Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureResearch graph
References from Interactions between gut microbes and NLRP3 inflammasome in the gut-brain axis. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1038/nri.2016.58
10.1038/nri.2016.58 · External reference
10.1017/s0954422417000269
10.1017/s0954422417000269 · External reference
Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance
10.1084/jem.20201416 · 2021 · External reference
10.1038/nm.3265
10.1038/nm.3265 · External reference
10.1038/nature08938
10.1038/nature08938 · External reference
Ursolic acid reverses liver fibrosis by inhibiting NOX4/NLRP3 inflammasome pathways and bacterial dysbiosis
10.1080/19490976.2021.1972746 · 2021 · External reference
Macrophage–NLRP3 activation promotes right ventricle failure in pulmonary arterial hypertension
10.1164/rccm.202110-2274oc · 2022 · External reference
10.1093/eurheartj/ehab107
10.1093/eurheartj/ehab107 · External reference
Invariant natural killer T cells shape the gut microbiota and regulate neutrophil recruitment and function during intestinal inflammation
10.3389/fimmu.2018.00999 · 2018 · External reference
10.1038/npp.2016.103
10.1038/npp.2016.103 · External reference
The microbiota-inflammasome hypothesis of major depression
10.1002/bies.201800027 · 2018 · External reference
10.1111/imr.12285
10.1111/imr.12285 · External reference
10.1146/annurev-immunol-042718-041841
10.1146/annurev-immunol-042718-041841 · External reference
10.1038/nrd.2018.97
10.1038/nrd.2018.97 · External reference
10.1002/ibd.21478
10.1002/ibd.21478 · External reference
Strategies to dissect host-microbial immune interactions that determine mucosal homeostasis vs. intestinal inflammation in gnotobiotic mice
10.3389/fimmu.2020.00214 · 2020 · External reference
10.1016/j.pharmthera.2019.03.006
10.1016/j.pharmthera.2019.03.006 · External reference
Gut microbiota interact with the brain through systemic chronic inflammation: implications on neuroinflammation, neurodegeneration, and aging
10.3389/fimmu.2022.796288 · 2022 · External reference
10.1016/j.bbi.2017.05.009
10.1016/j.bbi.2017.05.009 · External reference
10.1038/nature09944
10.1038/nature09944 · External reference
10.3390/microorganisms7010014
10.3390/microorganisms7010014 · External reference
Relationship between gut microbiota, gut hyperpermeability and obesity
10.2174/0929867327666200721160313 · 2021 · External reference
10.1177/1756283x13482996
10.1177/1756283x13482996 · External reference
10.1016/j.mib.2013.03.009
10.1016/j.mib.2013.03.009 · External reference
10.3389/fimmu.2020.571731
10.3389/fimmu.2020.571731 · External reference
10.1038/nrg3182
10.1038/nrg3182 · External reference
Intestinal microbiota as a contributor to chronic inflammation and its potential modifications
10.3390/nu13113839 · 2021 · External reference
10.1016/j.jnutbio.2022.108991
10.1016/j.jnutbio.2022.108991 · External reference
Microbiota impacts on chronic inflammation and metabolic syndrome - related cognitive dysfunction
10.1007/s11154-019-09537-5 · 2019 · External reference
10.1016/j.jcmgh.2021.02.007
10.1016/j.jcmgh.2021.02.007 · External reference
10.1016/j.beem.2021.101542
10.1016/j.beem.2021.101542 · External reference
10.1093/humupd/dmab035
10.1093/humupd/dmab035 · External reference
10.1073/pnas.1000092107
10.1073/pnas.1000092107 · External reference
10.3748/wjg.v21.i40.11411
10.3748/wjg.v21.i40.11411 · External reference
10.1038/nri.2016.42
10.1038/nri.2016.42 · External reference
10.1128/mmbr.00036-17
10.1128/mmbr.00036-17 · External reference
10.3109/08830185.2010.529976
10.3109/08830185.2010.529976 · External reference
10.1089/sur.2017.264
10.1089/sur.2017.264 · External reference
