Research graph
References from Proteomic and computational analyses followed by functional validation of protective effects of trigonelline against calcium oxalate-induced renal cell deteriorations. Local targets link to admitted publications; unresolved targets remain external evidence.
Recent therapeutic interventions of fenugreek seed: a mechanistic approach
10.1055/a-1320-0479 · 2021 · External reference
Pharmacological effects of Trigonella foenum-graecum l. In health and disease
10.3109/13880209.2013.826247 · 2014 · External reference
Effect of roasting degree on major coffee compounds: a comparative study between coffee beans with and without supercritical co(2) decaffeination treatment
10.5650/jos.ess22194 · 2022 · External reference
Exploring correlations between green coffee bean components and thermal contaminants in roasted coffee beans
10.1016/j.foodres.2023.112700 · 2023 · External reference
Quantification of caffeine, trigonelline and nicotinic acid in espresso coffee: The influence of espresso machines and coffee cultivars
10.3109/09637486.2013.873890 · 2014 · External reference
10.3390/molecules28083460
10.3390/molecules28083460 · External reference
Trigonelline in coffee. Ii. Content of green, roasted and instant coffee
1994 · External reference
Urinary n-methylpyridinium and trigonelline as candidate dietary biomarkers of coffee consumption
10.1002/mnfr.201000656 · 2011 · External reference
Metabolomics in nutritional epidemiology: Identifying metabolites associated with diet and quantifying their potential to uncover diet-disease relations in populations
10.3945/ajcn.113.078758 · 2014 · External reference
Biomarkers of intake for coffee, tea, and sweetened beverages
10.1186/s12263-018-0607-5 · 2018 · External reference
The neuroprotective and antidiabetic effects of trigonelline: a review of signaling pathways and molecular mechanisms
10.1016/j.biochi.2022.10.009 · 2023 · External reference
Trigonelline recovers memory function in alzheimer's disease model mice: evidence of brain penetration and target molecule
10.1038/s41598-020-73514-1 · 2020 · External reference
Trigonelline protects hippocampus against intracerebral abeta(1-40) as a model of alzheimer's disease in the rat: insights into underlying mechanisms
10.1007/s11011-018-0338-8 · 2019 · External reference
Urinary stone composition in germany: results from 45,783 stone analyses
10.1007/s00345-022-04060-w · 2022 · External reference
Stone composition of renal stone formers from different global regions
10.4081/aiua.2021.3.307 · 2021 · External reference
Prophylaxis effect of trigonella foenum graecum l. Seeds on renal stone formation in rats
10.1002/ptr.2190 · 2007 · External reference
Trigonelline prevents kidney stone formation processes by inhibiting calcium oxalate crystallization, growth and crystal-cell adhesion, and downregulating crystal receptors
10.1016/j.biopha.2022.112876 · 2022 · External reference
10.1016/j.kint.2017.09.033
10.1016/j.kint.2017.09.033 · External reference
How tubular epithelial cell injury contributes to renal fibrosis
10.1007/978-981-13-8871-2_11 · 2019 · External reference
Update on the mechanisms of tubular cell injury in diabetic kidney disease
10.3389/fmed.2021.661076 · 2021 · External reference
10.1155/2018/3068365
10.1155/2018/3068365 · External reference
Severe acute kidney injury caused by decompression sickness syndrome
10.5414/cn110662 · 2022 · External reference
Drug-induced fanconi syndrome in patients with kidney allograft transplantation
10.3389/fimmu.2022.979983 · 2022 · External reference
Nag-1/gdf15 inhibits diabetic nephropathy via inhibiting age/rage-mediated inflammation signaling pathways in c57bl/6 mice and hk-2 cells
10.1016/j.lfs.2022.121142 · 2022 · External reference
10.1016/j.cbi.2022.110299
10.1016/j.cbi.2022.110299 · External reference
Cpd-42 protects against calcium oxalate nephrocalcinosis-induced renal injury and inflammation by targeting ripk3-mediated necroptosis
10.3389/fphar.2022.1041117 · 2022 · External reference
Neat1 regulates caox crystal-induced renal tubular oxidative injury via mir-130/irf1
10.1089/ars.2022.0008 · 2023 · External reference
Gallic acid ameliorates calcium oxalate crystal-induced renal injury via upregulation of nrf2/ho-1 in the mouse model of stone formation
