Research graph
References from Single-cell and spatial transcriptomics: Advances in heart development and disease applications. Local targets link to admitted publications; unresolved targets remain external evidence.
Anatomy, Function, and Dysfunction of the Right Ventricle: JACC State-of-the-Art Review
10.1016/j.jacc.2018.12.076 · 2019 · External reference
Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study
2020 · External reference
From genetic testing to precision medicine in epilepsy
10.1007/s13311-020-00835-4 · 2020 · External reference
What is precision medicine?
10.1183/13993003.00391-2017 · 2017 · External reference
Unresolved reference
2011 · External reference
10.1161/circulationaha.119.043053
10.1161/circulationaha.119.043053 · External reference
10.1007/s10741-021-10139-0
10.1007/s10741-021-10139-0 · External reference
10.1038/nrcardio.2016.101
10.1038/nrcardio.2016.101 · External reference
Precision medicine and therapies of the future
10.1111/epi.16539 · 2021 · External reference
Construction of a cross-species cell landscape at single-cell level
2022 · External reference
10.1038/s41586-020-2797-4
10.1038/s41586-020-2797-4 · External reference
Advances in spatial transcriptomic data analysis
10.1101/gr.275224.121 · 2021 · External reference
10.1126/science.abb9536
10.1126/science.abb9536 · External reference
Identifying multicellular spatiotemporal organization of cells with SpaceFlow
10.1038/s41467-022-31739-w · 2022 · External reference
10.1016/j.jhep.2020.06.004
10.1016/j.jhep.2020.06.004 · External reference
Dissecting Cellular Heterogeneity Using Single-Cell RNA Sequencing
2019 · External reference
10.1016/j.stem.2018.04.014
10.1016/j.stem.2018.04.014 · External reference
10.1161/circresaha.119.315576
10.1161/circresaha.119.315576 · External reference
10.1126/science.aam8940
10.1126/science.aam8940 · External reference
10.1038/s42003-022-03175-5
10.1038/s42003-022-03175-5 · External reference
10.1038/s41576-021-00370-8
10.1038/s41576-021-00370-8 · External reference
10.1016/j.tibtech.2020.05.006
10.1016/j.tibtech.2020.05.006 · External reference
SnapShot: Spatial transcriptomics
10.1016/j.cell.2022.06.002 · 2022 · External reference
10.1126/science.aaf2403
10.1126/science.aaf2403 · External reference
10.1016/j.cell.2020.06.038
10.1016/j.cell.2020.06.038 · External reference
Integration of computational analysis and spatial transcriptomics in single-cell study
2022 · External reference
10.1038/s42003-020-01247-y
10.1038/s42003-020-01247-y · External reference
10.1038/s41556-019-0439-6
10.1038/s41556-019-0439-6 · External reference
Development of the human heart
10.1002/ajmg.a.35896 · 2014 · External reference
10.1038/s41569-018-0086-9
10.1038/s41569-018-0086-9 · External reference
Cardiomyocyte orientation modulated by the Numb family proteins-N-cadherin axis is essential for ventricular wall morphogenesis
10.1073/pnas.1904684116 · 2019 · External reference
Abstract 20546: dynamic transcriptomics analyses uncover gene regulatory networks for atrial septation and cardiac chamber development
2016 · External reference
Ventricular, atrial, and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak
10.1371/journal.pbio.3001200 · 2021 · External reference
10.1016/j.cell.2019.11.025
10.1016/j.cell.2019.11.025 · External reference
10.1038/s41586-021-03775-x
10.1038/s41586-021-03775-x · External reference
10.1038/s41586-019-1917-5
10.1038/s41586-019-1917-5 · External reference
10.1016/j.isci.2022.105857
10.1016/j.isci.2022.105857 · External reference
10.1016/j.diff.2012.04.005
10.1016/j.diff.2012.04.005 · External reference
10.1146/annurev.physiol.60.1.267
10.1146/annurev.physiol.60.1.267 · External reference
10.1016/j.celrep.2019.01.079
10.1016/j.celrep.2019.01.079 · External reference
Single cell expression analysis reveals anatomical and cell cycle-dependent transcriptional shifts during heart development
2019 · External reference
10.1016/j.devcel.2018.03.019
10.1016/j.devcel.2018.03.019 · External reference
Characterizing Neonatal Heart Maturation, Regeneration, and Scar Resolution Using Spatial Transcriptomics
