Research graph
References from Network-based identification and mechanism exploration of active ingredients against Alzheimer’s disease via targeting endoplasmic reticulum stress from traditional chinese medicine. Local targets link to admitted publications; unresolved targets remain external evidence.
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10.1007/s13311-021-01146-y · External reference
Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study
10.1016/s2468-2667(20)30185-7 · 2020 · External reference
10.1007/s40265-020-01268-1
10.1007/s40265-020-01268-1 · External reference
Effect of Chinese herbal medicine on Alzheimer's disease
10.1016/bs.irn.2017.02.003 · 2017 · External reference
Neuroprotective mechanism of Lycium barbarum polysaccharides against hippocampal-dependent spatial memory deficits in a rat model of obstructive sleep apnea
2015 · External reference
Osthole stimulated neural stem cells differentiation into neurons in an Alzheimer's disease cell model via upregulation of MicroRNA-9 and rescued the functional impairment of hippocampal neurons in APP/PS1 transgenic mice
2017 · External reference
ER stress and UPR in Alzheimer's disease: mechanisms, pathogenesis, treatments
10.1038/s41419-022-05153-5 · 2022 · External reference
Protective effect of Huangpu Tongqiao capsule against Alzheimer's disease through inhibiting the apoptosis pathway mediated by endoplasmic reticulum stress in vitro and in vivo
10.1016/j.jsps.2022.08.001 · 2022 · External reference
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10.1038/s41401-021-00702-8 · External reference
Endophenotype network models: common core of complex diseases
10.1038/srep27414 · 2016 · External reference
Unresolved reference
External reference
Harnessing endophenotypes and network medicine for Alzheimer's drug repurposing
2020 · External reference
10.1038/s43587-021-00138-z
10.1038/s43587-021-00138-z · External reference
TCMIO: a comprehensive database of traditional chinese medicine on immuno-oncology
2020 · External reference
TCMID: traditional chinese medicine integrative database for herb molecular mechanism analysis
10.1093/nar/gks1100 · 2013 · External reference
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
2014 · External reference
TCM-Mesh: the database and analytical system for network pharmacology analysis for TCM preparations
2017 · External reference
TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine
10.1186/s12906-015-0758-5 · 2015 · External reference
Open Babel: an open chemical toolbox
2011 · External reference
ChEMBL: towards direct deposition of bioassay data
10.1093/nar/gky1075 · 2019 · External reference
BindingDB in 2015: a public database for medicinal chemistry, computational chemistry and systems pharmacology
10.1093/nar/gkv1072 · 2016 · External reference
STITCH 5: augmenting protein–chemical interaction networks with tissue and affinity data
10.1093/nar/gkv1277 · 2016 · External reference
HIT: linking herbal active ingredients to targets
10.1093/nar/gkq1165 · 2011 · External reference
A systems pharmacology approach uncovers wogonoside as an angiogenesis inhibitor of triple-negative breast cancer by targeting hedgehog signaling
10.1016/j.chembiol.2019.05.004 · 2019 · External reference
AlzGPS: a genome-wide positioning systems platform to catalyze multi-omics for Alzheimer's drug discovery
10.1186/s13195-020-00760-w · 2021 · External reference
10.1007/s00439-017-1779-6
10.1007/s00439-017-1779-6 · External reference
DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants
10.1093/nar/gkw943 · 2017 · External reference
MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search
10.1093/nar/gkw1012 · 2017 · External reference
10.1093/nar/gkw1055
10.1093/nar/gkw1055 · External reference
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
10.1038/srep42717 · 2017 · External reference
ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties
2021 · External reference
A genome-wide positioning systems network algorithm for in silico drug repurposing
10.1038/s41467-019-10744-6 · 2019 · External reference
Network-based in silico drug efficacy screening
10.1038/ncomms10331 · 2016 · External reference
IL-1β and TNF-α play an important role in modulating the risk of periodontitis and Alzheimer's disease
2023 · External reference
The PI3K/AKT signaling pathway and caspase-3 in alzheimer's disease: which one is the beginner?
