Research graph
References from Metabolic phenotypes: Molecular bridges between health homeostasis and disease imbalance. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1016/j.molmed.2025.01.016
10.1016/j.molmed.2025.01.016 · External reference
10.1038/s41392-023-01399-3
10.1038/s41392-023-01399-3 · External reference
Spatial metabolomics to unravel cellular metabolism
10.1038/s41576-025-00817-2 · 2025 · External reference
10.1016/j.jff.2024.106654
10.1016/j.jff.2024.106654 · External reference
Metabolomics Unveiled the Potential Role of N1-Acetylspermidine As a Biomarker in T-Lymphoblastic Lymphoma/Leukemia Monitoring
10.1182/blood-2023-186202 · 2023 · External reference
Metabolomic machine learning predictor for diagnosis and prognosis of gastric cancer
10.1038/s41467-024-46043-y · 2024 · External reference
Metabolomic investigation of urinary extracellular vesicles for early detection and screening of lung cancer
10.1186/s12951-023-01908-0 · 2023 · External reference
10.1021/acs.analchem.2c05807
10.1021/acs.analchem.2c05807 · External reference
Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer ' s disease brains
10.1002/alz.12800 · 2023 · External reference
Predictors of weight loss in patients with obesity treated with a Very Low-Calorie Ketogenic Diet
10.3389/fnut.2023.1058364 · 2023 · External reference
The Impact of Minimal Sunlight Exposure on Bone Health: Insights From a Cohort Study in Erythropoietic Protoporphyria
10.1210/clinem/dgae729 · 2025 · External reference
10.1016/j.cmet.2025.02.008
10.1016/j.cmet.2025.02.008 · External reference
Seed amplification assay-determined alpha-synuclein associates with Alzheimer’s pathology, clinical symptoms, and cognitive change
10.1002/alz.089741 · 2024 · External reference
Diagnostic performance RT-QuIC based detection of alpha-synuclein seeds in a clinical cohort with cognitive impairment
10.1002/alz.075515 · 2023 · External reference
10.1007/s11357-021-00382-6
10.1007/s11357-021-00382-6 · External reference
Exploring the Safety and Tolerability of IGC-AD1 in Alzheimer’s Patients: Insights from CYP2C9 Polymorphism Assessment
10.1002/alz.095385 · 2024 · External reference
Relationships between polymorphisms in EPHX2, CYP2J2, CYP2C9, and CYP2C8, white matter hyperintensities, and regional atrophy
10.1002/alz.061618 · 2023 · External reference
Gut microbiota-derived short-chain fatty acids and their role in human health and disease
10.1038/s41579-025-01183-w · 2025 · External reference
Short-chain fatty acids in diseases
10.1186/s12964-023-01219-9 · 2023 · External reference
Gut microbiota affects obesity susceptibility in mice through gut metabolites
10.3389/fmicb.2024.1343511 · 2024 · External reference
10.1021/acs.jafc.4c06392
10.1021/acs.jafc.4c06392 · External reference
Puerarin combined with Hericium erinaceus insoluble dietary fiber alleviates obesity induced by high-fat diet through regulating the glycerophospholipid metabolism pathway influenced by gut microbiota
10.1128/aem.02376-24 · 2025 · External reference
Integrative multi-omics reveals the metabolic and functional diversity of microbiomes in the gut microenvironment
10.3389/fmicb.2023.1168239 · 2023 · External reference
Decoding immune interactions of gut microbiota for understanding the mechanisms of diseases and treatment
10.3389/fmicb.2023.1238822 · 2023 · External reference
Gender Differences in Dietary Patterns and Eating Behaviours in Individuals with Obesity
10.3390/nu16234226 · 2024 · External reference
Diet Change Improves Obesity and Lipid Deposition in High-Fat Diet-Induced Mice
2023 · External reference
Association of dietary behavior patterns of middle-aged and older adults with their obesity metabolic phenotype: a cross-sectional study
10.1186/s12889-024-19781-3 · 2024 · External reference
Naringin Inhibits Macrophage Foam Cell Formation by Regulating Lipid Homeostasis and Metabolic Phenotype
2024 · External reference
Hair-straightening cosmetics containing glyoxylic acid induce crystalline nephropathy
