Research graph
References from drexml: A command line tool and Python package for drug repurposing. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1038/nrd1468
10.1038/nrd1468 · External reference
10.1038/nrd.2018.168
10.1038/nrd.2018.168 · External reference
10.1093/nar/gkx1037
10.1093/nar/gkx1037 · External reference
10.1093/nar/gkr777
10.1093/nar/gkr777 · External reference
10.1093/nar/gki033
10.1093/nar/gki033 · External reference
Unresolved reference
External reference
10.1126/science.1132939
10.1126/science.1132939 · External reference
10.1038/ng.2653
10.1038/ng.2653 · External reference
10.1093/nar/gkw369
10.1093/nar/gkw369 · External reference
10.1371/journal.pcbi.1004591
10.1371/journal.pcbi.1004591 · External reference
10.1016/j.coisb.2021.05.010
10.1016/j.coisb.2021.05.010 · External reference
10.15252/msb.20198955
10.15252/msb.20198955 · External reference
Using mechanistic models for the clinical interpretation of complex genomic variation
10.1038/s41598-019-55454-7 · 2019 · External reference
10.1038/nmeth.1861
10.1038/nmeth.1861 · External reference
10.15252/msb.202211036
10.15252/msb.202211036 · External reference
Systems biology driving drug development: from design to the clinical testing of the anti-ErbB3 antibody seribantumab (MM-121)
10.1038/npjsba.2016.34 · 2017 · External reference
Deep learning in bioinformatics
2017 · External reference
10.1038/nbt.4233
10.1038/nbt.4233 · External reference
10.1016/j.cels.2018.10.013
10.1016/j.cels.2018.10.013 · External reference
10.1016/j.ebiom.2019.08.027
10.1016/j.ebiom.2019.08.027 · External reference
Opportunities and challenges for machine learning in rare diseases
10.3389/fmed.2021.747612 · 2021 · External reference
The DisGeNET knowledge platform for disease genomics: 2019 update
10.1093/nar/gkz1021 · 2019 · External reference
Unresolved reference
2017 · External reference
10.1016/j.compbiomed.2023.106969
10.1016/j.compbiomed.2023.106969 · External reference
10.1016/j.cell.2017.10.049
10.1016/j.cell.2017.10.049 · External reference
High throughput estimation of functional cell activities reveals disease mechanisms and predicts relevant clinical outcomes
10.18632/oncotarget.14107 · 2016 · External reference
10.1093/bioinformatics/btp616
10.1093/bioinformatics/btp616 · External reference
10.1016/j.csbj.2021.05.022 · Admitted local publication
10.1093/nar/gks1114
10.1093/nar/gks1114 · External reference
Multivariate random forests
10.1002/widm.12 · 2011 · External reference
10.1038/s42256-019-0138-9
10.1038/s42256-019-0138-9 · External reference
On the stability of feature selection algorithms
2018 · External reference
Hyperband: a novel bandit-based approach to hyperparameter optimization
2018 · External reference
Scikit-learn: machine learning in Python
2011 · External reference
10.1093/bioinformatics/17.6.520
10.1093/bioinformatics/17.6.520 · External reference
10.1038/s41586-020-2649-2
10.1038/s41586-020-2649-2 · External reference
10.1038/s41592-019-0686-2
10.1038/s41592-019-0686-2 · External reference
GPUTreeShap: massively parallel exact calculation of SHAP scores for tree ensembles
10.7717/peerj-cs.880 · 2022 · External reference
Unresolved reference
External reference
Exploring the druggable space around the Fanconi anemia pathway using machine learning and mechanistic models
10.1186/s12859-019-2969-0 · 2019 · External reference
10.1038/nrm.2016.48
10.1038/nrm.2016.48 · External reference
10.1016/j.gde.2015.07.002
10.1016/j.gde.2015.07.002 · External reference
Inherited bone marrow failure syndromes: considerations pre- and posttransplant
10.1182/blood-2017-05-781799 · 2017 · External reference
10.1111/j.1745-7254.2008.00889.x
10.1111/j.1745-7254.2008.00889.x · External reference
