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References from Molecular interactions between a diphenyl scaffold and PED/PEA15: Implications for type II diabetes therapeutics targeting PED/PEA15 – Phospholipase D1 interaction. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1016/s0021-9258(18)53407-4
10.1016/s0021-9258(18)53407-4 · External reference
10.1046/j.1471-4159.1995.64031016.x
10.1046/j.1471-4159.1995.64031016.x · External reference
The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human*
10.1074/jbc.271.25.14800 · 1996 · External reference
Frontiers: PED/PEA-15, a multifunctional protein controlling cell survival and glucose metabolism
10.1152/ajpendo.00228.2009 · 2009 · External reference
The anti-apoptotic protein PEA-15 is a tight binding inhibitor of ERK1 and ERK2, which blocks docking interactions at the D-recruitment site
10.1021/bi700206u · 2007 · External reference
10.1038/sj.onc.1202831
10.1038/sj.onc.1202831 · External reference
10.1074/jbc.271.25.14800
10.1074/jbc.271.25.14800 · External reference
PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase biological outputs by phosphorylating nuclear and cyto-plasmic substrates. Nuclear substrates include tran-scription factors such as Elk-1, and cytoplasmic sub
2001 · External reference
Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNF-induced apoptosis.
10.1523/jneurosci.19-19-08244.1999 · 1999 · External reference
Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitro
10.1046/j.1471-4159.1998.71031307.x · 1998 · External reference
Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK
2013 · External reference
10.1091/mbc.11.9.2863
10.1091/mbc.11.9.2863 · External reference
10.1128/mcb.23.13.4511-4521.2003
10.1128/mcb.23.13.4511-4521.2003 · External reference
10.1074/jbc.m202946200
10.1074/jbc.m202946200 · External reference
10.1093/emboj/cdf641
10.1093/emboj/cdf641 · External reference
Profound conformational changes of PED/PEA-15 in ERK2 complex revealed by NMR backbone dynamics
10.1016/j.bbapap.2012.07.001 · 2012 · External reference
High-definition NMR structure of PED/PEA-15 death effector domain reveals details of key polar side chain interactions
10.1016/j.bbrc.2012.06.091 · 2012 · External reference
Targetting PED/PEA-15 for diabetes treatment
2017 · External reference
The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes
10.1007/s00125-006-0455-5 · 2006 · External reference
PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus
10.1093/emboj/17.14.3858 · 1998 · External reference
10.1128/mcb.4.11.5005-5015.2004
10.1128/mcb.4.11.5005-5015.2004 · External reference
10.2337/db06-1260
10.2337/db06-1260 · External reference
Residues 762-801 of PLD1 mediate the interaction with PED/PEA15
10.1039/c005272h · 2010 · External reference
Molecular basis of the PED/PEA15 interaction with the C-terminal fragment of phospholipase D1 revealed by NMR spectroscopy
10.1016/j.bbapap.2013.04.012 · 2013 · External reference
10.1074/jbc.m803771200
10.1074/jbc.m803771200 · External reference
Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them
10.1074/jbc.m003329200 · 2000 · External reference
Expression and purification of the D4 region of PLD1 and characterization of its interaction with PED-PEA15
10.1016/j.pep.2008.02.012 · 2008 · External reference
Expression and purification of the D4 region of PLD1 and characterization of its interaction with PED-PEA15
10.1016/j.pep.2008.02.012 · 2008 · External reference
Screening a molecular fragment library to modulate the PED/PEA15-phospholipase D1 interaction in cellular lysate environments
10.1021/acschembio.1c00688 · 2021 · External reference
Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
10.1038/nrd1343 · 2004 · External reference
Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
10.1007/s10822-013-9644-8 · 2013 · External reference
Unresolved reference
External reference
OPLS4: improving force field accuracy on challenging regimes of chemical space
10.1021/acs.jctc.1c00302 · 2021 · External reference
Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
10.1021/jm0306430 · 2004 · External reference
10.1021/jm051256o
10.1021/jm051256o · External reference
Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment Factors in Database Screening
10.1021/jm030644s · 2004 · External reference
Unresolved reference
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10.1021/acs.jctc.1c00810
10.1021/acs.jctc.1c00810 · External reference
Unresolved reference
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Novel procedure for modeling ligand/receptor induced fit effects
10.1021/jm050540c · 2006 · External reference
10.1002/jcc.20222
10.1002/jcc.20222 · External reference
10.1517/17460441.2015.1032936
10.1517/17460441.2015.1032936 · External reference
10.1021/jp003919d
10.1021/jp003919d · External reference
Unresolved reference
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Scalable algorithms for molecular dynamics simulations on commodity clusters
2006 · External reference
Canonical dynamics: equilibrium phase-space distributions
10.1103/physreva.31.1695 · 1985 · External reference
10.1063/1.447334
10.1063/1.447334 · External reference
Constant pressure molecular dynamics algorithms
10.1063/1.467468 · 1994 · External reference
10.1126/science.1136800
10.1126/science.1136800 · External reference
New method for fast and accurate binding-site identification and analysis
10.1111/j.1747-0285.2007.00483.x · 2007 · External reference
Identifying and characterizing binding sites and assessing druggability
10.1021/ci800324m · 2009 · External reference
10.3390/ijms20020378
10.3390/ijms20020378 · External reference
Protein interaction patterns in different cellular environments are revealed by in-cell NMR
10.1038/srep14456 · 2015 · External reference
Unresolved reference
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NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy
10.1093/bioinformatics/btu830 · 2015 · External reference
Unresolved reference
External reference
10.1016/j.pnmrs.2013.02.001
10.1016/j.pnmrs.2013.02.001 · External reference
PEA-15 engages in allosteric interactions using a common scaffold in a phosphorylation-dependent manner
10.1038/s41598-021-04099-6 · 2022 · External reference
