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References from Simulation- and AI-directed optimization of 4,6-substituted 1,3,5-triazin-2(1 H )-ones as inhibitors of human DNA topoisomerase IIα. Local targets link to admitted publications; unresolved targets remain external evidence.
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Cancer statistics, 2021
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Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue
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Structural basis for allosteric regulation of Human Topoisomerase IIα
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Monocyclic 4-amino-6-(phenylamino)-1,3,5-triazines as inhibitors of human DNA topoisomerase IIα
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4,6-Substituted-1,3,5-triazin-2(1H)-ones as monocyclic catalytic inhibitors of human DNA topoisomerase IIα targeting the ATP binding site
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Discovery of a new class of catalytic topoisomerase II inhibitors targeting the ATP-binding site by structure based design. Part I
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Topoisomerase II-α expression in different cell cycle phases in fresh human breast carcinomas
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10.1093/oxfordjournals.annonc.a058700 · External reference
Expression of DNA topoisomerase IIα: clinical significance in laryngeal carcinoma
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Detection of human topoisomerase IIα in cell lines and tissues: characterization of five novel monoclonal antibodies
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Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues
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Carbocation Catalyzed Bromination of Alkyl Arenes, a Chemoselective sp3vs. sp2C−H functionalization
10.1002/adsc.201800788 · 2018 · External reference
Quinoline carboxamide-type ABCG2 modulators: indole and quinoline moieties as anilide replacements
10.1002/cmdc.201300319 · 2013 · External reference
Enantioselective Intermolecular [2 + 2] Photocycloaddition Reactions of 2(1H)-Quinolones Induced by Visible Light Irradiation
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10.1021/acs.jcim.0c00202
10.1021/acs.jcim.0c00202 · External reference
Dynophore-based approach in virtual screening: a case of human DNA topoisomerase IIα
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Bioassays and in silico methods in the identification of human DNA topoisomerase IIα inhibitors
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10.1006/jmbi.1996.0897 · 1997 · External reference
Catalytic mechanism of ATP hydrolysis in the ATPase domain of human DNA topoisomerase IIα
10.1021/acs.jcim.2c00303 · 2022 · External reference
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10.1074/jbc.m116.735431
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The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities
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