10.1016/j.phymed.2022.154429 · 2022 · External reference
Celastrol attenuates renal injury in 5/6 nephrectomized rats via inhibiting epithelial-mesenchymal transition and transforming growth factor-beta1/smad3 pathway
10.1177/15353702221118087 · 2022 · External reference
Salvianolic acid b attenuates iopromide-induced renal tubular epithelial cell injury by inhibiting the tlr4/nf-kappab/nlrp3 signaling pathway
2022 · External reference
Oxidized forms of uromodulin promote calcium oxalate crystallization and growth, but not aggregation
10.1016/j.ijbiomac.2022.06.132 · 2022 · External reference
Oxidative modifications switch modulatory activities of urinary proteins from inhibiting to promoting calcium oxalate crystallization, growth, and aggregation
10.1016/j.mcpro.2021.100151 · 2021 · External reference
Effects of secretome derived from macrophages exposed to calcium oxalate crystals on renal fibroblast activation
10.1038/s42003-021-02479-2 · 2021 · External reference
Chlorogenic acid enhances endothelial barrier function and promotes endothelial tube formation: a proteomics approach and functional validation
10.1016/j.biopha.2022.113471 · 2022 · External reference
10.1038/nprot.2016.136
10.1038/nprot.2016.136 · External reference
10.1074/mcp.m113.031591
10.1074/mcp.m113.031591 · External reference
10.1021/acs.jproteome.5b00354
10.1021/acs.jproteome.5b00354 · External reference
Characterization of calcium oxalate crystal-induced changes in the secretome of u937 human monocytes
10.1039/c5mb00728c · 2016 · External reference
Differential proteomics of lesional vs. Non-lesional biopsies revealed non-immune mechanisms of alopecia areata
10.1038/s41598-017-18282-1 · 2018 · External reference
Factors determining types and morphologies of calcium oxalate crystals: molar concentrations, buffering, ph, stirring and temperature
10.1016/j.cca.2005.11.033 · 2006 · External reference
Urinary trefoil factor 1 is a novel potent inhibitor of calcium oxalate crystal growth and aggregation
10.1016/j.juro.2007.11.041 · 2008 · External reference
High glucose induces phosphorylation and oxidation of mitochondrial proteins in renal tubular cells: A proteomics approach
10.1038/s41598-020-62665-w · 2020 · External reference
Caffeine inhibits hypoxia-induced renal fibroblast activation by antioxidant mechanism
10.1080/19336918.2019.1638691 · 2019 · External reference
Induction of mesenchymal-epithelial transition (met) by epigallocatechin-3-gallate to reverse epithelial-mesenchymal transition (emt) in snai1-overexpressed renal cells: a potential anti-fibrotic strategy
10.1016/j.jnutbio.2022.109066 · 2022 · External reference
Prolonged k(+) deficiency increases intracellular atp, cell cycle arrest and cell death in renal tubular cells
10.1016/j.metabol.2016.12.014 · 2017 · External reference
10.1016/j.cbi.2021.109557
10.1016/j.cbi.2021.109557 · External reference
Alpha-tubulin relocalization is involved in calcium oxalate-induced tight junction disruption in renal epithelial cells
10.1016/j.cbi.2022.110236 · 2022 · External reference
Lamin a/c in renal tubular cells is important for tissue repair, cell proliferation, and calcium oxalate crystal adhesion, and is associated with potential crystal receptors
10.1096/fj.201600426r · 2016 · External reference
Characterizations of pmca2-interacting complex and its role as a calcium oxalate crystal-binding protein
10.1007/s00018-017-2699-2 · 2018 · External reference
Epigallocatechin-3-gallate prevents tgf-beta1-induced epithelial-mesenchymal transition and fibrotic changes of renal cells via gsk-3beta/beta-catenin/snail1 and nrf2 pathways
10.1016/j.jnutbio.2019.108266 · 2020 · External reference
10.1038/s41420-018-0053-6
10.1038/s41420-018-0053-6 · External reference
Performance of plasma trigonelline as a marker of coffee consumption in an epidemiologic setting
10.1093/ajcn/nqy059 · 2018 · External reference
Absorption, pharmacokinetics, and urinary excretion of pyridines after consumption of coffee and cocoa-based products containing coffee in a repeated dose, crossover human intervention study
10.1002/mnfr.202000489 · 2020 · External reference
Trigonelline, a plant derived alkaloid prevents ultraviolet-b-induced oxidative DNA damage in primary human dermal fibroblasts and balb/c mice via modulation of phosphoinositide 3-kinase-akt-nrf2 signalling axis
