence.
The centrosome is a selective condensate that nucleates microtubules by concentrating tubulin
10.1016/j.cell.2017.05.028 · 2017 · External reference
10.1016/j.tcb.2019.04.001
10.1016/j.tcb.2019.04.001 · External reference
10.1016/j.cell.2015.09.015
10.1016/j.cell.2015.09.015 · External reference
10.1038/s41580-020-0272-6
10.1038/s41580-020-0272-6 · External reference
10.1016/j.ceb.2012.03.010
10.1016/j.ceb.2012.03.010 · External reference
10.1016/j.semcdb.2018.07.001
10.1016/j.semcdb.2018.07.001 · External reference
10.1146/annurev-cellbio-100913-013325
10.1146/annurev-cellbio-100913-013325 · External reference
10.1038/nrm.2017.7
10.1038/nrm.2017.7 · External reference
10.1038/s41580-020-00303-z
10.1038/s41580-020-00303-z · External reference
10.1038/nature10879
10.1038/nature10879 · External reference
10.1016/j.cell.2016.05.026
10.1016/j.cell.2016.05.026 · External reference
10.1146/annurev-biophys-121219-081629
10.1146/annurev-biophys-121219-081629 · External reference
10.1021/acs.biochem.1c00376
10.1021/acs.biochem.1c00376 · External reference
10.1126/science.1172046
10.1126/science.1172046 · External reference
G3BP1 is a tunable switch that triggers phase separation to assemble stress granules
10.1016/j.cell.2020.03.046 · 2020 · External reference
Transcription factors activate genes through the phase-separation capacity of their activation domains
10.1016/j.cell.2018.10.042 · 2018 · External reference
10.1126/science.aar4199
10.1126/science.aar4199 · External reference
10.1126/science.aar3958
10.1126/science.aar3958 · External reference
10.1126/science.aax4240
10.1126/science.aax4240 · External reference
Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity
10.1016/j.cell.2016.07.008 · 2016 · External reference
10.1126/science.aat5671
10.1126/science.aat5671 · External reference
RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation
2019 · External reference
10.1038/s41593-019-0579-9
10.1038/s41593-019-0579-9 · External reference
10.1038/s41586-020-2942-0
10.1038/s41586-020-2942-0 · External reference
Membraneless condensates by Rapsn phase separation as a platform for neuromuscular junction formation
10.1016/j.neuron.2021.04.021 · 2021 · External reference
10.1126/science.aad9964
10.1126/science.aad9964 · External reference
10.1126/science.aat1022
10.1126/science.aat1022 · External reference
10.1126/science.aau5721
10.1126/science.aau5721 · External reference
Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness
10.1038/s41467-020-14544-1 · 2020 · External reference
Myosin VII, USH1C, and ANKS4B or USH1G Together Form Condensed Molecular Assembly via Liquid-Liquid Phase Separation
2019 · External reference
10.1016/j.celrep.2021.108770
10.1016/j.celrep.2021.108770 · External reference
Promotion of row 1-specific tip complex condensates by Gpsm2-Galphai provides insights into row identity of the tallest stereocilia
2022 · External reference
10.1016/s0896-6273(00)80385-2
10.1016/s0896-6273(00)80385-2 · External reference
Rethinking how hearing happens
10.1016/j.neuron.2009.04.019 · 2009 · External reference
10.1002/cphy.c160049
10.1002/cphy.c160049 · External reference
10.1083/jcb.201001138
10.1083/jcb.201001138 · External reference
Actin-Filaments, Stereocilia, and Hair-Cells - How Cells Count and Measure
10.1146/annurev.cb.08.110192.001353 · 1992 · External reference
10.1091/mbc.e14-04-0940
10.1091/mbc.e14-04-0940 · External reference
10.1038/nn1818
10.1038/nn1818 · External reference
Sensorineural hearing loss in children
10.1016/s0140-6736(05)71047-3 · 2005 · External reference
10.1056/nejmra1616601
10.1056/nejmra1616601 · External reference
Congenital hearing loss
10.1038/nrdp.2016.94 · 2017 · External reference
Hearing loss in children: a review
10.1001/jama.2020.17647 · 2020 · External reference
10.1146/annurev-genom-121321-094136
10.1146/annurev-genom-121321-094136 · External reference
10.1007/s00439-022-02448-7
10.1007/s00439-022-02448-7 · External reference
10.1242/jcs.02636
10.1242/jcs.02636 · External reference
10.1038/nn.2330
10.1038/nn.2330 · External reference
10.1146/annurev-physiol-012110-142228
10.1146/annurev-physiol-012110-142228 · External reference
10.1016/j.bbadis.2014.11.020
10.1016/j.bbadis.2014.11.020 · External reference
A type VII myosin encoded by the mouse deafness gene shaker-1
10.1038/374062a0 · 1995 · External reference
Defective myosin VIIA gene responsible for Usher syndrome type 1B
10.1038/374060a0 · 1995 · External reference
10.1038/79178
10.1038/79178 · External reference
10.1038/79171
10.1038/79171 · External reference
10.1038/83667
10.1038/83667 · External reference
10.1086/316954
10.1086/316954 · External reference
Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D
10.1038/83660 · 2001 · External reference
Mutations of the protocadherin gene PCDH15 cause Usher syndrome type 1F
10.1086/321277 · 2001 · External reference
Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F
10.1093/hmg/10.16.1709 · 2001 · External reference
Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmonin
10.1093/hmg/ddg051 · 2003 · External reference
10.1038/ng.2426
10.1038/ng.2426 · External reference
10.1086/302855
10.1086/302855 · External reference
10.1086/381685
10.1086/381685 · External reference
10.1038/ng1208
10.1038/ng1208 · External reference
