Research graph
References from Antibody glycan quality predicted from CHO cell culture media markers and machine learning. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1016/j.drudis.2016.01.006
10.1016/j.drudis.2016.01.006 · External reference
10.1093/glycob/cwz065
10.1093/glycob/cwz065 · External reference
10.1002/bit.25450
10.1002/bit.25450 · External reference
10.1002/bit.21598
10.1002/bit.21598 · External reference
10.1016/j.jbiotec.2014.08.026
10.1016/j.jbiotec.2014.08.026 · External reference
10.1016/j.molimm.2016.03.002
10.1016/j.molimm.2016.03.002 · External reference
The “less-is-more” in therapeutic antibodies: afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity
2018 · External reference
10.1093/glycob/cwr027
10.1093/glycob/cwr027 · External reference
Enhancing pharmacokinetic and pharmacodynamic properties of recombinant therapeutic proteins by manipulation of sialic acid content
10.1016/j.biopha.2023.114757 · 2023 · External reference
Media supplementation for targeted manipulation of monoclonal antibody galactosylation and fucosylation
10.1002/bit.27496 · 2020 · External reference
10.1002/bit.23075
10.1002/bit.23075 · External reference
A novel sugar analog enhances sialic acid production and biotherapeutic sialylation in CHO cells
10.1002/bit.26291 · 2017 · External reference
Factors affecting the quality of therapeutic proteins in recombinant Chinese hamster ovary cell culture
10.1016/j.biotechadv.2021.107831 · 2022 · External reference
Sequential multivariate cell culture modeling at multiple scales supports systematic shaping of a monoclonal antibody toward a quality target
10.1002/biot.201700461 · 2018 · External reference
Multivariate data analysis of growth medium trends affecting antibody glycosylation
10.1002/btpr.2903 · 2020 · External reference
Roadmap for implementation of quality by design (QbD) for biotechnology products
10.1016/j.tibtech.2009.06.006 · 2009 · External reference
Bioprocess systems analysis, modeling, estimation, and control
10.1016/j.coche.2021.100705 · 2021 · External reference
Harnessing the potential of machine learning for advancing “quality by design” in biomanufacturing
2022 · External reference
Design of experiment (DOE) applied to artificial neural network architecture enables rapid bioprocess improvement
10.1007/s00449-021-02529-3 · 2021 · External reference
Modelling of bioprocess non-linear fluorescence data for at-line prediction of etanercept based on artificial neural networks optimized by response surface methodology
10.1016/j.talanta.2019.120664 · 2020 · External reference
AI-ML applications in bioprocessing: ML as an enabler of real time quality prediction in continuous manufacturing of mAbs
10.1016/j.compchemeng.2022.107896 · 2022 · External reference
Synergising stoichiometric modelling with artificial neural networks to predict antibody glycosylation patterns in Chinese hamster ovary cells
10.1016/j.compchemeng.2021.107471 · 2021 · External reference
Clustering and curation of electropherograms: an efficient method for analyzing large cohorts of capillary electrophoresis glycomic profiles for bioprocessing operations
10.3762/bjoc.16.176 · 2020 · External reference
von Hippel-Lindau protein maintains metabolic balance to regulate the survival of naive B lymphocytes
10.1016/j.isci.2019.07.002 · 2019 · External reference
10.1038/s41591-019-0423-5
10.1038/s41591-019-0423-5 · External reference
10.1021/ac051437y
10.1021/ac051437y · External reference
Random forest for bioinformatics
2012 · External reference
The WEKA data mining software: an update
10.1145/1656274.1656278 · 2009 · External reference
Controlling the false discovery rate: a practical and powerful approach to multiple testing
10.1111/j.2517-6161.1995.tb02031.x · 1995 · External reference
10.1016/j.patrec.2005.10.010
10.1016/j.patrec.2005.10.010 · External reference
pROC: an open-source package for R and S+ to analyze and compare ROC curves
10.1186/1471-2105-12-77 · 2011 · External reference
Triple-internal standard based glycan structural assignment method for capillary electrophoresis analysis of carbohydrates
10.1021/acs.analchem.6b03596 · 2016 · External reference
Comparison of cell lines for stable production of fucose-negative antibodies with enhanced ADCC
10.1002/bit.20880 · 2006 · External reference
Improving effector functions of antibodies for cancer treatment: enhancing ADCC and CDC
2009 · External reference
Cell culture processes for monoclonal antibody production
2010 · External reference
Combined multivariate statistical and flux balance analyses uncover media bottlenecks to the growth and productivity of Chinese hamster ovary cell cultures
10.1002/bit.28104 · 2022 · External reference
10.1016/j.jbiotec.2018.07.042
10.1016/j.jbiotec.2018.07.042 · External reference
A consensus genome-scale reconstruction of Chinese hamster ovary cell metabolism
10.1016/j.cels.2016.10.020 · 2016 · External reference
Influence of N-glycosylation on effector functions and thermal stability of glycoengineered IgG1 monoclonal antibody with homogeneous glycoforms
2019 · External reference
10.1093/bioinformatics/btm344
10.1093/bioinformatics/btm344 · External reference
Unresolved reference
External reference
Impact of nucleotide sugar metabolism on protein N-glycosylation in Chinese Hamster Ovary (CHO) cell culture
10.1016/j.coche.2018.10.002 · 2018 · External reference
10.1016/j.biotechadv.2018.06.008
10.1016/j.biotechadv.2018.06.008 · External reference
10.1038/s41590-023-01544-8
10.1038/s41590-023-01544-8 · External reference
Model‐based optimization of antibody galactosylation in CHO cell culture
10.1002/bit.26960 · 2019 · External reference
Raman based chemometric model development for glycation and glycosylation real time monitoring in a manufacturing scale CHO cell bioreactor process
10.1002/btpr.3223 · 2022 · External reference
