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References from Mechanistic insights into P-glycoprotein ligand transport and inhibition revealed by enhanced molecular dynamics simulations. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1146/annurev-biochem-011520-105201
10.1146/annurev-biochem-011520-105201 · External reference
ABC transporters: from microorganisms to man
10.1146/annurev.cb.08.110192.000435 · 1992 · External reference
10.1038/nrm2646
10.1038/nrm2646 · External reference
Blood–brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P‐glycoprotein on a novel verapamil influx carrier.
10.1111/bph.13376 · 2016 · External reference
Evaluation of transporters in drug development: current status and contemporary issues
10.1016/j.addr.2017.07.020 · 2017 · External reference
10.1016/j.addr.2015.03.006
10.1016/j.addr.2015.03.006 · External reference
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
10.1016/0005-2736(76)90160-7 · 1976 · External reference
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
10.1073/pnas.86.2.695 · 1989 · External reference
10.1016/j.bbamem.2017.10.028
10.1016/j.bbamem.2017.10.028 · External reference
10.1021/acs.biochem.2c00056
10.1021/acs.biochem.2c00056 · External reference
10.2217/14622416.9.1.105
10.2217/14622416.9.1.105 · External reference
10.1124/dmd.113.056176
10.1124/dmd.113.056176 · External reference
Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors
1982 · External reference
10.1016/s0021-9258(18)61633-3
10.1016/s0021-9258(18)61633-3 · External reference
Drug-resistance in multiple myeloma and non-Hodgkin’s lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy
10.1200/jco.1989.7.4.415 · 1989 · External reference
Three decades of P-gp inhibitors: skimming through several generations and scaffolds
10.2174/092986712800167392 · 2012 · External reference
Structure–activity relationships of tariquidar analogs as multidrug resistance modulators
10.1208/s12248-009-9118-z · 2009 · External reference
10.1586/14737140.7.4.447
10.1586/14737140.7.4.447 · External reference
10.1146/annurev-biophys-111622-091232
10.1146/annurev-biophys-111622-091232 · External reference
10.3390/molecules28020495
10.3390/molecules28020495 · External reference
10.1073/pnas.2010264117
10.1073/pnas.2010264117 · External reference
10.1021/acs.jmedchem.1c01272
10.1021/acs.jmedchem.1c01272 · External reference
10.1126/science.aav7102
10.1126/science.aav7102 · External reference
10.1126/science.aar7389
10.1126/science.aar7389 · External reference
10.3390/membranes11120923
10.3390/membranes11120923 · External reference
10.1002/pro.2387
10.1002/pro.2387 · External reference
10.1124/mol.58.3.624
10.1124/mol.58.3.624 · External reference
10.1021/ci400195v
10.1021/ci400195v · External reference
10.1038/s41586-023-05854-7
10.1038/s41586-023-05854-7 · External reference
10.1126/science.ade2216
10.1126/science.ade2216 · External reference
Phosphorylation by protein kinase C and cyclic AMP-dependent protein kinase of synthetic peptides derived from the linker region of human P-glycoprotein
10.1042/bj2990309 · 1994 · External reference
Phosphorylation site mutations in the human multidrug transporter modulate its drug-stimulated ATPase activity
10.1074/jbc.272.37.23165 · 1997 · External reference
10.1074/jbc.m116.755884
10.1074/jbc.m116.755884 · External reference
Unresolved reference
2003 · External reference
10.1002/jcc.20084
10.1002/jcc.20084 · External reference
10.1038/s41586-021-03819-2
10.1038/s41586-021-03819-2 · External reference
10.1093/nar/gkab1061
10.1093/nar/gkab1061 · External reference
10.1038/nprot.2010.5
10.1038/nprot.2010.5 · External reference
10.1038/nmeth.3213
10.1038/nmeth.3213 · External reference
CHARMM general force field: a force field for drug‐like molecules compatible with the CHARMM all‐atom additive biological force fields
10.1002/jcc.21367 · 2010 · External reference
10.1002/jcc.20945
10.1002/jcc.20945 · External reference
10.1021/acs.jctc.5b00935
10.1021/acs.jctc.5b00935 · External reference
CHARMM-GUI ligand reader and modeler for CHARMM force field generation of small molecules: CHARMM-GUI ligand reader and modeler for CHARMM force field generation of small molecules
10.1002/jcc.24829 · 2017 · External reference
