Research graph
References from Insights into the structure of NLR family member X1: Paving the way for innovative drug discovery. Local targets link to admitted publications; unresolved targets remain external evidence.
Targeting the NLRP3 inflammasome in inflammatory diseases
10.1038/nrd.2018.97 · 2018 · External reference
10.1242/jcs.051193
10.1242/jcs.051193 · External reference
10.1111/imm.13291
10.1111/imm.13291 · External reference
NLRX1 modulates immunometabolic mechanisms controlling the host-gut microbiota interactions during inflammatory bowel disease
10.3389/fimmu.2018.00363 · 2018 · External reference
NOD-like receptor X1 functions as a tumor suppressor by inhibiting epithelial-mesenchymal transition and inducing aging in hepatocellular carcinoma cells
10.1186/s13045-018-0573-9 · 2018 · External reference
The innate immune receptor NLRX1 functions as a tumor suppressor by reducing colon tumorigenesis and key tumor-promoting signals
10.1016/j.celrep.2016.02.064 · 2016 · External reference
10.1016/j.bbadis.2019.02.018
10.1016/j.bbadis.2019.02.018 · External reference
10.18632/oncotarget.23208
10.18632/oncotarget.23208 · External reference
10.3233/jpd-223338
10.3233/jpd-223338 · External reference
NF-kappaB signaling in inflammation
10.1038/sigtrans.2017.23 · 2017 · External reference
10.1016/j.immuni.2011.02.022
10.1016/j.immuni.2011.02.022 · External reference
10.1016/j.immuni.2011.03.026
10.1016/j.immuni.2011.03.026 · External reference
10.1016/j.immuni.2011.12.018
10.1016/j.immuni.2011.12.018 · External reference
NLRX1 is a multifaceted and enigmatic regulator of immune system function
10.3389/fimmu.2019.02419 · 2019 · External reference
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10.1038/nature06501
10.1038/nature06501 · External reference
10.1038/sj.embor.7401161
10.1038/sj.embor.7401161 · External reference
Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation
10.1073/pnas.2121353119 · 2022 · External reference
10.1038/s41586-022-04467-w
10.1038/s41586-022-04467-w · External reference
10.1126/science.1236381
10.1126/science.1236381 · External reference
10.1126/science.aac5789
10.1126/science.aac5789 · External reference
10.1038/cr.2017.148
10.1038/cr.2017.148 · External reference
Genetic intolerance analysis as a tool for protein science
2020 · External reference
MTR-Viewer: Identifying regions within genes under purifying selection
2019 · External reference
10.1126/science.1143690
10.1126/science.1143690 · External reference
10.1038/s41586-022-05621-0
10.1038/s41586-022-05621-0 · External reference
Allosteric control of Ubp6 and the proteasome via a bidirectional switch
10.1038/s41467-022-28186-y · 2022 · External reference
Crystal structure and biochemical characterization of a Mycobacterium smegmatis AAA-Type nucleoside triphosphatase phosphohydrolase (Msm0858)
10.1128/jb.00905-15 · 2016 · External reference
10.1038/s41586-022-05231-w
10.1038/s41586-022-05231-w · External reference
Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6
10.1038/s41467-020-18067-7 · 2020 · External reference
HDOCK update for modeling protein-RNA/DNA complex structures
2022 · External reference
A knowledge-based scoring function for protein-RNA interactions derived from a statistical mechanics-based iterative method
10.1093/nar/gku077 · 2014 · External reference
Activation of NLRX1 by NX-13 alleviates inflammatory bowel disease through immunometabolic mechanisms in CD4(+) T cells
10.4049/jimmunol.1900364 · 2019 · External reference
Exploratory studies with NX-13: Oral toxicity and pharmacokinetics in rodents of an orally active, gut-restricted first-in-class therapeutic for IBD that targets NLRX1
10.1080/01480545.2019.1679828 · 2019 · External reference
The safety, tolerability, pharmacokinetics, and clinical efficacy of the NLRX1 agonist NX-13 in active ulcerative colitis: results of a phase 1b study
10.1093/ecco-jcc/jjad192 · 2024 · External reference
Detection of cave pockets in large molecules: Spaces into which internal probes can enter, but external probes from outside cannot
10.2142/biophysico.16.0_391 · 2019 · External reference
10.1002/prot.22639
10.1002/prot.22639 · External reference
10.1002/prot.21283
10.1002/prot.21283 · External reference
Modeling-enabled characterization of novel NLRX1 ligands
2015 · External reference
10.1038/nrm1684
10.1038/nrm1684 · External reference
ATP-binding and hydrolysis of human NLRP3
10.1038/s42003-022-04120-2 · 2022 · External reference
10.1002/iub.1210
10.1002/iub.1210 · External reference
10.1074/jbc.m114.598227
10.1074/jbc.m114.598227 · External reference
10.1016/j.immuni.2012.03.002
10.1016/j.immuni.2012.03.002 · External reference
10.1038/sj.embor.7401161
10.1038/sj.embor.7401161 · External reference
10.1038/ni.3853
10.1038/ni.3853 · External reference
10.1002/cpbi.3
10.1002/cpbi.3 · External reference
10.1038/s41586-021-03819-2
10.1038/s41586-021-03819-2 · External reference
10.1110/ps.062416606
10.1110/ps.062416606 · External reference
DynaMut: Predicting the impact of mutations on protein conformation, flexibility and stability
10.1093/nar/gky300 · 2018 · External reference
DALI shines a light on remote homologs: one hundred discoveries
10.1002/pro.4519 · 2023 · External reference
ConSurf-DB: An accessible repository for the evolutionary conservation patterns of the majority of PDB proteins
10.1002/pro.3779 · 2020 · External reference
10.1093/nar/gkw408
10.1093/nar/gkw408 · External reference
10.1038/s41596-020-0312-x
10.1038/s41596-020-0312-x · External reference
Molecular basis of double-stranded RNA-protein interactions: structure of a dsRNA-binding domain complexed with dsRNA.
10.1093/emboj/17.24.7505 · 1998 · External reference
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
10.1002/jcc.21334 · 2010 · External reference
