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References from Recent progress toward understanding the role of ZIP14 in regulating systemic manganese homeostasis. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1016/j.febslet.2004.12.006
10.1016/j.febslet.2004.12.006 · External reference
10.1073/pnas.0502257102
10.1073/pnas.0502257102 · External reference
Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells
10.1073/pnas.0606424103 · 2006 · External reference
ZRT/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin
10.1074/jbc.m110.143248 · 2010 · External reference
10.1124/mol.107.043588
10.1124/mol.107.043588 · External reference
Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells
10.1039/c2mt20024d · 2012 · External reference
Localization of ZIP14 and ZIP8 in HIBCPP Cells
10.3390/brainsci10080534 · 2020 · External reference
Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron
10.1152/ajpcell.00479.2010 · 2011 · External reference
Clinical profile and treatment outcomes of hypermanganesemia with dystonia 1 and 2 among 27 indian children
10.1002/mdc3.13516 · 2022 · External reference
A novel mutation in SLC39A14 causing hypermanganesemia associated with infantile onset dystonia
10.1002/jgm.3012 · 2018 · External reference
Effect of chelation therapy on a korean patient with brain manganese deposition resulting from a compound heterozygous mutation in the SLC39A14 gene
10.14802/jmd.21143 · 2022 · External reference
Hypermanganesemia due to mutations in SLC39A14: further insights into Mn deposition in the central nervous system
10.1186/s13023-018-0758-x · 2018 · External reference
Novel founder intronic variant in SLC39A14 in two families causing Manganism and potential treatment strategies
10.1016/j.ymgme.2018.04.002 · 2018 · External reference
Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia
10.1038/ncomms11601 · 2016 · External reference
Autosomal-recessive iron deficiency anemia, dystonia and hypermanganesemia caused by new variant mutation of the manganese transporter gene SLC39A14
10.1007/s13760-018-1024-7 · 2019 · External reference
Can AlphaFold2 predict the impact of missense mutations on structure?
10.1038/s41594-021-00714-2 · 2022 · External reference
10.1073/pnas.96.26.14765
10.1073/pnas.96.26.14765 · External reference
10.1111/j.1742-4658.2005.04580.x
10.1111/j.1742-4658.2005.04580.x · External reference
10.1101/2022.04.08.487609
10.1101/2022.04.08.487609 · External reference
The human transmembrane proteome
10.1186/s13062-015-0061-x · 2015 · External reference
Enhanced recognition of protein transmembrane domains with prediction-based structural profiles
10.1093/bioinformatics/bti784 · 2006 · External reference
10.1021/ci010263s
10.1021/ci010263s · External reference
10.1093/nar/gkv485
10.1093/nar/gkv485 · External reference
10.1016/j.jmb.2004.03.016
10.1016/j.jmb.2004.03.016 · External reference
10.1038/s41586-021-03819-2
10.1038/s41586-021-03819-2 · External reference
Manganese: recent advances in understanding its transport and neurotoxicity
10.1016/j.taap.2007.03.001 · 2007 · External reference
10.1146/annurev-nutr-071714-034419
10.1146/annurev-nutr-071714-034419 · External reference
Manganese metabolism in humans
10.2741/4665 · 2018 · External reference
Regulation of the Metal Transporters ZIP14 and ZnT10 by Manganese Intake in Mice
10.3390/nu11092099 · 2019 · External reference
Unresolved reference
External reference
Manganese and developmental neurotoxicity
10.1007/978-3-319-60189-2_2 · 2017 · External reference
10.1016/j.neuro.2012.01.005
10.1016/j.neuro.2012.01.005 · External reference
Nutritional aspects of manganese homeostasis
10.1016/j.mam.2005.07.003 · 2005 · External reference
Manganese in health and disease
2013 · External reference
10.1007/s40572-015-0056-x · 2015 · Admitted local publication
Familial manganese-induced neurotoxicity due to mutations in SLC30A10 or SLC39A14
10.1016/j.neuro.2017.07.030 · 2018 · External reference
SLC39A8 deficiency: a disorder of manganese transport and glycosylation
10.1016/j.ajhg.2015.11.003 · 2015 · External reference
Intestine-specific deletion of metal transporter Zip14 (Slc39a14) causes brain manganese overload and locomotor defects of manganism
10.1152/ajpgi.00301.2019 · 2020 · External reference
10.1074/jbc.ra119.008762
10.1074/jbc.ra119.008762 · External reference
10.1074/mcp.m113.035600
10.1074/mcp.m113.035600 · External reference
Zinc transporter Slc39a14 regulates inflammatory signaling associated with hypertrophic adiposity
10.1152/ajpendo.00421.2015 · 2016 · External reference
Metal transporter Zip14 (Slc39a14) deletion in mice increases manganese deposition and produces neurotoxic signatures and diminished motor activity
10.1523/jneurosci.0285-17.2017 · 2017 · External reference
SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice
10.1073/pnas.1720739115 · 2018 · External reference
Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice
10.1038/celldisc.2017.25 · 2017 · External reference
Manganese transporter Slc30a10 controls physiological manganese excretion and toxicity
10.1172/jci129710 · 2019 · External reference
SLC30A10 transporter in the digestive system regulates brain manganese under basal conditions while brain SLC30A10 protects against neurotoxicity
10.1074/jbc.ra118.005628 · 2019 · External reference
10.1172/jci90896
10.1172/jci90896 · External reference
10.1016/j.jphs.2021.10.011
10.1016/j.jphs.2021.10.011 · External reference
The Functions of ZIP8, ZIP14, and ZnT10 in the Regulation of Systemic Manganese Homeostasis
2020 · External reference
Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
10.1016/s0016-5085(89)80072-1 · 1989 · External reference
Transport of micro-opioid receptor agonists and antagonist peptides across Caco-2 monolayer
10.1016/j.peptides.2008.01.018 · 2008 · External reference
Food derived carbonyl compounds affect basal and stimulated secretion of interleukin-6 and -8 in Caco-2 cells
10.1007/s00394-009-0035-9 · 2009 · External reference
Influence of ZIP14 (slc39A14) on intestinal zinc processing and barrier function
10.1152/ajpgi.00021.2014 · 2015 · External reference
The Combined Inactivation of Intestinal and Hepatic ZIP14 Exacerbates Manganese Overload in Mice
2022 · External reference
"Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies"
10.1186/s40360-016-0099-0 · 2016 · External reference
Neurobehavioral effects of manganese in workers from a ferroalloy plant after temporary cessation of exposure
10.5271/sjweh.1369 · 1995 · External reference
Occupational Mn parkinsonism: magnetic resonance imaging and clinical patterns following CaNa2-EDTA chelation
2000 · External reference
Hernandez et al., Follow-up of patients affected by manganese-induced Parkinsonism after treatment with CaNa2EDTA
10.1016/j.neuro.2005.09.003 · 2006 · External reference
Neuroprotective and therapeutic strategies for manganese-induced neurotoxicity
2017 · External reference