2021 · External reference
10.1186/s13059-018-1416-2
10.1186/s13059-018-1416-2 · External reference
Spatiotemporal single-cell RNA sequencing of developing chicken hearts identifies interplay between cellular differentiation and morphogenesis
10.1038/s41467-021-21892-z · 2021 · External reference
Development of the heart: (3) formation of the ventricular outflow tracts, arterial valves, and intrapericardial arterial trunks
10.1136/heart.89.9.1110 · 2003 · External reference
10.1016/j.celrep.2019.06.092
10.1016/j.celrep.2019.06.092 · External reference
10.1016/j.devcel.2019.01.005
10.1016/j.devcel.2019.01.005 · External reference
Mechanisms of heart valve development and disease
10.1242/dev.183020 · 2020 · External reference
Maturation of heart valve cell populations during postnatal remodeling
10.1242/dev.173047 · 2019 · External reference
Development of the cardiac conduction system
10.1101/cshperspect.a037408 · 2020 · External reference
10.1161/circresaha.118.314578
10.1161/circresaha.118.314578 · External reference
Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking
10.1038/s41467-019-10709-9 · 2019 · External reference
Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing
10.1038/s41467-020-20448-x · 2021 · External reference
The intrinsic cardiac nervous system and its role in cardiac pacemaking and conduction
2020 · External reference
10.1016/j.isci.2021.102713
10.1016/j.isci.2021.102713 · External reference
Single-cell transcriptomic landscape of cardiac neural crest cell derivatives during development
10.15252/embr.202152389 · 2021 · External reference
10.1146/annurev-physiol-021119-034527
10.1146/annurev-physiol-021119-034527 · External reference
Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart
2019 · External reference
10.1016/j.stem.2019.05.020
10.1016/j.stem.2019.05.020 · External reference
Single-cell analysis of murine fibroblasts identifies neonatal to adult switching that regulates cardiomyocyte maturation
10.1038/s41467-020-16204-w · 2020 · External reference
10.1172/jci8154
10.1172/jci8154 · External reference
Single-Cell Resolution of Temporal Gene Expression during Heart Development
10.1016/j.devcel.2016.10.001 · 2016 · External reference
10.1016/j.devcel.2016.10.014
10.1016/j.devcel.2016.10.014 · External reference
10.1038/s41467-018-07307-6
10.1038/s41467-018-07307-6 · External reference
10.1161/circresaha.119.315243
10.1161/circresaha.119.315243 · External reference
BNC1 regulates cell heterogeneity in human pluripotent stem cell-derived epicardium
10.1242/dev.174441 · 2019 · External reference
10.1038/s41467-018-07333-4
10.1038/s41467-018-07333-4 · External reference
10.1038/s41586-019-1414-x
10.1038/s41586-019-1414-x · External reference
The lncRNA Hand2os1/Uph locus orchestrates heart development through regulation of precise expression of Hand2
2019 · External reference
10.1126/science.aao4174
10.1126/science.aao4174 · External reference
10.1016/j.stem.2018.09.009
10.1016/j.stem.2018.09.009 · External reference
10.1161/circulationaha.121.056666
10.1161/circulationaha.121.056666 · External reference
Identification of Novel TTN Mutations in Three Chinese Familial Dilated Cardiomyopathy Pedigrees by Whole Exome Sequencing
2020 · External reference
Epigenetics and hypertension
10.1007/s11906-010-0173-8 · 2011 · External reference
10.1161/circresaha.117.312509
10.1161/circresaha.117.312509 · External reference
Myocardial ischemia: From disease to syndrome
10.1016/j.ijcard.2020.04.074 · 2020 · External reference
Valvular disease: Cadherin 11 in calcific aortic valve disease
10.1038/nrcardio.2017.99 · 2017 · External reference
10.1038/s41467-021-20905-1
10.1038/s41467-021-20905-1 · External reference
10.1146/annurev-genom-120219-083220
10.1146/annurev-genom-120219-083220 · External reference
10.1016/j.isci.2018.03.013
10.1016/j.isci.2018.03.013 · External reference
10.3389/fcvm.2021.707529
10.3389/fcvm.2021.707529 · External reference
10.1161/circresaha.117.312513
10.1161/circresaha.117.312513 · External reference