10.1016/j.kint.2024.07.032 · 2024 · External reference
Food additives impair gut microbiota from healthy individuals and IBD patients in a colonic in vitro fermentation model
10.1016/j.foodres.2024.114157 · 2024 · External reference
Two-dimensional Health State Map to define metabolic health using separated static and dynamic homeostasis features: a proof-of-concept study
10.1093/nsr/nwae425 · 2025 · External reference
The Metabolic Switch of Physical Activity in Non-Obese Insulin Resistant Individuals
10.3390/ijms24097816 · 2023 · External reference
10.1016/j.fbio.2025.106757
10.1016/j.fbio.2025.106757 · External reference
10.1016/j.cmet.2024.03.002
10.1016/j.cmet.2024.03.002 · External reference
Circadian regulation in human white adipose tissue revealed by transcriptome and metabolic network analysis
10.1038/s41598-019-39668-3 · 2019 · External reference
Synchronous Interventions of Glucose and Mitochondrial Metabolisms for Antitumor Bioenergetic Therapy
10.1002/adma.202301099 · 2023 · External reference
Alterations of hepatic energy metabolism in murine models of obesity, diabetes and fatty liver diseases
10.1016/j.ebiom.2023.104714 · 2023 · External reference
Phenotypic and metabolomic characteristics of mouse models of metabolic associated steatohepatitis
10.1186/s40364-023-00555-9 · 2024 · External reference
Phenotypic and metabolomic characteristics of mouse models of metabolic associated steatohepatitis
10.1186/s40364-023-00555-9 · 2024 · External reference
Novel Metabolites Genetically Linked to Salt Sensitivity of Blood Pressure: Evidence from mGWAS in Chinese Population
2025 · External reference
10.1016/j.jnutbio.2024.109694
10.1016/j.jnutbio.2024.109694 · External reference
10.1016/j.jare.2024.06.018
10.1016/j.jare.2024.06.018 · External reference
10.1016/j.celrep.2023.112169
10.1016/j.celrep.2023.112169 · External reference
Comparison of Adiposomal Lipids between Obese and Non-Obese Individuals
10.3390/metabo14080464 · 2024 · External reference
lncRNA Hnscr Regulates Lipid Metabolism by Mediating Adipocyte Lipolysis
2023 · External reference
Intestinal IL-22RA1 signaling regulates intrinsic and systemic lipid and glucose metabolism to alleviate obesity-associated disorders
10.1038/s41467-024-45568-6 · 2024 · External reference
Combined Association of Plasma Metabolites with Body Mass Index and Physical Activity Level
2024 · External reference
10.1016/j.cmet.2023.06.009
10.1016/j.cmet.2023.06.009 · External reference
Ghrelin Promotes Lipid Uptake into White Adipose Tissue via Endothelial Growth Hormone Secretagogue-Receptor in Mice
10.3390/nu17010146 · 2024 · External reference
10.1016/j.metabol.2024.156049
10.1016/j.metabol.2024.156049 · External reference
Integrated Metabolomics and Proteomics to Decipher Simiao Pill Improving Lipid Homeostasis through PTGES3-mediated Arachidonic Acid Metabolism in AIA Model
10.2174/0113816128374077250410042947 · 2025 · External reference
Role of Impaired Glycolysis in Perturbations of Amino Acid Metabolism in Diabetes Mellitus
10.3390/ijms24021724 · 2023 · External reference
LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes
10.1172/jci185290 · 2024 · External reference
10.1016/j.clim.2023.109729
10.1016/j.clim.2023.109729 · External reference
Role of Impaired Glycolysis in Perturbations of Amino Acid Metabolism in Diabetes Mellitus
10.3390/ijms24021724 · 2023 · External reference
Long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice
10.1038/s41467-023-35944-z · 2023 · External reference
10.1016/j.lfs.2025.123411
10.1016/j.lfs.2025.123411 · External reference
Global burden of cardiovascular diseases: projections from 2025 to 2050
2024 · External reference
Upregulation of Hsp27 via further inhibition of histone H2A ubiquitination confers protection against myocardial ischemia/reperfusion injury by promoting glycolysis and enhancing mitochondrial function
10.1038/s41420-023-01762-x · 2023 · External reference
10.1161/hypertensionaha.123.21382
10.1161/hypertensionaha.123.21382 · External reference
10.1016/j.cmet.2024.10.016
