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References from Drug repurposing screens to identify potential drugs for chronic kidney disease by targeting prostaglandin E2 receptor. Local targets link to admitted publications; unresolved targets remain external evidence.
Inflammation and oxidative stress in chronic kidney disease—potential therapeutic role of minerals, vitamins and plant-derived metabolites
2020 · External reference
10.1038/s41581-020-0309-2
10.1038/s41581-020-0309-2 · External reference
Inflammation, senescence and microRNAs in chronic kidney disease
10.3389/fcell.2020.00739 · 2020 · External reference
Fibrosis in chronic kidney disease: pathogenesis and consequences
10.3390/ijms22010408 · 2021 · External reference
10.1007/s10557-020-07071-0
10.1007/s10557-020-07071-0 · External reference
Post-injury inhibition of endothelin-1 dependent renal vasoregulation mitigates rhabdomyolysis-induced acute kidney injury
10.1093/function/zqad022 · 2023 · External reference
The discovery of endothelins
10.1016/s0008-6363(98)00153-9 · 1998 · External reference
The role of endothelin and endothelin antagonists in chronic kidney disease
10.1159/000504623 · 2020 · External reference
Regulation of endoplasmic reticulum stress on the damage and apoptosis of renal tubular epithelial cells induced by calcium oxalate crystals
10.1007/s00240-021-01261-7 · 2021 · External reference
NLRP3 inflammasome of renal tubular epithelial cells induces kidney injury in acute hemolytic transfusion reactions
10.1002/ctm2.373 · 2021 · External reference
Therapeutic effect of endothelin-converting enzyme inhibitor on chronic kidney disease through the inhibition of endoplasmic reticulum stress and the NLRP3 inflammasome
2021 · External reference
Endothelin converting enzyme-1 (ECE-1) deletion in association with Endothelin-1 downregulation ameliorates kidney fibrosis in mice
10.1016/j.lfs.2020.118223 · 2020 · External reference
Prostanoids and resolution of inflammation–beyond the lipid-mediator class switch
10.3389/fimmu.2021.714042 · 2021 · External reference
Hypertension in chronic kidney disease: What lies behind the scene
10.3389/fphar.2022.949260 · 2022 · External reference
10.1172/jci97953
10.1172/jci97953 · External reference
10.1194/jlr.r800094-jlr200
10.1194/jlr.r800094-jlr200 · External reference
Cyclooxygenases: structural and functional insights
10.1194/jlr.r800042-jlr200 · 2009 · External reference
10.1111/bph.14530
10.1111/bph.14530 · External reference
10.1111/bph.13400
10.1111/bph.13400 · External reference
10.1021/acsbiomaterials.9b01180
10.1021/acsbiomaterials.9b01180 · External reference
10.7150/thno.63396
10.7150/thno.63396 · External reference
The role of the effects of autophagy on NLRP3 inflammasome in inflammatory nervous system diseases
10.3389/fcell.2021.657478 · 2021 · External reference
10.1038/ncb0910-831
10.1038/ncb0910-831 · External reference
10.1038/s41423-021-00670-3
10.1038/s41423-021-00670-3 · External reference
Pathogen-associated molecular patterns and extracellular Hsp70 interplay in NLRP3 inflammasome activation in monocytic and bronchial epithelial cellular models of COPD exacerbations
10.1111/apm.13089 · 2021 · External reference
Autophagy function and regulation in kidney disease
10.3390/biom10010100 · 2020 · External reference
10.1038/s41581-020-0266-9
10.1038/s41581-020-0266-9 · External reference
10.1021/acs.jcim.5b00559
10.1021/acs.jcim.5b00559 · External reference
10.1093/nar/gkx1037
10.1093/nar/gkx1037 · External reference
10.1021/acsmedchemlett.7b00462
10.1021/acsmedchemlett.7b00462 · External reference
10.1038/s41589-018-0131-3
10.1038/s41589-018-0131-3 · External reference
