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References from Molecular dynamics analysis of superoxide dismutase 1 mutations suggests decoupling between mechanisms underlying ALS onset and progression. Local targets link to admitted publications; unresolved targets remain external evidence.
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H46R SOD1 mutation is consistently associated with a relatively benign form of amyotrophic lateral sclerosis with slow progression
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Decreased stability and increased formation of soluble aggregates by immature superoxide dismutase do not account for disease severity in ALS
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Unresolved reference
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A common property of amyotrophic lateral sclerosis-associated variants: destabilization of the copper/zinc superoxide dismutase electrostatic loop
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Superoxide dismutase 1 encoding mutations linked to ALS adopts a spectrum of misfolded states
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Molecular mechanisms underlying the impact of mutations in SOD1 on its conformational properties associated with amyotrophic lateral sclerosis as revealed with molecular modelling
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Unresolved reference
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