Research graph
References from Understanding the characteristic behaviour of the wild-type and mutant structure of FLT3 protein by computational methods. Local targets link to admitted publications; unresolved targets remain external evidence.
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Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signalling
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FLT3 is sumoylated and localizes to the nucleus in acute myeloid leukemia
10.1182/blood-2019-127914 · 2019 · External reference
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10.1038/s41375-018-0357-9 · External reference
Impact of FLT3-ITD length on prognosis of acute myeloid leukemia
10.3324/haematol.2018.191809 · 2019 · External reference
How ITD insertion sites orchestrate the biology and disease of FLT3-ITD-Mutated acute myeloid leukemia
10.3390/cancers15112991 · 2023 · External reference
FLT3/ITD AML and the law of unintended consequences
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Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD
10.1007/s00018-017-2494-0 · 2017 · External reference
Understanding the role of activation loop mutants in drug efficacy for FLT3-ITD
2023 · External reference
Unresolved reference
2022 · External reference
A structure-based drug discovery paradigm
10.3390/ijms20112783 · 2019 · External reference
10.1016/j.neuron.2018.08.011
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Protein flexibility in the light of structural alphabets
10.3389/fmolb.2015.00020 · 2015 · External reference
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2008 · External reference
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2019 · External reference
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Unresolved reference
External reference
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Unresolved reference
External reference
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10.1002/pro.3942 · External reference
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Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML)
10.1182/blood-2004-02-0660 · 2005 · External reference
Potent inhibitor design against H1N1 swine influenza: structure-based and molecular dynamics analysis for M2 inhibitors from traditional Chinese Medicine database
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10.1002/jcc.21367 · External reference
The structural effect of FLT3 mutations at 835th position and their interaction with acute myeloid leukemia inhibitors: in silico approach
2021 · External reference
Conformational modifications induced by internal tandem duplications on the FLT3 kinase and juxtamembrane domains
10.1039/c9cp02938a · 2019 · External reference
Pattern and dynamics of FLT3 duplications
10.1021/acs.jcim.0c00544 · 2020 · External reference
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10.1111/febs.15209 · External reference
Heterogeneity in structure and dynamics of water near bilayers using TIP3P and TIP4P/2005 water models
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10.1038/s41586-021-03819-2 · External reference
10.1093/nar/gku340
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Applications of molecular dynamics simulation in protein study
10.3390/membranes12090844 · 2022 · External reference
Docking and dynamic simulation study of crizotinib and temozolomide drug with glioblastoma and NSCLC target to identify better efficacy of the drug
2021 · External reference
Structure and thermal stability of wtrop and RM6 proteins through All-Atom molecular dynamics simulations and experiments
10.3390/ijms22115931 · 2021 · External reference
Importance of fluctuating amino acid residues in folding and binding of proteins
2019 · External reference
An analysis based on molecular docking and molecular dynamics simulation study of bromelain as anti-SARS-CoV-2 variants
10.3389/fphar.2021.717757 · 2021 · External reference
A rapid solvent accessible surface area estimator for coarse grained molecular simulations
10.1002/jcc.24709 · 2017 · External reference
Application of conventional molecular dynamics simulation in evaluating the stability of apomyoglobin in urea solution
10.1038/srep44651 · 2017 · External reference
10.1371/journal.pone.0098243
10.1371/journal.pone.0098243 · External reference
Intra-protein hydrogen bonding is dynamically stabilized by electronic polarization
10.1063/1.3089723 · 2009 · External reference
10.1002/pro.2449
10.1002/pro.2449 · External reference
10.1038/nchembio.232
10.1038/nchembio.232 · External reference
Dynamozones are the most obvious sign of the evolution of conformational dynamics in HIV-1 protease
10.1038/s41598-023-40818-x · 2023 · External reference
10.1038/s41467-023-35795-8
10.1038/s41467-023-35795-8 · External reference
10.1371/journal.pcbi.1006981
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Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome
10.1182/blood-2009-03-209999 · 2009 · External reference
Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications
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