References

Tumor biomarkers for diagnosis, prognosis and targeted therapy

10.1038/s41392-024-01823-2 · 2024 · External reference

10.1053/j.gastro.2019.01.259

10.1053/j.gastro.2019.01.259 · External reference

10.1016/j.semcancer.2025.02.009

10.1016/j.semcancer.2025.02.009 · External reference

Advances in biomarker research for pancreatic cancer

10.2174/13816128112092439 · 2012 · External reference

The clinical utility of CA 19-9 in pancreatic adenocarcinoma: diagnostic and prognostic updates

2013 · External reference

Identification of diagnostic biomarkers via weighted correlation network analysis in colorectal cancer using a system biology approach

10.1038/s41598-023-40953-5 · 2023 · External reference

Machine learning and weighted gene co-expression network analysis identify a three-gene signature to diagnose rheumatoid arthritis

10.3389/fimmu.2024.1387311 · 2024 · External reference

Weighted gene co-expression network analysis reveals key stromal prognostic markers in pancreatic cancer

10.1038/s41598-024-82563-9 · 2024 · External reference

Circular RNAs expression profiles in human gastric cancer

10.1038/s41598-017-09076-6 · 2017 · External reference

10.1016/j.csbj.2024.03.024 · Admitted local publication

Down regulation of cathepsin w is associated with poor prognosis in pancreatic cancer

10.1038/s41598-023-42928-y · 2023 · External reference

EPYC functions as a novel prognostic biomarker for pancreatic cancer

10.1038/s41598-024-51478-w · 2024 · External reference

Machine learning algorithms reveal potential miRNAs biomarkers in gastric cancer

10.1038/s41598-023-32332-x · 2023 · External reference

Machine learning-based identification of biomarkers and drugs in immunologically cold and hot pancreatic adenocarcinomas

10.1186/s12967-024-05590-0 · 2024 · External reference

Pan-cancer analysis of SERPINE family genes as biomarkers of cancer prognosis and response to therapy

10.3389/fmolb.2023.1277508 · 2024 · External reference

Machine learning algorithms and biomarkers identification for pancreatic cancer diagnosis using multi-omics data integration

10.1016/j.prp.2024.155602 · 2024 · External reference

Machine learning and network analyses reveal disease subtypes of pancreatic cancer and their molecular characteristics

10.1038/s41598-020-58290-2 · 2020 · External reference

Machine learning identifies SLC6A14 as a novel biomarker promoting the proliferation and metastasis of pancreatic cancer via Wnt/β-catenin signaling

10.1038/s41598-024-52646-8 · 2024 · External reference

In-silico identification of therapeutic targets in pancreatic ductal adenocarcinoma using WGCNA and trader

10.1038/s41598-024-74252-4 · 2024 · External reference

TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data

10.1093/nar/gkv1507 · 2016 · External reference

10.1371/journal.pcbi.1006701

10.1371/journal.pcbi.1006701 · External reference

10.1093/bioinformatics/bts034

10.1093/bioinformatics/bts034 · External reference

10.1093/bioinformatics/btp616

10.1093/bioinformatics/btp616 · External reference

10.1093/nar/gkv007

10.1093/nar/gkv007 · External reference

10.1186/gb-2014-15-2-r29

10.1186/gb-2014-15-2-r29 · External reference

10.1038/nprot.2009.97

10.1038/nprot.2009.97 · External reference

WGCNA: an r package for weighted correlation network analysis

10.1186/1471-2105-9-559 · 2008 · External reference

10.1089/omi.2011.0118

10.1089/omi.2011.0118 · External reference

Scikit-learn: machine learning in python

2011 · External reference

10.1613/jair.953

10.1613/jair.953 · External reference

Comparison of values of Pearson’s and Spearman’s correlation coefficients on the same sets of data

2011 · External reference

Package ‘survival’

2015 · External reference

Survminer: drawing survival curves using’ggplot2’

10.32614/cran.package.survminer · 2016 · External reference

ggplot2

10.1002/wics.147 · 2011 · External reference

Identification of survival-associated hub genes in pancreatic adenocarcinoma based on WGCNA

10.3389/fgene.2021.814798 · 2022 · External reference

Identification of novel potential homologous repair deficiency-associated genes in pancreatic adenocarcinoma via WGCNA coexpression network analysis and machine learning

10.1080/15384101.2023.2293594 · 2023 · External reference

Identification of the real hub gene and construction of a novel prognostic signature for pancreatic adenocarcinoma based on the weighted gene Co-expression network analysis and least absolute shrinkage and selection operator algorithms