10.1016/j.exger.2022.112028 · 2023 · External reference
Trigonelline reverses high glucose-induced proliferation, fibrosis of mesangial cells via modulation of wnt signaling pathway
10.1186/s13098-022-00798-w · 2022 · External reference
Trigonelline, an alkaloid from Leonurus japonicus houtt., suppresses mast cell activation and ova-induced allergic asthma
10.3389/fphar.2021.687970 · 2021 · External reference
Trigonelline inhibits nrf2 via egfr signalling pathway and augments efficacy of cisplatin and etoposide in nsclc cells
10.1016/j.tiv.2020.105038 · 2021 · External reference
Protein network analysis and functional studies of calcium oxalate crystal-induced cytotoxicity in renal tubular epithelial cells
10.1002/pmic.201800008 · 2018 · External reference
Calcium oxalate toxicity in renal epithelial cells: the mediation of crystal size on cell death mode
10.1038/cddiscovery.2015.55 · 2015 · External reference
Cytotoxicity of alpha-tocopheryl succinate, malonate and oxalate in normal and cancer cells in vitro and their anti-cancer effects on mouse melanoma in vivo
10.3177/jnsv.51.392 · 2005 · External reference
Trigonelline induces autophagy to protect mesangial cells in response to high glucose via activating the mir-5189-5p-ampk pathway
10.1016/j.phymed.2021.153614 · 2021 · External reference
10.1016/j.fct.2018.09.011
10.1016/j.fct.2018.09.011 · External reference
10.1016/s1995-7645(14)60328-x
10.1016/s1995-7645(14)60328-x · External reference
Multivariate analysis in metabolomics
2013 · External reference
Urinary proteome profiles associated with cognitive decline in community elderly residents-a pilot study
10.3389/fneur.2023.1134976 · 2023 · External reference
10.1016/j.csbj.2020.07.009 · Admitted local publication
Discovery and validation of bladder cancer related excreted nucleosides biomarkers by dilution approach in cell culture supernatant and urine using uhplc-ms/ms
10.1016/j.jprot.2022.104737 · 2023 · External reference
Metabolomic analysis of white, green and purple morphs of sea cucumber Apostichopus japonicus during body color pigmentation process
2021 · External reference
Label-free proteomics for discovering biomarker candidates of rad140 administration to castrated horses
10.1002/dta.2988 · 2021 · External reference
Integrated proteomics and metabolomics reveals the comprehensive characterization of antitumor mechanism underlying shikonin on colon cancer patient-derived xenograft model
10.1038/s41598-020-71116-5 · 2020 · External reference
Proteomics and metabolomics analysis reveal potential mechanism of extended-spectrum beta-lactamase production in Escherichia coli
10.1039/d0ra04250a · 2020 · External reference
Metabolomic profiling and antidiabetic activity of callerya speciosa
2023 · External reference
Revealing the chemical differences and their application in the storage year prediction of qingzhuan tea by swath-ms based metabolomics analysis
10.1016/j.foodres.2023.113238 · 2023 · External reference
Proteomic profiling of cerebrospinal fluid in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease
2022 · External reference
Comparative analysis of therapeutic effects between medium cut-off and high flux dialyzers using metabolomics and proteomics: exploratory, prospective study in hemodialysis
10.1038/s41598-021-96974-5 · 2021 · External reference
Quantitative proteomic profiling of marine diatom skeletonema dohrnii in response to temperature and silicate induced environmental stress
10.3389/fmicb.2020.554832 · 2020 · External reference
Coffee or tea: anti-inflammatory properties in the context of atherosclerotic cardiovascular disease prevention
10.1016/j.phrs.2022.106596 · 2022 · External reference
Protective effect of bee pollen in acute kidney injury, proteinuria, and crystalluria induced by ethylene glycol ingestion in rats
10.1038/s41598-022-12086-8 · 2022 · External reference
Efficacy of chlorogenic acid against ethylene glycol-induced renal stone model: the role of nfkb-runx2-ap1-osterix signaling pathway
10.1016/j.tice.2022.101960 · 2022 · External reference
Protective effects of total flavonoids from lysimachia christinae on calcium oxalate-induced oxidative stress in a renal cell line and renal tissue
2021 · External reference