10.1016/j.cmet.2024.10.016 · External reference
Angiotensin Regulation of Vascular Homeostasis: Exploring the Role of ROS and RAS Blockers
10.3390/ijms241512111 · 2023 · External reference
Mitochondrial Oxidative Stress Promotes Cardiac Remodeling in Myocardial Infarction through the Activation of Endoplasmic Reticulum Stress
2022 · External reference
Integrating metabolomics and proteomics to identify novel drug targets for heart failure and atrial fibrillation
10.1186/s13073-024-01395-4 · 2024 · External reference
Biomarker discovery and metabolic profiling in serum of cardiovascular disease patients with untargeted metabolomics and machine learning
10.1002/ctm2.1722 · 2024 · External reference
10.1016/j.cell.2020.02.016
10.1016/j.cell.2020.02.016 · External reference
Untargeted Lipidomic Profiling Reveals Lysophosphatidylcholine and Ceramide as Atherosclerotic Risk Factors in apolipoprotein E Knockout Mice
2023 · External reference
10.1161/circulationaha.120.047689
10.1161/circulationaha.120.047689 · External reference
Gut microbiota regulates postprandial GLP-1 response via ileal bile acid-TGR5 signaling
10.1080/19490976.2023.2274124 · 2023 · External reference
Targeting Glutamine Metabolism Transporter SLC25A22 Enhances CD8+ T-Cell Function and Anti-PD-1 Therapy Efficacy in Cervical Squamous Cell Carcinoma: Integrated Metabolomics, Transcriptomics and T-Cell-Incorporated Tumor Organoid Studies
10.1002/advs.202502225 · 2025 · External reference
Glutamine signaling specifically activates c-Myc and Mcl-1 to Facilitate cancer cell proliferation and survival
2025 · External reference
10.1016/j.celrep.2024.114633
10.1016/j.celrep.2024.114633 · External reference
DDIT3 Directs a Dual Mechanism to Balance Glycolysis and Oxidative Phosphorylation during Glutamine Deprivation
10.1002/advs.202003732 · 2021 · External reference
HuR controls glutaminase RNA metabolism
10.1038/s41467-024-49874-x · 2024 · External reference
Filament formation drives catalysis by glutaminase enzymes important in cancer progression
10.1038/s41467-024-46351-3 · 2024 · External reference
A Novel Lactate Dehydrogenase Inhibitor, 1-(Phenylseleno)-4-(Trifluoromethyl) Benzene, Suppresses Tumor Growth through Apoptotic Cell Death
10.1038/s41598-019-40617-3 · 2019 · External reference
Metabolomics strategy for diagnosing urinary tract infections
10.1038/s41467-025-57765-y · 2025 · External reference
Constructing Built-In Electric Field in Hierarchical-Flower Heterostructure for High-Performance Serum Metabolic Assay
10.1021/acs.analchem.5c01100 · 2025 · External reference
Serum metabolomics improves risk stratification for incident heart failure
10.1002/ejhf.3226 · 2024 · External reference
Labile Metabolite Profiling in Human Blood Using Phosphorus NMR Spectroscopy
10.1021/acs.analchem.3c03040 · 2023 · External reference
10.1016/j.stem.2022.10.008
10.1016/j.stem.2022.10.008 · External reference
Integrative single-cell metabolomics and phenotypic profiling reveals metabolic heterogeneity of cellular oxidation and senescence
10.1038/s41467-025-57992-3 · 2025 · External reference
10.1093/nar/gkae253
10.1093/nar/gkae253 · External reference
Assessment of XCMS Optimization Methods with Machine-Learning Performance
10.1021/acs.analchem.1c02000 · 2021 · External reference
A New Comprehensive Platform for Profile-Mode-Based Untargeted Metabolomics for Efficient Data Mining to Improve Compound Extraction and Identification
10.1021/acs.analchem.4c05768 · 2025 · External reference
AntDAS-GCMS: A New Comprehensive Data Analysis Platform for GC-MS-Based Untargeted Metabolomics with the Advantage of Addressing the Time Shift Problem
10.1021/acs.analchem.4c00100 · 2024 · External reference
MetMiner: A user-friendly pipeline for large-scale plant metabolomics data analysis
10.1111/jipb.13774 · 2024 · External reference
DA-SRN: Omics data analysis based on the sample network optimization for complex diseases
10.1016/j.compbiomed.2023.107252 · 2023 · External reference
