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References from Repurposing thioridazine as a potential CD2068 inhibitor to mitigate antibiotic resistance in Clostridioides difficile infection. Local targets link to admitted publications; unresolved targets remain external evidence.
Influence of antibiotic exposure intensity on the risk of Clostridioides difficile infection
2024 · External reference
Update on antimicrobial resistance in Clostridium difficile: resistance mechanisms and antimicrobial susceptibility testing
10.1128/jcm.02250-16 · 2017 · External reference
Insights into drug resistance mechanisms in Clostridium difficile.
10.1042/ebc20160062 · 2017 · External reference
10.1016/j.csbj.2021.05.012 · Admitted local publication
CD2068 potentially mediates multidrug efflux in Clostridium difficile.
10.1038/s41598-017-10155-x · 2017 · External reference
Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)
10.1093/cid/cix1085 · 2018 · External reference
10.1093/nar/gky427
10.1093/nar/gky427 · External reference
Ab initio modeling of small proteins by iterative TASSER simulations
2007 · External reference
10.1073/pnas.1914677117
10.1073/pnas.1914677117 · External reference
10.1093/nar/gkh468
10.1093/nar/gkh468 · External reference
Tools for comparative protein structure modeling and analysis
10.1093/nar/gkg543 · 2003 · External reference
10.1126/science.abj8754
10.1126/science.abj8754 · External reference
10.1038/s41586-021-03819-2
10.1038/s41586-021-03819-2 · External reference
mTM-align: a server for fast protein structure database search and multiple protein structure alignment
2018 · External reference
10.1002/pro.3943
10.1002/pro.3943 · External reference
10.1002/jcc.21334
10.1002/jcc.21334 · External reference
5.0: a major update to the DrugBank database for 2018
10.1093/nar/gkx1037 · 2018 · External reference
Open Babel: an open chemical toolbox
10.1186/1758-2946-3-33 · 2011 · External reference
Scalable algorithms for molecular dynamics simulations on commodity clusters
2006 · External reference
Extraction and quantification of polyphosphate in the budding yeast Saccharomyces cerevisiae
10.21769/bioprotoc.1874 · 2016 · External reference
Unresolved reference
External reference
Methods for in vitro evaluating antimicrobial activity: a review
10.1016/j.jpha.2015.11.005 · 2016 · External reference
Auranofin, at clinically achievable dose, protects mice and prevents recurrence from Clostridioides difficile infection
10.1038/s41598-020-64882-9 · 2020 · External reference
Thioridazine induces major changes in global gene expression and cell wall composition in methicillin-resistant Staphylococcus aureus USA300
10.1371/journal.pone.0064518 · 2013 · External reference
Thioridazine reduces resistance of methicillin-resistant Staphylococcus aureus by inhibiting a reserpine-sensitive efflux pump
2006 · External reference
A comparative analysis of in vitro and in vivo efficacies of the enantiomers of thioridazine and its racemate
10.1371/journal.pone.0057493 · 2013 · External reference
In vitro activity of phenothiazine derivatives in Enterococcus faecalis and Enterococcus faecium
10.1111/j.1742-7843.2005.pto960105.x · 2005 · External reference
Phenothiazines alter resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) to oxacillin in vitro
10.1016/s0924-8579(03)00200-0 · 2003 · External reference
Systemic thioridazine in combination with dicloxacillin against early aortic graft infections caused by Staphylococcus aureus in a porcine model: in vivo results do not reproduce the in vitro synergistic activity
10.1371/journal.pone.0173362 · 2017 · External reference
Modified mouse model of Clostridioides difficile infection as a platform for probiotic efficacy studies
10.1128/aac.00111-19 · 2019 · External reference
10.1053/j.gastro.2020.09.036
10.1053/j.gastro.2020.09.036 · External reference
10.1128/msphere
10.1128/msphere · External reference