10.1038/s41590-019-0368-3
10.1038/s41590-019-0368-3 · External reference
10.2337/db07-1403
10.2337/db07-1403 · External reference
10.2337/db06-1491
10.2337/db06-1491 · External reference
10.1038/ni.2833
10.1038/ni.2833 · External reference
10.1016/j.immuni.2016.11.007
10.1016/j.immuni.2016.11.007 · External reference
10.1002/jlb.3mir1118-434r
10.1002/jlb.3mir1118-434r · External reference
10.1111/imm.12787
10.1111/imm.12787 · External reference
10.1038/cmi.2017.122
10.1038/cmi.2017.122 · External reference
Bacterial flagellin—a potent immunomodulatory agent
10.1038/emm.2017.172 · 2017 · External reference
10.1038/cmi.2017.12
10.1038/cmi.2017.12 · External reference
Gram-positive bacteria cell wall-derived lipoteichoic acid induces inflammatory alveolar bone loss through prostaglandin E production in osteoblasts
10.1038/s41598-021-92744-5 · 2021 · External reference
10.1038/nri.2017.136
10.1038/nri.2017.136 · External reference
10.1038/s41564-019-0381-1
10.1038/s41564-019-0381-1 · External reference
10.1074/jbc.r500001200
10.1074/jbc.r500001200 · External reference
10.1016/j.cmet.2021.12.011
10.1016/j.cmet.2021.12.011 · External reference
10.1194/jlr.r036012
10.1194/jlr.r036012 · External reference
10.1016/j.cell.2016.05.041
10.1016/j.cell.2016.05.041 · External reference
10.1111/1462-2920.13589
10.1111/1462-2920.13589 · External reference
10.1080/19490976.2015.1134082
10.1080/19490976.2015.1134082 · External reference
10.1016/j.it.2011.04.001
10.1016/j.it.2011.04.001 · External reference
10.1016/j.ebiom.2018.03.030
10.1016/j.ebiom.2018.03.030 · External reference
10.1038/ncomms7734
10.1038/ncomms7734 · External reference
10.1371/journal.ppat.1007954
10.1371/journal.ppat.1007954 · External reference
Trimethylamine N-oxide exacerbates cardiac fibrosis via activating the NLRP3 inflammasome
10.3389/fphys.2019.00866 · 2019 · External reference
10.1182/blood.2019003990
10.1182/blood.2019003990 · External reference
Gut microbiota-dependent marker TMAO in promoting cardiovascular disease: inflammation mechanism, clinical prognostic, and potential as a therapeutic target
10.3389/fphar.2019.01360 · 2019 · External reference
Trimethylamine-N-oxide promotes vascular calcification through activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) inflammasome and NF-κB (Nuclear Factor κB) signals
10.1161/atvbaha.119.313414 · 2020 · External reference
The fibrotic effects of TMAO on human renal fibroblasts is mediated by NLRP3, caspase-1 and the PERK/Akt/mTOR pathway
10.3390/ijms222111864 · 2021 · External reference
The role of a gut microbial-derived metabolite, trimethylamine N-oxide (TMAO), in neurological disorders
10.1007/s12035-022-02990-5 · 2022 · External reference
10.1016/s1097-2765(02)00599-3
10.1016/s1097-2765(02)00599-3 · External reference
10.1016/j.cell.2010.01.040
10.1016/j.cell.2010.01.040 · External reference
10.1038/ni.1859
10.1038/ni.1859 · External reference
10.1038/ni.1932
10.1038/ni.1932 · External reference
10.1038/nature13449
10.1038/nature13449 · External reference
10.1146/annurev-immunol-032712-095944
10.1146/annurev-immunol-032712-095944 · External reference
10.1038/ng1724
10.1038/ng1724 · External reference
Functional degradation: a mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes
10.1126/science.aau1330 · 2019 · External reference
10.1038/nri3452
10.1038/nri3452 · External reference
10.1038/ni1344
10.1038/ni1344 · External reference
10.1038/ni.1864
10.1038/ni.1864 · External reference
Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol
10.1016/j.chom.2010.04.004 · 2010 · External reference
Sensing damage by the NLRP3 inflammasome: NLRP3 inflammasome in sterile inflammation
