Research graph
References from NaCTR: Natural product-derived compound-based drug discovery pipeline from traditional oriental medicine by search space reduction. Local targets link to admitted publications; unresolved targets remain external evidence.
Innovation in the pharmaceutical industry: new estimates of r&d costs
10.1016/j.jhealeco.2016.01.012 · 2016 · External reference
10.1038/nrd.2018.168
10.1038/nrd.2018.168 · External reference
10.1038/nrd4309
10.1038/nrd4309 · External reference
Refining the impact of genetic evidence on clinical success
2024 · External reference
Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at novartis institute of biomedical research
2014 · External reference
The clinical trials puzzle: how network effects limit drug discovery
2023 · External reference
10.1038/s41573-023-00774-7
10.1038/s41573-023-00774-7 · External reference
10.3390/ijms19061578
10.3390/ijms19061578 · External reference
10.3390/molecules21050559
10.3390/molecules21050559 · External reference
10.3390/healthcare9030257
10.3390/healthcare9030257 · External reference
Molecular understanding and modern application of traditional medicines: triumphs and trials
10.1016/j.cell.2007.08.021 · 2007 · External reference
Traditional medicine: a culture in the balance
10.1038/448126a · 2007 · External reference
Tcm: made in China
10.1038/480s82a · 2011 · External reference
Harnessing nature's wisdom: turning to nature for inspiration and avoiding her follies
10.1038/embor.2008.160 · 2008 · External reference
10.1038/s41573-020-00114-z
10.1038/s41573-020-00114-z · External reference
10.1038/nbt.3167
10.1038/nbt.3167 · External reference
Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019
10.1021/acs.jnatprod.9b01285 · 2020 · External reference
10.1038/nm.2471
10.1038/nm.2471 · External reference
10.1016/j.tips.2005.09.006
10.1016/j.tips.2005.09.006 · External reference
What has traditional Chinese medicine delivered for modern medicine?
10.1017/erm.2018.3 · 2018 · External reference
Network medicine framework reveals generic herb-symptom effectiveness of traditional Chinese medicine
2023 · External reference
The role and advantage of traditional Chinese medicine in the prevention and treatment of covid-19
2023 · External reference
10.1093/bib/bbz103
10.1093/bib/bbz103 · External reference
Omim. org: leveraging knowledge across phenotype–gene relationships
10.1093/nar/gky1151 · 2019 · External reference
Disgenet: a discovery platform for the dynamical exploration of human diseases and their genes
2015 · External reference
10.1093/nar/gkad751
10.1093/nar/gkad751 · External reference
10.1093/nar/gkac833
10.1093/nar/gkac833 · External reference
10.1093/nar/gkad1004
10.1093/nar/gkad1004 · External reference
Unresolved reference
External reference
A data-driven approach for identifying medicinal combinations of natural products
10.1109/access.2018.2874089 · 2018 · External reference
Parkinson disease
2017 · External reference
Unresolved reference
External reference
10.1093/bioinformatics/btp697
10.1093/bioinformatics/btp697 · External reference
Bindingdb in 2015: a public database for medicinal chemistry, computational chemistry and systems pharmacology
10.1093/nar/gkv1072 · 2016 · External reference
Drugbank 5.0: a major update to the drugbank database for 2018
10.1093/nar/gkx1037 · 2018 · External reference
Unresolved reference
External reference
Tcmid 2.0: a comprehensive resource for tcm
10.1093/nar/gkx1028 · 2018 · External reference
Cmaup: a database of collective molecular activities of useful plants
10.1093/nar/gky965 · 2019 · External reference
Traditional Chinese medicine information database
10.1016/j.clpt.2005.03.010 · 2005 · External reference
10.1093/nar/gkx1026
10.1093/nar/gkx1026 · External reference
10.1021/ci300367a
10.1021/ci300367a · External reference
10.3390/ijms23094508
10.3390/ijms23094508 · External reference
10.1016/s1474-4422(18)30295-3
10.1016/s1474-4422(18)30295-3 · External reference
Parkinson disease-associated cognitive impairment
2021 · External reference
The burden of Parkinson's disease on society, family, and the individual
10.1111/j.1532-5415.1997.tb01512.x · 1997 · External reference
Current and projected future economic burden of Parkinson's disease in the us
10.1038/s41531-020-0117-1 · 2020 · External reference
Diagnosis and treatment of Parkinson disease: a review