Kaempferol alleviates calcium oxalate crystal-induced renal injury and crystal deposition via regulation of the ar/nox2 signaling pathway
10.1016/j.phymed.2021.153555 · 2021 · External reference
S AT. Trigonelline, a naturally occurring alkaloidal agent protects ultraviolet-b (uv-b) irradiation induced apoptotic cell death in human skin fibroblasts via attenuation of oxidative stress, restoration of cellular calcium homeostasis and prevention of endoplasmic reticulum (er) stress
10.1016/j.jphotobiol.2019.111720 · 2020 · External reference
Trigonelline through the attenuation of oxidative stress exerts antidepressant- and anxiolytic-like effects in a mouse model of maternal separation stress
10.1159/000503728 · 2020 · External reference
Trigonelline and curcumin alone, but not in combination, counteract oxidative stress and inflammation and increase glycation product detoxification in the liver and kidney of mice with high-fat diet-induced obesity
10.1016/j.jnutbio.2019.108303 · 2020 · External reference
Inflammatory responses bridge comorbid cardiac disorder in experimental model of ibd induced by dss: protective effect of the trigonelline
10.1007/s10787-019-00581-w · 2019 · External reference
10.1038/s41388-021-02105-9
10.1038/s41388-021-02105-9 · External reference
Adaptive regulations of nrf2 alleviates silver nanoparticles-induced oxidative stress-related liver cells injury
10.1016/j.cbi.2022.110287 · 2023 · External reference
Blue light exposure enhances oxidative stress, causes DNA damage, and induces apoptosis signaling in b16f1 melanoma cells
10.1016/j.mrgentox.2022.503562 · 2022 · External reference
10.1126/scitranslmed.aav4754
10.1126/scitranslmed.aav4754 · External reference
Cell cycle shift from g0/g1 to s and g2/m phases is responsible for increased adhesion of calcium oxalate crystals on repairing renal tubular cells at injured site
10.1038/s41420-018-0123-9 · 2018 · External reference
10.3892/ijmm.2014.1955
10.3892/ijmm.2014.1955 · External reference
Inactivation of the wnt/beta-catenin signaling contributes to the epithelial barrier dysfunction induced by sodium oxalate in canine renal epithelial cells
10.1093/jas/skab268 · 2021 · External reference
Effects of calcium oxalate monohydrate crystals on expression and function of tight junction of renal tubular epithelial cells
10.1038/labinvest.2010.167 · 2011 · External reference
P38 mapk mediates calcium oxalate crystal-induced tight junction disruption in distal renal tubular epithelial cells
10.1038/srep01041 · 2013 · External reference
Probiotic lactobacilli attenuate oxysterols-induced alteration of intestinal epithelial cell monolayer permeability: focus on tight junction modulation
10.1016/j.fct.2022.113558 · 2022 · External reference
Dietary ellagic acid supplementation attenuates intestinal damage and oxidative stress by regulating gut microbiota in weanling piglets
10.1016/j.aninu.2022.08.004 · 2022 · External reference
Lycopene alleviates multiple-mycotoxin-induced toxicity by inhibiting mitochondrial damage and ferroptosis in the mouse jejunum
10.1039/d2fo02994d · 2022 · External reference
Risk of esrd and mortality in kidney and bladder stone formers
10.1053/j.ajkd.2018.06.012 · 2018 · External reference
New insights into the role and mechanism of partial epithelial-mesenchymal transition in kidney fibrosis
10.3389/fphys.2020.569322 · 2020 · External reference
Effect of high glucose supplementation on pulmonary fibrosis involving reactive oxygen species and tgf-beta
10.3389/fnut.2022.998662 · 2022 · External reference
Caffeine prevents oxalate-induced epithelial-mesenchymal transition of renal tubular cells by its anti-oxidative property through activation of nrf2 signaling and suppression of snail1 transcription factor
10.1016/j.biopha.2021.111870 · 2021 · External reference
Pharmacokinetics and pharmacodynamics of the combination of rhein and curcumin in the treatment of chronic kidney disease in rats
10.3389/fphar.2020.573118 · 2020 · External reference
10.1016/j.intimp.2012.10.004
10.1016/j.intimp.2012.10.004 · External reference
Protective roles of trigonelline against oxalate-induced epithelial-to-mesenchymal transition in renal tubular epithelial cells: an in vitro study
10.1016/j.fct.2019.110915 · 2020 · External reference
