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References from Coevolution combined with molecular dynamics simulations provides structural and mechanistic insights into the interactions between the integrator complex subunits. Local targets link to admitted publications; unresolved targets remain external evidence.
Incorporating information on predicted solvent accessibility to the co-evolution-based study of protein interactions
10.1039/c2mb25325a · 2013 · External reference
Direct-coupling analysis of residue coevolution captures native contacts across many protein families
10.1073/pnas.1111471108 · 2011 · External reference
10.1126/science.286.5438.295
10.1126/science.286.5438.295 · External reference
Sequence co-evolution gives 3D contacts and structures of protein complexes
2014 · External reference
10.1016/j.cell.2012.04.012
10.1016/j.cell.2012.04.012 · External reference
Coevolution of residues provides evidence of a functional heterodimer of 5-HT2AR and 5-HT2CR involving both intracellular and extracellular domains
10.1016/j.neuroscience.2019.05.013 · 2019 · External reference
Regulation of local GTP availability controls RAC1 activity and cell invasion
2021 · External reference
Evolutionary couplings and molecular dynamic simulations highlight details of GPCRs heterodimers’ interfaces
10.3390/molecules28041838 · 2023 · External reference
Dimeric interactions and complex formation using direct coevolutionary couplings
10.1038/srep13652 · 2015 · External reference
10.1016/j.sbi.2016.04.006
10.1016/j.sbi.2016.04.006 · External reference
Protein sectors: statistical coupling analysis versus conservation
10.1371/journal.pcbi.1004091 · 2015 · External reference
UET: a database of evolutionarily-predicted functional determinants of protein sequences that cluster as functional sites in protein structures
10.1093/nar/gkv1279 · 2016 · External reference
10.1002/prot.24374
10.1002/prot.24374 · External reference
10.1021/ja209895m
10.1021/ja209895m · External reference
Robust and accurate prediction of residue-residue interactions across protein interfaces using evolutionary information
10.7554/elife.02030 · 2014 · External reference
InterEvDock: a docking server to predict the structure of protein-protein interactions using evolutionary information
10.1093/nar/gkw340 · 2016 · External reference
Detection and sequence/structure mapping of biophysical constraints to protein variation in saturated mutational libraries and protein sequence alignments with a dedicated server(vol 1, 242, 2016)
2016 · External reference
Coevolution analysis of Hepatitis C virus genome to identify the structural and functional dependency network of viral proteins
10.1038/srep26401 · 2016 · External reference
Inter-protein sequence co-evolution predicts known physical interactions in bacterial ribosomes and the trp operon
10.1371/journal.pone.0149166 · 2016 · External reference
10.1371/journal.pone.0028766
10.1371/journal.pone.0028766 · External reference
10.1093/nar/gkx386
10.1093/nar/gkx386 · External reference
Direct coupling analysis for protein contact prediction
10.1007/978-1-4939-0366-5_5 · 2014 · External reference
Sequence co-evolution gives 3D contacts and structures of protein complexes
2014 · External reference
Evolutionary couplings and molecular dynamic simulations highlight details of GPCRs heterodimers’ interfaces
10.3390/molecules28041838 · 2023 · External reference
10.1073/pnas.1616605114
10.1073/pnas.1616605114 · External reference
Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module
10.1093/nar/gky100 · 2018 · External reference
10.1126/science.aaz7758
10.1126/science.aaz7758 · External reference
10.1261/rna.079322.122
10.1261/rna.079322.122 · External reference
Inositol hexakisphosphate is required for Integrator function
10.1038/s41467-022-33506-3 · 2022 · External reference
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase
10.1126/science.abb5872 · 2020 · External reference
10.1101/2021.11.29.470345
10.1101/2021.11.29.470345 · External reference
10.1126/science.abk0154
10.1126/science.abk0154 · External reference
10.1016/j.molcel.2021.01.005
10.1016/j.molcel.2021.01.005 · External reference
Integrator is a global promoter-proximal termination complex
10.1016/j.molcel.2022.11.012 · 2023 · External reference
10.1016/j.molcel.2019.10.034
10.1016/j.molcel.2019.10.034 · External reference
10.1016/j.molcel.2020.08.016
10.1016/j.molcel.2020.08.016 · External reference
Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed loci
2022 · External reference
10.1371/journal.pgen.1006809
10.1371/journal.pgen.1006809 · External reference
10.3390/ijms18050936
10.3390/ijms18050936 · External reference
Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways
10.1186/s12864-017-3628-3 · 2017 · External reference
The integrator complex subunit 6 (ints6) confines the dorsal organizer in vertebrate embryogenesis
10.1371/journal.pgen.1003822 · 2013 · External reference
10.1016/j.bbrc.2013.03.029
10.1016/j.bbrc.2013.03.029 · External reference
10.1128/mcb.06511-11
10.1128/mcb.06511-11 · External reference
A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAs
10.1016/j.molcel.2009.04.024 · 2009 · External reference
10.1038/nature05363
10.1038/nature05363 · External reference
10.1016/j.jcp.2014.07.024
10.1016/j.jcp.2014.07.024 · External reference
10.1093/nar/gkt381
10.1093/nar/gkt381 · External reference
10.1128/mcb.06511-11
10.1128/mcb.06511-11 · External reference
Integrator subunit 4 is a ‘Symplekin-like’scaffold that associates with INTS9/11 to form the Integrator cleavage module
10.1093/nar/gky100 · 2018 · External reference
10.1261/rna.049551.115
10.1261/rna.049551.115 · External reference
Identification of 14-3-3 proteins phosphopeptide-binding specificity using an affinity-based computational approach
2016 · External reference
Machine learning based identification of protein-protein interactions using derived features of physiochemical properties and evolutionary profiles
2017 · External reference
Unresolved reference
External reference
Coarse-grained modeling and molecular dynamics simulations of ca2+-calmodulin
10.3389/fmolb.2021.661322 · 2021 · External reference
10.1038/ncomms6531
10.1038/ncomms6531 · External reference
10.1002/prot.21804
10.1002/prot.21804 · External reference
10.1016/0263-7855(96)00018-5
10.1016/0263-7855(96)00018-5 · External reference
GenBank
10.1093/nar/21.13.2963 · 1993 · External reference
10.1016/s0022-2836(05)80360-2
10.1016/s0022-2836(05)80360-2 · External reference
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega
10.1038/msb.2011.75 · 2011 · External reference
10.1126/science.abb5872
10.1126/science.abb5872 · External reference
10.1126/science.aaz7758
10.1126/science.aaz7758 · External reference
10.1021/jp212541y
10.1021/jp212541y · External reference
10.1201/9781315374284
10.1201/9781315374284 · 2017 · External reference