MBROLE3: improved functional enrichment of chemical compounds for metabolomics data analysis
10.1093/nar/gkad405 · 2023 · External reference
Single cell sequencing and spatial multiomics of diabetic kidney segmentation insights zonation-specific therapeutic metabolic pathways
10.1016/j.cellin.2025.100252 · 2025 · External reference
Integrative Metabolomics and Whole Transcriptome Sequencing Reveal Role for TREM2 in Metabolism Homeostasis in Alzheimer’s Disease
10.1007/s12035-023-03840-8 · 2024 · External reference
10.1038/s41380-025-02919-z
10.1038/s41380-025-02919-z · External reference
Spatially segregated multiomics decodes metformin-mediated functional-specific metabolic characteristics in diabetic kidney disease
10.1093/lifemeta/loaf019 · 2025 · External reference
Ethanolamine as a biomarker and biomarker-based therapy for diabetic retinopathy in glucose-well-controlled diabetic patients
10.1016/j.scib.2023.12.053 · 2024 · External reference
10.1016/j.jfutfo.2025.09.020
10.1016/j.jfutfo.2025.09.020 · External reference
Integrated Omics Reveal Dendrobium nobile Lindl.'s Anti-Diabetic Mechanisms via Arginine/Proline and Glycerophospholipid Pathways
10.3390/ph18071061 · 2025 · External reference
Discovery of plasma biomarkers for Parkinson's disease diagnoses based on metabolomics and lipidomics
10.1016/j.cclet.2024.109653 · 2024 · External reference
10.1002/fft2.70107
10.1002/fft2.70107 · External reference
10.1038/s43856-025-01152-7
10.1038/s43856-025-01152-7 · External reference
Diagnosing, Typing, and Staging of Renal Cell Carcinoma by Designer Matrix-Based Urinary Metabolic Analysis
10.1021/acs.analchem.2c01563 · 2022 · External reference
Multimodal single-cell analyses reveal molecular markers of neuronal senescence in human drug-resistant epilepsy
2025 · External reference
Immunological biomarkers of response and resistance to treatment with cabozantinib and nivolumab in recurrent endometrial cancer
10.1136/jitc-2024-010541 · 2025 · External reference
10.1007/s10120-021-01267-5
10.1007/s10120-021-01267-5 · External reference
Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases
10.1038/s41591-022-02122-5 · 2023 · External reference
Effects of Genetic Polymorphisms of Drug Metabolizing Enzymes and co-Medications on Tamoxifen Metabolism in Black South African Women with Breast Cancer
10.1002/cpt.2904 · 2023 · External reference
Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes
2025 · External reference
Polyphenol-based pH-responsive nanoparticles enhance chemo-immunotherapy in pancreatic cancer
10.1016/j.jconrel.2025.02.021 · 2025 · External reference
10.1021/acs.nanolett.5c01811
10.1021/acs.nanolett.5c01811 · External reference
Ubiquinol-mediated suppression of mitochondria-associated ferroptosis is a targetable function of lactate dehydrogenase B in cancer
10.1038/s41467-025-57906-3 · 2025 · External reference
10.1038/s43018-024-00811-3
10.1038/s43018-024-00811-3 · External reference
Paeonia x suffruticosa Andrews leaf extract and its main component apigenin 7-O-glucoside ameliorate hyperuricemia by inhibiting xanthine oxidase activity and regulating renal urate transporters
10.1016/j.phymed.2023.154957 · 2023 · External reference
Discovery of a Potent and Orally Bioavailable Xanthine Oxidase/Urate Transporter 1 Dual Inhibitor as a Potential Treatment for Hyperuricemia and Gout
10.1021/acs.jmedchem.4c01480 · 2024 · External reference
10.1016/j.cell.2025.01.015
10.1016/j.cell.2025.01.015 · External reference
Hyperglycemia Aggravates 6-Hydroxydopamine-Induced Neuronal Ferroptosis via SLC7A11-Dependent Pathway in Diabetic PD Rat Model
10.1111/cns.70487 · 2025 · External reference
The role of SLC19A2 variants in the wide spectrum of non-autoimmune abnormalities of glucose homeostasis
10.1007/s00125-025-06485-5 · 2025 · External reference
Empagliflozin Normalizes Fasting Hyperglycemia and Improves Postprandial Glucose Tolerance in Totally Pancreatectomized Patients: A Randomized, Double-Blind, Placebo-Controlled Crossover Study
10.2337/dc23-0645 · 2024 · External reference
