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References from The chromatin remodeling factors EP300 and TRRAP are novel SMYD3 interactors involved in the emerging ‘nonmutational epigenetic reprogramming’ cancer hallmark. Local targets link to admitted publications; unresolved targets remain external evidence.
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SMYD3: an oncogenic driver targeting epigenetic regulation and signaling pathways
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Structural and functional profiling of the human histone methyltransferase SMYD3
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SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1
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P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain
10.1359/jbmr.2003.18.8.1419 · 2003 · External reference
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Acetylation of Sirt2 by p300 attenuates its deacetylase activity
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EP300 facilitates human trophoblast stem cell differentiation
10.1073/pnas.2217405120 · 2023 · External reference
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E2F1-EP300 co-activator complex potentiates immune escape in nasopharyngeal carcinoma through the mediation of MELK
2023 · External reference
EP300 promotes ferroptosis via HSPA5 acetylation in pancreatic cancer
10.1038/s41598-023-42136-8 · 2023 · External reference
P300 increases CSNK2A1 expression which accelerates colorectal cancer progression through activation of the PI3K-AKT-mTOR axis
10.1016/j.yexcr.2023.113694 · 2023 · External reference
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Human cell line (HGC-27) derived from the metastatic lymph node of gastric cancer
1976 · External reference
Heterogeneity of malignant cells from a human colonic carcinoma
1981 · External reference
Mutation analysis of EP300 in colon, breast and ovarian carcinomas
10.1002/ijc.10682 · 2002 · External reference
WiDr is a derivative of another colon adenocarcinoma cell line, HT-29
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Codon number shapes peptide redundancy in the universal proteome composition
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