10.3389/fgene.2021.692953 · 2021 · External reference

Significance of TP53, CDKN2A, SMAD4 and KRAS in pancreatic cancer

10.3390/cimb46040177 · 2024 · External reference

Mutations of p53 associated with pancreatic cancer and therapeutic implications

10.14701/ahbps.2021.25.3.315 · 2021 · External reference

10.3390/cells11142155

10.3390/cells11142155 · External reference

Multifaceted role for p53 in pancreatic cancer suppression

10.1073/pnas.2211937120 · 2023 · External reference

10.1158/1541-7786.mcr-16-0180

10.1158/1541-7786.mcr-16-0180 · External reference

Therapeutic efficacy of anti-MMP9 antibody in combination with nab-paclitaxel-based chemotherapy in pre-clinical models of pancreatic cancer

10.1111/jcmm.14242 · 2019 · External reference

Elevation of MMP-9 and IDO induced by pancreatic cancer cells mediates natural killer cell dysfunction

2014 · External reference

10.3390/biology9040080

10.3390/biology9040080 · External reference

Matrix metalloproteinase 2 (MMP-2) and its tissue inhibitor 2 (TIMP-2) in pancreatic cancer (PC)

10.18632/oncotarget.26571 · 2019 · External reference

TIMP-2 suppresses tumor growth and metastasis in murine model of triple-negative breast cancer

10.1093/carcin/bgz172 · 2020 · External reference

Over-expression and prognostic significance of FN1, correlating with immune infiltrates in thyroid cancer

10.3389/fmed.2021.812278 · 2022 · External reference

10.1186/s13046-021-01908-8

10.1186/s13046-021-01908-8 · External reference

The effect and clinical significance of FN1 expression on biological functions of gastric cancer cells

10.14715/cmb/2020.66.5.32 · 2020 · External reference

FN1 encoding fibronectin as a pivotal signaling gene for therapeutic intervention against pancreatic cancer

10.1007/s00438-022-01943-w · 2022 · External reference

10.3389/fimmu.2021.612271

10.3389/fimmu.2021.612271 · External reference

Loss of pancreatic E-cadherin causes pancreatitis-like changes and contributes to carcinogenesis

10.1016/j.jcmgh.2019.09.001 · 2020 · External reference

Worsened outcome in patients with pancreatic ductal carcinoma on long-term diabetes: association with E-cadherin1 (CDH1) promoter methylation

10.1038/s41598-017-18438-z · 2017 · External reference

GPRC5A is a potential oncogene in pancreatic ductal adenocarcinoma cells that is upregulated by gemcitabine with help from HuR

10.1038/cddis.2016.169 · 2016 · External reference

Integrated analysis of scRNA-seq and bulk RNA-seq reveals that GPRC5A is an important prognostic gene in pancreatic cancer and is associated with B-cell infiltration in pancreatic cancer

10.3389/fonc.2024.1283164 · 2024 · External reference

GPRC5A: an emerging prognostic biomarker for predicting malignancy of pancreatic cancer based on bioinformatics analysis

10.7150/jca.52578 · 2021 · External reference

Upregulated GPRC5A disrupting the hippo pathway promotes the proliferation and migration of pancreatic cancer cells via the cAMP-CREB axis

10.1007/s12672-023-00626-1 · 2023 · External reference

10.3390/jcm12010200

10.3390/jcm12010200 · External reference

Targeting the HGF/c-MET pathway in advanced pancreatic cancer: a key element of treatment that limits primary tumour growth and eliminates metastasis

10.1038/s41416-020-0782-1 · 2020 · External reference

IGF2BP2 promotes pancreatic carcinoma progression by enhancing the stability of B3GNT6 mRNA via m6A methylation

10.1002/cam4.5096 · 2023 · External reference

10.1080/15548627.2020.1826689

10.1080/15548627.2020.1826689 · External reference

Silencing Tspan1 inhibits migration and invasion, and induces the apoptosis of human pancreatic cancer cells

2018 · External reference

TSPAN1-elevated FAM110A promotes pancreatic cancer progression by transcriptionally regulating HIST1H2BK

10.7150/jca.66404 · 2022 · External reference

Deciphering the dual roles of PHD finger proteins from oncogenic drivers to tumor suppressors

10.3389/fcell.2024.1403396 · 2024 · External reference

Expression of PHF20 protein contributes to good prognosis of NSCLC and is associated with bax expression

2015 · External reference

PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65

10.1038/ncomms3062 · 2013 · External reference

MUC1 and metastatic cancer: expression, function and therapeutic targeting

10.4161/cam.23131 · 2013 · External reference

Mucin-1 protein is a prognostic marker for pancreatic ductal adenocarcinoma: results from the CONKO-001 study

