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References from Translation of biophysical environment in bone into dynamic cell culture under flow for bone tissue engineering. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1615/critrevbiomedeng.v40.i5.10
10.1615/critrevbiomedeng.v40.i5.10 · External reference
10.1126/science.8493529
10.1126/science.8493529 · External reference
10.3389/fmolb.2020.00033
10.3389/fmolb.2020.00033 · External reference
10.1016/j.biomaterials.2005.02.002
10.1016/j.biomaterials.2005.02.002 · External reference
10.1089/ten.teb.2012.0437
10.1089/ten.teb.2012.0437 · External reference
Porous 3-D Scaffolds from regenerated silk fibroin
10.1021/bm034327e · 2004 · External reference
Tissue engineered bone: measurement of nutrient transport in three-dimensional matrices
10.1002/jbm.a.10111 · 2003 · External reference
10.1038/s41413-020-0099-y
10.1038/s41413-020-0099-y · External reference
10.1007/s11914-010-0015-2
10.1007/s11914-010-0015-2 · External reference
10.1038/nrrheum.2009.239
10.1038/nrrheum.2009.239 · External reference
What do we currently know from in vivo bone strain measurements in humans?
2011 · External reference
The effect of shoe gear on human tibial strains recorded during dynamic loading: a pilot study
10.1177/107110079601701104 · 1996 · External reference
10.1016/8756-3282(96)00028-2
10.1016/8756-3282(96)00028-2 · External reference
Bone mass and the mechanostat: a proposal
10.1002/ar.1092190104 · 1987 · External reference
Bone’s mechanostat: a 2003 update
10.1002/ar.a.10119 · 2003 · External reference
Mechanical signaling for bone modeling and remodeling
10.1615/critreveukargeneexpr.v19.i4.50 · 2013 · External reference
Guyton and hall: textbook of medical physiology
10.4103/sni.sni_327_17 · 2017 · External reference
In vivo demonstration of load-induced fluid flow in the rat tibia and its potential implications for processes associated with functional adaptation
10.1242/jeb.203.18.2737 · 2000 · External reference
10.1016/0021-9290(94)90010-8
10.1016/0021-9290(94)90010-8 · External reference
Blood and interstitial flow in the hierarchical pore space architecture of bone tissue
10.1016/j.jbiomech.2014.12.013 · 2015 · External reference
10.1007/bf00302070
10.1007/bf00302070 · External reference
10.1007/bf02351006
10.1007/bf02351006 · External reference
10.1096/fj.04-2210fje
10.1096/fj.04-2210fje · External reference
10.1152/ajpendo.1997.273.4.e751
10.1152/ajpendo.1997.273.4.e751 · External reference
Primary human osteoblast proliferation and prostaglandin E2 release in response to mechanical strain in vitro
10.1016/s8756-3282(98)00047-7 · 1998 · External reference
10.1359/jbmr.1999.14.7.1123
10.1359/jbmr.1999.14.7.1123 · External reference
Sensitivity of osteocytes to biomechanical stress in vitro
10.1096/fasebj.9.5.7896017 · 1995 · External reference
Mechanotransduction in bone: osteoblasts are more responsive to fluid forces than mechanical strain
10.1152/ajpcell.1997.273.3.c810 · 1997 · External reference
10.1115/1.1287161
10.1115/1.1287161 · External reference
Cyclic tensile strain enhances osteogenesis and angiogenesis in mesenchymal stem cells from osteoporotic donors
10.1089/ten.tea.2013.0006 · 2014 · External reference
10.1016/j.jbiomech.2007.11.024
10.1016/j.jbiomech.2007.11.024 · External reference
Effects of mechanical strain on proliferation and differentiation of bone marrow stromal cell line ST2
10.1007/s00774-004-0587-y · 2005 · External reference
Tensile mechanical strain up-regulates Runx2 and osteogenic factor expression in human periosteal cells: Implications for distraction osteogenesis
10.1016/j.joms.2004.07.023 · 2005 · External reference
10.1007/s10439-008-9577-x
10.1007/s10439-008-9577-x · External reference
Fluid shear stress in trabecular bone marrow due to low-magnitude high-frequency vibration
10.1016/j.jbiomech.2012.06.020 · 2012 · External reference