10.1038/sj.ejhg.5200831
10.1038/sj.ejhg.5200831 · External reference
10.1038/nature06091
10.1038/nature06091 · External reference
Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction
10.1038/nature11590 · 2012 · External reference
10.1073/pnas.97.24.13336
10.1073/pnas.97.24.13336 · External reference
Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle
10.1093/emboj/cdf689 · 2002 · External reference
10.1073/pnas.232579599
10.1073/pnas.232579599 · External reference
Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23
10.1073/pnas.0901819106 · 2009 · External reference
10.1073/pnas.0911385107
10.1073/pnas.0911385107 · External reference
Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia
10.1073/pnas.1017114108 · 2011 · External reference
10.1073/pnas.1104161108
10.1073/pnas.1104161108 · External reference
10.1016/j.cell.2012.10.041
10.1016/j.cell.2012.10.041 · External reference
10.1073/pnas.1402152111
10.1073/pnas.1402152111 · External reference
10.1016/j.neuron.2014.10.041
10.1016/j.neuron.2014.10.041 · External reference
Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5
2018 · External reference
10.1038/s41467-017-00061-1
10.1038/s41467-017-00061-1 · External reference
CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells
10.1016/j.neuron.2021.05.007 · 2021 · External reference
The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles
10.1523/jneurosci.0693-06.2006 · 2006 · External reference
10.1523/jneurosci.0342-07.2007
10.1523/jneurosci.0342-07.2007 · External reference
Individual USH2 proteins make distinct contributions to the ankle link complex during development of the mouse cochlear stereociliary bundle
2015 · External reference
Hair-bundle links: genetics as the gateway to function
10.1101/cshperspect.a033142 · 2019 · External reference
10.1002/cne.20513
10.1002/cne.20513 · External reference
10.1074/jbc.m114.610535
10.1074/jbc.m114.610535 · External reference
Deciphering the molecular interaction between the adhesion G protein-coupled receptor ADGRV1 and its PDZ-containing regulator PDZD7
10.3389/fmolb.2022.923740 · 2022 · External reference
The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene
10.1523/jneurosci.0311-12.2012 · 2012 · External reference
10.1083/jcb.201404016
10.1083/jcb.201404016 · External reference
10.1172/jci94351
10.1172/jci94351 · External reference
10.1016/0378-5955(85)90010-3
10.1016/0378-5955(85)90010-3 · External reference
Displacement-clamp measurement of the forces exerted by gating springs in the hair bundle
10.1073/pnas.90.4.1330 · 1993 · External reference
10.1126/science.1198848
10.1126/science.1198848 · External reference
Structure of Myo7b/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosins
2017 · External reference
Myosin 7 and its adaptors link cadherins to actin
10.1038/ncomms15864 · 2017 · External reference
10.1074/jbc.m112.378505
10.1074/jbc.m112.378505 · External reference
Structure of the Harmonin PDZ2 and coiled-coil domains in a complex with CDHR2 tail and its implications
10.1096/fj.202200403rr · 2022 · External reference
10.1016/j.cell.2014.01.067
10.1016/j.cell.2014.01.067 · External reference
10.1016/j.devcel.2015.12.020
10.1016/j.devcel.2015.12.020 · External reference
The kinocilia of cochlear hair cells: structures, functions, and diseases
10.3389/fcell.2021.715037 · 2021 · External reference
Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain
10.1242/dev.060061 · 2011 · External reference
10.1038/ncb1219
10.1038/ncb1219 · External reference
10.1016/j.cub.2010.12.046
10.1016/j.cub.2010.12.046 · External reference
10.1371/journal.pbio.1001048
10.1371/journal.pbio.1001048 · External reference
10.1126/science.280.5368.1444
10.1126/science.280.5368.1444 · External reference
10.1038/s41580-021-00384-4
10.1038/s41580-021-00384-4 · External reference
10.1146/annurev.biochem.73.011303.073756
10.1146/annurev.biochem.73.011303.073756 · External reference
10.1016/j.ajhg.2012.04.008
10.1016/j.ajhg.2012.04.008 · External reference
Defective Gpsm2/Galphai3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome
10.1038/ncomms14907 · 2017 · External reference
GPSM2-GNAI specifies the tallest stereocilia and defines hair bundle row identity
2019 · External reference
10.1016/j.jmb.2020.09.012
10.1016/j.jmb.2020.09.012 · External reference
10.1038/s41586-021-03819-2
10.1038/s41586-021-03819-2 · External reference
10.1016/j.cell.2004.10.028
10.1016/j.cell.2004.10.028 · External reference
10.1074/jbc.m112.391607
10.1074/jbc.m112.391607 · External reference
10.1073/pnas.1304644110
10.1073/pnas.1304644110 · External reference
EPS8L2 is a new causal gene for childhood onset autosomal recessive progressive hearing loss
10.1186/s13023-015-0316-8 · 2015 · External reference
Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells
10.1038/s41598-020-73158-1 · 2020 · External reference
10.1016/j.celrep.2016.03.081
10.1016/j.celrep.2016.03.081 · External reference
10.1038/ncb1851
10.1038/ncb1851 · External reference
10.1016/j.cub.2011.12.053
10.1016/j.cub.2011.12.053 · External reference
Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like
10.1038/ncomms10833 · 2016 · External reference
Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin
2016 · External reference
10.1093/hmg/ddr503
10.1093/hmg/ddr503 · External reference