10.3389/fonc.2021.670396 · 2021 · External reference

MUC1 induces acquired chemoresistance by upregulating ABCB1 in EGFR-dependent manner

2017 · External reference

MUC1 induces drug resistance in pancreatic cancer cells via upregulation of multidrug resistance genes

10.1038/oncsis.2013.16 · 2013 · External reference

The biology and role of CD44 in cancer progression: therapeutic implications

2018 · External reference

10.1158/1078-0432.ccr-15-3115

10.1158/1078-0432.ccr-15-3115 · External reference

10.21037/tgh.2019.06.02

10.21037/tgh.2019.06.02 · External reference

The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma

10.1038/nm.3548 · 2014 · External reference

10.1038/s41556-018-0122-3

10.1038/s41556-018-0122-3 · External reference

Design and activity of a murine and humanized anti-CEACAM6 single-chain variable fragment in the treatment of pancreatic cancer

10.1158/0008-5472.can-08-2707 · 2009 · External reference

Mature MUC5AC expression in resected pancreatic ductal adenocarcinoma predicts treatment response and outcomes

10.3390/ijms25169041 · 2024 · External reference

10.1158/0008-5472.can-19-2578

10.1158/0008-5472.can-19-2578 · External reference

Identification of fucosylated SERPINA1 as a novel plasma marker for pancreatic cancer using lectin affinity capture coupled with iTRAQ-based quantitative glycoproteomics

10.3390/ijms22116079 · 2021 · External reference

Soluble stroma-related biomarkers of pancreatic cancer

10.15252/emmm.201708741 · 2018 · External reference

FGFR2-fusions define a clinically actionable molecular subset of pancreatic cancer

10.1038/s41698-024-00683-x · 2024 · External reference

10.1038/s41388-020-01564-w

10.1038/s41388-020-01564-w · External reference

10.1016/j.ejca.2005.04.044

10.1016/j.ejca.2005.04.044 · External reference

SMAD4 endows TGF-β1-induced highly invasive tumor cells with ferroptosis vulnerability in pancreatic cancer

10.1038/s41401-023-01199-z · 2024 · External reference

10.1053/j.gastro.2023.10.026

10.1053/j.gastro.2023.10.026 · External reference

10.3389/fimmu.2012.00234

10.3389/fimmu.2012.00234 · External reference

Tumor Cell-Intrinsic SETD2 deficiency reprograms neutrophils to foster immune escape in pancreatic tumorigenesis

10.1002/advs.202202937 · 2023 · External reference

10.1038/s41591-018-0024-8

10.1038/s41591-018-0024-8 · External reference

Pan-cancer analysis predict that FAT1 is a therapeutic target and immunotherapy biomarker for multiple cancer types including non-small cell lung cancer

10.3389/fimmu.2024.1369073 · 2024 · External reference

NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma

10.1016/j.celrep.2022.111623 · 2022 · External reference

10.3390/ijms21228841

10.3390/ijms21228841 · External reference

10.3390/ijms25063285

10.3390/ijms25063285 · External reference

10.1158/0008-5472.can-20-4125

10.1158/0008-5472.can-20-4125 · External reference

10.1016/j.omto.2020.03.025

10.1016/j.omto.2020.03.025 · External reference

RRM2 promotes liver metastasis of pancreatic cancer by stabilizing YBX1 and activating the TGF-beta pathway

2024 · External reference

10.1016/j.biomaterials.2017.12.015

10.1016/j.biomaterials.2017.12.015 · External reference

Repurposing metformin, simvastatin and digoxin as a combination for targeted therapy for pancreatic ductal adenocarcinoma

10.1016/j.canlet.2020.08.002 · 2020 · External reference

BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study

10.1038/gim.2014.153 · 2015 · External reference

TGFB1/INHBA homodimer/nodal-SMAD2/3 signaling network: a pivotal molecular target in PDAC treatment

10.1016/j.ymthe.2021.01.002 · 2021 · External reference

10.1158/1078-0432.ccr-19-1398

10.1158/1078-0432.ccr-19-1398 · External reference

The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells

10.1038/ncomms12961 · 2016 · External reference

10.1038/s41416-020-0756-3

10.1038/s41416-020-0756-3 · External reference

Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma

2020 · External reference

LIM-only protein FHL2 critically determines survival and radioresistance of pancreatic cancer cells

10.1016/j.canlet.2015.04.019 · 2015 · External reference

Profile of MMP and TIMP expression in human pancreatic stellate cells: regulation by IL-1α and TGFβ and implications for migration of pancreatic cancer cells

10.1016/j.neo.2016.06.003 · 2016 · External reference

Mutant kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer

10.1038/s43018-020-00134-z · 2021 · External reference

NAD+ depletion by type I interferon signaling sensitizes pancreatic cancer cells to NAMPT inhibition