Modeling the mechanical consequences of vibratory loading in the vertebral body: microscale effects
10.1007/s10237-007-0085-y · 2008 · External reference
Pressure and shear stress in trabecular bone marrow during whole bone loading
10.1016/j.jbiomech.2015.07.028 · 2015 · External reference
Mechanosensation and fluid transport in living bone
2002 · External reference
10.1016/s8756-3282(00)00245-3
10.1016/s8756-3282(00)00245-3 · External reference
10.1210/edrv.21.2.0395
10.1210/edrv.21.2.0395 · External reference
10.1002/jbmr.320
10.1002/jbmr.320 · External reference
10.1016/j.bone.2012.10.013
10.1016/j.bone.2012.10.013 · External reference
10.1111/joim.12368
10.1111/joim.12368 · External reference
10.1016/j.bone.2021.116087
10.1016/j.bone.2021.116087 · External reference
10.1016/s0021-9290(00)00231-1
10.1016/s0021-9290(00)00231-1 · External reference
10.1074/jbc.m705092200
10.1074/jbc.m705092200 · External reference
10.1016/j.cmet.2007.05.001
10.1016/j.cmet.2007.05.001 · External reference
10.1359/jbmr.080222
10.1359/jbmr.080222 · External reference
Candidates for the mechanosensory system in bone
10.1115/1.2891234 · 1991 · External reference
10.1007/978-4-431-89757-6_8
10.1007/978-4-431-89757-6_8 · 2011 · External reference
10.3389/fendo.2012.00075
10.3389/fendo.2012.00075 · External reference
10.1016/j.bone.2007.12.224
10.1016/j.bone.2007.12.224 · External reference
Osteocytes and bone lining cells: Which are the best candidates for mechano-sensors in cancellous bone?
10.1016/s8756-3282(97)00036-7 · 1997 · External reference
Large-scale expansion of human mesenchymal stem cells
10.1155/2020/9529465 · 2020 · External reference
10.1038/nature09262
10.1038/nature09262 · External reference
Physical activity increases the total number of bone-marrow-derived mesenchymal stem cells, enhances their osteogenic potential, and inhibits their adipogenic properties
10.1155/2015/379093 · 2015 · External reference
Endurance exercise training promotes medullary hematopoiesis
10.1096/fj.11-189043 · 2011 · External reference
10.1016/j.bone.2008.04.022
10.1016/j.bone.2008.04.022 · External reference
Treadmill exercise enhances therapeutic potency of transplanted bone mesenchymal stem cells in cerebral ischemic rats via anti-apoptotic effects
10.1186/s12868-015-0196-9 · 2015 · External reference
Intensity‑dependent effect of treadmill running on differentiation of rat bone marrow stromal cells
2018 · External reference
Medium-intensity treadmill exercise exerts beneficial effects on bone modeling through bone marrow mesenchymal stromal cells
10.3389/fcell.2020.600639 · 2020 · External reference
10.1359/jbmr.080817
10.1359/jbmr.080817 · External reference
Comparison of senescence-related changes between three- and two-dimensional cultured adipose-derived mesenchymal stem cells
10.1186/s13287-020-01744-1 · 2020 · External reference
10.1126/science.284.5411.143
10.1126/science.284.5411.143 · External reference
Human mesenchymal stem cell responses to hydrostatic pressure and shear stress
10.22203/ecm.v031a11 · 2016 · External reference
10.1111/j.1600-0722.2009.00709.x
10.1111/j.1600-0722.2009.00709.x · External reference
Oscillatory shear stress mediates directional reorganization of actin cytoskeleton and alters differentiation propensity of mesenchymal stem cells
10.1002/stem.1860 · 2015 · External reference
Low intermittent flow promotes rat mesenchymal stem cell differentiation in logarithmic fluid shear device
10.1063/5.0024437 · 2020 · External reference
10.3390/ijms22063123
10.3390/ijms22063123 · External reference
Cell contractility arising from topography and shear flow determines human mesenchymal stem cell fate
10.1038/srep20415 · 2016 · External reference
10.1002/jcp.25278
10.1002/jcp.25278 · External reference
10.2217/rme.10.60
10.2217/rme.10.60 · External reference
Laminar shear stress delivers cell cycle arrest and anti-apoptosis to mesenchymal stem cells
