Research graph
References from Single-cell multi-omics in the study of digestive system cancers. Local targets link to admitted publications; unresolved targets remain external evidence.
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2023 · External reference
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10.1186/s13073-022-01075-1 · 2022 · External reference
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Single-Cell RNA Sequencing and Its Combination with Protein and DNA Analyses
2020 · External reference
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10.1007/978-1-0716-2756-3_15 · 2023 · External reference
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Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma
2019 · External reference
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Identification of radioresponsive genes in esophageal cancer from longitudinal and single cell exome sequencing
10.1016/j.ijrobp.2020.06.015 · 2020 · External reference
Single-cell transcriptomic analysis in a mouse model deciphers cell transition states in the multistep development of esophageal cancer
2020 · External reference
Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis
2021 · External reference
Single‑cell intratumoral stemness analysis reveals the involvement of cell cycle and DNA damage repair in two different types of esophageal cancer.
2019 · External reference
Prognostic Biomarkers Identification in Esophageal Cancer Based on WGCNA and Single-Cell Analysis
2022 · External reference
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Epithelial cells activate fibroblasts to promote esophageal cancer development
10.1016/j.ccell.2023.03.001 · 2023 · External reference
Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer
2023 · External reference
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Population and single‑cell transcriptome analyses reveal diverse transcriptional changes associated with radioresistance in esophageal squamous cell carcinoma.
2019 · External reference
Single-cell RNA-seq of esophageal squamous cell carcinoma cell line with fractionated irradiation reveals radioresistant gene expression patterns
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Dissecting the single-cell transcriptome network underlying esophagus non-malignant tissues and esophageal squamous cell carcinoma
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2019 · External reference
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2020 · External reference
Immune characteristics and genetic markers of esophageal cancer by single-cell analysis: implications for immunotherapy
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Spatially resolved expression landscape and gene-regulatory network of human gastric corpus epithelium
2023 · External reference
Joint single cell DNA-seq and RNA-seq of gastric cancer cell lines reveals rules of evolution
2020 · External reference
Single-cell transcriptional analyses identify lineage-specific epithelial responses to inflammation and metaplastic development in the gastric corpus
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Single-cell transcriptome analysis identifies distinct cell types and niche signaling in a primary gastric organoid model
2019 · External reference
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Single-cell landscape reveals active cell subtypes and their interaction in the tumor microenvironment of gastric cancer
10.7150/thno.71833 · 2022 · External reference
Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric cancer
10.7150/thno.60540 · 2022 · External reference
Revealing the transcriptional heterogeneity of organ-specific metastasis in human gastric cancer using single-cell RNA Sequencing
10.1002/ctm2.730 · 2022 · External reference
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Dissecting the single-cell transcriptome network underlying gastric premalignant lesions and early gastric cancer
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Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis
2023 · External reference
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Characterization and validation of somatic mutation spectrum to reveal heterogeneity in gastric cancer by single cell sequencing
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Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors
2019 · External reference
Single-Cell RNA sequencing reveals immuno-oncology characteristics of tumor-infiltrating t lymphocytes in photodynamic therapy-treated colorectal cancer mouse model
2023 · External reference
Single-cell DNA and RNA sequencing reveals the dynamics of intra-tumor heterogeneity in a colorectal cancer model
2021 · External reference
Clinical significance of circulating tumor cell induced epithelial-mesenchymal transition in patients with metastatic colorectal cancer by single-cell RNA-sequencing
10.3390/cancers13194862 · 2021 · External reference
Single-Cell RNA sequencing reveals heterogeneity in the tumor microenvironment between young-onset and old-onset colorectal cancer
2022 · External reference
Elucidating cancer stem cells heterogeneity in colorectal cancer by single-cell RNA sequencing
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Capturing tumour heterogeneity in pre- and post-chemotherapy colorectal cancer ascites-derived cells using single-cell RNA-sequencing
10.1042/bsr20212093 · 2021 · External reference
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Deep single-cell RNA sequencing data of individual T cells from treatment-naïve colorectal cancer patients
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Single-cell multiomics sequencing reveals prevalent genomic alterations in tumor stromal cells of human colorectal cancer
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Single-cell mtDNA heteroplasmy in colorectal cancer
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Clonality and timing of relapsing colorectal cancer metastasis revealed through whole-genome single-cell sequencing
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Single-cell transcriptional profiling reveals the heterogenicity in colorectal cancer
2019 · External reference
Resolving the difference between left-sided and right-sided colorectal cancer by single-cell sequencing
2022 · External reference
Traditional chinese medicine syndromes classification associates with tumor cell and microenvironment heterogeneity in colorectal cancer: a single cell RNA sequencing analysis