10.1073/pnas.2012469118 · 2021 · External reference

High expression of DDR1 is associated with the poor prognosis in Chinese patients with pancreatic ductal adenocarcinoma

2015 · External reference

Genomic loss of DUSP4 contributes to the progression of intraepithelial neoplasm of pancreas to invasive carcinoma

10.1158/0008-5472.can-15-1846 · 2016 · External reference

Manassantin a inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity

2023 · External reference

Quiescin sulfhydryl oxidase 1 promotes invasion of pancreatic tumor cells mediated by matrix metalloproteinases

10.1158/1541-7786.mcr-11-0018 · 2011 · External reference

Loss of ARID1A promotes epithelial–mesenchymal transition and sensitizes pancreatic tumors to proteotoxic stress

10.1158/0008-5472.can-19-3922 · 2021 · External reference

10.1016/j.cellsig.2019.109470

10.1016/j.cellsig.2019.109470 · External reference

10.1126/science.1200609

10.1126/science.1200609 · External reference

10.1158/0008-5472.can-20-1822

10.1158/0008-5472.can-20-1822 · External reference

USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities

2023 · External reference

10.1038/s42003-022-03994-6

10.1038/s42003-022-03994-6 · External reference

Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer

2020 · External reference

10.1158/2159-8290.cd-22-0043

10.1158/2159-8290.cd-22-0043 · External reference

10.1016/j.canlet.2011.04.010

10.1016/j.canlet.2011.04.010 · External reference

Isoforms of MUC16 activate oncogenic signaling through EGF receptors to enhance the progression of pancreatic cancer

10.1016/j.ymthe.2020.12.029 · 2021 · External reference

Expression and significance of CD44 and p-AKT in pancreatic head cancer

10.1186/s12957-015-0746-8 · 2015 · External reference

10.1038/onc.2013.487

10.1038/onc.2013.487 · External reference

Overexpression of laminin-5 gamma-2 promotes tumorigenesis of pancreatic ductal adenocarcinoma through EGFR/ERK1/2/AKT/mTOR cascade

10.1007/s00018-022-04392-1 · 2022 · External reference

S100 family proteins are linked to organoid morphology and EMT in pancreatic cancer

10.1038/s41418-023-01126-z · 2023 · External reference

ANLN-induced EZH2 upregulation promotes pancreatic cancer progression by mediating miR-218-5p/LASP1 signaling axis

10.1186/s13046-019-1340-7 · 2019 · External reference

10.1126/sciadv.adj3551

10.1126/sciadv.adj3551 · External reference

10.1158/1078-0432.ccr-11-1539

10.1158/1078-0432.ccr-11-1539 · External reference

Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer

2024 · External reference

10.1016/j.canlet.2021.06.027

10.1016/j.canlet.2021.06.027 · External reference

Targeting KRAS mutations in pancreatic cancer: opportunities for future strategies

10.3389/fmed.2024.1369136 · 2024 · External reference

10.1038/s41575-019-0245-4

10.1038/s41575-019-0245-4 · External reference

Multiple roles of mucins in pancreatic cancer, a lethal and challenging malignancy

10.1038/sj.bjc.6602163 · 2004 · External reference

10.1038/nrgastro.2013.120

10.1038/nrgastro.2013.120 · External reference

10.1038/sj.bjc.6602232

10.1038/sj.bjc.6602232 · External reference

MUC1 induces drug resistance in pancreatic cancer cells via upregulation of multidrug resistance genes

10.1038/oncsis.2013.16 · 2013 · External reference

The MUC1–HIF-1α signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling

10.1073/pnas.2315509121 · 2024 · External reference

Expression of MUC1 in different tumours and its clinical significance

10.3892/mco.2022.2594 · 2022 · External reference

MUC3A promotes non-small cell lung cancer progression via activating the NFκB pathway and attenuates radiosensitivity

10.7150/ijbs.59430 · 2021 · External reference

GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin

10.1038/onc.2010.459 · 2011 · External reference

10.1016/j.cell.2014.01.066

10.1016/j.cell.2014.01.066 · External reference

Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer

10.1038/s41388-022-02368-w · 2022 · External reference

Association of MUC19 mutation with clinical benefits of anti-PD-1 inhibitors in non-small cell lung cancer

10.3389/fonc.2021.596542 · 2021 · External reference

SERPINE1 overexpression promotes malignant progression and poor prognosis of gastric cancer

2022 · External reference

SERPINE1 as an independent prognostic marker and therapeutic target for nicotine-related oral carcinoma

10.21053/ceo.2022.01480 · 2023 · External reference