10.1093/abbs/gmr004 · 2011 · External reference
Effect of Intermittent Shear Stress on Mechanotransductive Signaling and Osteoblastic Differentiation of Bone Marrow Stromal Cells
10.1089/tea.2007.0068 · 2008 · External reference
Hydrodynamic shear stimulates osteocalcin expression but not proliferation of bone marrow stromal cells
10.1089/1076327041348455 · 2004 · External reference
Fluid flow stimulates expression of osteopontin and bone sialoprotein by bone marrow stromal cells in a temporally dependent manner
10.1016/j.bone.2005.03.008 · 2005 · External reference
10.1089/ten.tec.2012.0017
10.1089/ten.tec.2012.0017 · External reference
10.1016/j.bej.2022.108685
10.1016/j.bej.2022.108685 · External reference
Notch signaling and fluid shear stress in regulating osteogenic differentiation
10.3389/fbioe.2022.1007430 · 2022 · External reference
10.1002/jbm.a.37413
10.1002/jbm.a.37413 · External reference
Fluid shear stress and endothelial cells synergistically promote osteogenesis of mesenchymal stem cells via integrin β1-FAK-ERK1/2 pathway
10.3906/biy-2104-20 · 2021 · External reference
Influence of mechanical fluid shear stress on the osteogenic differentiation protocols for Equine adipose tissue-derived mesenchymal stem cells
10.1016/j.acthis.2019.02.002 · 2019 · External reference
The rate of fluid shear stress is a potent regulator for the differentiation of mesenchymal stem cells
10.1002/jcp.28296 · 2019 · External reference
Oscillatory fluid flow induces the osteogenic lineage commitment of mesenchymal stem cells: The effect of shear stress magnitude, frequency, and duration
10.1016/j.jbiomech.2017.02.002 · 2017 · External reference
Mechanosensitive TRPM7 mediates shear stress and modulates osteogenic differentiation of mesenchymal stromal cells through Osterix pathway
10.1038/srep16522 · 2015 · External reference
10.1039/c4bm00291a
10.1039/c4bm00291a · External reference
Growing bone tissue-engineered niches with graded osteogenicity: an in vitro method for biomimetic construct assembly
10.1089/ten.tec.2012.0445 · 2013 · External reference
10.5661/bger-26-163
10.5661/bger-26-163 · External reference
10.1002/biot.201200162
10.1002/biot.201200162 · External reference
Bioreactor studies and computational fluid dynamics
2009 · External reference
10.1089/ten.teb.2010.0612
10.1089/ten.teb.2010.0612 · External reference
Optimization and validation of a custom-designed perfusion bioreactor for bone tissue engineering: flow assessment and optimal culture environmental conditions
10.3389/fbioe.2022.811942 · 2022 · External reference
A versatile modular bioreactor platform for Tissue Engineering
10.1002/biot.201600326 · 2017 · External reference
10.4161/biom.22170
10.4161/biom.22170 · External reference
Mesenchymal stem cell ingrowth and differentiation on coralline hydroxyapatite scaffolds
10.1016/j.biomaterials.2006.10.003 · 2007 · External reference
Characterisation of stresses on microcarriers in a stirred bioreactor
10.1016/j.apm.2016.02.025 · 2016 · External reference
10.1016/j.bej.2020.107533
10.1016/j.bej.2020.107533 · External reference
10.1007/bf01404744
10.1007/bf01404744 · External reference
Fabrication, characterization and evaluation of bioceramic hollow microspheres used as microcarriers for 3-D bone tissue formation in rotating bioreactors
10.1016/s0142-9612(98)00183-5 · 1999 · External reference
10.1073/pnas.0402532101
10.1073/pnas.0402532101 · External reference
The fluid dynamic and shear environment in the NASA/JSC rotating-wall perfused-vessel bioreactor
10.1002/1097-0290(20001005)70:1<32::aid-bit5>3.0.co;2-v · 2000 · External reference
Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells via depolymerizing F-actin to impede TAZ nuclear translocation
10.1038/srep30322 · 2016 · External reference
Long-term osteogenic differentiation of human bone marrow stromal cells in simulated microgravity: novel proteins sighted
