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References from The CDR3 region as the major driver of TREM-1 interaction with its ligands, an in silico characterization. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1182/blood-2010-06-292136
10.1182/blood-2010-06-292136 · External reference
Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes
10.4049/jimmunol.164.10.4991 · 1950 · External reference
TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development
10.1016/s0161-5890(02)00004-4 · 2002 · External reference
The role of the triggering receptor expressed on myeloid cells-1 (TREM-1) in non-bacterial infections
10.1080/1040841x.2020.1751060 · 2020 · External reference
10.1080/1040841x.2021.1878106
10.1080/1040841x.2021.1878106 · External reference
Therapeutic potential of targeting TREM-1 in inflammatory diseases and cancer
10.2174/1381612822666160826110539 · 2016 · External reference
Enhanced expression of TREM-1 in splenic cDCs in lupus prone mice and it was modulated by miRNA-150
10.1016/j.molimm.2016.12.006 · 2017 · External reference
TREM receptors connecting bowel inflammation to neurodegenerative disorders
10.3390/cells8101124 · 2019 · External reference
Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as a diagnostic marker of ventilator-associated pneumonia
10.4187/respcare.01703 · 2012 · External reference
10.1016/j.pharmthera.2017.02.043
10.1016/j.pharmthera.2017.02.043 · External reference
10.1128/iai.72.2.937-948.2004
10.1128/iai.72.2.937-948.2004 · External reference
Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes
10.4049/jimmunol.179.6.4065 · 1950 · External reference
Production of soluble triggering receptor expressed on myeloid cells by lipopolysaccharide-stimulated human neutrophils involves de novo protein synthesis
10.1128/cvi.13.4.492-495.2006 · 2006 · External reference
Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis of infectious diseases
10.1007/s11684-017-0505-z · 2017 · External reference
COVID-19 risk stratification algorithms based on sTREM-1 and IL-6 in emergency department
10.1016/j.jaci.2020.10.001 · 2021 · External reference
10.1189/jlb.0312145
10.1189/jlb.0312145 · External reference
10.1038/s41423-018-0003-5
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10.1086/374754 · External reference
10.1016/j.yexcr.2016.05.018
10.1016/j.yexcr.2016.05.018 · External reference
10.1080/08830185.2020.1762597
10.1080/08830185.2020.1762597 · External reference
TREM-1 promotes survival during septic shock in mice
10.1002/eji.200636387 · 2007 · External reference
10.1172/jci64181
10.1172/jci64181 · External reference
10.1371/journal.ppat.1003900
10.1371/journal.ppat.1003900 · External reference
Targeting TREM-1 signaling in the presence of antibiotics is effective against streptococcal toxic-shock-like syndrome (STSLS) caused by Streptococcus suis
10.3389/fcimb.2015.00079 · 2015 · External reference
10.1016/j.jmb.2004.07.089
10.1016/j.jmb.2004.07.089 · External reference
Crystal structure of the human myeloid cell activating receptor TREM-1
10.1016/j.str.2003.11.001 · 2003 · External reference
10.1038/35074114
10.1038/35074114 · External reference
10.1016/j.imlet.2007.04.011
10.1016/j.imlet.2007.04.011 · External reference
10.1186/cc9235
10.1186/cc9235 · External reference
Hsp70 interacts with the TREM-1 receptor expressed on monocytes and thereby stimulates generation of cytotoxic lymphocytes active against MHC-negative tumor cells
10.3390/ijms22136889 · 2021 · External reference
10.1158/0008-5472.can-12-0938
10.1158/0008-5472.can-12-0938 · External reference
10.1080/13543776.2021.1883587
10.1080/13543776.2021.1883587 · External reference
10.1038/nprot.2015.043
10.1038/nprot.2015.043 · External reference
10.1093/bioinformatics/btp036
10.1093/bioinformatics/btp036 · External reference
10.1073/pnas.1101835108
10.1073/pnas.1101835108 · External reference
Computational mapping reveals dramatic effect of Hoogsteen breathing on duplex DNA reactivity with formaldehyde
10.1093/nar/gks519 · 2012 · External reference
SeRenDIP-CE: sequence-based interface prediction for conformational epitopes
10.1093/bioinformatics/btab321 · 2021 · External reference
SeRenDIP: SEquential REmasteriNg to DerIve profiles for fast and accurate predictions of PPI interface positions
10.1093/bioinformatics/btz428 · 2019 · External reference
10.1093/bioinformatics/btx005
10.1093/bioinformatics/btx005 · External reference
10.1016/j.neuron.2016.06.015
10.1016/j.neuron.2016.06.015 · External reference
10.1038/s41592-022-01488-1
10.1038/s41592-022-01488-1 · External reference
MolProbity: more and better reference data for improved all-atom structure validation
10.1002/pro.3330 · 2018 · External reference
10.1107/s0021889892009944
10.1107/s0021889892009944 · External reference
AQUA and PROCHECK NMR: programs for checking the quality of protein structures solved by NMR
10.1007/bf00228148 · 1996 · External reference
Assessing the performance of the MM/PBSA and MM/GBSA methods. 6. Capability to predict protein-protein binding free energies and re-rank binding poses generated by protein-protein docking, Physical chemistry chemical physics
10.1039/c6cp03670h · 2016 · External reference
10.1021/ci100275a