Multiscale molecular dynamics simulations of lipid interactions with P-glycoprotein in a complex membrane
10.1016/j.jmgm.2017.12.022 · 2018 · External reference
10.1002/pro.4219
10.1002/pro.4219 · External reference
10.1093/nar/gkr703
10.1093/nar/gkr703 · External reference
10.1002/jcc.23354
10.1002/jcc.23354 · External reference
10.1021/jp101759q
10.1021/jp101759q · External reference
10.1016/j.softx.2015.06.001 · Admitted local publication
Unresolved reference
External reference
10.1063/1.447334
10.1063/1.447334 · External reference
10.1063/1.328693
10.1063/1.328693 · External reference
10.1063/1.464397
10.1063/1.464397 · External reference
10.1002/(sici)1096-987x(199709)18:12<1463::aid-jcc4>3.0.co;2-h
10.1002/(sici)1096-987x(199709)18:12<1463::aid-jcc4>3.0.co;2-h · External reference
10.1016/j.csbj.2022.07.035
10.1016/j.csbj.2022.07.035 · External reference
10.1063/1.478259
10.1063/1.478259 · External reference
10.1016/j.cpc.2013.09.018
10.1016/j.cpc.2013.09.018 · External reference
10.1021/ct400341p
10.1021/ct400341p · External reference
10.1002/bip.360221211
10.1002/bip.360221211 · External reference
A novel evaluation of residue and protein volumes by means of laguerre tessellation
10.1021/ci9004892 · 2010 · External reference
Integrating protein structural dynamics and evolutionary analysis with Bio3D
10.1186/s12859-014-0399-6 · 2014 · External reference
10.1063/5.0020974
10.1063/5.0020974 · External reference
Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening
2020 · External reference
10.1016/0263-7855(96)00018-5
10.1016/0263-7855(96)00018-5 · External reference
Unresolved reference
External reference
Structures of ABCB4 provide insight into phosphatidylcholine translocation
10.1073/pnas.2106702118 · 2021 · External reference
10.1126/science.1168750
10.1126/science.1168750 · External reference
10.1107/s2052252520005709
10.1107/s2052252520005709 · External reference
10.1085/jgp.201711907
10.1085/jgp.201711907 · External reference
10.1016/j.bpj.2019.12.016
10.1016/j.bpj.2019.12.016 · External reference
10.1021/acs.jmedchem.2c02005
10.1021/acs.jmedchem.2c02005 · External reference
10.1021/acsomega.2c08273
10.1021/acsomega.2c08273 · External reference
Cysteines introduced into extracellular loops 1 and 4 of human P-glycoprotein that are close only in the open conformation spontaneously form a disulfide bond that inhibits drug efflux and ATPase activity
10.1074/jbc.m114.583021 · 2014 · External reference
10.1371/journal.pcbi.1002036
10.1371/journal.pcbi.1002036 · External reference
10.3390/ijms21114058
10.3390/ijms21114058 · External reference
10.1038/nature21414
10.1038/nature21414 · External reference
Exploring movement and energy in human P-glycoprotein conformational rearrangement
10.1080/07391102.2018.1461133 · 2019 · External reference
Efflux dynamics of the antiseizure drug, levetiracetam, through the P-glycoprotein channel revealed by advanced comparative molecular simulations
10.1038/s41598-022-17994-3 · 2022 · External reference
10.1021/ct300083m
10.1021/ct300083m · External reference
10.1002/minf.201200175
10.1002/minf.201200175 · External reference
10.1016/j.cell.2021.12.009
10.1016/j.cell.2021.12.009 · External reference
The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane
10.1073/pnas.162366399 · 2002 · External reference
10.1107/s1399004715000978
10.1107/s1399004715000978 · External reference
10.3390/ijms23010362
10.3390/ijms23010362 · External reference
10.3390/molecules25246006
10.3390/molecules25246006 · External reference
A review on dynamics of permeability-glycoprotein in efflux of chemotherapeutic drugs
10.3389/fddsv.2024.1363364 · 2024 · External reference
10.1074/jbc.m109.047290
10.1074/jbc.m109.047290 · External reference
10.1016/j.tox.2024.153732
10.1016/j.tox.2024.153732 · External reference
Locking intracellular helices 2 and 3 together inactivates human P-glycoprotein
10.1074/jbc.m113.527804 · 2014 · External reference
10.1074/jbc.m100407200
10.1074/jbc.m100407200 · External reference
10.3390/molecules27217383
10.3390/molecules27217383 · External reference
10.1371/journal.pone.0082463
10.1371/journal.pone.0082463 · External reference
Linker domains: why ABC transporters ‘live in fragments no longer’
10.1016/j.tibs.2019.11.004 · 2020 · External reference