10.1007/s00018-022-04553-2 · 2022 · External reference
Formation of three-dimensional cell/polymer constructs for bone tissue engineering in a spinner flask and a rotating wall vessel bioreactor
10.1002/jbm.10150 · 2002 · External reference
10.3390/ijms22031447
10.3390/ijms22031447 · External reference
Induction of osteogenic differentiation of bone marrow stromal cells on 3D polyester-based scaffolds solely by subphysiological fluidic stimulation in a laminar flow bioreactor
10.1177/20417314211019375 · 2021 · External reference
Perfusion bioreactor culture of bone marrow stromal cells enhances cranial defect regeneration
10.1097/prs.0000000000005529 · 2019 · External reference
Improved osteogenic differentiation of umbilical cord blood MSCs using custom made perfusion bioreactor
10.1016/j.bj.2018.07.002 · 2018 · External reference
10.1007/s12010-017-2671-5
10.1007/s12010-017-2671-5 · External reference
10.1016/j.biomaterials.2017.08.044
10.1016/j.biomaterials.2017.08.044 · External reference
Deformation strain is the main physical driver for skeletal precursors to undergo osteogenesis in earlier stages of osteogenic cell maturation
2018 · External reference
10.1002/jbm.a.36197
10.1002/jbm.a.36197 · External reference
Flow velocity-driven differentiation of human mesenchymal stromal cells in silk fibroin scaffolds: A combined experimental and computational approach
10.1371/journal.pone.0180781 · 2017 · External reference
Application of a Parallelizable Perfusion Bioreactor for Physiologic 3D Cell Culture
10.1159/000457792 · 2017 · External reference
<scp>C</scp> ollagen hydrogel scaffold promotes mesenchymal stem cell and endothelial cell coculture for bone tissue engineering
10.1002/jbm.a.36008 · 2017 · External reference
10.1021/acsami.6b10745
10.1021/acsami.6b10745 · External reference
10.3390/ijms21197233
10.3390/ijms21197233 · External reference
A single short session of media perfusion induces osteogenesis in hBMSCs cultured in porous scaffolds, dependent on cell differentiation stage
10.1002/bit.25937 · 2016 · External reference
A perfusion bioreactor system efficiently generates cell-loaded bone substitute materials for addressing critical size bone defects
10.1002/biot.201400813 · 2015 · External reference
10.1007/s10856-014-5170-z
10.1007/s10856-014-5170-z · External reference
10.1002/stem.1482
10.1002/stem.1482 · External reference
A novel bidirectional continuous perfusion bioreactor for the culture of large-sized bone tissue-engineered constructs
10.1002/jbm.b.32955 · 2013 · External reference
10.1002/bab.1009
10.1002/bab.1009 · External reference
A differential pressure laminar flow reactor supports osteogenic differentiation and extracellular matrix formation from adipose mesenchymal stem cells in a macroporous ceramic Scaffold
10.1089/biores.2012.9901 · 2012 · External reference
Dynamic perfusion bioreactor system for 3D culture of rat bone marrow mesenchymal stem cells on nanohydroxyapatite/polyamide 66 scaffold in vitro
10.1002/jbm.b.32894 · 2013 · External reference
10.1073/pnas.1201830109
10.1073/pnas.1201830109 · External reference
Effect of pulse frequency on the osteogenic differentiation of mesenchymal stem cells in a pulsatile perfusion bioreactor
10.1115/1.4004919 · 2011 · External reference
Culture of 3D bioprinted bone constructs requires an increased fluid dynamic stimulation
10.1016/j.actbio.2022.09.011 · 2022 · External reference
Flow perfusion culture of human mesenchymal stem cells on coralline hydroxyapatite scaffolds with various pore sizes
10.1002/jbm.a.33051 · 2011 · External reference
10.1002/term.338
10.1002/term.338 · External reference
10.1073/pnas.0905439106
10.1073/pnas.0905439106 · External reference
An optimized 3D-printed perfusion bioreactor for homogeneous cell seeding in bone substitute scaffolds for future chairside applications
10.1038/s41598-021-01516-8 · 2021 · External reference
