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References from Acidic sphingomyelinase interactions with lysosomal membranes and cation amphiphilic drugs: A molecular dynamics investigation. Local targets link to admitted publications; unresolved targets remain external evidence.
Lysosomal enzyme trafficking: from molecular mechanisms to human diseases
10.1016/j.tcb.2023.06.005 · 2023 · External reference
10.1002/jcp.30928
10.1002/jcp.30928 · External reference
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
10.1038/s41580-023-00676-x · 2023 · External reference
10.1016/j.canlet.2023.216307
10.1016/j.canlet.2023.216307 · External reference
Neuronal ganglioside and glycosphingolipid (GSL) metabolism and disease
10.1007/978-3-031-12390-0_12 · 2023 · External reference
Unresolved reference
2020 · External reference
Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
10.1038/s41467-019-14009-0 · 2020 · External reference
10.1016/j.tcb.2023.01.001
10.1016/j.tcb.2023.01.001 · External reference
10.3390/ijms22169001
10.3390/ijms22169001 · External reference
Secretory sphingomyelinase in health and disease
10.1515/hsz-2015-0109 · 2015 · External reference
Human acid sphingomyelinase structures provide insight to molecular basis of Niemann–Pick disease
10.1038/ncomms13082 · 2016 · External reference
Structure of human acid sphingomyelinase reveals the role of the saposin domain in activating substrate hydrolysis
10.1016/j.jmb.2016.06.012 · 2016 · External reference
Functional characterization of the N‐glycosylation sites of human acid sphingomyelinase by site‐directed mutagenesis
10.1111/j.1432-1033.1997.511_1a.x · 1997 · External reference
Emerging mechanisms of drug-induced phospholipidosis
10.1515/hsz-2019-0270 · 2019 · External reference
Repurposing cationic amphiphilic drugs and derivatives to engage lysosomal cell death in cancer treatment
10.3389/fonc.2020.605361 · 2020 · External reference
The Achilles’ heel of cancer: targeting tumors via lysosome-induced immunogenic cell death
10.1038/s41419-022-04912-8 · 2022 · External reference
10.1016/j.ceb.2016.02.009
10.1016/j.ceb.2016.02.009 · External reference
10.1016/j.tcb.2021.12.009
10.1016/j.tcb.2021.12.009 · External reference
10.1159/000315101
10.1159/000315101 · External reference
10.3390/cells11244079
10.3390/cells11244079 · External reference
10.1016/j.ccr.2013.08.003
10.1016/j.ccr.2013.08.003 · External reference
10.1016/j.celrep.2023.112137
10.1016/j.celrep.2023.112137 · External reference
Repurposing phenothiazines for cancer therapy: compromising membrane integrity in cancer cells
10.3389/fonc.2023.1320621 · 2023 · External reference
Repurposing cationic amphiphilic antihistamines for cancer treatment
10.1016/j.ebiom.2016.06.013 · 2016 · External reference
Tricyclic antidepressants and the incidence of certain cancers: a study using the GPRD
10.1038/sj.bjc.6605996 · 2011 · External reference
A high content screening assay for identifying lysosomotropic compounds
10.1016/j.tiv.2010.12.010 · 2011 · External reference
Lysosomal sequestration (Trapping) of lipophilic amine (Cationic Amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 Cells
10.1124/dmd.112.050054 · 2013 · External reference
The lysosomotropic activity of hydrophobic weak base drugs is mediated via their intercalation into the lysosomal membrane
10.3390/cells9051082 · 2020 · External reference
10.1002/cmdc.200900052
10.1002/cmdc.200900052 · External reference
Cationic amphiphilic drugs induce elevation in lysoglycerophospholipid levels and cell death in leukemia cells