10.1021/ci100275a · External reference
10.1039/c4cp01388c
10.1039/c4cp01388c · External reference
10.3389/fmolb.2021.729513
10.3389/fmolb.2021.729513 · External reference
PRODIGY: a contact-based predictor of binding affinity in protein-protein complexes
10.21769/bioprotoc.2124 · 2017 · External reference
10.1093/bioinformatics/btw514
10.1093/bioinformatics/btw514 · External reference
CCharPPI web server: computational characterization of protein–protein interactions from structure
10.1093/bioinformatics/btu594 · 2014 · External reference
pyDock: electrostatics and desolvation for effective scoring of rigid-body protein-protein docking
10.1002/prot.21419 · 2007 · External reference
Prediction and scoring of docking poses with pyDock
10.1002/prot.21796 · 2007 · External reference
10.1002/prot.21495
10.1002/prot.21495 · External reference
10.1093/bioinformatics/btq007
10.1093/bioinformatics/btq007 · External reference
10.1039/c3mb25484d
10.1039/c3mb25484d · External reference
10.1093/protein/8.2.127
10.1093/protein/8.2.127 · External reference
10.1021/ct100578z
10.1021/ct100578z · External reference
10.1021/acs.jctc.9b00591
10.1021/acs.jctc.9b00591 · External reference
Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
10.1007/s10822-013-9644-8 · 2013 · External reference
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10.1021/ct5010406 · External reference
Lessons learned from comparing molecular dynamics engines on the SAMPL5 dataset
10.1007/s10822-016-9977-1 · 2017 · External reference
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10.1002/jcc.20290 · External reference
10.1016/0021-9991(77)90098-5
10.1016/0021-9991(77)90098-5 · External reference
10.1063/1.470117
10.1063/1.470117 · External reference
Assessment of ab initio models of protein complexes by molecular dynamics
10.1371/journal.pcbi.1006182 · 2018 · External reference
10.1021/ct400341p
10.1021/ct400341p · External reference
Inhibition of a triggering receptor expressed on myeloid cells-1 (TREM-1) with an extracellular cold-inducible RNA-binding protein (eCIRP)-derived peptide protects mice from intestinal ischemia-reperfusion injury
10.1016/j.surg.2020.04.010 · 2020 · External reference
10.1089/ars.2010.3356
10.1089/ars.2010.3356 · External reference
Cutting edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1
10.4049/jimmunol.1402303 · 1950 · External reference
10.1089/mdr.2012.0002
10.1089/mdr.2012.0002 · External reference
Mechanisms of action of the PGLYRP1/Tag7 protein in innate and acquired immunity
10.32607/actanaturae.11102 · 2021 · External reference
Innate immunity protein Tag7 induces 3 distinct populations of cytotoxic cells that use different mechanisms to exhibit their antitumor activity on human leukocyte antigen-deficient cancer cells
10.1159/000479382 · 2017 · External reference
10.1182/blood-2007-01-069195
10.1182/blood-2007-01-069195 · External reference
Identification of extracellular actin as a ligand for triggering receptor expressed on myeloid cells-1 signaling
10.3389/fimmu.2017.00917 · 2017 · External reference
Extracellular actin in health and disease, biochemistry
10.1134/s0006297917010011 · 2017 · External reference
10.1523/jneurosci.2070-06.2006
10.1523/jneurosci.2070-06.2006 · External reference
Actin is a surface component of calf pulmonary artery endothelial cells in culture
10.1073/pnas.90.9.3815 · 1993 · External reference
10.1016/j.immuni.2012.03.008
10.1016/j.immuni.2012.03.008 · External reference
The extracellular actin-scavenger system and actin toxicity
10.1056/nejm199205143262006 · 1992 · External reference
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10.1016/0006-291x(82)92142-8 · External reference
Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster
10.7554/elife.19662 · 2016 · External reference
10.1016/j.sbi.2020.07.001
10.1016/j.sbi.2020.07.001 · External reference
Exosome-mediated eCIRP release from macrophages to induce inflammation in sepsis
10.3389/fphar.2021.791648 · 2021 · External reference
10.1016/j.jmb.2010.07.045
10.1016/j.jmb.2010.07.045 · External reference
Post-translational modification of HMGB1 disulfide bonds in stimulating and inhibiting inflammation
10.3390/cells10123323 · 2021 · External reference
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10.1084/jem.20111739 · External reference
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10.1084/jem.20141318 · External reference
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10.1007/s12192-016-0676-6 · External reference
10.1038/74697
10.1038/74697 · External reference
Extracellular Hsp70 induces inflammation and modulates LPS/LTA-stimulated inflammatory response in THP-1 cells
10.1007/s12192-017-0847-0 · 2018 · External reference
10.1083/jcb.137.4.899
10.1083/jcb.137.4.899 · External reference
10.1002/jlb.3mir1118-443r
10.1002/jlb.3mir1118-443r · External reference
10.1038/nm.3368
10.1038/nm.3368 · External reference
Extracellular CIRP as an endogenous TREM-1 ligand to fuel inflammation in sepsis
10.1172/jci.insight.134172 · 2020 · External reference
Targeting the eCIRP/TREM-1 interaction with a small molecule inhibitor improves cardiac dysfunction in neonatal sepsis
10.1186/s10020-020-00243-6 · 2020 · External reference
