Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Smad4 regulates TGF-β1-mediated hedgehog activation to promote epithelial-to-mesenchymal transition in pancreatic cancer cells by suppressing Gli1 activity. Local targets link to admitted publications; unresolved targets remain external evidence.
10.3322/caac.21492
10.3322/caac.21492 · External reference
10.1101/gad.275776.115
10.1101/gad.275776.115 · External reference
10.1016/s1470-2045(19)30795-8
10.1016/s1470-2045(19)30795-8 · External reference
10.1038/nature22963
10.1038/nature22963 · External reference
The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer
10.1186/s12943-017-0624-9 · 2017 · External reference
10.1038/nature14169
10.1038/nature14169 · External reference
10.3390/ijms21103534
10.3390/ijms21103534 · External reference
10.1038/nature02006
10.1038/nature02006 · External reference
10.3390/cells8050424
10.3390/cells8050424 · External reference
Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
10.1002/ijc.26323 · 2011 · External reference
10.1016/j.canlet.2009.01.014
10.1016/j.canlet.2009.01.014 · External reference
10.1038/nm.3389
10.1038/nm.3389 · External reference
10.1016/j.tcb.2006.02.004
10.1016/j.tcb.2006.02.004 · External reference
10.1007/s10565-020-09562-0
10.1007/s10565-020-09562-0 · External reference
Hypoxic tumor microenvironment activates GLI2 via HIF-1alpha and TGF-beta2 to promote chemoresistance in colorectal cancer.
2018 · External reference
TGFBR2 regulates Hedgehog pathway and cervical cancer cell proliferation and migration by mediating SMAD4
10.1021/acs.jproteome.0c00239 · 2020 · External reference
Inhibition of the sonic hedgehog pathway activates TGF-beta-activated kinase (TAK1) to induce autophagy and suppress apoptosis in thyroid tumor cells
10.1038/s41419-021-03744-2 · 2021 · External reference
10.1074/jbc.m113.545194
10.1074/jbc.m113.545194 · External reference
Calcium channel protein ORAI1 mediates TGF-beta induced epithelial-to-mesenchymal transition in colorectal cancer cells
10.3389/fonc.2021.649476 · 2021 · External reference
10.1038/s41419-020-03271-6
10.1038/s41419-020-03271-6 · External reference
The anthelmintic drug niclosamide induces GSK-beta-mediated beta-catenin degradation to potentiate gemcitabine activity, reduce immune evasion ability and suppress pancreatic cancer progression
10.1038/s41419-022-04573-7 · 2022 · External reference
lncRNA H19 promotes glioblastoma multiforme development by activating autophagy by sponging miR-491-5p
10.1080/21655979.2022.2065947 · 2022 · External reference
Combinational blockade of MET and PD-L1 improves pancreatic cancer immunotherapeutic efficacy
10.1186/s13046-021-02055-w · 2021 · External reference
Identification of the shared gene signatures and biological mechanism in type 2 diabetes and pancreatic cancer
10.3389/fendo.2022.847760 · 2022 · External reference
Sonic hedgehog-mediated epithelial-mesenchymal transition in renal tubulointerstitial fibrosis
10.3892/ijmm.2016.2546 · 2016 · External reference
Pathway crosstalk enables cells to interpret TGF-β duration
10.1038/s41540-018-0060-5 · 2018 · External reference
Transforming growth factor-beta1 stimulates hedgehog signaling to promote epithelial-mesenchymal transition after kidney injury
10.1111/febs.13842 · 2016 · External reference
TGF-beta1 promotes proliferation and invasion of hepatocellular carcinoma cell line HepG2 by activating GLI-1 signaling
2018 · External reference
GLI-1 facilitates the EMT induced by TGF-beta1 in gastric cancer
2018 · External reference
The mechanism of epithelial-mesenchymal transition induced by TGF-beta1 in neuroblastoma cells
10.3892/ijo.2017.3954 · 2017 · External reference
In the quest for potent and selective malic enzyme 3 inhibitors for the treatment of pancreatic ductal adenocarcinoma
10.1021/acsmedchemlett.2c00369 · 2023 · External reference
Molecular alterations in basal cell carcinoma subtypes
10.1038/s41598-021-92592-3 · 2021 · External reference
10.1016/j.celrep.2022.110779
10.1016/j.celrep.2022.110779 · External reference
Inherited rare and common variants in PTCH1 and PTCH2 contributing to the predisposition to reproductive cancers
10.1016/j.gene.2021.146157 · 2022 · External reference
10.1016/s0960-9822(01)00179-8
10.1016/s0960-9822(01)00179-8 · External reference
10.1046/j.1523-1747.2003.12423.x
10.1046/j.1523-1747.2003.12423.x · External reference
10.1097/md.0000000000002996
10.1097/md.0000000000002996 · External reference
Regulation of epithelial-mesenchymal transition via sonic hedgehog/glioma-associated oncogene homolog 1 signaling pathway in peritoneal mesothelial cells
10.1002/cbin.11363 · 2020 · External reference
Cananginone abrogates EMT in breast cancer cells through Hedgehog signaling
10.1002/cbdv.202100823 · 2022 · External reference
Inhibitory effect of bufalin combined with Hedgehog signaling pathway inhibitors on proliferation and invasion and metastasis of liver cancer cells
10.3892/ijo.2016.3667 · 2016 · External reference
TGF-beta/SMAD pathway and its regulation in hepatic fibrosis
10.1369/0022155415627681 · 2016 · External reference
Eribulin rapidly inhibits TGF-beta-induced Snail expression and can induce Slug expression in a Smad4-dependent manner
10.1038/s41416-019-0556-9 · 2019 · External reference
10.1038/s41388-020-1189-4
10.1038/s41388-020-1189-4 · External reference
10.1093/nar/gkr500
10.1093/nar/gkr500 · External reference