10.1002/jcc.540040211
10.1002/jcc.540040211 · External reference
10.1002/1097-0134(20010501)43:2<113::aid-prot1023>3.0.co;2-t
10.1002/1097-0134(20010501)43:2<113::aid-prot1023>3.0.co;2-t · External reference
Biphasic actions of prostaglandin E2 on the renal afferent arteriole: role of EP3 and EP4 receptors
10.1161/01.res.86.6.663 · 2000 · External reference
Involvement of PGE2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages
10.1042/bj20111052 · 2012 · External reference
Effect of endothelin on sex-dependent regulation of tone in coronary resistance vessels
10.1016/j.bbrc.2020.12.103 · 2021 · External reference
Endothelin-1-induced prostaglandin E2-EP2, EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion
10.1074/jbc.m408584200 · 2004 · External reference
Endothelial cell prostaglandin E2 receptor EP4 is essential for blood pressure homeostasis
2020 · External reference
PGE2 exerts its effect on the LPS-induced release of TNF-α, ET-1, IL-lα, IL-6 and IL-10 via the EP2 and EP4 receptor in rat liver macrophages
10.1016/j.prostaglandins.2004.07.005 · 2004 · External reference
Prostaglandin E2 receptor 2 modulates macrophage activity for cardiac repair
10.1161/jaha.118.009216 · 2018 · External reference
Characterization of the signaling modalities of prostaglandin E2 receptors EP2 and EP4 reveals crosstalk and a role for microtubules
10.3389/fimmu.2020.613286 · 2021 · External reference
10.1111/imm.13417
10.1111/imm.13417 · External reference
Prostaglandin E2 induced cardiac hypertrophy through EP2 receptor-dependent activation of β-catenin in 5/6 nephrectomy rats
10.1002/ehf2.13269 · 2021 · External reference
The transcription factor FRA-1/AP-1 controls lipocalin-2 expression and inflammation in sepsis model
10.3389/fimmu.2021.701675 · 2021 · External reference
A different facet of p53 function: regulation of immunity and inflammation during tumor development
10.3389/fcell.2021.762651 · 2021 · External reference
10.3390/molecules26010229
10.3390/molecules26010229 · External reference
10.7150/ijbs.75876
10.7150/ijbs.75876 · External reference
C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer
10.1038/s41467-021-27734-2 · 2022 · External reference
Prostaglandin E2/EP2 receptor signalling pathway promotes diabetic retinopathy in a rat model of diabetes
10.1007/s00125-018-4755-3 · 2019 · External reference
Nuciferine attenuates lipopolysaccharide-stimulated inflammatory responses by inhibiting p38 MAPK/ATF2 signaling pathways
10.1007/s10787-022-01075-y · 2022 · External reference
Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy
10.1080/15548627.2020.1848971 · 2021 · External reference
Shizhifang ameliorates pyroptosis of renal tubular epithelial cells in hyperuricemia through inhibiting NLRP3 inflammasome
10.1016/j.jep.2023.116777 · 2023 · External reference
Complanatoside a targeting NOX4 blocks renal fibrosis in diabetic mice by suppressing NLRP3 inflammasome activation and autophagy
10.1016/j.phymed.2022.154310 · 2022 · External reference
10.1038/nm.2807
10.1038/nm.2807 · External reference
10.1056/nejmra1705751
10.1056/nejmra1705751 · External reference
10.23876/j.krcp.21.222
10.23876/j.krcp.21.222 · External reference
Activation of the prostaglandin E2 EP2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices
10.1111/apha.13291 · 2019 · External reference
The positive effect of selective prostaglandin E2 receptor EP2 and EP4 blockade on cystogenesis in vitro is counteracted by increased kidney inflammation in vivo
10.1016/j.kint.2020.02.012 · 2020 · External reference
Autophagy in renal fibrosis: protection or promotion
10.3389/fphar.2022.963920 · 2022 · External reference
