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References from Predicted conformations of 5-HT3 receptor ion channels are modified by subunit D. Local targets link to admitted publications; unresolved targets remain external evidence.
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Gating mechanisms in Cys-loop receptors
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Structure, function and physiology of 5-hydroxytryptamine receptors subtype 3
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Tapping into 5-HT(3) receptors to modify metabolic and immune responses
2021 · External reference
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A gating mechanism of the serotonin 5-HT3 receptor
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Agonists and antagonists bind to an A-A interface in the heteromeric 5-HT3AB receptor
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Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E
10.1002/cne.22525 · 2011 · External reference
Subtle differences among 5-HT3AC, 5-HT3AD, and 5-HT3AE receptors are revealed by partial agonists
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Visualising functional 5-HT3 receptors containing A and C subunits at or near the cell surface
10.1016/j.biopha.2020.110860 · 2020 · External reference
A cluster of novel serotonin receptor 3-like genes on human chromosome 3
2003 · External reference
Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E
10.1016/s0378-1119(03)00503-1 · 2003 · External reference
10.1016/j.pharmthera.2010.07.001
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Heterogeneity amongst 5-HT₃ receptor subunits: is this significant?
10.2174/156652411794474392 · 2011 · External reference
Phylogenetic analyses of 5-hydroxytryptamine 3 (5-HT3) receptors in Metazoa
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Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E
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The GeneCards suite: from gene data mining to disease genome sequence analyses
10.1002/cpbi.5 · 2016 · External reference
The human serotonin type 3 receptor gene (HTR3A-E) allelic variant database
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Common variants of HTR3 genes are associated with obsessive-compulsive disorder and its phenotypic expression
10.1038/srep32564 · 2016 · External reference
Exploring association between serotonin and neurogenesis related genes in obsessive-compulsive disorder in Chinese Han people: promising association between DMRT2, miR-30a-5p, and early-onset patients
10.3389/fpsyt.2022.857574 · 2022 · External reference
5-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option
10.1016/j.euroneuro.2013.07.003 · 2014 · External reference
Genetic association of the PARL-ABCC5-HTR3D-HTR3C locus with primary angle-closure glaucoma in Chinese
10.1167/iovs.17-22304 · 2017 · External reference
Multi-step gene set analysis identified HTR3 family genes involving childhood acute lymphoblastic leukemia susceptibility
2024 · External reference
The transmembrane domain of the 5-HT3 receptor: its role in selectivity and gating
10.1042/bst0320535 · 2004 · External reference
10.1085/jgp.201110686
10.1085/jgp.201110686 · External reference
10.1124/mol.114.094540
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Proline residues in the transmembrane/extracellular domain interface loops have different behaviors in 5-HT3 and nACh receptors
10.1021/acschemneuro.9b00315 · 2019 · External reference
Cryo-EM structure of 5-HT(3A) receptor in its resting conformation
10.1038/s41467-018-02997-4 · 2018 · External reference
Molecular mechanism of setron-mediated inhibition of full-length 5-HT(3A) receptor
10.1038/s41467-019-11142-8 · 2019 · External reference
High-resolution structures of multiple 5-HT(3A)R-setron complexes reveal a novel mechanism of competitive inhibition
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Folding non-homologous proteins by coupling deep-learning contact maps with I-TASSER assembly simulations
2021 · External reference
AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models
10.1093/nar/gkab1061 · 2022 · External reference
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10.1016/s0028-3908(97)00044-0
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10.1016/s0026-895x(24)23236-3
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Structure of tetrameric forms of the serotonin-gated 5-HT3(A) receptor ion channel
10.1038/s44318-024-00191-5 · 2024 · External reference
RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D, and -E subunits
10.1074/jbc.m110.122838 · 2010 · External reference
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10.1021/jp0604591 · External reference
An introduction to sequence similarity ("homology") searching
10.1002/0471250953.bi0301s42 · 2013 · External reference
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10.1016/j.bpj.2013.07.015 · External reference
The L293 residue in transmembrane domain 2 of the 5-HT3A receptor is a molecular determinant of allosteric modulation by 5-hydroxyindole
10.1016/j.neuropharm.2008.03.009 · 2008 · External reference
Mutagenic analysis of the intracellular portals of the human 5-HT3A receptor
10.1074/jbc.m113.503300 · 2013 · External reference
High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor
10.1073/pnas.0708454105 · 2008 · External reference
10.1097/fpc.0b013e328310f950
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Naturally occurring variations in the human 5-HT3A gene profoundly impact 5-HT3 receptor function and expression
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Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor
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A review of the literature on the relationships between genetic polymorphisms and chemotherapy-induced nausea and vomiting
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Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy
10.1007/s00432-008-0387-1 · 2008 · External reference
Association of ABCB1, 5-HT3B receptor and CYP2D6 genetic polymorphisms with ondansetron and metoclopramide antiemetic response in Indonesian cancer patients treated with highly emetogenic chemotherapy
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