10.1038/s41591-019-0512-5
10.1038/s41591-019-0512-5 · External reference
10.1161/circulationaha.120.048378
10.1161/circulationaha.120.048378 · External reference
Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci
10.1161/circresaha.121.318971 · 2021 · External reference
10.1161/circresaha.120.316770
10.1161/circresaha.120.316770 · External reference
Integrated single-cell analysis based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis
2022 · External reference
10.1038/s41591-019-0590-4
10.1038/s41591-019-0590-4 · External reference
System genetics including causal inference identify immune targets for coronary artery disease and the lifespan
10.1161/circgen.120.003196 · 2021 · External reference
Single-cell RNA sequencing reveals cell type- and artery type-specific vascular remodelling in male spontaneously hypertensive rats
10.1093/cvr/cvaa164 · 2021 · External reference
10.1161/circulationaha.117.027832
10.1161/circulationaha.117.027832 · External reference
10.3389/fgene.2022.912572
10.3389/fgene.2022.912572 · External reference
10.1007/s00018-013-1349-6
10.1007/s00018-013-1349-6 · External reference
10.1161/circresaha.111.243162
10.1161/circresaha.111.243162 · External reference
Cardiac fibrosis: cellular effectors, molecular pathways, and exosomal roles
10.3389/fcvm.2021.715258 · 2021 · External reference
Spatial transcriptomics provides a mechanistic insight into SOX9 mediated cardiac fibrosis
2022 · External reference
10.1161/circulationaha.117.030742
10.1161/circulationaha.117.030742 · External reference
Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury
2019 · External reference
Cardiac remodeling and repair: recent approaches, advancements, and future perspective
10.3390/ijms222313104 · 2021 · External reference
Left ventricular remodeling after myocardial infarction: from physiopathology to treatment
2022 · External reference
10.1161/circulationaha.119.044557
10.1161/circulationaha.119.044557 · External reference
Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction
10.1038/s44161-022-00140-7 · 2022 · External reference
Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair
10.1038/s42003-020-01636-3 · 2021 · External reference
The myeloid type I interferon response to myocardial infarction begins in bone marrow and is regulated by Nrf2-activated macrophages
10.1126/sciimmunol.aaz1974 · 2020 · External reference
10.1038/s41586-022-05060-x
10.1038/s41586-022-05060-x · External reference
10.1038/s41467-022-32284-2
10.1038/s41467-022-32284-2 · External reference
Single-Cell RNA Sequencing Reveals the Temporal Diversity and Dynamics of Cardiac Immunity after Myocardial Infarction
10.1002/smtd.202100752 · 2022 · External reference
SiglecF(HI) Marks Late-Stage Neutrophils of the Infarcted Heart: A Single-Cell Transcriptomic Analysis of Neutrophil Diversification
10.1161/jaha.120.019019 · 2021 · External reference
10.1093/eurheartj/ehz305
10.1093/eurheartj/ehz305 · External reference
Single-cell imaging and transcriptomic analyses of endogenous cardiomyocyte dedifferentiation and cycling
10.1038/s41421-019-0095-9 · 2019 · External reference
Specific ablation of CD4(+) T-cells promotes heart regeneration in juvenile mice
10.7150/thno.42943 · 2020 · External reference
Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases
10.1093/eurheartj/ehm342 · 2008 · External reference
10.1101/gad.316802.118
10.1101/gad.316802.118 · External reference
Common and Distinctive Intercellular Communication Patterns in Human Obstructive and Nonobstructive Hypertrophic Cardiomyopathy
10.3390/ijms23020946 · 2022 · External reference
10.1161/circulationaha.120.049844
10.1161/circulationaha.120.049844 · External reference
10.1007/s00395-021-00897-1
10.1007/s00395-021-00897-1 · External reference
10.1038/s41586-022-04817-8
10.1038/s41586-022-04817-8 · External reference
10.1161/circulationaha.120.052928
10.1161/circulationaha.120.052928 · External reference
Spatial transcriptomics unveils ZBTB11 as a regulator of cardiomyocyte degeneration in arrhythmogenic cardiomyopathy
2022 · External reference