DNA damage-induced nuclear factor-kappa B activation and its roles in cancer progression
10.20517/2394-4722.2017.03 · 2017 · External reference
Targeting the PI3K pathway and DNA damage response as a therapeutic strategy in ovarian cancer
2020 · External reference
Treatment of fanconi anemia-associated head and neck cancer: opportunities to improve outcomes, clinical cancer research: an official
2021 · External reference
10.1016/j.exphem.2020.11.002
10.1016/j.exphem.2020.11.002 · External reference
Gefitinib and Afatinib show potential efficacy for Fanconi anemia–related head and neck cancer
10.1158/1078-0432.ccr-19-1625 · 2020 · External reference
TNF patterns and tumor microenvironment characterization in head and neck squamous cell carcinoma
10.3389/fimmu.2021.754818 · 2021 · External reference
10.12688/f1000research.17023.1
10.12688/f1000research.17023.1 · External reference
10.1016/s1074-7613(01)00094-2
10.1016/s1074-7613(01)00094-2 · External reference
Targeting growth hormone in cancer: future perspectives
10.1530/erc-23-0033 · 2023 · External reference
10.3390/jcm10163760
10.3390/jcm10163760 · External reference
P53 signaling in cancer progression and therapy
10.1186/s12935-021-02396-8 · 2021 · External reference
10.3390/cells10061334
10.3390/cells10061334 · External reference
Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling
10.1038/s41467-022-32754-7 · 2022 · External reference
10.1038/nature05660
10.1038/nature05660 · External reference
10.1016/j.critrevonc.2016.12.003
10.1016/j.critrevonc.2016.12.003 · External reference
Melanin content in melanoma metastases affects the outcome of radiotherapy
10.18632/oncotarget.7528 · 2016 · External reference
Melanogenesis affects overall and disease-free survival in patients with stage III and IV melanoma
10.1016/j.humpath.2013.02.022 · 2013 · External reference
Photodynamic therapy-induced killing is enhanced in depigmented metastatic melanoma cells
10.1042/cbi20110103 · 2011 · External reference
Depigmentation in melanomas increases the efficacy of hypericin-mediated photodynamic-induced cell death
10.1016/j.pdpdt.2011.09.003 · 2012 · External reference
Inhibitors of melanogenesis increase toxicity of cyclophosphamide and lymphocytes against melanoma cells
10.1002/ijc.24005 · 2009 · External reference
Advances in the design of genuine human tyrosinase inhibitors for targeting melanogenesis and related pigmentations
10.1021/acs.jmedchem.0c00994 · 2020 · External reference
CD44 as a tumor biomarker and therapeutic target
10.1186/s40164-020-00192-0 · 2020 · External reference
Increase in gene expression of TYMP, DPYD and HIF1A are associated with response to preoperative chemoradiotherapy including S-1 or UFT for rectal cancer
2016 · External reference
10.1245/s10434-022-11752-5
10.1245/s10434-022-11752-5 · External reference
Fanconi anemia pathway as a prospective target for cancer intervention
10.1186/s13578-020-00401-7 · 2020 · External reference
Androgen receptor is a determinant of melanoma targeted drug resistance
10.1038/s41467-023-42239-w · 2023 · External reference
An SPM-enriched marine oil supplement shifted microglia polarization toward M2, ameliorating retinal degeneration in rd10 mice
10.3390/antiox12010098 · 2022 · External reference
Drug repurposing for COVID-19 using machine learning and mechanistic models of signal transduction circuits related to SARS-CoV-2 infection
10.1038/s41392-020-00417-y · 2020 · External reference
Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patients
10.1038/s41598-021-02701-5 · 2021 · External reference
Real-world evidence with a retrospective cohort of 15,968 COVID-19 hospitalized patients suggests 21 new effective treatments
10.1186/s12985-023-02195-9 · 2023 · External reference