10.1111/j.1600-065x.2011.01043.x · 2011 · External reference
TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies
10.1172/jci90699 · 2017 · External reference
Spotlight on the NLRP3 inflammasome pathway
10.2147/jir.s141220 · 2018 · External reference
Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors
10.1038/s41419-019-1413-8 · 2019 · External reference
10.1016/j.tips.2022.04.003
10.1016/j.tips.2022.04.003 · External reference
10.1038/s41423-021-00740-6
10.1038/s41423-021-00740-6 · External reference
10.1038/s41423-019-0260-y
10.1038/s41423-019-0260-y · External reference
10.1016/j.intimp.2018.12.019
10.1016/j.intimp.2018.12.019 · External reference
10.3389/fimmu.2019.00276
10.3389/fimmu.2019.00276 · External reference
10.1080/15548627.2019.1635384
10.1080/15548627.2019.1635384 · External reference
The interplay between the gut microbiota and NLRP3 activation affects the severity of acute pancreatitis in mice
10.1080/19490976.2020.1770042 · 2020 · External reference
10.1007/s00401-018-1856-5
10.1007/s00401-018-1856-5 · External reference
10.1128/aem.03044-15
10.1128/aem.03044-15 · External reference
10.1371/journal.ppat.1005121
10.1371/journal.ppat.1005121 · External reference
10.1039/d1fo02405a
10.1039/d1fo02405a · External reference
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis
10.1016/j.immuni.2019.02.006 · 2019 · External reference
10.1038/s41564-020-00832-5
10.1038/s41564-020-00832-5 · External reference
Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome
10.1016/j.ijmm.2014.01.002 · 2014 · External reference
10.1038/s41467-020-14534-3
10.1038/s41467-020-14534-3 · External reference
IRGB10 liberates bacterial ligands for sensing by the AIM2 and caspase-11-NLRP3 inflammasomes
2016 · External reference
10.1016/j.immuni.2015.03.004
10.1016/j.immuni.2015.03.004 · External reference
10.1158/2326-6066.cir-20-1019
10.1158/2326-6066.cir-20-1019 · External reference
Antibiotics induced intestinal tight junction barrier dysfunction is associated with microbiota dysbiosis, activated NLRP3 inflammasome and autophagy
10.1371/journal.pone.0218384 · 2019 · External reference
Tamoxifen-induced, intestinal-specific deletion of Slc5a6 in adult mice leads to spontaneous inflammation: involvement of NF-κB, NLRP3, and gut microbiota
10.1152/ajpgi.00172.2019 · 2019 · External reference
The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
10.1016/j.immuni.2010.03.003 · 2010 · External reference
Reduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression
10.1186/s12974-018-1328-9 · 2018 · External reference
10.1093/cvr/cvab114
10.1093/cvr/cvab114 · External reference
10.1136/gutjnl-2018-316670
10.1136/gutjnl-2018-316670 · External reference
The crosstalk between NLRP3 inflammasome and gut microbiome in atherosclerosis
10.1016/j.phrs.2022.106289 · 2022 · External reference
Giardia spp. promote the production of antimicrobial peptides and attenuate disease severity induced by attaching and effacing enteropathogens via the induction of the NLRP3 inflammasome
10.1016/j.ijpara.2019.12.011 · 2020 · External reference
Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2
10.1186/s40168-019-0733-3 · 2019 · External reference
Effect of temperature stress on gut-brain axis in mice: Regulation of intestinal microbiome and central NLRP3 inflammasomes
10.1016/j.scitotenv.2020.144568 · 2021 · External reference
Gut to brain dysbiosis: mechanisms linking western diet consumption, the microbiome, and cognitive impairment
2017 · External reference
10.3390/microorganisms6040107
10.3390/microorganisms6040107 · External reference
10.1016/j.arr.2016.10.005
10.1016/j.arr.2016.10.005 · External reference