Management of acute myocarditis and chronic inflammatory cardiomyopathy: an expert consensus document
10.1161/circheartfailure.120.007405 · 2020 · External reference
Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis
10.1161/circulationaha.119.043545 · 2020 · External reference
10.1038/s44161-022-00138-1
10.1038/s44161-022-00138-1 · External reference
Pathophysiology of Heart Failure
10.1002/j.2040-4603.2016.tb00669.x · 2015 · External reference
10.1038/s41467-018-06639-7
10.1038/s41467-018-06639-7 · External reference
Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-beta-IGFBP7 axis
10.1038/s41467-022-30630-y · 2022 · External reference
Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure
10.1038/s41467-020-18128-x · 2020 · External reference
Spatial detection of fetal marker genes expressed at low level in adult human heart tissue
10.1038/s41598-017-13462-5 · 2017 · External reference
Prediction of single-cell mechanisms for disease progression in hypertrophic remodelling by a trans-omics approach
10.1038/s41598-021-86821-y · 2021 · External reference
10.1016/j.yjmcc.2018.12.018
10.1016/j.yjmcc.2018.12.018 · External reference
10.1038/s44161-022-00028-6
10.1038/s44161-022-00028-6 · External reference
10.1038/s41556-019-0446-7
10.1038/s41556-019-0446-7 · External reference
10.1161/circulationaha.119.041694
10.1161/circulationaha.119.041694 · External reference
Single-Cell Analysis Revealed the Role of CD8(+) Effector T Cells in Preventing Cardioprotective Macrophage Differentiation in the Early Phase of Heart Failure
10.3389/fimmu.2021.763647 · 2021 · External reference
10.1161/circresaha.120.317104
10.1161/circresaha.120.317104 · External reference
10.1093/cvr/cvaa101
10.1093/cvr/cvaa101 · External reference
10.1161/circulationaha.119.045115
10.1161/circulationaha.119.045115 · External reference
10.1161/atvbaha.120.314789
10.1161/atvbaha.120.314789 · External reference
10.1161/atvbaha.120.314670
10.1161/atvbaha.120.314670 · External reference
10.1161/circulationaha.120.046528
10.1161/circulationaha.120.046528 · External reference
Visualization and analysis of gene expression in stanford type A aortic dissection tissue section by spatial transcriptomics
10.3389/fgene.2021.698124 · 2021 · External reference
10.1161/circulationaha.121.058173
10.1161/circulationaha.121.058173 · External reference
Genetics of congenital heart disease
10.3390/biom9120879 · 2019 · External reference
Cell atlas of the foetal human heart and implications for autoimmune-mediated congenital heart block
10.1093/cvr/cvz257 · 2020 · External reference
10.1016/j.devcel.2020.11.020
10.1016/j.devcel.2020.11.020 · External reference
Spatial Gene Expression Changes in the Mouse Heart After Base-targeted Irradiation
2022 · External reference
Transcriptional heterogeneity of fibroblasts is a hallmark of the aging heart
10.1172/jci.insight.131092 · 2019 · External reference
NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis
10.1161/circresaha.121.319153 · 2021 · External reference
10.1161/circresaha.121.320449
10.1161/circresaha.121.320449 · External reference
Gene-environment interaction impacts on heart development and embryo survival
2019 · External reference
10.1161/circulationaha.119.045401
10.1161/circulationaha.119.045401 · External reference
Single-cell transcriptomics: new insights in heart research
10.1161/circulationaha.120.046043 · 2020 · External reference
10.1016/j.matbio.2020.04.004
10.1016/j.matbio.2020.04.004 · External reference
10.1038/s41592-022-01409-2
10.1038/s41592-022-01409-2 · External reference
10.1038/s41586-021-03634-9
10.1038/s41586-021-03634-9 · External reference
Reducing the Global Burden of Cardiovascular Disease, Part 2: Prevention and Treatment of Cardiovascular Disease
10.1161/circresaha.117.311849 · 2017 · External reference
10.1186/s13059-020-1926-6
10.1186/s13059-020-1926-6 · External reference
10.1038/nmeth.2772
10.1038/nmeth.2772 · External reference
10.1038/550451a
10.1038/550451a · External reference
10.1038/s41587-021-00830-w
10.1038/s41587-021-00830-w · External reference