10.1001/jama.2019.22360 · 2020 · External reference
The history of Parkinson's disease: early clinical descriptions and neurological therapies
2011 · External reference
Systematic review of the prevalence and incidence of Parkinson's disease in Asia
10.2188/jea.je20081034 · 2009 · External reference
Traditional and complementary therapies in Parkinson's disease
1999 · External reference
Ancient Chinese description of Parkinson's disease
10.1016/j.parkreldis.2017.11.224 · 2018 · External reference
Therapeutic history of Parkinson's disease in Chinese medical treatises
10.1089/acm.2009.0101 · 2009 · External reference
Molecularly and clinically related drugs and diseases are enriched in phenotypically similar drug-disease pairs
2014 · External reference
10.3390/molecules25173926
10.3390/molecules25173926 · External reference
Anti-inflammatory role of prunus persica l. batsch methanol extract on lipopolysaccharide-stimulated glial cells
2020 · External reference
Tomato (solanum lycopersicum l.) seed: a review on bioactives and biomedical activities
2021 · External reference
10.3390/biomedicines10082009
10.3390/biomedicines10082009 · External reference
Effect of papaya supplementation on oxidative stress markers in parkinsons disease
10.5455/oams.190416.or.096 · 2016 · External reference
Anti-cholinesterase and antioxidant properties of alkaloid and phenolic-rich extracts from pawpaw (carica papaya) leaf: a comparative study
10.1002/ffj.3615 · 2021 · External reference
Toxicological screening
10.4103/0976-500x.81895 · 2011 · External reference
cardiotoxcsm: a web server for predicting cardiotoxicity of small molecules
10.1021/acs.jcim.2c00822 · 2022 · External reference
Accurate prediction of human oral bioavailability for small molecules
2022 · External reference
Toxstar: drug-induced liver injury prediction tool for the web environment
10.1093/bioinformatics/btac490 · 2022 · External reference
10.1007/978-1-4612-4828-6_10
10.1007/978-1-4612-4828-6_10 · 1987 · External reference
Unresolved reference
2024 · External reference
An overview of clinical pharmacology of ibuprofen
10.5001/omj.2010.49 · 2010 · External reference
Levodopa-induced abnormal involuntary movements correlate with altered permeability of the blood-brain-barrier in the basal ganglia
2017 · External reference
Role of two efflux proteins, abcb1 and abcg2 in blood-brain barrier transport of bromocriptine in a murine model of mptp-induced dopaminergic degeneration
10.18433/j3b596 · 2009 · External reference
Effect of entacapone, a peripherally acting catechol-o-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease
10.1136/jnnp.57.2.186 · 1994 · External reference
Enrichr: interactive and collaborative html5 gene list enrichment analysis tool
2013 · External reference
Central nervous system uptake of intranasal glutathione in Parkinson's disease
2016 · External reference
10.3390/ijms22168689
10.3390/ijms22168689 · External reference
Tyrosine hydroxylase is inactivated by catechol-quinones and converted to a redox-cycling quinoprotein: possible relevance to Parkinson's disease
10.1046/j.1471-4159.1999.0731309.x · 1999 · External reference
10.1126/science.1063522
10.1126/science.1063522 · External reference
Antioxidant role of glutathione s-transferases: 4-hydroxynonenal, a key molecule in stress-mediated signaling
10.1016/j.taap.2015.10.006 · 2015 · External reference
Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson's disease
10.1002/mds.22401 · 2009 · External reference
Phase iib study of intranasal glutathione in Parkinson's disease
10.3233/jpd-161040 · 2017 · External reference
Potential use of glutathione as a treatment for Parkinson's disease
2021 · External reference
Phenolic compounds of therapeutic interest in neuroprotection
10.3390/jox14010014 · 2024 · External reference
Neurological and psychiatric management using comt inhibitors: a review
2020 · External reference
10.1021/acsmedchemlett.3c00272
10.1021/acsmedchemlett.3c00272 · External reference
Compounds against inflammation and oxidative insult as potential agents for neurodegenerative disorders
10.1007/s00044-011-9726-x · 2012 · External reference
Amine-related neurotoxins in Parkinson's disease: past, present, and future
10.1016/s0892-0362(02)00209-x · 2002 · External reference
10.1016/j.cell.2017.10.049
10.1016/j.cell.2017.10.049 · External reference