Role of diet and nutritional supplements in parkinson’s disease progression
10.1155/2017/6405278 · 2017 · External reference
Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury
10.1016/j.intimp.2017.11.007 · 2018 · External reference
10.1074/jbc.m117.791715
10.1074/jbc.m117.791715 · External reference
Omega-3 fatty acids regulate NLRP3 inflammasome activation and prevent behavior deficits after traumatic brain injury
10.1016/j.expneurol.2017.01.005 · 2017 · External reference
10.1155/2016/5460302
10.1155/2016/5460302 · External reference
10.1038/nm.3804
10.1038/nm.3804 · External reference
10.1016/j.biopha.2021.111442
10.1016/j.biopha.2021.111442 · External reference
10.1016/j.cytogfr.2021.03.003
10.1016/j.cytogfr.2021.03.003 · External reference
10.1016/j.autrev.2013.06.004
10.1016/j.autrev.2013.06.004 · External reference
10.1038/s41575-020-0331-7
10.1038/s41575-020-0331-7 · External reference
10.1038/nri3661
10.1038/nri3661 · External reference
10.1038/nrgastro.2017.88
10.1038/nrgastro.2017.88 · External reference
10.1038/ng.285
10.1038/ng.285 · External reference
10.4049/jimmunol.163.1.143
10.4049/jimmunol.163.1.143 · External reference
10.1177/1753425919826367
10.1177/1753425919826367 · External reference
10.1136/gut.2009.197822
10.1136/gut.2009.197822 · External reference
10.1084/jem.20100050
10.1084/jem.20100050 · External reference
Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen
10.1038/mi.2013.94 · 2014 · External reference
Protective and aggravating effects of Nlrp3 inflammasome activation in IBD models: influence of genetic and environmental factors
10.1159/000341681 · 2012 · External reference
Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia
10.1186/s40168-021-01165-z · 2021 · External reference
A novel combination therapy using rosuvastatin and lactobacillus combats dextran sodium sulfate-induced colitis in high-fat diet-fed rats by targeting the TXNIP/NLRP3 interaction and influencing gut microbiome composition
10.3390/ph14040341 · 2021 · External reference
10.1128/spectrum.00730-21
10.1128/spectrum.00730-21 · External reference
Sanguinarine ameliorates DSS induced ulcerative colitis by inhibiting NLRP3 inflammasome activation and modulating intestinal microbiota in C57BL/6 mice
10.1016/j.phymed.2022.154321 · 2022 · External reference
Interactions between diet and the intestinal microbiota alter intestinal permeability and colitis severity in mice
10.1053/j.gastro.2017.11.030 · 2018 · External reference
10.1136/gutjnl-2018-316250
10.1136/gutjnl-2018-316250 · External reference
10.1016/j.intimp.2020.106288
10.1016/j.intimp.2020.106288 · External reference
10.7150/thno.62046
10.7150/thno.62046 · External reference
Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota
10.1016/j.phrs.2019.104489 · 2019 · External reference
The Mediterranean Osteoporosis Study (MEDOS): theoretical and practical issues of a major international project on hip fracture epidemiology
10.1016/8756-3282(93)90348-e · 1993 · External reference
Role of NLRP3 inflammasome in Bifidobacterium longum -regulated visceral hypersensitivity of postinfectious irritable bowel syndrome
10.3109/21691401.2015.1111238 · 2016 · External reference
10.1152/physrev.00018.2018
10.1152/physrev.00018.2018 · External reference
10.1016/s1474-4422(19)30356-4
10.1016/s1474-4422(19)30356-4 · External reference
10.1016/j.ynstr.2017.03.001
10.1016/j.ynstr.2017.03.001 · External reference
10.3390/cells10092370
10.3390/cells10092370 · External reference
10.1073/pnas.0812874106
10.1073/pnas.0812874106 · External reference
10.1093/advances/nmz127
10.1093/advances/nmz127 · External reference
10.1016/j.brainres.2018.03.015
10.1016/j.brainres.2018.03.015 · External reference
