Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureResearch graph
References from Integrating bulk RNA-seq and scRNA-seq analyses revealed the function and clinical value of thrombospondins in colon cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions
10.1038/nm.3174 · 2013 · External reference
10.1016/s0140-6736(19)32319-0
10.1016/s0140-6736(19)32319-0 · External reference
The immunomodulatory role of matrix metalloproteinases in colitis-associated cancer
2022 · External reference
Thrombospondins in the tumor microenvironment
2023 · External reference
10.1016/j.addr.2015.11.001
10.1016/j.addr.2015.11.001 · External reference
The matrix revolution: matricellular proteins and restructuring of the cancer microenvironment
10.1158/0008-5472.can-18-2098 · 2020 · External reference
The role of cancer-associated fibroblasts in cancer invasion and metastasis
2021 · External reference
10.1016/j.pharmthera.2016.09.002
10.1016/j.pharmthera.2016.09.002 · External reference
Cancer-associated fibroblasts: implications for cancer therapy
10.3390/cancers13143526 · 2021 · External reference
Cancer extracellular matrix proteins regulate tumour immunity
10.3390/cancers12113331 · 2020 · External reference
10.3390/ijms140612249
10.3390/ijms140612249 · External reference
Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses
10.1074/jbc.m804860200 · 2009 · External reference
Thrombospondins in the tumor microenvironment
10.1016/j.semcdb.2023.05.010 · 2024 · External reference
Thrombospondin-2 promotes the proliferation and migration of glioma cells and contributes to the progression of glioma
10.1186/s41016-022-00308-x · 2022 · External reference
10.1158/2326-6066.cir-18-0367
10.1158/2326-6066.cir-18-0367 · External reference
Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling
10.1126/scitranslmed.3000139 · 2009 · External reference
Functions of Thrombospondin-1 in the tumor microenvironment
10.3390/ijms22094570 · 2021 · External reference
10.1038/mt.2013.236
10.1038/mt.2013.236 · External reference
Thrombospondin 4/integrin alpha2/HSF1 axis promotes proliferation and cancer stem-like traits of gallbladder cancer by enhancing reciprocal crosstalk between cancer-associated fibroblasts and tumor cells
10.1186/s13046-020-01812-7 · 2021 · External reference
Tsp2 facilitates tumor-associated fibroblasts formation and promotes tumor progression in retroperitoneal liposarcoma
10.7150/ijbs.70083 · 2022 · External reference
Systematic analysis of integrated bioinformatics to identify upregulated THBS2 expression in colorectal cancer cells inhibiting tumour immunity through the HIF1A/Lactic Acid/GPR132 pathway
10.1186/s12935-023-03103-5 · 2023 · External reference
The integrative analysis of thrombospondin family genes in pan-cancer reveals that THBS2 facilitates gastrointestinal cancer metastasis
10.1155/2021/4405491 · 2021 · External reference
The cancer-associated fibroblasts-related gene COMP is a novel predictor for prognosis and immunotherapy efficacy and is correlated with m2 macrophage infiltration in colon cancer
2022 · External reference
10.1158/2159-8290.cd-21-0316
10.1158/2159-8290.cd-21-0316 · External reference
IOBR: multi-omics immuno-oncology biological research to decode tumor microenvironment and signatures
10.3389/fimmu.2021.687975 · 2021 · External reference
10.1016/j.cell.2020.03.048
10.1016/j.cell.2020.03.048 · External reference
Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancer
10.1126/sciadv.adf5464 · 2023 · External reference
10.1016/j.ymthe.2020.04.023
10.1016/j.ymthe.2020.04.023 · External reference
10.1093/nar/gky900
10.1093/nar/gky900 · External reference
10.1038/s41596-020-0292-x
10.1038/s41596-020-0292-x · External reference
Identification and characterization of robust hepatocellular carcinoma prognostic subtypes based on an integrative metabolite-protein interaction network
2021 · External reference
Pan-cancer landscape of T-cell exhaustion heterogeneity within the tumor microenvironment revealed a progressive roadmap of hierarchical dysfunction associated with prognosis and therapeutic efficacy
10.1016/j.ebiom.2022.104207 · 2022 · External reference
Cartilage oligomeric matrix protein (COMP) promotes cell proliferation in early-onset colon cancer tumorigenesis