2021 · External reference
Multiplexed single-cell analysis reveals prognostic and nonprognostic T cell types in human colorectal cancer
10.1172/jci.insight.154646 · 2022 · External reference
Single-cell analyses reveal suppressive tumor microenvironment of human colorectal cancer
2021 · External reference
Single-cell exome sequencing reveals multiple subclones in metastatic colorectal carcinoma
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Colorectal cancer stem cell states uncovered by simultaneous single-cell analysis of transcriptome and telomeres
10.1002/advs.202004320 · 2021 · External reference
Systematic evaluation of colorectal cancer organoid system by single-cell RNA-Seq analysis
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Multiregion single-cell sequencing reveals the transcriptional landscape of the immune microenvironment of colorectal cancer
10.1002/ctm2.253 · 2021 · External reference
Single-cell sequencing reveals the immune microenvironment landscape related to anti-PD-1 resistance in metastatic colorectal cancer with high microsatellite instability
2023 · External reference
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Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer
10.1016/j.cell.2020.03.048 · 2020 · External reference
Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer
10.1016/j.celrep.2022.111929 · 2023 · External reference
Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancer
10.1126/sciadv.adf5464 · 2023 · External reference
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Human intestinal organoids: promise and challenge
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Systematic identification of cancer-associated-fibroblast-derived genes in patients with colorectal cancer based on single-cell sequencing and transcriptomics
2022 · External reference
Single-cell RNA-Seq and bulk RNA-Seq reveal reliable diagnostic and prognostic biomarkers for CRC
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Integrated single-cell and bulk RNA sequencing analysis identifies a cancer associated fibroblast-related signature for predicting prognosis and therapeutic responses in colorectal cancer
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Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer
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Hepatocellular carcinoma
2021 · External reference
Single-cell RNA sequencing of early-relapse hepatocellular carcinoma
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2022 · External reference
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Molecular subgroups of intrahepatic cholangiocarcinoma discovered by single-cell RNA Sequencing-assisted multiomics analysis
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Single-cell profiling of human CD127(+) innate lymphoid cells reveals diverse immune phenotypes in hepatocellular carcinoma.
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10.1016/j.ccell.2021.03.012
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CD36(+) cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor.
2023 · External reference
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Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma
2023 · External reference
Intratumoral PPT1-positive macrophages determine immunosuppressive contexture and immunotherapy response in hepatocellular carcinoma
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Trajectory and functional analysis of PD-1(high) CD4(+)CD8(+) T cells in hepatocellular carcinoma by single-cell cytometry and transcriptome sequencing
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Spatial proteomics of immune microenvironment in nonalcoholic steatohepatitis-associated hepatocellular carcinoma
2023 · External reference
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Combined inhibition of surface CD51 and γ-secretase-mediated CD51 cleavage improves therapeutic efficacy in experimental metastatic hepatocellular carcinoma
2023 · External reference
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N6-methyladenosine-mediated up-regulation of FZD10 regulates liver cancer stem cells' properties and lenvatinib resistance through WNT/β-catenin and hippo signaling pathways
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Normalization of tumor vessels by lenvatinib-based metallo-nanodrugs alleviates hypoxia and enhances calreticulin-mediated immune responses in orthotopic HCC and organoids
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Single-cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progression
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KRT17High/CXCL8+ tumor cells display both classical and basal features and regulate myeloid infiltration in the pancreatic cancer microenvironment
2023 · External reference
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Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells' heterogeneity
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Single-cell transcriptome analysis of tumor and stromal compartments of pancreatic ductal adenocarcinoma primary tumors and metastatic lesions
2020 · External reference
Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution
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Spatially resolved single-cell assessment of pancreatic cancer expression subtypes reveals co-expressor phenotypes and extensive intratumoral heterogeneity
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Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasion
10.1172/jci162054 · 2023 · External reference
Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution
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Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture system
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OX40L-armed oncolytic virus boosts T-cell response and remodels tumor microenvironment for pancreatic cancer treatment
10.7150/thno.83495 · 2023 · External reference
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scRNA-Seq and imaging mass cytometry analyses unveil iNKT cells-mediated anti-tumor immunity in pancreatic cancer liver metastasis
2023 · External reference
The evolution of single-cell RNA sequencing technology and application: progress and perspectives
10.3390/ijms24032943 · 2023 · External reference
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