10.3233/jad-221157 · 2023 · External reference
In silico polypharmacology of natural products
2018 · External reference
10.1609/icwsm.v3i1.13937
10.1609/icwsm.v3i1.13937 · External reference
Caffeic acid protects against Aβ toxicity and prolongs lifespan in Caenorhabditis elegans models
10.1039/d0fo02784g · 2021 · External reference
Influence of in vitro neuronal membranes on the anti-amyloidogenic activity of gallic acid: Implication for the therapy of Alzheimer's disease
10.1016/j.abb.2021.109022 · 2021 · External reference
10.1002/ptr.5764
10.1002/ptr.5764 · External reference
Eleutheroside B or E enhances learning and memory in experimentally aged rats. Neural Regeneration
2013 · External reference
Ellagic acid induces apoptosis in TSGH8301 human bladder cancer cells through the endoplasmic reticulum stress- and mitochondria-dependent signaling pathways
2014 · External reference
Quercetin activates the Sestrin2/AMPK/SIRT1 axis to improve amyotrophic lateral sclerosis
2023 · External reference
10.1016/j.neurobiolaging.2015.05.006
10.1016/j.neurobiolaging.2015.05.006 · External reference
Myricetin protects hippocampal CA3 pyramidal neurons and improves learning and memory impairments in rats with Alzheimer's disease
10.4103/1673-5374.197141 · 2016 · External reference
Myricetin protects against high glucose-induced β-cell apoptosis by attenuating endoplasmic reticulum stress via inactivation of cyclin-dependent kinase 5
10.4093/dmj.2018.0052 · 2019 · External reference
Echinacoside inhibited cardiomyocyte pyroptosis and improved heart function of HF rats induced by isoproterenol via suppressing NADPH/ROS/ER stress
10.1111/jcmm.17564 · 2022 · External reference
Attenuation of endoplasmic reticulum stress enhances carvacrol-induced apoptosis in osteosarcoma cell lines
2023 · External reference
Danthron ameliorates obesity and MAFLD through activating the interplay between PPARα/RXRα heterodimer and adiponectin receptor 2
2021 · External reference
Danthron, an anthraquinone isolated from a marine fungus, is a new inhibitor of angiogenesis exhibiting interesting antitumor and antioxidant properties
2023 · External reference
Lamin A/C maintains exocrine pancreas homeostasis by regulating stability of RB and activity of E2F
10.1053/j.gastro.2018.01.024 · 2018 · External reference
Hippocampal LMNA gene expression is increased in late-stage Alzheimer's disease
10.3390/ijms20040878 · 2019 · External reference
The endoplasmic reticulum stress and unfolded protein response in Alzheimer's disease: a calcium dyshomeostasis perspective
2023 · External reference
10.1007/s10495-023-01848-y
10.1007/s10495-023-01848-y · External reference
Genistein attenuates memory impairment in Alzheimer's disease via ERS-mediated apoptotic pathway in vivo and in vitro
2022 · External reference
10.53388/tmr20191102145
10.53388/tmr20191102145 · External reference
A two-year treatment of amnestic mild cognitive impairment using a compound chinese medicine: a placebo controlled randomized trial
2016 · External reference
A randomized, double-blind, placebo-controlled clinical trial of the Chinese herbal medicine "ba wei di huang wan" in the treatment of dementia
10.1111/j.1532-5415.2004.52415.x · 2004 · External reference
Echinacoside: a promising active natural products and pharmacological agents
10.1016/j.phrs.2023.106951 · 2023 · External reference
Echinacoside ameliorates the memory impairment and cholinergic deficit induced by amyloid beta peptides via the inhibition of amyloid deposition and toxicology
10.1039/c7fo00267j · 2017 · External reference
10.1016/j.ijbiomac.2014.08.034
10.1016/j.ijbiomac.2014.08.034 · External reference
Echinacoside's nigrostriatal dopaminergic protection against 6-OHDA-Induced endoplasmic reticulum stress through reducing the accumulation of Seipin
10.1111/jcmm.13285 · 2017 · External reference
Echinacoside upregulates Sirt1 to suppress endoplasmic reticulum stress and inhibit extracellular matrix degradation in vitro and ameliorates osteoarthritis in vivo
2021 · External reference
Echinacoside inhibited cardiomyocyte pyroptosis and improved heart function of HF rats induced by isoproterenol via suppressing NADPH/ROS/ER stress
10.1111/jcmm.17564 · 2022 · External reference
Danthron inhibits the neurotoxicity induced by various compounds causing oxidative damages including beta-amyloid (25-35) in primary cortical cultures
10.1248/bpb.27.723 · 2004 · External reference
10.1021/acs.jcim.7b00216
10.1021/acs.jcim.7b00216 · External reference
10.1021/acssynbio.8b00237
10.1021/acssynbio.8b00237 · External reference
Network target for screening synergistic drug combinations with application to traditional Chinese medicine
10.1186/1752-0509-5-s1-s10 · 2011 · External reference