Bioreactor cultivation condition for engineered bone tissue: Effect of various bioreactor designs on extra cellular matrix synthesis
10.1002/jbm.a.36932 · 2020 · External reference
Vargas Luna, J. L., Giordano, E. & Sigurjónsson, Ó. E. A standalone bioreactor system to deliver compressive load under perfusion flow to hBMSC-seeded 3D chitosan-graphene templates
10.1038/s41598-019-53319-7 · 2019 · External reference
Improvement of osteogenic differentiation of human mesenchymal stem cells on composite poly l-lactic acid/nano-hydroxyapatite scaffolds for bone defect repair
10.1016/j.jbiosc.2019.08.001 · 2020 · External reference
Enhanced osteogenesis of bone marrow stem cells cultured on hydroxyapatite/collagen I scaffold in the presence of low-frequency magnetic field
10.1007/s10856-019-6289-8 · 2019 · External reference
10.1007/s11033-019-04903-7
10.1007/s11033-019-04903-7 · External reference
Unique osteogenic profile of bone marrow stem cells stimulated in perfusion bioreactor is Rho‐ROCK‐mediated contractility dependent
10.1002/btm2.10509 · 2023 · External reference
Alternatives to animal testing: current status and future perspectives
10.1007/s00204-011-0718-x · 2011 · External reference
The Effects of Static and Dynamic Loading on Biodegradable Magnesium Pins In Vitro and In Vivo
10.1038/s41598-017-14836-5 · 2017 · External reference
10.1016/j.jbiosc.2019.03.015
10.1016/j.jbiosc.2019.03.015 · External reference
Long-term osteogenic differentiation of human bone marrow stromal cells in simulated microgravity: novel proteins sighted
10.1007/s00018-022-04553-2 · 2022 · External reference
Physiological cyclic hydrostatic pressure induces osteogenic lineage commitment of human bone marrow stem cells: a systematic study
10.1186/s13287-018-1025-8 · 2018 · External reference
10.1016/j.jmbbm.2018.04.002
10.1016/j.jmbbm.2018.04.002 · External reference
10.1002/bit.24424
10.1002/bit.24424 · External reference
Porous geometry guided micro-mechanical environment within scaffolds for cell mechanobiology study in bone tissue engineering
10.3389/fbioe.2021.736489 · 2021 · External reference
Hydromechanical mechanism behind the effect of pore size of porous titanium scaffolds on osteoblast response and bone ingrowth
10.1016/j.matdes.2019.108151 · 2019 · External reference
10.1016/j.compbiomed.2020.103826
10.1016/j.compbiomed.2020.103826 · External reference
Computational fluid dynamics for improved bioreactor design and 3D culture
10.1016/j.tibtech.2007.11.012 · 2008 · External reference
Challenges in computational fluid dynamics applications for bone tissue engineering
2022 · External reference
Modeling and design of optimal flow perfusion bioreactors for tissue engineering applications
10.1002/bit.24368 · 2012 · External reference
Interstitial fluid flow: The mechanical environment of cells and foundation of meridians
10.1155/2012/853516 · 2012 · External reference
Modeling the flow and mass transport in a mechanically stimulated parametric porous scaffold under fluid-structure interaction approach
10.1016/j.icheatmasstransfer.2018.05.014 · 2018 · External reference
10.1080/15476278.2021.1954769
10.1080/15476278.2021.1954769 · External reference
Engineered bone tissue associated with vascularization utilizing a rotating wall vessel bioreactor
10.1002/jbm.a.34340 · 2013 · External reference
Osteogenic preconditioning in perfusion bioreactors improves vascularization and bone formation by human bone marrow aspirates
10.1126/sciadv.aay2387 · 2020 · External reference
Establishing and testing a robot-based platform to enable the automated production of nanoparticles in a flexible and modular way
10.1038/s41598-023-38535-6 · 2023 · External reference
10.3389/fbioe.2020.00811
10.3389/fbioe.2020.00811 · External reference
Anticipatory standards and the commercialization of nanotechnology
10.1023/a:1025590811529 · 2003 · External reference
