Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureResearch graph
References from Context-dependent genomic locus effects on antibody production in recombinant Chinese hamster ovary cells generated through random integration. Local targets link to admitted publications; unresolved targets remain external evidence.
CHO cells in biotechnology for production of recombinant proteins: current state and further potential
10.1007/s00253-011-3758-5 · 2012 · External reference
10.3390/ph6050579
10.3390/ph6050579 · External reference
The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line
10.1038/nbt.1932 · 2011 · External reference
Biopharmaceutical benchmarks 2022
10.1038/s41587-022-01582-x · 2022 · External reference
Development of recombinant Chinese hamster ovary cell lines for therapeutic protein production
10.1016/j.coche.2013.08.002 · 2013 · External reference
A proline metabolism selection system and its application to the engineering of lipid biosynthesis in Chinese hamster ovary cells
10.1016/j.mec.2021.e00179 · 2021 · External reference
CHO cell line development and engineering via site-specific integration: challenges and opportunities
10.1007/s12257-020-0093-7 · 2020 · External reference
10.1016/0022-2836(82)90103-6
10.1016/0022-2836(82)90103-6 · External reference
High level expression of tissue inhibitor of metalloproteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification
1990 · External reference
10.1016/j.tibtech.2019.02.007
10.1016/j.tibtech.2019.02.007 · External reference
Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway
10.1038/srep08572 · 2015 · External reference
10.1093/nar/gky216
10.1093/nar/gky216 · External reference
Recombinase‐mediated cassette exchange (RMCE) for monoclonal antibody expression in the commercially relevant CHOK1SV cell line
10.1002/btpr.2175 · 2015 · External reference
CHOK1SV GS‐KO SSI expression system: A combination of the Fer1L4 locus and glutamine synthetase selection
2021 · External reference
A compendium of stable hotspots in the CHO genome
10.1002/bit.28390 · 2023 · External reference
Single copy transgene integration in a transcriptionally active site for recombinant protein synthesis
10.1002/biot.201800226 · 2018 · External reference
10.1016/j.jbiosc.2017.12.003
10.1016/j.jbiosc.2017.12.003 · External reference
Site-specific integration ushers in a new era of precise CHO cell line engineering
10.1016/j.coche.2018.09.011 · 2018 · External reference
CRISPOR: intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens
10.1093/nar/gky354 · 2018 · External reference
Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases
10.1093/bioinformatics/btu048 · 2014 · External reference
10.1038/nbt.3198
10.1038/nbt.3198 · External reference
10.1016/j.ymben.2022.03.017
10.1016/j.ymben.2022.03.017 · External reference
Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing
10.1021/acssynbio.8b00290 · 2018 · External reference
Fast and accurate short read alignment with Burrows–Wheeler transform
10.1093/bioinformatics/btp324 · 2009 · External reference
10.1101/gr.074492.107
10.1101/gr.074492.107 · External reference
10.1016/s0022-2836(05)80360-2
10.1016/s0022-2836(05)80360-2 · External reference
10.1038/s41588-022-01048-5
10.1038/s41588-022-01048-5 · External reference
Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies
10.1038/s41598-018-23720-9 · 2018 · External reference
Optimized CRISPR/Cas9 strategy for homology‐directed multiple targeted integration of transgenes in CHO cells
10.1002/bit.27315 · 2020 · External reference
10.1093/nar/gku936
10.1093/nar/gku936 · External reference
Hybrid cell line development system utilizing site-specific integration and methotrexate-mediated gene amplification in Chinese hamster ovary cells
2022 · External reference
Knockout of the lysosomal membrane protein, LAMP2C, improves transient gene expression in HEK293 cells via increased intracellular plasmid availability
2023 · External reference
Unresolved reference
External reference
10.1038/nbt.1754
10.1038/nbt.1754 · External reference
Sequencing the CHO DXB11 genome reveals regional variations in genomic stability and haploidy
2015 · External reference
10.1038/nmeth.1906
10.1038/nmeth.1906 · External reference
10.1038/nprot.2017.124
10.1038/nprot.2017.124 · External reference
Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time
10.1002/bit.25990 · 2016 · External reference
10.1002/bit.26891
10.1002/bit.26891 · External reference
10.1101/gr.229102
10.1101/gr.229102 · External reference
Preselection of recombinant gene integration sites enabling high transcription rates in CHO cells using alternate start codons and recombinase mediated cassette exchange
10.1002/bit.26388 · 2017 · External reference
10.1038/nbt.2959
10.1038/nbt.2959 · External reference
Deciphering integration loci of CHO manufacturing cell lines using long read nanopore sequencing
10.1016/j.nbt.2023.03.003 · 2023 · External reference
10.1016/j.bbapap.2014.06.004
10.1016/j.bbapap.2014.06.004 · External reference
Model-directed engineering of "difficult-to-express" monoclonal antibody production by Chinese hamster ovary cells
10.1002/bit.25116 · 2014 · External reference
On the optimal ratio of heavy to light chain genes for efficient recombinant antibody production by CHO cells
10.1021/bp049780w · 2005 · External reference
A study of monoclonal antibody-producing CHO cell lines: what makes a stable high producer?
10.1002/bit.22158 · 2009 · External reference
10.1101/gr.212092.116
10.1101/gr.212092.116 · External reference