10.1038/nn.4030
10.1038/nn.4030 · External reference
Growing up in a bubble: using germ-free animals to assess the influence of the gut microbiota on brain and behavior
10.1093/ijnp/pyw020 · 2016 · External reference
Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition
10.1038/mp.2016.46 · 2016 · External reference
NLRP3 inflammasome-driven pathways in depression: Clinical and preclinical findings
10.1016/j.bbi.2017.03.002 · 2017 · External reference
10.1172/jci127330
10.1172/jci127330 · External reference
10.1016/j.biopsych.2017.11.018
10.1016/j.biopsych.2017.11.018 · External reference
10.1038/s41583-019-0233-2
10.1038/s41583-019-0233-2 · External reference
Chronic peripheral inflammation causes a region-specific myeloid response in the central nervous system
10.1016/j.celrep.2020.02.109 · 2020 · External reference
10.1016/j.semcdb.2019.05.004
10.1016/j.semcdb.2019.05.004 · External reference
10.1186/s40035-020-00221-2
10.1186/s40035-020-00221-2 · External reference
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice
10.1126/scitranslmed.aah4066 · 2018 · External reference
10.1038/s41583-018-0055-7
10.1038/s41583-018-0055-7 · External reference
Activation of NLRP3 inflammasome and onset of Alzheimer’s disease
10.3389/fimmu.2021.701282 · 2021 · External reference
Fecal microbiota transplantation ameliorates stress-induced depression-like behaviors associated with the inhibition of glial and NLRP3 inflammasome in rat brain
10.1016/j.jpsychires.2021.02.057 · 2021 · External reference
10.1038/mp.2016.50
10.1038/mp.2016.50 · External reference
10.1016/j.pneurobio.2020.101806
10.1016/j.pneurobio.2020.101806 · External reference
Canonical and non-canonical activation of NLRP3 inflammasome at the crossroad between immune tolerance and intestinal inflammation
2017 · External reference
10.1084/jem.20182191
10.1084/jem.20182191 · External reference
Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels
10.1038/s41598-017-02587-2 · 2017 · External reference
10.1038/s41598-017-13601-y
10.1038/s41598-017-13601-y · External reference
10.3233/jad-160926
10.3233/jad-160926 · External reference
10.1093/nutrit/nuw023
10.1093/nutrit/nuw023 · External reference
New mechanism of neuroinflammation in Alzheimer’s disease: the activation of NLRP3 inflammasome mediated by gut microbiota
10.1016/j.pnpbp.2020.109884 · 2020 · External reference
10.3390/cells10040779
10.3390/cells10040779 · External reference
Modulation of the gut microbiota and glycometabolism by a probiotic to alleviate amyloid accumulation and cognitive impairments in AD rats
10.1002/mnfr.202200265 · 2022 · External reference
Diet in Parkinson’s disease: critical role for the microbiome
10.3389/fneur.2019.01245 · 2019 · External reference
Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson’s disease
10.1016/j.cell.2016.11.018 · 2016 · External reference
Altered gut microbiota and inflammatory cytokine responses in patients with Parkinson’s disease
10.1186/s12974-019-1528-y · 2019 · External reference
10.1136/gutjnl-2018-316844
10.1136/gutjnl-2018-316844 · External reference
10.1007/s11064-020-03074-3
10.1007/s11064-020-03074-3 · External reference
CD36 deficiency affects depressive-like behaviors possibly by modifying gut microbiota and the inflammasome pathway in mice
10.1038/s41398-020-01130-8 · 2021 · External reference
10.1016/j.bbi.2018.05.020
10.1016/j.bbi.2018.05.020 · External reference
10.1016/j.bbr.2018.09.010
10.1016/j.bbr.2018.09.010 · External reference
Lactobacillus delbrueckii alleviates depression-like behavior through inhibiting toll-like receptor 4 (TLR4) signaling in mice
10.21037/atm-20-4411 · 2021 · External reference