10.1007/s11306-020-01710-1 · 2020 · External reference
10.1371/journal.pone.0000880
10.1371/journal.pone.0000880 · External reference
10.1021/acs.jcim.1c01514
10.1021/acs.jcim.1c01514 · External reference
10.1101/2023.11.24.568551
10.1101/2023.11.24.568551 · External reference
10.1016/j.jbc.2021.101012
10.1016/j.jbc.2021.101012 · External reference
10.1016/j.csbj.2022.06.054 · Admitted local publication
10.1002/jcc.23354
10.1002/jcc.23354 · External reference
10.1002/(sici)1521-3773(19990115)38:1/2<236::aid-anie236>3.0.co;2-m
10.1002/(sici)1521-3773(19990115)38:1/2<236::aid-anie236>3.0.co;2-m · External reference
10.1063/1.448118
10.1063/1.448118 · External reference
10.1063/1.449071
10.1063/1.449071 · External reference
10.1063/1.328693
10.1063/1.328693 · External reference
10.1080/00268978300102851
10.1080/00268978300102851 · External reference
10.1002/(sici)1096-987x(199709)18:12<1463::aid-jcc4>3.0.co;2-h
10.1002/(sici)1096-987x(199709)18:12<1463::aid-jcc4>3.0.co;2-h · External reference
10.1063/1.464397
10.1063/1.464397 · External reference
10.1063/1.470117
10.1063/1.470117 · External reference
10.1093/nar/gkaa971
10.1093/nar/gkaa971 · External reference
Gypsum-DL: an open-source program for preparing small-molecule libraries for structure-based virtual screening
10.1186/s13321-019-0358-3 · 2019 · External reference
10.1038/onc.2012.292
10.1038/onc.2012.292 · External reference
10.4155/bio.09.128
10.4155/bio.09.128 · External reference
Open babel: an open chemical toolbox
10.1186/1758-2946-3-33 · 2011 · External reference
CHARMM general force field: a force field for drug‐like molecules compatible with the CHARMM all‐atom additive biological force fields
10.1002/jcc.21367 · 2010 · External reference
Additive CHARMM36 force field for nonstandard amino acids
10.1021/acs.jctc.1c00254 · 2021 · External reference
MDAnalysis: a toolkit for the analysis of molecular dynamics simulations
10.1002/jcc.21787 · 2011 · External reference
10.1016/j.softx.2015.06.001 · 2015 · Admitted local publication
10.1080/15548627.2020.1847443
10.1080/15548627.2020.1847443 · External reference
Investigating the lipid fingerprint of SLC6 neurotransmitter transporters: a comparison of dDAT, hDAT, hSERT, and GlyT2
10.1016/j.bbadva.2021.100010 · 2021 · External reference
10.1016/j.bpj.2018.01.033
10.1016/j.bpj.2018.01.033 · External reference
10.3390/cells11050875
10.3390/cells11050875 · External reference
10.15252/embj.2022112677
10.15252/embj.2022112677 · External reference
Quantitative profiling of lysosomal lipidome by shotgun lipidomics
10.1007/978-1-4939-6934-0_2 · 2017 · External reference
Galactosyl- and glucosylsphingosine induce lysosomal membrane permeabilization and cell death in cancer cells
10.1371/journal.pone.0277058 · 2022 · External reference
10.1111/tra.12715
10.1111/tra.12715 · External reference
Trifluoperazine causes a disturbance in glycerophospholipid monolayers containing phosphatidylserine (PS): effects of pH, acyl unsaturation, and proportion of PS
10.1021/la061628b · 2007 · External reference
Amphiphilic drug-like molecules accumulate in a membrane below the head group region
10.1021/jp4112052 · 2014 · External reference
10.3390/ph14101062
10.3390/ph14101062 · External reference
Molecular dynamics simulations of the interactions of medicinal plant extracts and drugs with lipid bilayer membranes
10.1111/febs.12286 · 2013 · External reference
Drug-lipid membrane interaction mechanisms revealed through molecular simulations
10.2174/1877946811202040379 · 2012 · External reference