10.1007/s00464-019-07185-z · 2020 · External reference
10.1038/onc.2017.140
10.1038/onc.2017.140 · External reference
Identification of BGN and THBS2 as metastasis-specific biomarkers and poor survival key regulators in human colon cancer by integrated analysis
2022 · External reference
Activation of the myc oncoprotein leads to increased turnover of thrombospondin-1 mRNA
10.1093/nar/28.11.2268 · 2000 · External reference
10.1007/s10555-019-09806-4
10.1007/s10555-019-09806-4 · External reference
Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior
10.1083/jcb.200109098 · 2002 · External reference
Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy
10.7554/elife.57243 · 2020 · External reference
Fibrosis and cancer: a strained relationship
10.1016/j.bbcan.2020.188356 · 2020 · External reference
Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives
10.1186/s12943-021-01428-1 · 2021 · External reference
HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways
10.1186/s13046-018-0908-y · 2018 · External reference
10.1158/1078-0432.ccr-20-4226
10.1158/1078-0432.ccr-20-4226 · External reference
10.1038/s41588-022-01088-x
10.1038/s41588-022-01088-x · External reference
COL1A1: a potential therapeutic target for colorectal cancer expressing wild-type or mutant KRAS
2018 · External reference
Cancer-associated fibroblasts mediate cancer progression and remodel the tumouroid stroma
10.1038/s41416-020-0973-9 · 2020 · External reference
m(6)A regulator-based methylation modification patterns characterized by distinct tumor microenvironment immune profiles in colon cancer
10.7150/thno.52717 · 2021 · External reference
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2018 · External reference
Tumor microenvironment as a therapeutic target in cancer
10.1016/j.pharmthera.2020.107753 · 2021 · External reference
10.1158/1078-0432.ccr-18-1851
10.1158/1078-0432.ccr-18-1851 · External reference
Tumor microenvironment: extracellular matrix alterations influence tumor progression
10.3389/fonc.2020.00397 · 2020 · External reference
10.1016/j.matbio.2023.03.011
10.1016/j.matbio.2023.03.011 · External reference
10.2353/ajpath.2008.080237
10.2353/ajpath.2008.080237 · External reference
Platelets upregulate tumor cell programmed death ligand 1 in an epidermal growth factor receptor-dependent manner in vitro
10.1182/bloodadvances.2021006120 · 2022 · External reference
10.4049/jimmunol.178.9.5930
10.4049/jimmunol.178.9.5930 · External reference
Thrombospondin in tumor microenvironment
10.1007/978-3-030-48457-6_8 · 2020 · External reference
10.1016/j.ccell.2021.09.003
10.1016/j.ccell.2021.09.003 · External reference
10.1016/j.ccell.2021.02.007
10.1016/j.ccell.2021.02.007 · External reference
10.1016/j.celrep.2015.11.025
10.1016/j.celrep.2015.11.025 · External reference
Signaling receptors for TGF-beta family members
10.1101/cshperspect.a022053 · 2016 · External reference
Wnt signaling in colorectal cancer: pathogenic role and therapeutic target
10.1186/s12943-022-01616-7 · 2022 · External reference
Hedgehog signaling and truncated GLI1 in cancer
10.3390/cells9092114 · 2020 · External reference
Notch signaling pathway in cancer-review with bioinformatic analysis
10.3390/cancers13040768 · 2021 · External reference
10.3748/wjg.v22.i23.5301
10.3748/wjg.v22.i23.5301 · External reference
Cancer-associated fibroblasts expressing CXCL14 rely upon NOS1-derived nitric oxide signaling for their tumor-supporting properties
10.1158/0008-5472.can-13-2740 · 2014 · External reference
10.1038/nrd3810
10.1038/nrd3810 · External reference
10.1016/j.yexcr.2011.10.012
10.1016/j.yexcr.2011.10.012 · External reference
Multi-scale integrative analyses identify THBS2(+) cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma
10.7150/thno.69590 · 2022 · External reference
10.1158/1078-0432.ccr-10-2572
10.1158/1078-0432.ccr-10-2572 · External reference
Investigating the role of JAK/STAT pathway on dasatinib-induced apoptosis for CML cell model K562
10.1016/j.clml.2015.02.012 · 2015 · External reference
Docetaxel: a review of its use in metastatic breast cancer
10.2165/00003495-200565170-00007 · 2005 · External reference
